mechanisms of penicillin resistance in streptococcus pneumoniae targets gene transfer and mutations
Molecular characterization of the PhoPQ-PmrDPmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43 ppt
... effect of large amounts of CPS in polymyxin resistance PmrF is involved in polymyxin B resistance and survival within macrophage To investigate if the K pneumoniae pmr homologues played a role in ... Deletion effect of pmrA, pmrD or phoP on polymyxin B resistance in K pneumoniae To investigate how PmrA, PhoP and PmrD were involved in the regulation of polymyxin B resistance in K pneumoniae, ΔpmrA, ... that of the positive control cells was observed indicating an interaction between the PmrD and PmrA Analysis of EMSA indicates a direct binding of the recombinant PhoP to pmrD The binding of PhoP...
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Tài liệu Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrho pdf
... species and closely related bacteria The development of a pool of resistance genes and the ability of the gonococci to maintain these determinants of resistance within their genetic coding is part of ... proportion of strains tested continue to exhibit high-level plasmid-mediated resistance to tetracyclines, penicillin and quinolones and their use in treating gonorrhoea has long since been discontinued ... (for instance swabs, transport media and candle jars) • training laboratory technicians and building capacity for performing culture and AMR testing • increasing the availability of routine laboratory...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... and 22 h), and the HA production in the culture medium was quantitated by a sandwich binding protein assay using a very specific HABP (Fig 3) By h of culturing, a small amount of HA released into ... identifiable species In this regard, our most interesting result indicated that with increasing time of MU treatment there was a decrease in the proportion of smaller CL species and an increase in the larger ... rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 32 Laemmli, U.K (1970) Cleavage of structural...
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MECHANISMS OF AESTHETIC EXAPTATION IN ARTEFACT DESIGN: HOW A BEAUX-ARTS GARDEN EVOLVED INTO AN AVANT-GARDE ART PARK pptx
... new interdependencies created by the combination of different elements and it is rooted in a change in the capacity of seeing and perceiving relationships more than in an increased capacity in ... a process of making connections among different problem domains (e.g combining alternatives generated in the domain of fund-raising with alternatives generated in the domain of design) This process ... theories of change and innovation Then I turn to an illustration of the methods and the findings of the case study, which are analyzed and used to build a process model of cognition and exaptation in...
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Patterns of drug resistance in pulmonary tuberculosis cases in the Izmir district, Turkey pdf
... dimensions and measurements The aim of the study is to evaluate the possible combinations and proportions of H, R, S and E and four resistant modes, i.e mono, double, triple and quadruple resistance instead ... quadruple resistance instead of notifying the incidence of plain resistance rates, in the new and the previously treated cases in the Izmir district METHODS Setting The study was carried out ... wild strains of human type that have never come into contact with the drugs (Mitchison, 1984) Monoresistance is defined as resistance to one of the first-line drugs Any drug resistance is indicated...
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Báo cáo khoa học: On the mechanisms of glycolytic oscillations in yeast potx
... activating mode is the abundance of AMP and ADP, and scarcity of ATP (i.e the minimum of the ATP oscillation instead of the maximum), and the inhibitory mode is abundance of FBP and scarcity of G6P ... this understanding of the dynamic system to obtain an interpretation of the biochemical nature of the activating and inhibiting modes In essence, we this by mapping the measured phase and amplitude ... of G6P and F6P, and the inhibiting mode is high energy charge The activating and inhibiting feedback can be explained by the same reasoning as given for the interpretation in panels B and E;...
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Báo cáo khoa học: Characterization of the 16S rRNA- and membrane-binding domains of Streptococcus pneumoniae Era GTPase Structural and functional implications docx
... the RNA- and membrane-binding domain of Era may be involved in the regulation of cell cycle Fig Inhibition of the binding of Streptococcus pneumoniae Era to poly(U) RNA by liposome In each case, ... membrane-binding domain of Era also required the GTP-binding and GTPase activities of the protein for function and whether, biochemically, the RNAand membrane-binding domains overlap To investigate ... activity of the protein and whether the RNA-binding domain can bind RNA in the absence of the GTPase domain Structurally, it remained to be established whether the RNA-binding domain is functional in...
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Mechanisms of salt tolerance in halophytes pps
... salinity stress; with both a reduction in the total number of seeds germinating and a delay in the initiation of the germination process Seeds of many species, including Atriplex halimus and ... of sodium [77] This mechanism may be very important in Fig.9 The effect of changes in concentration of NaCl and KCl on stomatal opening in detached epidermis of Commelina communis, in light and ... rather than in vitro may occur due to increase in substrate concentration, and increase or decrease in levels of enzymes involved in intermediate metabolism The ability of halophytes to grow in highly...
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Báo cáo y học: " Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-γ and counteraction by interferon-γ" pot
... importance of STAT1 and IRF-1 in the inhibitory action of IFN-γ, the percentage of inhibition of the expression of GCP-2, RANKL and IL-6 mRNA induced by synergistic action of IL-17 and TNF-α was ... immunization by injecting 20 μg of CII in the left ears and vehicle in the right ears Bars in Figure 3d represent the percentages of swelling in the CII-challenged ears, normalized to the swelling of the ... [21] Mice, induction, evaluation and treatment of CIA Generation and basic characteristics of the mutant mouse strain (129/Sv/Ev) with a disruption in the gene encoding for the α-chain of the IFN-γ...
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Báo cáo y học: "Quantifying the mechanisms of domain gain in animal proteins" doc
... domain gain in animals and there are also indications of the importance of adjacent gene joining [11] and NAHR [43] in the formation of chimeric genes in the Drosophila lineage Terminal gains of ... duplication of pre-SET and SET domains through retroposition, insertion of the transposase domain and subsequent joining of these domains The SETMAR gene is in the intron of another gene (SUMF1), ... domain gains differs from the number of gained domains Additional file 3: Distribution of domain gain events according to the position of the domain insertion and the number of exons gained in...
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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
... The interpretations of genotyping data and subtyping were performed using Smartgene™ HIV software packages (Integrated Database Network System, Smartgene, Zug, Switzerland) Selection of drug resistance ... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... 1) and a new recombinant of A1 and D (n = 1) No major PR resistance mutations were seen in any of the sequences, but a mean of minor PR mutations were observed per sample (data not shown) Resistance...
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báo cáo khoa học: " Curbing the menace of antimicrobial resistance in developing countries" ppsx
... usefulness of the antimicrobials, insuring that humanity is not annihilated Discussion Curbing antimicrobial resistance Finland [10] had proposed that the dominant factor in the emergence and spread of ... socio-economic and political factors [16,17] Accordingly, several solutions have been proposed including education of health care and allied professionals and the general public, basic research and surveillance ... sub-therapeutic doses, increasing the chances of resistance developing Corruption which is a global pandemic encourages the importation of substandard drugs and the misappropriation of funds meant for...
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Báo cáo khoa học: "Bench-to-bedside review: Antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unit" pps
... of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: Guidelines for the prevention of antimicrobial resistance in hospitals Clin ... consisted of restricting the use of ceftazidime and ciprofloxacin along with cycling other antibiotics directed against Gram-negative bacteria Antibiotic consumption and resistance profiles were ... was highest during use of levofloxacin and piperacillin/ tazobactam The potential for selection of antibiotic-resistant Gram-negative bacteria during periods of homogeneous exposure increased from...
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MECHANISMS OF BINDING DIVERSITY IN PROTEIN DISORDER: MOLECULAR RECOGNITION FEATURES MEDIATING PROTEIN INTERACTION NETWORKS
... 1.2 Intrinsic Protein Disorder in Protein-Protein Interactions Many proteins execute their biological functions through protein-protein interactions By binding to interacting partners, proteins ... other hand, three distinct binding profiles were identified in the collected many-to-one dataset: similar, intersecting and independent For the similar binding profile, the distinct MoRFs interact ... .xiv Chapter 1: Introduction 1.1 Intrinsic Protein Disorder and Protein Functions .1 1.2 Intrinsic Protein Disorder in Protein-Protein Interactions 1.3 Characterization of Molecular Recognition...
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MECHANISMS OF CYTOSKELETAL DYSREGULATION IN THE KIDNEY PROXIMAL TUBULE DURING ATP DEPLETION AND ISCHEMIA
... rich in proline, serine and threonine residues, and then finally a C-terminal SH3 domain The SH3 domain of cortactin binds with multiple partners, for example the proline-rich domain of dynamin-II ... functional changes of cortactin Cortactin has many protein targets in vivo, and among the interactions with those multiple binding partners, the direct binding with F-actin and actin nucleation factor ... Tyrosine phosphorylation level of dynamin-II decreases in LLC-PK1 cells upon ATP-depletion and Src kinase inhibition The SH-3 domain at the C-terminus of cortactin binds with proline-rich domain of...
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real situation of antibiotic resistance in pneumonia in việt nam and guideline for initial antibiotic treatment
... ampicillin/sulbactam) Cephalosporins (2nd or 3rd generation) Fluoroquinolones (levofloxacin, moxifloxacin) Fluoroquinolones (ciprofloxacin, levofloxacin - high dose) or βlactam with P aeruginosa ... 2011) Resistance of pathogens causing HAP and VAP Principal pathogens in hospital Gram positive : MRSA VRE Gram negative : PA Acinetobacter R- Quinolone R- Cephalosporin & penicillin ... Fluoroquinolones (gemifloxacin, levofloxacin, moxifloxacin) Group C BN nguy nhiễm pseudomonas Fluoroquinolones (ciprofloxacin, levofloxacin high dose) Parenteral use β-lactam/β-lactamase inhibitor (Co-amoxiclav)...
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How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese
... not a boring task of reading, analyzing and comparing but actually a great pleasure III.2 Translation of dead metaphors in Harry Potter and the Prisoner of Azkaban and Harry Potter and the Deathly ... 42 42 All in all, translation in some certain meaning in a work of creativity and imagination Knowing the way is far different from actually going on that way In other words, theory and academic ... leading to inaccurate interpreting and translation For example, the sentence Hes a potato may imply Hes lazy and inactive in English, while in Vietnamese, it could be interpreted as Hes a kind...
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Analysis of Phosphorus Behavior in the Giant Reed for Phytoremediation and the Biomass Production System
... these findings, a management method adequate to obtain the biomass of the giant reed and maintain the wetland potential is proposed as shown in Fig 10 In this method, the above-ground part of the ... soil are not included, to avoid the adsorption loss of phosphorus and other changes that occur in soil The experimental equipment was placed on the rooftop terrace of the Institute of Industrial ... rhizomes and the roots of giant reeds were soaked in Na2HPO4 aqueous solution (3.0 mg-P/L) containing a trace amount of Na2H32PO4 The amount of phosphorus accumulated was continuously measured by using...
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CFD model of air movement in ventilated façade: comparison between natural and forced air flow
... air gap with a minimum of cm The role of this layer is to prevent heat getting into the building in summer and take moisture out of the building In this ventilated gap the aluminum substructure ... in winter and guarantee passive cooling effect by combining convective and heat transport between the outer and inner walls in summer; watertight to guarantee no water infiltration due to rain, ... presence of ventilated façade in a building leads to a cooling effect in the skin of this building due to the action of the air movement in the gap as demonstrated in many references [10, 11] In summer...
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