pharmacology pharmacokinetics and safety of recombinant human erythropoietin preparations
Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
... platelet count of 9.2 × 104/μL, PT of 37% (PT-INR 1.78), T-Bil level of 11.7 mg/dL, ALT level of 260 IU/L, and serum albumin level of 2.9 g/dL Serum HGF and AFP levels were 1.07 and 3.9 ng/mL, ... points The primary endpoint of interest was the safety of repeated doses of intravenous rh-HGF, which was evaluated on the basis of the occurrence, frequency, and severity of adverse events All patients ... intravenously for 14 days, and urinary excretion of albumin and protein was measured before (day 1), during (days and 14), and and 14 days after HGF administration Repeated doses of rh-HGF induced an...
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Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
... providing lead candidates for the treatment of Type diabetes [23] In order to examine the mechanism of action of this class of inhibitors, 3, 5, the stereoisomers of salacinol 6, [25], and the six-membered ... four-carbon chain of salacinol and the seven-carbon chain of kotalanol Fig Schematic diagram of MGA protein organization and expression construct Amino acid boundaries of each of the domains comprising ... blintol inhibited 50% of MGA activity, and the chain extended analogues (13–15) inhibited 88%, 91%, and 90% of MGA activity, respectively, when tested at lm 2676 Expression of active recombinant MGAnt...
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Báo cáo khoa học: Pressure and heat inactivation of recombinant human acetylcholinesterase Importance of residue E202 for enzyme stability pdf
... D74N and E202Q, allowing flexibility of the gorge for entrance and binding of substrates or inhibitors and exit of reaction products The carboxylic groups of E202 and E450, the hydroxyl group of ... in the active site gorges of TcAChE and HuAChE is evidence for the importance of water in the structure of AChE The structure and number of water molecules in the gorge and bound to the enzyme ... terms of hydration change of carboxylic residues present in the active site gorge of HuAChE As the X-ray crystal structures of TcAChE [19] and HuAChE [56] revealed, the conserved position of water...
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Báo cáo Y học: Purification and biochemical characterization of some of the properties of recombinant human kynureninase pptx
... assay [13] Recombinant human kynureninase from the final anion-exchange step was assayed for purity using both SDS/PAGE and MALDITOF MS of the whole protein Both purified and crude samples of recombinant ... FEBS 2002 Recombinant human kynureninase (Eur J Biochem 269) 2071 tryptic mass fingerprint obtained by matrix-assisted laser desorption ionization time -of- flight (MALDI-TOF) MS of a band of the expected ... (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408, 5–10 Koushik, S.V., Sundararaju, B & Phillips, R.S (1997) Cloning, sequence and expression of kynureninase...
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Báo cáo y học: "Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up" ppt
... management of the study and GM undertook patient care and management NI, AH, SW and JD carried out laboratory work, collected and analysed the data and conducted the transfer and interpretation of the ... removal of, HAART [13] The success of immune-based therapies will depend on full restoration of numbers and function of the CD4+ helper T lymphocytes (HTL), antigen presenting cells (APC) and CD8+ ... (purple) received alternate day dosing of rhGH and group C (blue) received twice weekly dosing of rhGH Significant p values of
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Báo cáo khoa học: " A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care" pot
... enrolment, and participated in writing and revising of the manuscript AGD provided statistical analysis of results and interpretation, and participated in the writing and revising of the manuscript ... failure and admission diagnosis), process of care variables (concomitant medications, procedures and so on) and outcomes (ICU mortality, length of stay, duration of mechanical ventilation and hospital ... assisted in co-ordination of the study, and participated in writing and revising of the manuscript RSF participated in patient enrolment, and participated in writing and revising of the manuscript CMM...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... to the function and structure of TFs from available information From a structural point of view, the overabundance of self-interactions is associated with a majority group of 55% of basic helix–loop– ... with the exception of some TAFII and NC2 and NF-Y factors that have histone fold motifs [52] Group G is a small subset that contains all the SMAD proteins of the HTFN and APC and b-catenin-related ... cycle and DNA repair-related factors (p53 and its direct interactors, and BCRA) It is noteworthy that it contains the structural and functional E2F ⁄ pRB pathway, which is made of a group of fork-head...
