noninvasive visualization of in vivo drug delivery of paramagnetic polymer conjugates with mri
nanotechnology for cancer therapy, 2007, p.810
... HPMA polymer with doxorubicin but lacking the HA targeting conjugate.18,19 Copolymer–peptide conjugates have also been developed as nanovectors using HPMA in combination with RGD targeting peptides,20 ... intracellular drug delivery and delivery of proteins such as antibodies and genes, as well as providing a window for cellular imaging.17 In addition to liposomes as an example of the prototype of nanovectors, ... Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI 201 Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee Jeong Section Polymeric...
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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY
... reduction of the critical cysteines in the DNA binding domains of the transcription factors increases their DNA binding ability thereby activating them and resulting in the transcription of several ... disctinct from each other Ape1 is a multifunctional protein with roles in DNA repair as well as in redox signaling in the cell besides making protein-protein interactions with a number of proteins ... Target in Cancer 19 Consequences of Inhibiting the BER Pathway Proteins in Cancer 19 Inhibition of the DNA Repair Function of Ape1 as a Target in Cancer 22 Existing Ape1 DNA Repair Inhibitors...
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Báo cáo sinh học: " Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy" pptx
... present in a crystalline state because it was dissolved within the NCs' oily core and the PLA shell The drug/ polymer interaction has been indeed thermodynamically explained using the Flory-Huggins interaction ... particles and high drug loading with sustained-release characteristics This allows releasing the drug in the target site in its therapeutic concentration and preventing drug inefficiency and side ... nanocapsules; drug loading Background In cancer therapy, most of the proposed formulations present certain drawbacks related to the formulation properties including low drug loading, toxicity,...
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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy" doc
... regulating ID3 expression The SH3-binding domain of PTTG1 has been shown to be involved in up-regulation of both VEGF and FGF-2 [76,77] The C-terminal portion of PTTG1 contains a DNA-binding domain ... months of age The urinary bladder was enlarged with wall thickening, increased in visualization, and filled with urine containing white deposits [6] The seminal vesicles and epididymis in some of ... by inducing apoptosis-inducing genes Yu et al [26] hypothesized the role of PTTG1 in apoptosis In their studies, they examined p53 involvement in PTTG1-induced cell death in cells expressing...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
... Curcumin was a kind gift of Indsaff, Inc (Batala, Punjab, India) Curcumin loading in the polymeric nanoparticles was done by using a post-polymerization method In this process of loading, the drug ... for 2-3 hours in water Dry powder of co-polymeric nanoparticles Lyophilization Pure co-polymeric nanoparticles in aqueous medium Co -polymer in H2O+ Drug in solvent Drug loaded in copolymeric nanoparticles ... cell lines in vitro, by inhibiting cell viability and colony formation in soft agar Further, our studies confirm that nanocurcumin retains the mechanistic specificity of free curcumin, inhibiting...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... reduction of actin filaments in MCF-7 breast carcinoma cells 48 hours after treatment Cells were stained with DAPI (4’,6-diamidino-2-fenilindol) to visualize the nucleus (in blue) and with Phalloidine-Alexa ... solution containing 0.686 mM L-a-phosphatidylcholine, 0.0137 mM L-a-lysophosphatidylcholine, was injected with a syringe into mL phosphate buffer solution (PBS), pH 7.4 The injection of 262 μL of maghemite ... PBS, and incubated with 1% bovine serum albumin (BSA) for 30 minutes Subsequently, the cells were stained with solution containing 2.5% Phaloidin-Alexa-Fluor 488 and 1% BSA (v/v) for 20 minutes...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... conversion of drugs into active forms, or inhibit the conversion of drugs into inactive forms [40] One example is co-administration of a P-glycoprotein inhibitor, cyclosporin A, with Pac As a single ... after three days of incubation with nanoparticle/lectin A-chain nanocomplexes containing a fixed concentration of lectin A-chain and P(MDS-co-CES) of varying concentration Lectin A-chain concentrations ... Chemotherapeutic drugs Trifluoperazine Adriamycin Facilitating Tumor blood flow increases in angiotensin II-induced hypertensive state but maintains constant in normal blood vessels Hence, delivery of drugs...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... randomly divided into two groups: A DTA-H19 group of 12 mice were intratumoral injected with 25 μg of the DTA-H19 plasmid and another group of 12 mice were intratumoral injected with 25 μg of the control ... 351:2519-2529 McGonigle KF, Dudzinski MR: Endometrioid carcinoma of the ovary presenting with an enlarged inguinal lymph node without evidence of abdominal carcinomatosis Gynecol Oncol 1992, 45:225-228 ... inhibit tumor growth in vitro and in vivo [[28,24,23] and [22]] The choice of the DT-A as a toxin gene ensured not only high killing activity but its use has a great advantage in avoiding unintended...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... bladder carcinoma cell line HT-1376 was kindly provided by Prof W Schulz, Heinrich-Heine University of Dusseldorf, Germany Cells were grown to confluency in a humidified incubator with 5% CO2 in polystyrene ... expression of DTA within the cells and in consequence triggering their necrosis Finally, we dealt with the question whether transfection of both single promoter vectors (expressing the diphtheria toxin) ... was further exhibited in vivo, in heterotopic tumors induced by T24P bladder cancer cell lines Heterotopic tumors treated with combination of total amount of 50 μg of both single promoter H19-DTA...
