... other OF 80 Event Times (1) 70 0.8 Event Times (2) 60 PaO2/FiO2 ratio (kPa) Cumulative survival ARF + OF 0.6 ARF + OF Event Times (3) ARF + OF 0.4 Event Times (4) ARF + or OF 0.2 50 40 30 20 Event ... failure (SOFA score or 4) during the ICU stay Because ofthe small number of patients, no further subdivisions of ARF and selected organ failure were evaluated This left us with six groups of patients: ... because ofthe small number of patients staying more than week in the ICU Likewise, we could not find any differences in outcome depending on the time of first occurrence of ARF Key messages • ARF is...
... during the course ofthe processing ofthe primary transcripts [9] At the peptide level, the CfiT transition, which leads to a Ser66 fi Leu66 substitution, gives rise to the loss of two ofthe five ... exon (TTGA instead of TCGA) To discriminate between the M and the F alleles, we took advantage ofthe presence of an 11-bp insertion in intron ofthe F allele, whichis lacking in the M allele Thus, ... the 9th exon ofthe A allele, whichis deleted in the F allele, is mutated to T in the M allele, giving rise to a Ser fi Leu substitution Analysis ofthe intronic flanking sequences The flanking...
... far as this is distinguishable from the other wound; further, of feelings of enmity against the successful rival, and of a greater or lesser amount of self-criticism which tries to hold the subject's ... be selfish and base, even though they should be persuaded that the fool, the dunce, or the rascal is better satisfied with his lot than they are with theirs They would not resign what they possess ... purpose (say the reflex of crying when the surface ofthe eye is irritated, or the secretion of tears in response to the violent contraction ofthe muscles around the eyes), these mechanisms will...
... issues are how the authorities determine what is considered traditional and how farmers are affected by these decisions (or rather lack of decisions) This paper provides two examples of how the ... saving the breed, which was by then close to extinction The rapid development of new technologies was another important factor in the rationalisation of agriculture For example, the expansion of ... However, there are farmers who would rather stop farming altogether than sell their milk cows The reason for this attitude is presumably the special bond that exists between farmers and their animals...
... yet to explore the precise mechanism of how this is achieved, but it is likely to reflect the imbalance between aggrecan synthesis/retention and aggrecan degradation The balance is more likely ... that ofthe collagen turnover In the current experiments, this is best visualized by the nanogram quantities of pro-collagen epitopes compared with the microgram quantities of S-GAG and the aggrecanase-generated ... cutting ofthe cartilage may induce alternative metabolism This may influence the cartilage metabolism and thereby allow for skewed interpretations ofthe turnover compared with that ofthe in...
... had full access to all ofthe study data and takes responsibility for the integrity ofthe data and the accuracy ofthe data analysis Both authors contributed equally to the study Study concept ... deep incision SSIs and 26 (2.5%) organ/space SSIs The intraoperative and postoperative PaO values were not associated with an increased risk of SSI either by univariate or multivariate analysis (Table ... patients is not related to SSI rate The strategy of administering supplemental inspired oxygen to reduce the incidence of SSIs does not appear to be clinically useful Author details Departament of...
... were able to confirm these results Nevertheless, they found the missense I157T mutation in 4.1% ofthe cases In this study, the incidence of this variant within the Page of tumor group did not ... showed the presence ofthe 1100delC variant Discussion None ofthe investigated 91 patients with SCCHN carried the CHK2 1100delC variant The incidence of 1100delC in the population ofthe state ... KS performed most ofthe sequencing, isolated DNA, organized the study and wrote most parts ofthe article GP collected the patient’s samples and isolated DNA MW wrote parts ofthe article, collected...
... clinical supervision to AM and isthe responsible clinician for the patient group IBC supervised the data analysis, co- supervised AM during the project and during the preparation ofthe initial ... aware ofthe risks of methadone to children In this case this was 47.7% ofthe sample population The performance on criteria to measured against the defined standards are shown in table Page of ... pharmacists report that methadone is always dispensed with child resistant caps on This was the only criterion that reached a 100% standard The provision of measuring devices When the methadone is...
... by assessing the requirements for restoration ofthe activity ofthe mutant Results The intracellular localization of Rev and mutants The intracellular distribution ofthe M4 and the M4 derived ... can be exposed while the complex is tethered to RNA via other basic domains Alternatively, the addition of extra sequences may have stabilized the structure ofthe otherwise unstable monomeric ... 61 The numbers represent the mean value of three or more independent experiments related to the activity of wild type Rev, the negative control and the amount of cellular protein Discussion The...
