nicotinic acetylcholine receptors in circuit excitability and epilepsy the many faces of nocturnal frontal lobe epilepsy
Tài liệu Báo cáo khoa học: A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken a7 nicotinic acetylcholine receptors docx
... of toxins on the 125 I-labelled a-Bgtx binding Varying amounts of toxins were incubated with nM of active sites of receptors and nM of 125I-labelled a-Bgtx for at least h With a7 receptors, the ... are in bold and underlined The regions coding for the putative signal peptides (CDS) and neurotoxins are shown The encoded amino acids are indicated in capital letters below the second base of ... demonstrated that the additional disulfide that is present in the second loop of the long neurotoxins is specifically involved in the capacity of these toxins to interact with a7 neuronal receptors [23,24,26,57]...
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Báo cáo khoa học: Novel a-conotoxins from Conus spurius and the a-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors doc
... superfamily, containing r-conotoxins and aS-conotoxins; the T superfamily, containing e-conotoxins and v-conotoxins; the P superfamily, containing the spasmodic peptides; the I superfamily, containing several ... jI-conotoxins, and the A superfamily, containing a-conotoxins, aA-conotoxins and jA-conotoxins [1] Competitive antagonists of the nicotinic acetylcholine receptors (nAChRs) belong to the a and aA ... describe the purification, amino acid sequence determination and cloning of the cDNA encoding two novel peptides, SrIA and SrIB, found in the venom of Conus spurius The pattern and the spacing of their...
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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt
... residue type and in the case of loop in both the type and number of residues The N- and C-termini are labeled (B) On the left is the three-dimensional structure of the 4/6 framework a-conotoxin, AuIB ... showing the residues important for binding is shown in Fig The increase in potency for [A10L]PnIA has been attributed to the longer side chain of the leucine at position 10 In general, for the ... especially for the side chains involved in binding, are associated with a loss of activity Analysis of the molecular surfaces reveals that the side chains of the active residues in ImI are on a solvent...
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Báo cáo khoa học: a-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californicaand some neuronal subtypes of nicotinic acetylcholine receptors pdf
... indicated a-conotoxins and their analogs Final concentrations of the radioligand and toxin-binding sites of receptor were 280 and 230 nM, respectively The data shown are the averages of two independent ... native toxin, the position of the C-terminus is stabilized by the ionic pair (salt bridge) between the N-terminus and the side chain of the aspartate D12 In the case of [D12S]SIA, the ionic link is ... enabled the identification of specific a-conotoxin and ⁄ or nAChR residues taking part in ligand–receptor interactions [12–15] The crystal structure of the acetylcholine- binding protein (AChBP) from the...
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Nicotinic acetylcholine receptors potx
... agonist acetylcholine, agonists of the nAChR are nicotine, epibatidine, and choline In neuronal nAChRs, the acetylcholine binding site is formed from amino acid residues of both the α and β subunits ... primary sites of expression: muscle-type nicotinic receptors and neuronal-type nicotinic receptors In the muscle-type receptors, found at the neuromuscular junction, receptors are either the embryonic ... receptors, the subunits are somewhat similar to one another, especially in the hydrophobic regions Binding the channel For ligands, see Nicotinic agonist and Nicotinic antagonist As with all ligand-gated...
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Báo cáo khoa hoc:" Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance" docx
... staining to detect estrogen-binding activity and found of tumors had estrogen-binding activity and the intensity of the staining was found to be much greater in the tumors from the women They ... competing interests Authors' contributions SJ: Principal investigator - did the study, collected data and wrote the paper; VA: Co-investigator - helped in doing the study and collecting the data; ... of estrogen and progesterone receptors and their potential role in the progression of vestibular schwannoma is still an area of controversy Many diverging studies, using various biochemical and...
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Báo cáo y học: "Expression of the α7 nicotinic acetylcholine receptor in human lung cells" pdf
... for the α7 nicotinic acetylcholine receptor, it was necessary to show if expression of the α7 nicotinic acetylcholine receptor protein in seen in these cell lines Using a specific antibody for the ... analysisof α7 nicotinic acetylcholine receptor protein in non-SCLC cell lines and normal SAE cells as assessed by western Expression Expression of α7 nicotinic acetylcholine receptor protein in non-SCLC ... laboratory and others In addition, it has been shown that the NCI-H82 cell line synthesized the highest levels of acetylcholine, and addition of nicotinic antagonists slowed growth of the NCI-H82...