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Báo cáo khoa học: Identification and characterization of oxidized human serum albumin A slight structural change impairs its ligand-binding and antioxidant functions pptx
... L(small)-Trp as an endogenous ligand which binds to site II, and of cefazolin (site I-ligand) and verapamil (site I and II-ligand) as exogenous ligands All these ligands are known for their high ... fragment of HSA N, nonoxidized HSA; H, highly oxidized HSA (B) Densitometric analysis of intensities of undigested HSA Changes in intensities of HSA bands relative to the band of starting point of ... prepared standard forms of nonoxidized HSA and oxidized HSA, using purified HSA from healthy human plasma The identities of prepared HSA samples were confirmed by LC-ESI-TOFMS (Fig 1) and FTMS analysis...
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Báo cáo Y học: Expression and characterization of recombinant vitamin K-dependent c-glutamyl carboxylase from an invertebrate, Conus textile doc
... proprothrombin), proFIX18 (residues )18 to )1 of proFactor IX), proFIX28 (residues )18 to +10 of proFactor IX), pro-e-TxIX/12 (residues )12 to )1 of e-TxIX precursor), e-TxIX12 (residues 1–12 of e-TxIX), ... of either the recombinant Conus carboxylase or the recombinant bovine carboxylase, and monitored carboxylation of FLEEL or e-TxIX12 as a function of propeptide concentration The effect of proFIX18 ... the human propeptides To compare the potency of the effect of these propeptides on the recombinant Conus carboxylase and recombinant bovine carboxylase, we added increasing concentrations of these...
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Báo cáo khoa học: Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2¢ of substrates pdf
... FEBS M K Andersson et al P2¢ specificity of the human mast cell chymase Results Production and purification of recombinant HC mutants Two single mutants of HC, Arg143 fi Gln and Lys192 fi Met, and a ... amino acid of Fig Analysis of cleavage specificity by the use of new types of recombinant protein substrate (A) The overall structure of the recombinant protein substrates used for analysis of the ... use of two unique restriction sites, one BamHI site and one SalI site, which are indicated at the bottom of (A) (B, D) The cleavage of a number of substrates by HC The names and sequences of the...
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Báo cáo khoa học: Expression and characterization of recombinant 2¢,5¢-oligoadenylate synthetase from the marine sponge Geodia cydonium ppt
... Experimental procedures of the porcine 2-5A synthetase (data not shown) Figure demonstrates the results of the purification of the recombinant proteins The occurrence of dominant bands of the recombinant ... evidence of a high degree of purification obtained by affinity chromatography Additionally, some fainter bands of higher and lower molecular weight could be seen in the preparations (Fig 1A) Bands of ... Expression and purification of the recombinant 2-5A synthetase from G cydonium Expression and purification of the porcine recombinant 2-5A synthetase N-terminally 6xHis-tagged construct The recombinant...
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Báo cáo Y học: Puri®cation and characterization of the human adenosine A2a receptor functionally expressed in Escherichia coli doc
... buer NiA and NiB; s, 0.2% CHS in solubilization buer and 0.02% in buers NiA and NiB The quanti®cation of interactions with speci®c ligands allows the structural integrity and homogeneity of a puri®ed ... assuming two binding sites (®ve out of six experiments) with a Kd1 value of 0.10 0.03 nM (44 5% of binding sites) and a Kd2 value of 1.42 0.47 nM (56 5% of binding sites) (Fig 6A) However, ... functions and is appropriate for structural and biophysical investigations Comparison of the aminoacid sequences of adenosine receptors with those of other GPCRs indicates that the C-terminus of the...
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QUALITY AND SAFETY OF ORGANIC PRODUCTS pdf
... Comparison of resveratrol content of Swiss wines from organic and integrated viticulture (1997 grape harvest).55 Dossier Quality and Safety of Organic Products Secondary metabolite content of organic and ... variety of direct parameters such as loss of water and substance, accumulation of harmful substances and microorganisms, and physiological parameters such as respiration, and enzymatic, defence and ... biodiversity and landscape, soil, water, climate and air, and also to energy consumption In short, organic is better for people, animals and the environment 22 Quality and Safety of Organic Products...
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.Paleontology and Geology of Laetoli: Human Evolution in Context.Vertebrate Paleobiology and Paleoanthropology SeriesEdited by Eric DelsonVertebrate Paleontology, American Museum of Natural History, New York, NY 10024, USA delson@amnh.orgEric J. Sar pdf
... Noiti suggests that woodlands and forest covered the lower slopes of the volcanic highlands to the east of Laetoli, and that a mosaic of woodland, bushland and wooded grasslands occurred more distally ... mosaic of closed woodland, open woodland, shrubland and grassland It was certainly more densely wooded than the modern-day Laetoli ecosystem, which is dominated by grassland and open woodland (Andrews ... This network of watercourses would have supported a complex vegetational mosaic, including dense stands of riverine woodland and bushland (Ditchfield and Harrison 2011) Ephemeral ponds and small...
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Báo cáo sinh học: " Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes" docx
... amplification of plasmid T3 and the recombinant one (lanes and 4, respectively); RT-PCR on RNA of YF17D/E200T3 and YF17D/Esa/5.1glic 2P viruses without and with the EGFP cassete (lanes and 6, respectively) ... were scraped off and lysed under nondenaturing conditions in the presence of the same protease inhibitors The volume of 250 µL of cell extracts and mL of the cell culture supernatant of each sample ... independent series of serial passages (at MOI of 0.02); P1 and P2 were analyzed by RT-PCR and flow citometry at passages and 10 and are represented in all panels as 5P1, 10P1, 5P2 and 10P2 In these...
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Báo cáo hóa học: " Construction and characterization of recombinant flaviviruses bearing insertions between E and NS1 genes" pdf
... amplification of plasmid T3 and the recombinant one (lanes and 4, respectively); RT-PCR on RNA of YF17D/E200T3 and YF17D/Esa/5.1glic 2P viruses without and with the EGFP cassete (lanes and 6, respectively) ... were scraped off and lysed under nondenaturing conditions in the presence of the same protease inhibitors The volume of 250 µL of cell extracts and mL of the cell culture supernatant of each sample ... independent series of serial passages (at MOI of 0.02); P1 and P2 were analyzed by RT-PCR and flow citometry at passages and 10 and are represented in all panels as 5P1, 10P1, 5P2 and 10P2 In these...
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Báo cáo hóa học: " Bacterial-based systems for expression and purification of recombinant Lassa virus proteins of immunological relevance" doc
... interests Luis M Branco, Alex Matschiner, and Darryl B Sampey are co-founders and sole members of the Board of Directors of BioFactura, Inc., and have received salary and other compensation from the company, ... 0.2 g/L of uridine, g/L of glucose, 0.372 mL/L of Dawes Trace 1, 2.14 mL/L of Dawes Trace 2, 0.072 mL/L of Dawes Trace 3, 0.606 mL/L of M calcium chloride dihydrate (CaCl2-2H2O), 0.30 mL/L of 0.43 ... instructions (New England BioLabs) The addition of dithiothreitol (DTT) was necessary to prevent aggregation and precipitation of protein before and during Factor Xa cleavage of LASV GP1-MBP and GP2-MBP...
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Báo cáo hóa học: " Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins" potx
... complex and assembled into a particulate structure in the absence of genomic RNA Figure Assembly of VLPs by expression of RVFV N and Gc proteins Assembly of VLPs by expression of RVFV N and Gc ... purification of proteins and VLPs, and EM studies CC carried out cell surface expression and cell to cell fusion studies PR contributed in the coordination and design of the study and helped in ... Morikawa S, Bishop DH: Sequences and coding strategies of the S RNAs of Toscana and Rift Valley fever viruses compared to those of Punta Toro, Sicilian Sandfly fever, and Uukuniemi viruses Virology...
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báo cáo hóa học:" Effectiveness and Safety of Generic Fixed-Dose Combination of Tenofovir/Emtricitabine/Efavirenz in HIV-1-Infected Patients in Western India" doc
... However, there are no data on the effectiveness and safety of this combination We assessed virologic, immunologic, and clinical benefits and safety of this combination in HIV-infected Indian patients ... developed IRIS on TDF/FTC/EFV (8 cases of tuberculosis, of cytomegalovirus vitreitis, of hepatitis B virus, of Pneumocystis jiroveci pneumonia, of herpes zoster, and of cryptococcal meningitis) One ... months of initiation of ART Toxicity was graded according the system mentioned in the WHO ART scale-up guidelines (modified from the grading system of Division of AIDS, National Institute of Allergic...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25