overview of strategic management and its role all organizations enterprises
bài giảng chapter 1 overview of financial management and the financial environment
... set-up and report filing 1-8 Becoming a Public Corporation and Growing Afterwards Initial Public Offering (IPO) of Stock Raises cash Allows founders and pre-IPO investors to “harvest” some of ... amounts of debt and equity) Interest rates Risk of the firm Stock market investors’ overall attitude toward risk - 17 What determines a firm’s value? A firm’s value is the sum of all the ... of the stock (or other financial asset) and place bid and ask “advertisements,” which are prices at which they are willing to buy and sell Computerized quotation system keeps track of bid and...
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Bacteria of the sulphur cycle An overview of microbiology, biokinetics and their role in petroleum and mining industries
... removal of sulphide and denitrification of wastewaters, possibility of capturing CO2 and finally development of microbial fuel cell type reactors for the treatment of sulphate, sulphide and nitrate ... are used for passive treatment of AMD Large land requirements, build up of heavy metals in the wetland, formation of H2 S and sludge are some of the drawbacks of the passive treatment Active ... treatment of AMD offers several advantages, including the permanent removal of sulphur and metals, production of clean water and possibility for the recovery of value metals Bioleaching of sulphide...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... series of GST-fused deletions of the CD2-1 region (Fig 3E) and examined the interactions between bacterially expressed proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the ... dendrites of cultured hippocampal neurons Fig S4 Domain structure of MAP2 and the alignment of v-KIND-binding core (BD) region of MAP2 CD2 domain (702–744 aa) in human, mouse and Gallus This ... critical for the v-KIND and MAP2 interaction We examined the 32 residues of the MAP2-binding core (amino acids 456–487) of mouse v-KIND by comparing them with those of human and Gallus v-KIND, as well...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... caspase activity and the expression of several apoptosis-related genes Owing to the overexpression of OccWT, the expression of the apoptotic genes BAX and Apaf-1 increased, and that of the antiapoptotic ... apoptosis and inhibits invasion [8] Occludin, one of the TJ proteins, has also been shown to have several types of splice variant and antitumorigenic activity [3,4,27]; however, its effects on and ... number of stained cells All results in (B), (C), (D), (E) and (F) are expressed as the fold ratio relative to control (Cont) All numerical data represent the means and standard deviations of three...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... stefin A and stefin B at pH and variant of stefin B and the P79S mutant of the variant at both pH and pH Each panel is a plot of heat change on ligand addition (kcalỈmole)1) against the ligand ⁄ stefin ... [5,6] In the present series of experiments we compared fibrillation of stefin B wildtype (E31 isoform), of stefin B variant (Y31 isoform) and the mutant P79S of the variant, all at pH 5.0 with 10% TFE, ... and B and the P79S mutant The two isoforms of stefin B have exactly the same far UV CD Regardless of the sequence differences (as highlighted in Fig 1), the secondary and tertiary structures of...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... at 260 nm Peak produced small amounts of HMG-CoA and large amounts of free CoA Peak produced HMG-CoA and also large amounts of free CoA Peak produced large amounts of HMG-CoA, but also free CoA ... abnormally increased plasma levels of this compound, further challenging our understanding of 3-methylglutaconic acid metabolism [9] Lastly, pregnancy was reported as a possible cause of MGA ... column and the mass spectrometer was used, and 100 lLỈmin)1 of eluent was introduced into the mass spectrometer A LCT TOF (time -of- flight) mass spectrometer (Micromass) was used in the negative and...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... inhibition of the L3 observed on day postculture and onwards A mild larvicidal effect of 10 mM NaF with progressive damage of the body wall and intestine was seen on day postculture and onwards ... body wall of parasitic roundworms consists of the cuticle, an underlying syncytial or cellular layer called the hypodermis, and the longitudinally oriented somatic musculature The ecdysis of an ... obtained from the lungs of New Zealand white rabbits days after inoculation with 2.5 · 105 embryonated infective eggs of A suum [26] Briefly, the rabbits were killed by an overdose of ketamine hydrochloride...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... distribution of VBARP is independent of the cycling stage of the cells Identification of biological function(s) of VBARP using a siRNA assay To examine the role of endogenous VBARP in the regulation of ... 2B that VBARP-L and VBARP-S are coded by these specific exons VBARP-L and VBARP-S code for precursor proteins of 627 and 435 amino acids and with calculated peptide masses of 69 and 49 kDa, respectively ... characterization of ANKHD1 splice variant A Fig Interaction of Vpr and VBARP proteins in vitro and in vivo (A) In vitro translated 35S-labeled VBARP-His isoforms were incubated with Vpr or Nef and immunoprecipitated...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... yeasts, mammalian cells and plants as a component of the docking complex and a point of convergence of the PEX5- and PEX7-dependent import pathways [15–17] The N-terminal part of PEX14 interacts with ... (first lane), band to TbPEX14-N,H (last lane), band to the complex formed by the two proteins (lane 3), and bands and correspond to noncomplexed TbPEX5 and TbPEX14-N,H, respectively (lane and 5) association ... inserted into a transcriptionally silent region of the genome by homologous recombination The production of the doublestranded RNA was induced by the addition of Tet and resulted, in bloodstream-form...
