molecular regulation of systemic iron metabolism

Tài liệu Regulation of cancer cell metabolism docx

... has profound effects on their metabolism Indeed, it seems that the integration of growth and proliferation signals with alterations to central metabolism is crucial for the oncogenic effects of ... Publishers Limited All rights reserved REVIEWS of genes that increase glucose metabolism and reduce mitochondrial respiration One of these genes encodes an isoform of PDK (PDK4) that has the same function ... splicing The inclusion of exon in the PK mrnA leads to translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (ReF 71) MyC upregulates the expression of heterogeneous nuclear...

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Báo cáo khoa học: Regulation of maize lysine metabolism and endosperm protein synthesis by opaque and ﬂoury mutations potx

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... initiated, with the aim of obtaining new insights into the regulation of lysine metabolism in maize During the course of this work Hunter et al [31] published an analysis of some of these mutants Our ... diversity (Fig 2) The eﬀect of each mutation on the amount of every isoform was tested using analyses of Table Quantitation of N constituents Percentage contribution of N constituents present in ... zein isoforms, but the effect of ﬂ2 was less pronounced than that of o2 In all, the o2 mutation markedly altered the pattern of low molecular mass zeins, as compared with the wild type Lysine metabolism...

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Molecular Regulation of Endocytosis Edited by Brian Ceresa pot

Danh mục: Sức khỏe giới tính

... further elucidation 34 Molecular Regulation of Endocytosis Figure Current model of the Vid pathway Growth of yeast cells under glucose starvation conditions induces the synthesis of gluconeogenic enzymes ... implications for metabolism Annu Rev Nutr 7: 19-40 [6] Wang CW, Klionsky DJ (2003) The molecular mechanism of autophagy Mol Med 9: 6576 * Corresponding Author 36 Molecular Regulation of Endocytosis ... uptake of cytosolic, peroxisomal and plasma membrane proteins by the yeast vacuole J Biol Chem 271: 9934-9941 38 Molecular Regulation of Endocytosis [40] Hoffman M, Chiang HL (1996) Isolation of...

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MOLECULAR REGULATION OF ENDOCYTOSIS pot

Danh mục: Điện - Điện tử

... further elucidation 34 Molecular Regulation of Endocytosis Figure Current model of the Vid pathway Growth of yeast cells under glucose starvation conditions induces the synthesis of gluconeogenic enzymes ... implications for metabolism Annu Rev Nutr 7: 19-40 [6] Wang CW, Klionsky DJ (2003) The molecular mechanism of autophagy Mol Med 9: 6576 * Corresponding Author 36 Molecular Regulation of Endocytosis ... uptake of cytosolic, peroxisomal and plasma membrane proteins by the yeast vacuole J Biol Chem 271: 9934-9941 38 Molecular Regulation of Endocytosis [40] Hoffman M, Chiang HL (1996) Isolation of...

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Molecular Biology of Secondary Metabolism - Case Study for Glycyrrhiza Plants

Danh mục: Sinh học

... export of the excess of reducing power via the malate valve, and productive consumption of the surplus of NADPH by the Calvin cycle Finally, as is the case with iron deﬁciency, the extent of protection ... biosynthesis of the respective triterpenes, molecular cloning of these cDNAs provides useful tools for studying regulation of triterpenoid biosyntheses in cultured licorice cells Thus, the mRNA levels of ... al., 2003) Molecular Biology of Secondary Metabolism 99 the high-level accumulation (more than 2% of dry weight) of soyasaponins (Hayashi et al., 2003) Furthermore, enzyme activity of UDP-glucuronic...

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Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot

Danh mục: Báo cáo khoa học

... Balancing acts: molecular control of mammalian iron metabolism Cell 117, 285–297 13 Richardson DR & Ponka P (1997) The molecular mechanisms of the metabolism and transport of iron in normal and ... Arosio P (1988) Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase activity of human liver, recombinant ... (1993) Regulating the fate of mRNA: the control of cellular iron metabolism Cell 72, 19–28 Munro HN & Linder MC (1978) Ferritin: structure, biosynthesis, and role in iron metabolism Physiol Rev 58,...

