monitoring spatial learning and memory in alzheimer s disease mouse models using the morris water maze
báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... represents the interquartile range that contains 50% of the values The whiskers extend from the box to the highest and lowest values The line across the box indicates the median Kruskall-Wallis ... pathological disease state and investigated brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... from the levels of the two extreme groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in ... Eur J Clin Invest 1999, 29:643-649 Foy CJ, Passmore AP, Vahidassr MD, Young IS, Lawson JT: Plasma chain-breaking antioxidants in Alzheimer' s disease, vascular dementia and Parkinson 's disease QJM ... analysing the involvement of oxidative stress in the course of AD and other diseases Anti-oxidant defences comprise enzymes [superoxide dismutase (SOD) and 2, catalase, glutathione peroxidase (GPx)],...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... processed in parallel, the corresponding stainings were weak in all of these areas as compared with the AD brain sections (data not shown) In AD brain, immunostainings with the antibody against p-eEF2 ... its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction and...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... production and aggregation in sporadic AD brain There is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... different steps in the complement cascade All of these regulatory proteins are produced in the human brain, but less is known about their CNS synthesis in other species [31] The status of some of these ... animal models of human disease generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease ... laboratory mouse strains [94], and the decreased efficiency of binding of mouse C1q by the human Aβ within the SPs in these animals [95] It is not known whether a similar decrease in the efficiency...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... http://www.jneuroinflammation.com/content/3/1/30 kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52] Activation of these signaling cascades are linked to the synthesis and secretion of proinflammatory molecules and cytokines ... Furthermore, global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved ... proinflammatory responses that act in concert to promote the progressive pathophysiology associated with this disease The results summarized in this review suggest that ROS and iNOS released...
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báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
... microglia is already increased in early pathological stages of AD and in cognitively normal subjects with frequent presence of plaques and tangles [3,4] Clinical studies using positron emission tomography ... occurrence of microglia and astrocytes decreases over age in AD, in contrast to control cases, suggesting that the association between neuroinflammation and AD is stronger in cases with relatively ... previously observed increased occurrence of these markers for microglia and astrocytes with normal aging suggests that these markers could be considered as markers for senescence rather than for inflammation...
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Effects of andrographolide and 14 deoxy 11, 12 didehydroandrographolide in obstructive respiratory disease mouse models
... arrows in insets) and the occasional intra-epithelial mast cell (black arrows in f) The lamina reticularis (asterisk in inset in d) is noticeably thickened The submucosa (doubleheaded arrows in ... contains many eosinophils (green arrows in inset in d) and other leukocytes, as well as mast cells (blue arrows in f) There is more bronchial smooth muscle (SM) than in a–c in figure 1.1, and there ... Chitinases Chitinases have been suggested to play a pivotal role in Th2-mediated allergic diseases such as asthma (Guan et al., 2009; Sutherland et al., 2009) Chitinases such as chitotriosidase and...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... were the main contributors (2) A visuospatial/cognitive factor, in which visuospatial and tests of reasoning were the main contributors These included the Rosen Drawing Test [45], matching and ... [66], and the non-verbal Identities and Oddities subtest of the Mattis Dementia Rating Scale [37] Visuospatial ability was evaluated using the Rosen Drawing Test [45], and a matching version of the ... individuals with and without an APOE-4 allele Please note The intervals on the X axis represent the average time of follow-up assessments after baseline These are smoothed regression lines that...
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Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... Discussion In the present study, Ab protofibril levels in young and aged animals were assessed in three different AD mouse models Ab protofibrils were present in both the brain and CSF of tg-ArcSwe ... protofibrils, displayed learning deficits A Morris water maze setting was chosen to measure spatial learning and memory because it depends upon hippocampal functions [28], and the hippocampus is a brain ... with spatial learning, measured as the improvement in escape latency (Fig 5A) The escape latency at the last learning trial was subtracted from the mean escape latency at the first training session...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive ... other diagnostic tests yield inconclusive findings Neuropsychological Testing A neuropsychological evaluation consists of administering a battery of standardized tests to assess cognition Test ... deficits are prominent and become more severe and global as AD progresses Behavioral and personality changes, including agitation, aggression, and psychosis, often emerge as the disease progresses...
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Báo cáo khoa học: "A Dynamic Bayesian Framework to Model Context and Memory in Edit Distance Learning: An Application to Pronunciation Classification" ppt
... modeling stochastic temporal processes such as speech and neural signals DBNs belong to the larger family of Graphical Models (GMs) In this paper, we restrict ourselves to the class of DBNs and use the ... strings resp.; source and target symbols, s and t; the hidden edit operation, Z; and consistency nodes sc and tc, which enforce the consistency constraint discussed in section Because of symmetry ... configurations of its parents, Z and s, that satisfy P (sc = 1 |s, z) > are such that (Z (s) = s) or (Z (s) = and Z = , ) This is the consistency constraint in equation In the following frame, the position...