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Báo cáo lâm nghiệp: "Evaluation of changes in the landscape management and its influence on animal migration in the vicinity of the D1 motorway in Central Bohemia" ppsx
... landscapes in Sweden – methods and data of landscape change In: Jongman R.H.G (ed.): Proceedings of the First ECNC Seminar on Land Use Change and its Ecological Consequences, Ecological and Landscape ... understanding of the mutual interaction between the landscape and the urbanization that transforms the landscape and is the basis for its sustainable management (Naveh 1993) Holistic dimension of ... urbanization and infrastructure (Eetvelde, Antrop 2004) These forms of land use further fragment agriculture and forest land and increase its separation effect Lipský (2000) stated that overall changes...
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báo cáo khoa học: " Study of ‘Redhaven’ peach and its white-fleshed mutant suggests a key role of CCD4 carotenoid dioxygenase in carotenoid and norisoprenoid volatile metabolism" ppsx
... http://www.biomedcentral.com/1471-2229/11/24 Page of 14 Table Carotenoid composition of RH and RHB fruits during ripening Stage Compound Table Carotenoid composition of RH and RHB fruits during ripening (Continued) (all- E)-violaxanthin ... including all five stages, and resulted in a poor separation of most samples (Figure 6A), with the exception of RHB-S1, RHS2, RH-S3 and RH-Br Principal components and explained 67% and 21% of the ... (Research Found of the Faculty of Medicine, University of Pécs) Authors wish to thank dr Tadao Asami (University of Tokyo) for the kind gift of abamine SG, and profs Péter Molnár and József Deli...
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Báo cáo y học: "Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release" pps
... largest amount of PDI protein, followed by the kidneys and fat tissues, and it has been shown that fasting and refeeding affect the PDI protein and its enzyme activities [25] PDI is one of the endoplasmic ... cytokines play a critical role in the initiation and progression of sepsis syndrome and that TNF-α, IL-1β, and IL-6 are important mediators of hemodynamic, metabolic, and immunologic alterations ... (Sigma-Aldrich, 0.25, 1.25, and 3.75 mM) and the supernatant and cell lysate were collected for the measurement of TNF-α The levels of TNF-α were determined by using commercially obtained enzymelinked...
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MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS
... differentiation and CE assembly (Candi et al 2002); and 7) band 4.2, also called ATP-binding erythrocyte membrane protein band 4.2, is important in the regulation of erythrocyte shape and mechanical ... The genes for FXIIIA (F13A1) and TG1 (TGM1) consist of 15 exons and 14 introns, whereas TGM2-7 (genes for TG2-7) and EPB42 (band 4.2 encoding gene) consist of 13 exons and 12 introns These genes ... and Peters 1983) TG2 acts as a multifunctional protein due to its multiple functional domains and its functions vary depending on the protein’s cellular localization and its regulators Ca2+ and...
