pathways and rates for structural transformations of peptides and proteins
Báo cáo khoa học: Flavogenomics – a genomic and structural view of flavin-dependent proteins potx
... distribution, and their structural topologies, we have assembled a list of flavoproteins and searched for the encoding sequences in a selection of genomes In addition, structural information on flavoproteins ... amounting to 10% of the total entries ( 1800 entries; 640 for FMN-utilizing proteins and 1160 for FAD-utilizing proteins) Analysis of the structural classification for FMN-dependent proteins reveals ... conducted to link the list of flavoproteins to the available structural information The current list of flavoproteins contains 276 fully classified enzymes and 98 entries for enzymes with no or incomplete...
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Báo cáo khoa học: Flavogenomics – a genomic and structural view of flavin-dependent proteins ppt
... distribution, and their structural topologies, we have assembled a list of flavoproteins and searched for the encoding sequences in a selection of genomes In addition, structural information on flavoproteins ... amounting to 10% of the total entries ( 1800 entries; 640 for FMN-utilizing proteins and 1160 for FAD-utilizing proteins) Analysis of the structural classification for FMN-dependent proteins reveals ... conducted to link the list of flavoproteins to the available structural information The current list of flavoproteins contains 276 fully classified enzymes and 98 entries for enzymes with no or incomplete...
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Báo cáo y học: "Sequence and structural analysis of BTB domain proteins" pps
... B1 to B3 for the three conserved β-strands, and A1 to A5 for the five α-helices Many families of BTB proteins are of the 'long form', with an amino-terminal extension of α1 and β1 Skp1 proteins ... BTB-ZF and BBK proteins in the vertebrates; the MATH-BTB proteins in the worm; the BTB-NPH3 proteins in the plant; the Skp1 proteins in the plant and worm; and the T1 proteins in worm and vertebrates ... Stogios et al of this fold An earlier study [30] is consistent with many of the results presented here, and we contribute an expanded structure and genome-centric analysis of BTB domain proteins, ...
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guide for structural maintenance of parking structures
... taken and a variety of tests performed The most important tests are those that determine the extent of corrosion and bond loss of the reinforcement and those that quantify the amount and extent of ... restore, and enhance structural members and improve or enhance protective functions of various waterproofing and anticorrosion systems See ACI 201.1R, 222R, and 224R for additional information ... supported deck slabs and underlying structural frame elements The most common cause for deterioration of deck slabs and surfaces is the penetration of water and deicing chemicals into and through the...
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Tiêu chuẩn thiết kế bê tông cốt thép Mỹ ACI 318M 2014 (Building code requirements for structural use of concrete ACI 318M 2014)
... A615/A615M-14Standard Specification for Deformed and Plain Carbon-Steel Bars for Concrete Reinforcement A706/A706M-14Standard Specification for Deformed and Plain Low-Alloy Steel Bars for Concrete Reinforcement ... Specification for Structural Steel Shapes A996/A996M-14Standard Specification for Rail-Steel and Axle-Steel Deformed Bars for Concrete Reinforcement A1022/A1022M-14Standard Specification for Deformed and ... Wire Reinforcement, Plain and Deformed, for Concrete A1064/A1064M-13Standard Specification for CarbonSteel Wire and Welded Wire Reinforcement, Plain and Deformed, for Concrete A1085-13Standard...
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Tài liệu Báo cáo khoa học: Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc docx
... 20,23-dihydroxyvitamin D3 (A) Expansion of proton–proton COSY correlations for 3-CH and 23-CH; (B) expansion of proton–proton TOCSY correlations for 3-CH and 23-CH; (C) expansion of proton–carbon HSQC showing ... C20 and C22 [1,14] Another difference between the metabolism of vitamin D3 and cholesterol by P450scc is that the dissociation of intermediates occurs for the metabolism of vitamin D3, but not for ... production of biologically active derivatives with potential physiological and therapeutic implications The present study aimed to determine the pathways for the metabolism of vitamin D3 by P450scc and...