... appears, rather than struggle to cure the patients after fulfilling the ALF criteria Of course, a new strategy is required to prevent the progression ofthe disease The difficulty in predicting the ... prognosis of ALF is mainly attributable to incomplete elucidation of its mechanism The most characteristic pathological finding of ALF is massive necrosis without regeneration, which implies the ... rapid decrease of LDH than ALT activity This phenomenon is convincing because the half-life of serum LDH is normally much shorter than that of serum ALT On the other hand, in the fatal patients...
... has published several mon- Part ofthe article was presented by one ofthe authors (KC) at the Regulatory Workshop Discussion Session ofthe 7th Meeting ofthe Consortium for Globalization of Chinese ... provided [28] Thai Herbal Pharmacopoeia is published by the subcommittee on the establishment ofthe Thai Herbal Pharmacopoeia under the supervision ofthe Thai Pharmacopoeia Committee [29] Thai ... of Health, Hong Kong, China Pharmaceutical Affairs, Japan Thai Food and Drug Administration, Thailand British Pharmacopoeia Commission, UK USA Unofficial Official Official Official Official Official...
... used and the process of comparison between the two definition schemes (RIFLE and AKIN) in various patient populations is not yet complete Further validation is required and modifications in the definition ... criteria These discrepancies can be expected to be found in other patient populations when non-uniform methods of determining RIFLE criteria are utilized Our findings may assist in interpretation of ... interpretation of other clinical studies Recently the RIFLE criteria have been modified by the Acute Kidney Injury Network (AKIN) [4], and the change in eGFR is no longer included in this consensus...
... neutrophils The onset of sepsis was defined, as recommended by the Consensus Conference [27], as the day on whichthe site of infection was identified The final diagnosis of sepsis was retrospectively ... slope of mHLA-DR of less than 1.2 was independently associated with the risk of developing sepsis, a finding that reflects the possible pivotal role of immune dysfunction in the increased risk of ... of carbon dioxide (PaCO2) of less than 32 mm Hg (less than 4.3 kPa), and (d) a white blood cell count of greater than 12,000 cells/mm or of less than 4,000 cells/mm3 or the presence of more than...
... information JŠ is a head ofthe Czech Society of Emergency and Disaster Medicine VČ is a national representative ofthe European Society of Intensive Care Medicine, a head ofthe Czech Society of Intensive ... Patients in the two groups did not differ in the in-hospital markers ofthe severity of post-cardiac arrest syndrome, in the intensity of organ-supporting therapy, or in the number of patients ... Effectiveness), which showed in the subgroup analysis the improvement of prognosis of OHCA patients by pre-hospital intranasal intra-arrest cooling Mostly, the studies analyzed the pre-hospital induction of...
... apart the contributions of individual members ofthe CLAVATA1 (CLV1), CLAVATA3 (CLV3), POLTERGEIST and REVOLUTA gene families in Arabidopsis A key result was the characterization ofthe ability of ... and backcrossed into susceptible cultivars The presence ofthe resistance gene makes the resistant plant less attractive to aphid infestation The resistance segregates as a single dominant gene, ... identities Steven Clark (University of Michigan, Ann Arbor, USA) described studies into how stem-cell populations are maintained in the apical meristem, the growing point of a plant shoot These focused...
... atoms in the aromatic ring of tyrosine with the neighbouring residues would be altered or abolished This could result in loosening ofthe stability ofthe structure in this part ofthe monomer ... increase in the amount of insoluble protein Because this is a dynamic process we cannot say from these experiments whether the increased temperature destabilizes the structure ofthe monomers, thereby ... increased thermal stability at the higher concentration and a further elevation ofthe concentration (0.33 mgÆmL)1; Fig 2B) further enhances the thermal stability likewise At the same time, the differences...
... one At this rate nobody would take it; and it dropped silently out of circulation The history ofthe American paper money, isthe history ofthe French Assignats; it isthe history ofthe government ... to the winding up ofthe First Bank ofthe United States, to the non-existence of a national bank These things followed the winding up ofthe Bank, therefore they were produced by it This is ... during the close of 1833 and the beginning of 1834 This event is commonly known as the Panic of 1833 34 The history of this panic whichis at once curious, instructive and entertaining, has hitherto...