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REGULATION OF CHOP TRANSLATION IN RESPONSE TO eIF2 PHOSPHORYLATION AND ITS ROLE IN CELL FATE
... mechanism of translational control explains how expression of CHOP and the fate of cells are tightly linked to the levels of phosphorylated eIF2 and stress damage Ronald C Wek, Ph.D., Chair vi TABLE OF ... underline and bold and a flanking purine at the -3 and a G at the +4 positions (15) Together the eIF1 and eIF1A facilitate the recognition and selection of initiating codons eIF1 plays a key role ... complex that consists of subunits, designated α, β, γ, δ and ε in mammals, and the yeast counterparts Gcn3p, Gcd7p, Gcd1p, Gcd2p, and Gcd6p, respectively (6, 21, 22) The γ and ε subunits facilitate...
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Supply chain management in the presence of strategic consumers and consumption externalities
... 2012 All Rights Reserved Abstract SUPPLY CHAIN MANAGEMENT IN THE PRESENCE OF STRATEGIC CONSUMERS AND CONSUMPTION EXTERNALITIES ˘ ˙ KENAN ARIFOGLU In this dissertation, I study the management of ... price, capacity and demand with potentially-optimal UP when the population is homogenous and consumer valuations are uncertain 4.3 133 Equilibrium price, capacity and demand with potentially-optimal ... aspects of SCM, i.e., number and location of facilities in a supply chain, amount of capacity at each facility, allocation of facilities to market locations, inventory control, coordination and information...
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Characterization of helicobacter pylori y glutamyl transpeptidase and its role in pathogenesis
... status of cagA, vacA, iceA, and babA2 162 5.2 Prominent role of GGT on the growth of H pylori 163 5.3 Comparison of amino acid sequences of GGTs 165 5.3.1 Between H pylori and other bacterial and ... in 1983 (Warren and Marshall) and the acceptance of its role in gastric pathophysiology (Halter et al., 1992; Blaser, 1995) represent a fundamental change in our understanding of gastroduodenal ... the presence of this organism and gastric inflammation Their discovery of the Helicobacter pylori and its role in gastritis and peptic ulcer disease succeeded them for the award of the Nobel...
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Characterization of rab22b, an astroglia enriched rab GTPase, and its role in golgi and post golgi membrane traffic
... and digested in a total volume of 2mL of 0.25% of trypsin/EDTA and 25 g/mL of DNaseI After enzymatic digestion, the mixture of trypsin/EDTA and DNaseI would be removed and replaced with 2mL of ... overview of Rab GTPases and membrane trafficking The enormous flux of membrane traffic within a cell at any point of its existence necessitates stringent control of both the rate and specificity of ... important role in myelin formation and maintenance in oligodendrocytes 26 Aims and rationale of current work 1.3 Aims and rationale of current work One of the main research focuses of the lab...
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A novel membrane pool of protein kinase c and its role in mammalian cell signaling
... in the formation and functioning of the bilayer Within the membrane, it is oriented with its small hydrophilic end facing the external surface of the bilayer and the bulk of its structure packed ... characteristic of the interiors of all cells is the high concentration of macromolecules and the dense network of membranes they contain347 Therefore the velocity and direction of protein diffusion ... curve of PKC by PS is sigmoidal PS concentrations of 15 mol % of total lipid in the plasma membrane are sufficient to totally activate PKC in the presence of saturating amounts of Ca2+ and DAG...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTORATE OF PHILOSOPHY INSTITUTE OF MOLECULAR AND CELL BIOLOGY AND DEPARTMENT OF PHYSIOLOGY NATIONAL UNIVERSITY OF SINGAPORE 2008 ACKNOWLEDGEMENTS I would ... guidance and her friendship all these years To Miss Yeo Wanlin and Dr Vinay Badal for their friendship and encouragement To Dr Oh Hue Kian and Miss Swa Li Foon for their collaborations Members of Prof ... thanks to my husband for his support and understanding throughout the years Finally, I would like to dedicate this thesis with great love to my parents and my husband, without whom none of this would...
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The role of CDC42, 1RSP53 and its binding partners in filopodia formation
... environment and motivating me especially during the period I have spent writing my thesis Finally, many thanks to my family and all my friends, who have continually been a source of inspiration and offered ... homologous to cofilin Both cofilin and ADF bind monomeric and filamentous actin and promote the disassembly of actin filaments They inhibit polymerization and nucleotide exchange of ATP-actin for ... the following activities; Profilin and ADF cofilin bind G- and F-actin and they are mostly concentrated at the leading edge of the cell They promote the disassembly of actin filament Gelsolin...
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