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Forecasting UK GDP growth, inflation and interest rates under structural change: a comparison of models with time-varying parameters potx
... distinguish between the forecasting performance of an AR(1) model and that of a TVP-VAR (standard) (and hence white cells on the right-hand side of Table C) Note also that allowing for heteroscedastic ... right-hand side offers an alternative evaluation of the forecasting performance in terms of the Diebold and Mariano (1995) test As for the RMSE, green indicates that these models outperform the ... our paper compares the forecast performance of a much wider range of models with time-varying parameters In particular, we compare the forecasting performance of (a range of) regime-switching models,...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... hydrophilicity, lack of structure and associated flexibility are essential for the solubilizing role of the extension in the sHsp and complexation of the sHsp with target proteins The unstructured and highly ... unstructured and solvent exposed, and therefore able to perform its solubilizing role in the sHsp and in the complexes formed with target proteins during chaperone action Indeed, the presence of significant ... rate of °CÆmin)1 Wild-type Hsp25 and Q194A remained in solution up to temperatures of 100 °C By contrast, the E190A, E199A and E204A mutants precipitated out of solution within °C of the onset of...
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Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf
... cluster encodes functions for synthesis and export of A-band O polysaccharide [21,22], and contains genes for the expression of GMD and RMD homologs, gmd (originally called gca) and rmd, respectively ... integration of the anomeric signals, the 4-keto and gem-diol forms of this compound coexist in equilibrium at an approximately : ratio Full assignment of the NMR spectra of compounds B and C and measurement ... aqua and light sand, respectively; the APPR portion of the cofactor (dark gray) and the ligand analog GDP-DMan (light gray) are represented as space-filling models Termini and secondary structural...
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Báo cáo khoa học: Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition pptx
... binding of the substrates The r.m.s.d of Ca atoms after superposition of the catalytic domains in complex with different substrates and the catalytic domain of the apo-enzyme The binding of the ... Europe and Switzerland (SCOPES) program of the Swiss National Science Foundation (SNSF), the Ministry of Science, Education and Sports of the Republic of Croatia (project 119-0982913-1358), and ... structures of ThrRS in complex with the cognate tRNA Because of the similar size of the motif loop in methanogenic-type SerRS and ThrRS and the involvement of zinc ions in the recognition of amino...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations J Mol Biol 255, 494–506 Wuthrich, K (1986) NMR of Proteins and Nucleic ... extended side chains of Arg16 and Glu20, as well as those of His13 and Glu17, are oriented towards the same direction and are relatively close The Oe1 and Oe2 atoms of Glu20 are 3.726 ˚ and 1.983 A, ... CaH shift values and the corresponding random coil values is presented in Fig 2B (lower panel) and provides strong evidence for the conformational preference of the majority of amino acids towards...
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SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures ppt
... (for proteins whose structure is essentially formed by a-helices), (2) all beta (for those whose structure is essentially formed by b-sheets), (3) alpha and beta (for proteins with a-helices and ... The unit of classification is usually the protein domain Small proteins, and most of those of medium size, have a single domain and are, therefore, treated as a whole The domains in large proteins ... in size and conformation and, in the more divergent cases, these differing regions may form half or more of each structure For proteins placed together in the same fold category, the structural...
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Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot
... in Table and Fig 4A For the cluster of lowest energy, both the position and the conformation of the ligand are close to those observed in the 3D structure of the complex between DPP-IV and valine-pyrrolidide ... stabilization of the substrate in the active site (Stb1 and Stb2); those forming the oxyanion hole (Oxa1 and Oxa2); and those responsible for the exopeptidase specificity ˚ (Exo1 and Exo2) For each ... site of the crystalline structure of PepX from L lactis; and 4, docked into the active site of the modeled structure of PepX from S gordonii c B C D 2055 Sites for the design of inhibitors of PepX...