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Improvement of different vaccine delivery systems for cancer therapy pptx
... delivery vectors is incorporating multiple functional domains into one polypeptide chain, such as a DNA-binding Page 13 of 20 domain linked with a receptor-targeting domain This kind of polypeptides ... priming vaccination with recombinant vaccinia (rV)-PSA-TRICOM and booster vaccinations with recombinant Page of 20 fowlpox (rF)-PSA-TRICOM Each vaccine consists of the transgenes for PSA, including ... EPmediated delivery of plasmid DNA in comparison with levels achieved by intramuscular injection of DNA alone Indeed, the addition of in vivo EP has been associated with a consistent enhancement of cell-mediated...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... signaling pathways involving the binding of ezrin to ezrin–radixin–moesin proteins, and thus actin cytoskeleton binding and Ras activation HGF elicits metastatic behavior in various types of cells, ... proteins exist in three states with respect to HA binding: nonbinding; nonbinding unless activated by physiological stimuli; and constitutively binding [17–19] HA induces signaling when it binds ... of CD44 binds to ankyrin and ezrin–radixin–moesin proteins, providing a link to the cytoskeleton, as well as to merlin, which abrogates this binding However, the multiple cellular functions of...
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recombinant antibodies for cancer therapy, methods and protocols
... connecting FR2 of the heavy chain with FR4 of the light chain and VH105-VL43 that links FR4 of the heavy chain with FR2 of the light chain (91) 4.1.3 Single Antibody-Like Domains To obtain even smaller ... stability of the native state of the protein, but of those of its folding intermediates in their particular environment (78,79) The degree of successful folding of antibody fragments in the bacterial ... for the engineering of loop regions will indeed permit the construction of independent ligand-binding sites with high affinity and specificity Nevertheless, such single immunoglobulin fold and...
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nanocarriers as an emerging platform for cancer therapy
... Doxorubicin, platinum-based drugs, Vinblastin, Vincristin, Topotecan, Paclitaxel In vivo In vivo Chemistry, structural analysis and in vitro In vitro / in vivo Clinical trials (Phase I) In vivo Immunotoxins, ... use of peptides as targeting agents — including arginine– glycine–aspartic acid (RGD), which is the ligand of the cell adhesion integrin αvβ3 on endothelial cells — results in increased intracellular ... ability to maintain stability during long-term storage Although antibody fragments including antigen-binding fragments (Fab), dimers of antigen-binding fragments (F(ab′)2), single-chain fragment...
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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx
... carboxy-terminal noncollagenous domain of Type XVIII collagen; mechanism of action unknown 29-kD amino-terminal and 40-kD carboxy-terminal heparin-binding fragments inhibit EC proliferation Carboxy-terminal ... Carboxy-terminal hemopexin-like domain of matrix metalloproteinase-2 inhibits EC proliferation and tumor growth in mice Naturally occurring 16-kD cleaved amino-terminal fragment of prolactin; retains activity ... homology to murine endostatin Amino-terminal fragment of calreticulin; inhibits EC proliferation and tumor growth in mice Interleukins IL-1 IL-4 IL-10 IL-12 IL-18 17-kD β-isoform inhibits FGF-stimulated...
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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
... of tamoxifen therapy at development of resistance to tamoxifen Our case-series and previously reported case series confirm this finding in clinical setting The lack of response in the remaining ... derived CB and including patient still on treatment Duration of treatment (DoT) is the duration of therapy in months of all patients (regardless of the type of response) and including patient still ... patients on withdrawal of tamoxifen could partly be explained by the growth promoting action of natural estrogen in the body as seen in the above in- vivo study [12] Therefore, if “withdrawal therapy”...
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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf
... available, even with the additional costs of HER2/new testing Low dose, prolonged infusion gemcitabine The encouraging response of phase I-II trials of low dose gemcitabine in prolonged infusion in the ... "The win-win initiative" It starts with communications and publications Then, we propose to hold small pilot working meetings with representatives of interested parties and willing leading pharmaceutical ... companies in investing in LMCs research and provide a strategy to overcome those barriers -Investment in creating infrastructure will create new markets -Old drugs can bring new profits and its...
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Báo cáo khoa học: "Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence" ppsx
... I: The pattern of lymph node involvement in carcinoma of the head of the pancreas A histologic study of the surgical findings in patients undergoing extensive nodal dissections Int J Pancreatol ... were studies including 73 patients with cancer of body/tail of pancreas which were analyzed (including a part of data in Study No.3) Commonly involved nodal regions in patients with pancreatic ... I: The pattern of lymph node involvement in carcinoma of the head of the pancreas A histologic study of the surgical findings in patients undergoing extensive nodal dissections Int J Pancreatol...
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Báo cáo khoa học: "Target splitting in radiation therapy for lung cancer: further developments and exemplary treatment plans" pps
... underdosages in the range of up to 10% within a zone of less than ± mm can be neglected Although this error might be increased in principal by connecting two opposing beams (knowing that the machine's ... resulting in a better sparing of the lung while maintaining good sparing of myelon and esophagus, This series is treated to 63,0 Gy; after 45 Gy the elective nodes of the upper mediastinum are withdrawn ... tissue only at a minimal size of about 0,5 cm, this mode has been retained unchanged also with the availability of PET staging In our experience of treating >100 patients with 45 Gy in 2,5 weeks,...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose