molecularly targeted agents in recurrent metastatic squamous cell carcinoma of the head and neck
Báo cáo khoa học: "Prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities" doc
... malignancy involving the parotid gland Head Neck 2001, 23:744-748 Joseph MG, Zulueta WP, Kennedy PJ: Squamous Cell Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their ... cutaneous squamous cell carcinoma of the head and neck Head Neck 2006, 28:785-791 O'Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS: Incidence of cervical node involvement in metastatic cutaneous ... squamous cell carcinoma of the skin: Defining a high-risk group Ann Surg Oncol 2006, 13:902-909 Johnson TM, Rowe DE, Nelson BR, Swanson NA: Squamous cell of the skin (excluding lip and oral mucosa)...
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Báo cáo khoa học: "Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer" pot
... reason to think more seriously about expanding the role of NAAD therapy in these patients Further study is needed to elucidate whether the rate of PSA normalization is linked to notable endpoints such ... level of less than ng/ mL were not included in the 133 patients as they were already below the decided upon standard for PSA normalization Time was initiated from the start of radiotherapy and ... significant in the regression analysis (p < 0.05) were included in the final equation Results Table describes the demographic and clinical data for the subjects Data for the subjects, related to the...
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Báo cáo khoa học: "Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)" docx
... complained of new headaches, and three of recurrent hyperlacrimation of the irradiated eye, one with change of taste perception None of the patients developed dysfunctions of the pituitary gland, neuropathy, ... followed, and patients with remaining useful vision and no tumor progression have been observed in the past [13] One main risk associated with surgery is the often inevitable dissection of the vascular ... of the lesion Tumor progression was determined by an increase in tumor size of more than 35% (product of the two orthogonal diameters) or any increase in tumor size on subsequent imaging examinations...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res 2004, 10:8204-8213 Ginos ... protein expression in UM-SCC cell lines (a) The p53 genotype of ten University of Michigan series head and neck squamous cell carcinoma (UM-SCC) cell lines was analyzed by two-directional sequencing ... activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines Mol Carcinog 1999,...
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Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
... alanyl residues into the N-terminus of the H-protein In conclusion, the substrate properties of the alternatively encoded Flaveria H-protein FtGLDHAA in the P-protein reaction of GDC differ significantly ... structure of pea H-protein showing the N-terminus and the position of the lipoyl arm Fig S2 Overexpression and effects on H-protein of E coli lipoate–protein ligase A Fig S3 Glycine saturation kinetics ... environments In this study, we examined whether the changes to the N-terminus of Flaveria H-protein alter its reactivity with P-protein, the actual glycine-decarboxylating subunit of GDC These experiments...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation ... hepatic and renal function (creatinine clearance >60 ml/min), and a computed tomography or magnetic resonance image scan of the head and neck region within three weeks prior to the initiation of treatment...
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AUDIT TOGETHER WITH INDEPENDENT AUDITORS* REPORT FOR THE PERIOD JULY potx
... entity and not included as part of the reporting entity of the University ' NOTE - Summary of Significant Accounting Policies: Principles of Accounting The financial statements are prepared in accordance ... Grambling Black and Gold Foundation, Inc Grambling, Louisiana We have audited the accompanying statement of financial position of Grambling Black and Gold Foundation, Inc (the Foundation) as of ... estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and the reported...
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Báo cáo sinh học: "Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" pot
... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring To investigate the significance of Her2 and ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation ... hepatic and renal function (creatinine clearance >60 ml/min), and a computed tomography or magnetic resonance image scan of the head and neck region within three weeks prior to the initiation of treatment...
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báo cáo hóa học:" Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" doc
... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... tissues and 17 recurrent HNSCC tissues The clinical information of these patients was obtained from the University of Immunohistochemistry and scoring To investigate the significance of Her2 and ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance...
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Báo cáo hóa học: " Unscented Kalman filter with parameter identifiability analysis for the estimation of multiple parameters in kinetic models" pptx
... number), in the order of the highest to the lowest sensitivity To make the adjustment of the net influence of each of the remaining parameters on the already selected parameters, all of the original ... During the UT, sigma points, a minimal set of sample points about the mean, are calculated to capture the statistics of the state model The sigma points are calculated according to the following ... sensitivity to the system output and then which of the parameters are linearly independent The method iterates over the columns of the sensitivity matrix Z to select the column with the highest sum of squared...
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Báo cáo hóa học: " A New MAC Protocol with Pseudo-TDMA Behavior for Supporting Quality of Service in 802.11 Wireless LANs" docx
... Thessaloniki, and in the year 1984 got his Diploma in electrical and computer engineering from the University of Patras He did his postgraduate studies in the University of Bradford in the United Kingdom, ... Diploma in electrical and computer engineering, Polytechnic School of Aristotle University of Thessaloniki (2002) He is currently in the process of defending his Ph.D thesis in telecommunications in ... Papapanagiotou has been studying in the Electrical and Computer Engineering School of University of Patras, Greece, since 2001, and he is currently in his last year of studies His interests include wireless...
