pacap vip and associated receptors signaling in the lut
Tài liệu Bank Credit - A Study of the Principles and Factors Underlying Advances Made by Banks to Borrowers docx
... consider in detail the nature of the process involved in the manufacture of bank credit, the relation of loans to other magnitudes in the balance sheet in both individual and collective banking, the ... the borrowing concern the floating of paper continuously in the market is almost tantamount to the issue and sale of bonds From the standpoint of the banking system the floating of such paper is ... equilibration of demand for and supply of the purchasing power that banks make it their business to lend The accepting bank buttresses the credit standing of the drawer, who then secures the funds desired...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
... of these genes Interestingly, the amino-terminal region of chicken HSF1 containing an alanine-rich sequence and the DNA-binding domain is sufficient to cause the functional difference between the ... activation domain during evolution Domains of mouse HSF3 were swapped with the corresponding domains of chicken HSF3, and the chimeras possessing the chicken HSF3 activation domain induced the expression ... Importantly, chicken HSF1 and mouse HSF3 are involved in protecting cells from heat shock and in maintaining protein homeostasis without inducing the expression of the classical heat shock genes...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... partners of Grb14 involved in insulin signaling have been identified: (a) protein kinase Cf interacting protein (ZIP), an adaptor protein that binds to the PIR domain of Grb14 and mediates the assembly ... residues of the IR kinase loop, which help position the PIR–BPS and increase binding affinity [8] Although the interaction of Grb14 with the IR is probably the major determinant of the insulin-induced ... declined more slowly, remaining elevated at 60 The insulin-induced increase in Grb14 content in the plasma membrane and Golgi ⁄ endosome fractions was significantly correlated with the increase in...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... using the network dataset taking into account self-interactions In any case, we obtained minor differences in the fitting of these distributions when self-interactions were not included For the ... dimerizing via histone-fold structural motifs [51] The evolution of HTFN could be also constrained by protein domain properties and their distribution along the proteins In fact, using domain–domain ... containing these self-interacting domains Attending to this simple rule of domain self-interaction, relative levels of these proteins could determine the final composition of a complex, by varying their...
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the weakness of factors affecting sales activities at the website
... more information, and turn the objections into reasons for buying Every salesperson needs training in the skills of handling objections 1.6 Closing After handling the prospect’s objections, the ... associatively in the single web 2.6 Selling advertising Selling advertising is the most exciting but most difficult process In addition to preparing for the Site, the business needs to find the suitable ... around the things the customers are wondering is provided to them so that they have the exact understanding about the service 2.6 Step – Closing The step of handling the objections is well done and...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... To further our understanding of ESE-1 function during in ammatory processes, we have now explored the involvement of ESE-1 in the regulation of another in ammation-related gene, COX-2, in monocytic ... ESE-1 binding sites drastically reduces activation of the COX-2 promoter by ESE-1 and by LPS To examine whether the Ets sites in the COX-2 promoter are responsive to ESE-1 and to determine whether ... encompasses the carboxy-terminal Ets DNA binding domain of ESE-1 and competes with intact endogenous ESE-1 for binding to target gene promoters The second dominant-negative mutant, Dominant Negative...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... GlnK–TnrA interaction in the presence of mm ATP On the other hand, 2-oxoglutarate did not in uence the GlnK–TnrA interaction, either alone, in the absence of divalent metals, or in combination ... observed during this kind of shift experiment in B subtilis AmtB-deficient and GlnK-deficient strains, despite TnrA being soluble in these cells [12,15] To gain deeper insights in the involvement ... analysis ATP and 2-oxoglutarate are known to be the primary effectors involved in PII signaling, and they strongly affect interactions of many GlnK proteins with their receptors [17] The divalent cations...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... least in part Nevertheless, the docking of these adaptor proteins to the JM could initiate additional sustained signalling events unrelated to the canonical docking of signalling proteins to the ... might not be involved in the allosteric regulation of ligand binding affinity in the receptor [86] Interestingly, the occurrence of in- frame tandem duplication of exons 18–25 ⁄ 18–26 in the EGFR gene ... al studies that, in the absence of ligand, the receptor is maintained in an inactive conformation by CaM, by which the T654 residue in the EGFR interacts with the E120 residue in CaM [82] By contrast,...
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Báo cáo khoa học: Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells pptx
... growth and differentiation On ligand binding, the insulin receptor tyrosine kinase initiates multiple signaling cascades, including activation of the phosphatidylinositol 3-kinase (PI3K) pathway and ... administered to establish the role of protein synthesis in insulin-induced HO-1 expression (Fig 2B,C) CHX abrogated HO-1 protein induction following insulin treatment but, in agreement with other ... protein expression was sensitive to PI3K ⁄ Akt inhibition and Nrf2 gene silencing The fold-increase in both HO-1 protein and mRNA in response to insulin was consistent, as well as being time and...
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Báo cáo khoa học: The 3¢-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR ppt
... panel) and the UV-crosslinking results (Fig 5B) further supporting the finding that HuR is one protein binding the MARCKS 3¢-UTR in Swiss 3T3 cells In contrast to the Hu antiserum, no interaction ... necessary to understand the linkage of cell signaling pathways to the mRNA degradation machinery This knowledge may aid in the design of novel approaches to the therapeutic intervention in the various ... blocked the interaction of Swiss 3T3 protein HuR and the RNA probe (crosslinked proteins indicated by arrows) The positions of protein markers are indicated on the right correlated precisely with the...