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Báo cáo Y học: Molecular interaction of neutral trehalase with other enzymes of trehalose metabolism in the ﬁssion yeast Schizosaccharomyces pombe pdf

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... pombe the regulation of Ntp1p activity under stress relies on the existence of some kind of interaction between Ntp1p and Tps1p, or other elements, that may be lost under the conditions of the in ... behavior of trehalase depending on the nature of the activation stress (Fig 5B) This shift might argue against the participation of a unique set of interactions involving association of Ntp1p ... Biochem 269) the existence of a multiprotein complex involved in the regulation of trehalose synthesis and breakdown in S pombe Trehalose- 6P phosphatase (Tpp1) is a member of the Ntp1–Tps1 complex...

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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc

Danh mục: Báo cáo khoa học

... )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was ... instead of RNA (lane +) were performed simultaneously The hrdB gene was used as control of RNA amounts probably because of the lack of iron- dependent respiratory metabolism after extended iron deprivation ... proved that iron control of the Regulation of the desferrioxamine gene cluster expression of the des cluster is mediated by the DmdR1 regulator Results Deletion of the desA gene of S coelicolor...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

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... up -regulation of glucokinase and a down -regulation of glucose-6-phosphatase gene expression, suggesting that this biofactor may also be involved in balancing the uptake and release of glucose from ... saturation ensured complete elimination of signals from outside of the volume of interest The localized signals of glycogen and glucose were acquired with spectrometer offset set to 100 p.p.m (64 scans ... volume of interest using a three-dimensional localization method The location of the volume of interest, with a nominal volume of 400 lL was based on sagittal and transverse MR images of the...

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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Danh mục: Báo cáo khoa học

... nucleus Regulation of gene expression by HIPPI Caspase Nuclear pore complex HIP1 Fig Possible mechanisms of regulation of transcription and apoptosis by HIPPI and HIP-1 in HD Interaction of HIP-1 ... independent of each other Detailed descriptions of these processes are beyond the scope of this review In the present review, we speciﬁcally focus on the role of Htt-interacting protein HIP-1 and its molecular ... translocation of AR to the nucleus Facilitation of nuclear transport of AR by HIP-1 depends on its C-terminal nuclear localization signal for HIP-1 In addition to that of AR, mediation of transcriptional...

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Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx

Danh mục: Báo cáo khoa học

... identiﬁcation of a speciﬁc receptor for GALP is of considerable importance if the physiological functions and mechanism of action of GALP are to be fully understood Little is known about the role of alarin, ... maturation of reproductive function Fasting decreases both the number of GALPexpressing neurons [23] and the expression of GALP mRNA [24] Leptin administration restores the number of GALP-expressing ... to the MPA, bed nucleus of the stria terminalis and lateral septal nucleus Central administration of GALP activates neurons in various regions of the rat brain Injection of GALP into the third...

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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf

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... expected, a protein of molecular weight 49 kDa was induced from transformant bearing the p19C-S in the presence, but not in the absence, of IPTG For immunization, a protein of molecular mass 49 ... binding site of the repressor Therefore, the possibility that Mrg19p could be a member of Hap1p complex remains to be tested If MRG19 were a repressor of CYC1 involved in the regulation of carbon ... importance of mitochondrial function in galactose metabolism has been well recognized, the molecular basis for the same has largely remained unexplored We had reported the isolation of MRG19 as...

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inorganic biochemistry of iron metabolism

Danh mục: Sinh học

... Distribution of Iron Deﬁciency Acquired Iron Deﬁciency Genetic Forms of Iron Deﬁciency Clinical Stages of Iron Deﬁciency Symptoms and Signs of Iron Deﬁciency Treatment of Iron Deﬁciency Iron Overload ... Communication Between Iron Donor and Iron Acceptor Cells Maintenance of Iron Balance in Cells Contents x 9.3 Iron Absorption in Disorders of Iron Metabolism 9.3.1 9.3.2 9.4 Iron Deficiency 9.4.1 ... 8.2 Sources of Dietary Iron in Man and the Importance of Luminal Factors 192 8.3 Molecular Mechanisms of Mucosal Iron Absorption 8.3.1 8.3.2 8.3.3 Iron Uptake at the Apical Pole Iron Transfer...

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Báo cáo sinh học: "Regulation of metabolism in Caenorhabditis elegans longevity" ppsx

Danh mục: Báo cáo khoa học

... lead to the speculation that the longevity of IIS mutants is at least partially derived from downregulation of TOR Mutation of DAF-15/RAPTOR, an activator of TOR, results in increased C elegans life ... development, metabolism and life span Development 2004, 131:3897-3906 doi:10.1186/jbiol215 Cite this article as: Gallo M, Riddle DL: Regulation of metabolism in Caenorhabditis elegans longevity Journal of ... Although the role of metabolism in aging is not straightforward, the metabolomics of longevity mutants may provide some answers It is interesting to notice that several classes of long-lived mutants...

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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx

Danh mục: Báo cáo khoa học

... effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating experiments did not show any strong evidence of ... previous report of increased TNF levels in the serum of SLE patients [2], suggested that an abnormality in TNF signaling might exist Meanwhile, a cluster of MHC class II genes consisting of HLA-DRA, ... of SLE patients and healthy individuals to assess the TNF regulation on the immune response-related molecules in SLE On the other hand, although the expression of IFN was Gene expression profiles...

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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

Danh mục: Báo cáo khoa học

... amount of 7α-OHDHEA is expressed as the percentage of 3H-labelled 7α-OHDHEA of the total amount of 3H-label measured Recoveries after extraction were in the range 85–95%, and identification of 7α-OH-DHEA ... chromatography The amount of 7α-OH-DHEA is expressed as the percentage [3H]-7α-OH-DHEA of the total amount of [3H]-label measured Results are expressed as the mean ± standard error of the mean of triplicate ... transducer and activator of transcription Discussion The findings of the present study suggest involvement of AP1 and NF-κB, but not of p38 or ERK1/2, in the TNF-αenhanced formation of the immunostimulating...

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Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx

Danh mục: Báo cáo khoa học

... effect of TNF on the IFN signature induced by IFN, at least, exists in the network regulation of cytokines in vivo The results of the co-stimulating experiments did not show any strong evidence of ... previous report of increased TNF levels in the serum of SLE patients [2], suggested that an abnormality in TNF signaling might exist Meanwhile, a cluster of MHC class II genes consisting of HLA-DRA, ... of SLE patients and healthy individuals to assess the TNF regulation on the immune response-related molecules in SLE On the other hand, although the expression of IFN was Gene expression profiles...

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Báo cáo y học: " Molecular imaging of transcriptional regulation during inflammation" docx

Danh mục: Báo cáo khoa học

... a gene Page of 11 of interest and artificial promoters where a set of selected cis-elements are combined Often combinations of the two strategies are used A promoter is composed of a core promoter ... which took part in regulation of gene expression [29,30] A list of unique transgenic reporter mice used to study gene regulation in inflammation is shown in table Applications of NF-κB transgenic ... dynamics of NF-κB activity was imaged after induction of brain injury by intracerebral injection of IL-1β This led to an excep- Page of 11 tionally rapid NF-κB activation in the liver, suggestive of...

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Báo cáo y học: "Molecular imaging of transcriptional regulation during inflammationƠ" docx

Danh mục: Báo cáo khoa học

... a gene Page of 11 of interest and artificial promoters where a set of selected cis-elements are combined Often combinations of the two strategies are used A promoter is composed of a core promoter ... which took part in regulation of gene expression [29,30] A list of unique transgenic reporter mice used to study gene regulation in inflammation is shown in table Applications of NF-κB transgenic ... dynamics of NF-κB activity was imaged after induction of brain injury by intracerebral injection of IL-1β This led to an excep- Page of 11 tionally rapid NF-κB activation in the liver, suggestive of...

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báo cáo khoa học: "Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana" pdf

Danh mục: Báo cáo khoa học

... number of enriched categories was higher than that of any comparisons involving nas4x-1 samples Multiple reasons may have accounted for differential regulation of these categories Regulation of the ... amino acid metabolism) , and 17 repressed categories belonging to 11 different areas (dolichol metabolism, cold response, prenol metabolism, chloroplast, flavonoid metabolism, nucleoside metabolism, ... Confirmation of molecular phenotypes by GSEA, and identification of differentially expressed categories GSEA of general biochemical and cell biological categories demonstrated that roots and leaves of...

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