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imidazoline receptors in insulin signaling and metabolic regulation
... through an interaction with PI3P The potential imidazoline binding region and ruthenium red binding region are possibly overlapping within the coiled coil domain The integrin α5 binding site also ... stimulate the uptake and storage of carbohydrates, fatty acids, and amino acids into glycogen, fat, and protein, respectively Insulin binding induces tyrosine 32 autophosphorylation of the insulin receptor ... mediates interactions with rac and PAK The insulin receptor substrate (IRS) proteins binding site resides at the C-terminal region of IRAS Within proteins that contain them, PX domains usually...
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Serotonin and serotonin receptors in neural stem and progenitor cell proliferation
... prespective The first identification of the presence of NSPCs in the brain comes from the discovery through thymidine-H3 incorporation into the dividing cells that the cells in certain regions of the ... in the body TPH, being the rate limiting enzyme in the biosynthesis of 5-HT, therefore determines the biosynthesis rate of the 5-HT via its enzyme levels and activity Two different isoforms of ... the brain must determine which cells and which connections are required by the mature brain and maintain those The rest of the cells and connections will be lost during 18 the process of brain...
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O NEUROTOXINS NOVEL ANTAGONISTS OF NICOTINIC ACETYLCHOLINE RECEPTORS FROM SNAKE VENOM
... to the involvement of loop I in the short-chain toxin erabutoxin-a, mutations in the loop I residues of the long-chain toxin α-cobratoxin did not confer decrease in the affinity of the toxin ... 2007), but the absence of the complementary subunit of the ligand-binding site posed limitations in the accuracy of orientation of the toxin and the inter residue interactions In 2013, the crystal ... identifying the nature of the ligand-binding domains and of the subunit interfaces of 21 protein (AChBP), from the snail Lymnaea stagnalis, solved at an overall resolution of 4.2A°, revealed the...
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Sustaining an Interest in Learning English and Increasing the Motivation to Learn English
... for the welfare and the development of the Jengka district in Pahang LKWJ has been working hard to raise the educational level and the economic standards of the Jengka settlers The majority of the ... reflected upon the ideas and concepts found within the visual representations (the drawings that showed what a teacher stands for) and symbols they had drawn in the beginning of the workshop and compared ... before they were introduced to the suggested enrichment program framework and the theoretical underpinnings of the approach The teachers were later introduced to a variety of in- class activities and...
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Tài liệu Negotiations in project sales and delivery process: An application of negotiation analysis pdf
... negotiation model positions the signing of the contract in the beginning of the next phase, i.e., in the beginning of the implementation of the project Nevertheless, the focus in this study is on negotiations ... creating and claiming within a fixed configuration of the elements of negotiation The behavioral dynamics of claiming and creating influence the construction of the perceived ZOPA, but the parties ... between creating joint value, i.e increasing the payoffs to all parties, and claiming individual value, i.e increasing the payoffs to a single party unilaterally, often referred to as the “negotiators...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
... made on the basis of the structure of the 5¢UTR of the plus-RNA, the structure of the 3¢-end of the minusstrand RNA being at that time unavailable In the present study we investigated the involvement ... of synthesis of the viral genome In this report we investigated the template and binding properties of mutated and deleted RNA fragments of the 3¢-end of the minus-strand HCV RNA in further detail ... structure of the SL-A1 and of the SL-B1 hairpin and the nt at the 3¢-end remained free as in the wild-type (–)IRES RNA synthesis obtained with the (–)IRES 104 RNA was only 24% of that of the wild-type...