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Báo cáo y học: "κ The roles of the classical and alternative nuclear factor-κB pathways: potential implications for autoimmunity and rheumatoid arthritis" ppsx
... role and in thymic stromal cells in the form of RelB [33] κ Nuclear factor-κB and immune tolerance Both classical and alternative pathways of NF-κB activation are involved in the control of autoimmune ... lymph nodes and spleen) Several authors have shown that NF-κB is required for the development of mTECs and organization of the thymic stroma, and the development and differentiation of DCs [38-43] ... needed for B-cell maturation and for protection of otherwise negatively selected B cells It is also needed for plasma cell differentiation and survival, and it is these cells that are responsible for...
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Báo cáo y học: "The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis" pps
... laboratories of several members of the Committee for the Standardization of Autoantibodies in Rheumatic and Related Diseases, using the same substrate and using kits commercially available in Europe, and ... available for comparative diagnostic studies The use of a universal set of RA patients and control sera will allow a direct comparison of the diagnostic performance of current tests and those ... the predictive accuracy for the rate of joint destruction [17] Similar results were reported by Dejaco and colleagues [36], Page of Majka and colleagues [46], and Syversen and colleagues [47] It...
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Báo cáo y học: "Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease" pot
... the GOTree In GOTree, O stands for observed gene number in the category; E for expected gene number in the category; R for ratio of enrichment for the category; and P for p value calculated from ... out and candidate DE genes with >2-fold change and B-statistic > were identified for each comparison The number of DE genes identified in each comparison is listed in Table and the list of DE ... number in the category; E for expected gene number in the category; R for ratio of enrichment for the category; and P for p value calculated from the statistical test given for the categories with...
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Báo cáo y học: "Review Native aggregation as a cause of origin of temporary cellular structures needed for all forms of cellular activity, signaling and transformations" ppsx
... a cause of origin of temporary cellular structures needed for all forms of cellular activity, signaling and transformations Theoretical Biology and Medical Modelling 2010, 7:19 Page 22 of 22 ... definitions, for the denaturation of natively folded (globular) proteins and for natively unfolded proteins A key notion in physiology is the resting state of the cell This is implicit in the concept of ... compartments, and structures, and activation of proteins is of a threshold rather than a spontaneous character The meaning of the proposed hypothesis of native aggregation is that the primary cause of any...
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Báo cáo y học: "Kappa-alpha plot derived structural alphabet and BLOSUM-like substitution matrix for rapid search of protein structure database" ppsx
... database and the SASM matrix improve the ability of BLAST to search for structural homology of a query sequence to a known protein structure or a family of proteins This tool searches for the structural ... 2): helix letters (A, Y, B, C, and D), helix-like letters (G, I, and L), strand letters (E, F, and H), strand-like letters (K and N), and others The 3D shapes of representative segments in the ... conformations of the five main classes of the 23-state structural alphabet, including helix letter (A, Y, B, C, and D), helix-like letters (G, I, and L), strand letters (E, F, and H), strand-like...
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IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE
... grateful to you for believing in me and letting me pursue my dreams The person I am today is because of you To my dear uncle and my aunt Khem Kandel and Laxmi Kandel: your support and friendship ... (GxxxxG) and are necessary for cofactor binding Also, residues Lys192, Glu399 and Phe401 are important for proper cofactor positioning and, thus, impact catalysis Crystal structures of mammalian ... chemotherapeutic agent and in the mobilization and conditioning regimens for blood and marrow transplantation Reviewing the chemistry and pharmacology of cyclophosphamide is crucial for understanding its...
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guide for the use of preplaced aggregate concrete for structural and mass concrete applications
... Requirements for Reinforced 318 Concrete 347R Guide for Formwork for Concrete ASTM Specification for Concrete Aggregate Test Method for Obtaining and Testing Drilled Cores and Sawed Beams of Concrete ... proportions are rounded off to whole bags of cement and pozzolan, cubic feet of sand (damp and loose) measured in cubic foot boxes, and gallons of water A typical mixture for a small routine bridge ... Practice for Making Test Cylinders and Prisms for Determining Strength and Density of Preplaced-Aggregate Concrete in the Laboratory C 953 Test Method for Time of Setting of Grouts for Preplaced-Aggregate...
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