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Báo cáo hóa học: " ITERATIVE SCHEMES WITH SOME CONTROL CONDITIONS FOR A FAMILY OF FINITE NONEXPANSIVE MAPPINGS IN BANACH SPACES" docx
... Proof As in the proof of [1, Theorem 1], we proceed with the following steps Step xn − z ≤ max{ x0 − z , a − z } for all n ≥ and all z ∈ F and so {xn } is bounded We use an inductive argument The ... Deutsch and I Yamada, Minimizing certain convex functions over the intersection of the fixed point sets of nonexpansive mappings, Numer Funct Anal Optim 19 (1998), no 1-2, 33–56 K Goebel and W A ... if Q2 = Q If a mapping Q of C into itself is a retraction, then Qz = z for every z ∈ R(Q), where R(Q) is range of Q Let D be a subset of C and let Q be a mapping of C into D Then Q is said to...
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báo cáo khoa học: "Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature" ppsx
... invasive perineal squamous cell carcinoma (B) Blue-stained inguinal sentinel lymph node Figure Wide excision of perineal squamous cell carcinoma: H&E staining at 2X (A) and 40X (B) Sentinel lymph ... staining, there was no evidence of metastatic carcinoma in any of the submitted lymph nodes Immunostaining was performed with pancytokeratin in three cases which showed no evidence of micrometastatic ... Gabrielli F, Migliano E, Pagan M, Concolino F, Ruatti P: Lymphatic mapping and sentinel node identification in squamous cell carcinoma and melanoma of the head and neck Tumori 2002, 88:S39-41 29 Tartaglione...
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Báo cáo khoa học: "Large volume unresectable locally advanced nonsmall cell lung cancer: acute toxicity and initial outcome results with rapid arc" potx
... NSCLC We also investigated the possibility of sparing lung tissue, esophagus, heart and spinal cord using RA with the aim of paving the way for further study of dose escalation In the present study, ... CT scan and were immobilized in a supine position within a personal bodyfix pillow During the scan, and the treatment, patients breathed freely, with the indication to maintain a breathing cycle ... received by the x% of the volume; Vx% = volume receiving at least x% of the prescribed dose; CI = ratio between the patient volume receiving at least 95% of the prescribed dose and the volume of the...
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Báo cáo khoa học: "Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy" pdf
... simulation The need to outline a gross tumour volume (GTV) and clinical target volume (CTV) to aid definition of the PTV was at the discretion of the clinician The second method of outlining the target ... pathologically and reviewed within the multidisciplinary head- and- neck team As part of the study, the imaging of the all patients who experienced LRR was reviewed by a head and neck specialist ... http://www.ro-journal.com/content/6/1/54 consisted of clinical examination, nasopharyngolaryngoscopy and CT or MRI imaging of the primary site and the neck Any suspicious findings in the primary tumour site or neck were evaluated...
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Báo cáo khoa học: "Parotid gland-recovery after radiotherapy in the head and neck region: 36 months follow-up of a prospective clinical study" pdf
... reference point in the target volume as described in ICRU reports 50, 62 and 83 Determination of the parotid gland doses The planning target volumes and both parotid glands, the mandible, and the larynx ... treatment of carcinomas of the oral cavity, the oropharynx, and the larynx/ hypopharynx, the sparing of submandibular salivary glands can only be taken into consideration in special cases Sparing of ... 3DCRT in terms of parotid gland sparing The IMRT technique should therefore represent the standard of care for the treatment of head and neck tumors Parotid-gland-sparing up to mean doses of 26...
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Báo cáo khoa học: "Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions" ppsx
... FU and MMC remains the standard of care for squamous cell carcinoma of the anal canal The RTOG initiated a multi-institutional effort to prospectively treat patients with IMRT-based chemoradiotherapy ... Aided in the design of the study, helped draft the manuscript D.W.L.: Aided in the design of the study, helped draft the manuscript J.F.Q.: Aided in the design of the study, helped draft the manuscript ... and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol...
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Báo cáo khoa học: " Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans" ppsx
... Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of ... three-dimensional cm margin, the anal canal, and the draining lymphatic regions, including the perirectal, internal iliac, external iliac, obturator and inguinal lymphatics in all cases For the five patients ... Comparison of OAR sparing between IMRT and conventional 3D plans Incorporation of IMRT in phase or in phase and significantly reduced the volume of bladder and genitalia/ perineum receiving ≥ 30 Gy and...
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Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps
... was involved in the interpretation of the data, and drafting of this article IO was involved in the conception and design of this project, analysis and interpretation of the data, and critiquing ... of the data, and critiquing of drafts of this article BB was involved in the design of this project, analysis and interpretation of the data, and critiquing of drafts of this article MR was involved ... involved in data acquisition, interpretation of the data and critiquing of drafts of this article HF was involved in the analysis of data from this study and interpretation and presentation of results...
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