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Báo cáo khoa học: "Exploring and Exploiting the Limited Utility of Captions in Recognizing Intention in Information Graphics∗" pdf
... with the minimum value and in the caption of graphics pear on the bars and sometimes next to them, and the heading for the dependent axis appears in the empty white space of the graphic instead of ... focuses on the decades of increasing immigration and the caption strengthens increasing trend in immigration as the intended message of the graphic If we not include the caption, our system hypothesizes ... (increasing, decreasing, or stable), where the change in trend occurred, the end of the second trend, and the slope of the second trend If there was disagreement between the coders on either the...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... occludens-domain-containing proteins such as syntenin, Ga-interacting protein (GAIP)-interacting C-terminus ⁄ synectin and calcium ⁄ calmodulin-associated serine kinase, since the C2 region contains a ... catalytic domain with a zinc-binding site (Zn, HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc Interaction between cysteine–zinc maintains proMMPs in an inactive state ... full-length TIMP-1 and TIMP-3 are [31] The C-terminal domain of TIMPs can stabilize proMMP by binding to its hemopexin domain, leaving the N-terminal fully capable of interacting with other MMPs Most...
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Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
... reorganization of the actin filament system, playing a role in the migration of endothelial cells and in recovery of cells from wounding [40] In a variety of cells, in addition to the induction of hsp25 and ... before the addition of recombinant hsp25, as described in Materials and methods Following isolation and washing of the resin, protein was eluted and visualized by SDS/PAGE and Coomassie staining The ... fragment of eIF4G (M-FAG [48,49,52]); containing the eIF4E binding site and central domain of eIF4G (lane vs lane 1), less with the N-terminal domain of eIF4G (N-FAG; lane 3), and not to the C-terminal...
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báo cáo hóa học:" Social care and changes in occupational accidents and diseases - the situation in Eastern Europe in general and for skin diseases in particular" pptx
... contributions to the conception and design of the study, as well as to the analysis and interpretation of the data He was involved in the critical revision of the article and gave final approval of the version ... Rep., the Ukraine, Hungary and Belarus The rates decreased strikingly in Romania, Moldavia, the Czech Republic and Hungary On the other hand, the rates in Croatia and Turkey increased strikingly in ... the way in which this risk is covered according to insurance law In addition, there are differences in the definition of insurance groups, including the level of the insurance premia and who...
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Scientific report: "The potential energy recovery from landfills and evaluate the environmental benefits of the generation system using gas from landfills in Nam Son landfill, Vietnam" docx
... important in accounting of GHG emission mitigation from utilization of recovered LFG RESULTS AND DISCUSSION 3.1 Determining site-specific input of NS landfill 3.1.1 Determining the concentration of ... concentration of LFG in Nam Son landfill To define the concentration of landfill gas, total samples were taken in the different cells and locations and analyzed on GC machine Using of vacuum pump and Tedlar ... number of studies and project relevant landfill gas recovery and power generation, for example: project of Landfill gas capture and power generation in Dong Thanh and in Go Cat landfill Landfilling...
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Scientific report: "The potential energy recovery from landfills and evaluate the environmental benefits of the generation system using gas from landfills in Nam Son landfill, Vietnam" pps
... important in accounting of GHG emission mitigation from utilization of recovered LFG RESULTS AND DISCUSSION 3.1 Determining site-specific input of NS landfill 3.1.1 Determining the concentration of ... concentration of LFG in Nam Son landfill To define the concentration of landfill gas, total samples were taken in the different cells and locations and analyzed on GC machine Using of vacuum pump and Tedlar ... number of studies and project relevant landfill gas recovery and power generation, for example: project of Landfill gas capture and power generation in Dong Thanh and in Go Cat landfill Landfilling...
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Báo cáo lâm nghiệp: "Macronutrients in tree stems and foliage: a comparative study of six temperate forest species planted at the same sites" pps
... than in foliage With the exception of low Mg in stemwood of oak and low K in stemwood of birch, the concentrations of N, P, K, Mg and S in spruce stem wood were, on average, about half those in the ... concentrations in oak and beech were similar in our study, as the bark was included in the analysed samples Concentrations of Ca in the stemwood may depend on water consumption [5], and the uptake of this ... between the species than by site conditions This is in correspondence with the previous investigations of forests in southern Sweden In spruce forests in the province of Scania, Ca was the only...
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