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learning and memory - the brain in action
... exists in the areas of the brain dealing with emotions and thinking Glutamare and GABA appear in most information-processing transmissions as onc activa1es cenain neurons and the other quiets ... replaces them As the brain makes and strengthens connections, outside factors can easily influence it These factors mal' include addictive substances, as well as somcthing as simple as the food ... Monoamines Monoomincs are dil'ided infO twO classes: cmecholamines and indoleamilWS The catocholalllltles include the ncurotr,lllsminers epinephrine, norepinephrint, and dopamine, and the indolemnines...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... analysis, data analysis and presentation and assisted with perfusions and animal care; OY performed immunohistochemistry and image analysis; DC assisted with the design of the study and manuscript ... Reversible memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics ... reagent that stains proteins in beta sheet conformation [31] Therefore, the accumulation of thioflavine stained plaques in animals immunized at ages 12–16 months was assessed in hippocampus and cortical...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... differences, and the small sample sizes used in some studies In previous ELISA studies comparing these antibodies in AD subjects vs normal controls, only Moir et al [3], Gruden et al [14,15], and Nath ... undissociated and dissociated serum samples), although the mean concentrations of these antibodies tended to be increased in AD vs NCI sera (by 20% in undissociated samples and 29% in dissociated ... considered statistically significant All p-values were two-tailed Statistical analyses were performed using The SAS System for Windows version 9.2 Power and sample size analyses All calculations...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
... enlargement The mouse was then returned to its original cage Grooming was measured during playback by counting the number of seconds a mouse rubbed its face and/ or flinched its head during the session The ... neighboring section The first sections on each glass slide represented the anterior portion of the brain, the next sections the middle and the last sections represented the posterior third of the ... how is joint osteoarthritis linked to AD pathology? Numerous clinical and animal reports in the past showed an increase in circulating pro-inflammatory cytokines in the serum of patients and small...
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Báo cáo y học: "rug discovery from Chinese medicine against neurodegeneration in Alzheimer’s and vascular dementia" pdf
... plants is less potent than crude extract [32] Researchers often not use any Chinese medicine theory as the basis for their investigation when studying these compounds Therefore, some Chinese medicine ... dementia subtype in Chinese medicine diagnosis As exemplified in a clinical trial for respiratory diseases, it should be feasible to incorporate Chinese medicine diagnosis in the clinical trials for ... (Re) and Toxin (Du) accumulation syndrome, (6) the Qi and Blood (Xie) deficiency syndrome, and (7) the constipation and toxin in intestines syndrome SDSVD employs a detailed scoring system to assist...
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Báo cáo y học: "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer''''s disease" pot
... all subjects comprising the groups (including the ten sent for splice array analysis) was used in the rtPCR analyses A total RNA sample from all subjects was reverse transcribed into cDNA using ... brain structure regardless of disease state, and not if they failed solely in the control or diseased brain tissue structure, interactions Brain tissue was ground in liquid nitrogen (mortar and ... individuals for the presence of the polymorphism and certain clinical phenotypes, such as measures of disease severity or responsiveness to medications In doing this, we would be able to indirectly associate...
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STUDENT MOTIVATION, PARENTAL ATTITUDES AND INVOLVEMENT IN CHILDREN’S ENGLISH LEARNING AT DUONG QUANG HAM SENIOR HIGH SCHOOL
... weaknesses, intrinsic their and goals and preferences, effectively desires their utilize Successful strengths strengths and and compensate for weaknesses Successful language learning is linked to the ... important study in the Philippines The researchers switched from the study of French to the study of English, which is the most prestigious language in the Philippines The subjects in this study ... This chapter consists of four main sections Section 3.1 provides details on the data collection instruments Section 3.2 describes the subjects participating in the study The procedures and the setting...
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Washback Effects of the TOEIC Examination A study of Adult Learner’s Attitudes toward English Exams, Learning and Teaching in a TOEIC Preparation Class
... English inside and outside the classroom Improve students‟ listening and reading Increase one s competitiveness in the workplace Enhance one s self-image in work and discussion in class Limited Integrated ... classes for two years As for teaching style, this teacher lectures most of the time and uses power point slides as a visual aid in the classroom Ⅵ Results and Discussions 4.1 Adult Learners’ ... all aspects of their study, especially in the area of speaking and writing As for the washback on learning, adult learners pointed out the TOEIC test has pushed them study harder in learning English...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25