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Feasibility Study – The critical success factor in project management pot
... different stages in development and implementation 10 Preparation for investment Implementation of investment Investment license Operation Payment Hand-over Supervision Bidding Contracts signing Tender ... Selection of Project Manager and leave all the rest to him - Project manager will select and manage the project team including many kind of experts : legal, market, technical, finance, sale, operation, ... Organizing , problem solving, conflict management • Communication skill and leadership • Presentation skill 19 V Case Study • International project invested by foreign investor in Vietnam : The...
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Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx
... Residues E99 and L104 are located in the TF1 domain, and T197 is situated in the N-terminal portion of the TF2 domain, i.e close to the TF1 domain at the level of EGF1 in FVIIa in the sTF–FVIIa ... regarding the binding area between sTF and FXa in this complex Regarding the ternary sTF–FVIIa–FX complex other investigators have performed functional analyses to investigate the binding region ... sitedirected fluorescence labeling approach that can determine whether the labeled positions are involved in the interaction Ó FEBS 2003 between the proteins in the complex The main advantage of this experimental...
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Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... of the EGF receptor kinase Our findings that Src colocalizes with Hrs and can phosphorylate Hrs in vitro and in vivo suggest that this kinase may be involved in the phosphorylation of Hrs On the ... remains bound to the receptor at the acidic endosomal pH, thus activating the receptor kinase, transforming growth factor a (TGFa) rapidly dissociates and leaves the EGF receptor inactive after internalization ... Hrs construct into HeLa cells and studied their phosphorylation (Fig 7) in the presence of EGF Interestingly, both of these Fig Hrs is phosphorylated in cells lacking Src, Yes and Fyn SYF-2 cells,...
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Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... single domain in the membrane-proximal part of gp130 leads to a shift of the receptor areas involved in ligand binding closer to the membrane, resulting in the inability of the receptor chains to ... in this chimera, indicating that the reason for the missing signal transduction is not an incorrect spacing between the ligand binding epitopes of gp130 and the membrane Domain therefore is believed ... an intramolecular bond between the remaining cysteines C466 and C491 of gp130 This could result in a conformational change within the receptor chain enabling the activating interaction with the...
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Báo cáo khoa học: Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo ppt
... ischemic stroke without increasing the risk of intracranial hemorrhage [43] Altogether, targeting the vWF-binding domain, in addition to GPVI and integrin a2b1 binding sites in collagen appears to ... 2A), indicating that the G primary sequence is indeed sufficient for the interaction Aegyptin binds with low affinity to GPVI and integrin a2b1 binding sites in collagen Sequences involved in collagen ... Aegyptin binds with high affinity to the vWF binding site in collagen, independently of hydroxyproline In an attempt to identify the binding sites involved in collagen interaction with aegyptin,...
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Báo cáo khoa học: Control of transferrin expression by b-amyloid through the CP2 transcription factor pdf
... putative binding factors for transferrin promoter regions including CP2, specificity protein and p53 Interestingly, we found that the CP2 binding site was the most frequent motif in the conserved ... of the transferrin promoter region contain CP2 binding sites The iron regulatory protein transferrin is involved in ROS production, which causes neurotoxicity in neuronal cells We therefore investigated ... 1; mut1), CP2 binding site I, III and IV (mutant 2; mut2), and the entire CP2 binding site (mutant 3; mut3) (Fig 3A) As the CP2 binding site III sequence overlaps with the CP2 binding site IV sequence...
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The Ubiquitous Triclosan A common antibacterial agent exposed ppt
... cleaning agents containing anti-bacterial agents and on industry to stop marketing and advertising the antibacterial qualities of their products, calling their use in households, “superfluous and ... triclosan-containing toothpaste and soap prodDioxin Link Recently, there have been a number of ucts claim that the active ingredient continues to work for concerns about triclosan and its link to dioxin ... is possible that dioxin can be found in triclosan as synthesis impurities.34 In addition to being formed during the manufacturing process, dioxin may also be formed upon incineration of triclosan.35...
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Báo cáo khoa học: The potyviral virus genome-linked protein VPg forms a ternary complex with the eukaryotic initiation factors eIF4E and eIF4G and reduces eIF4E affinity for a mRNA cap analogue ppt
... conformation, enhancing the fit of the eIF4E-binding domain to pep4G The interaction of VPg with eIF4E affects the properties of both the cap-binding pocket and the eIF4G-binding domain Our observation ... is rather high It is likely that the major contribution to the intrinsic fluorescence of the protein comes from these two tryptophans in a polar environment, the fluorescence of the others being ... in favour of the presence of a VPg-binding site on eIF4E, which is distinct but structurally related to the cap-binding site A possible mixed-type noncompetitive ligand binding of eIF4E and the...
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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... right The reference indicates the GFP-injected control animals nuclear localization signal (NLS) in the homeodomain of the HNF1b protein is supported by the presence in the N-terminal region of the ... cells In contrast, the construct encoding the HNF1a-derived POUS and POUH domains fused to the HNF1b dimerization domain (HNF1baa) was localized both in the nucleus and the cytoplasm (Fig 4B) These ... truncated HNF1b proteins agenesis of the pronephros in Xenopus embryos [35,43], the retaining the DNA binding domain (e.g Y352insA) as well splice variant B (HNF1bD) lacking the 26 aa segment did...
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