mechanism of aging dependent apoptosis resistance by the nuclear barrier
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... adipocyte apoptosis, the expression of PPARc is increased by 80% [10] Furthermore, the activation of PPARc stimulates apoptosis in a variety of cell types, including cancer cells, endothelial cells ... analysis of GW9662 inhibition of adipocyte apoptosis AO ⁄ EB, apoptosis measured by AO ⁄ EB staining; Hoe ⁄ B.F, apoptosis measured by Hoechst 33258 staining Results are means ± SDs of three independent ... 6B–D) Akt-1 Discussion The function of PPARc in adipogenesis is well established [19] However, in many other types of cell, the activation of PPARc is linked to the induction of apoptosis It has been...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... Brownian rotation of the fluorescent nucleotide Fig Binding of Ant-dATP to AC (d) and AC–CaM (m) The degree of binding of the ligand was calculated from the value of the amplitude of the long lifetime, ... activation mechanism Recently, the resolution of the 3D structure of the AC exotoxin of B anthracis and of its complex with CaM led to the proposal of a different CaM -dependent regulatory mechanism, ... all of the residues of the catalytic mechanism are present in the neighborhood of the catalytic site, but they are not ordered correctly in the exotoxin alone CaM binding folds parts of the regulatory...
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Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... result of changes introduced by the mutations in the environment of the prosthetic group As a result of the important changes observed for each mutant in the differential spectra elicited by NADP+, ... interaction between the flavin, Y308 and the nicotinamide of NADP+ is precisely tuned by selecting amino acids that face the other side of the tyrosine phenol ring The specific volumes of the above-mentioned ... phenol as the tyrosine R group This system has been used previously to analyze the geometry of the tyrosine stacked on the si-face of the flavin in FNRs [12] The single point energies of the flavin–tyrosine...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... optimization of inhibitors, a molecular model of the methyltetrahydrofolate-binding domain of the rat liver MetS was constructed In the absence of a high-resolution structure of the methyltetrahydrofolate-binding ... structures of DHPS and 5-methyltetrahydrofolate The model of the methyltetrahydrofolate-binding site of MetS with one molecule of the substrate included was further optimized using charmm, and the ligand ... 5-methyltetrahydrofolate in the model of the active site was based on the approach followed by Doukov et al [30] to identify the interactions between the pterin cofactor and MeTr This approach was based on the...
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USE OF HEALTH AND NURSING CARE BY THE ELDERLY pptx
... calculated These allow a comparison of the results of the national sources with the results from the ECHP, and the trends revealed by the ECHP between 1994 and 2001 Table 13 gives an overview of the ... Survey Use of health care The aim of this section is to analyse the current use of health care services by the elderly and the determinants of this utilisation Indicators for the use of health ... ERIKA SCHULZ The other tasks of WP2 are to: • • • • • • show the current use of health care services by the elderly; analyse the determinants of the demand for health care services; show the extent...
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American Negro Slavery A Survey of the Supply, Employment and Control of Negro Labor as Determined by the Plantation Regime docx
... Aragon to Portugal Furthermore the conquest of the Canaries at the end of the fourteenth century and of Teneriffe and other islands in the fifteenth led to the bringing of many of their natives as ... having served out the terms fixed either by their indentures or by the custom of the country By the middle of the century several had become free landowners, and at least one of them owned a negro ... fell short of the ultimate plan by failing to bind the grantees to the performance of their undertaking and by failing to specify the grades and the proportion of the sexes among the slaves to...
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Báo cáo Y học: Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis pptx
... identical to that of the trial experiment The deuterium content of the olefinic fatty acid methyl esters in the cellular lipid extract Ó FEBS 2002 Fig Isotopomers of used to probe the kinetic isotope ... previously indicated that the production of was dependent on expression of the FAC2 enzyme The two regiospecifically dideuterated linoleates ([8,8-2H2]-1, [11,11-2H2]-1) required for the KIE study (Fig ... masking of the ÔintrinsicÕ KIE by 5026 D W Reed et al (Eur J Biochem 269) Fig Mass spectrum of biosynthetic methyl calendate Arrow indicates the molecular ion cluster used to calculate the isotopic...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... because of overloading of the SRP pathway The re-routing of (G-10L)prePhoE to the Sec translocon via the SRP instead of the SecB pathway could be explained by the increased hydrophobicity of the ... prePhoE in the case of the TF crosslinked complexes These amounts were set to 100%, and the relative cross-linking efficiencies of the other prePhoE forms to TF and P48 are shown of SecA The 40-kDa ... that substitution of this residue by a-helix-promoting residues (Ala, Cys or Leu) reduced the pmf dependency of the translocation across the inner membrane, but the actual role of the helix breaker...
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Synthesis and photoluminescence property of silicon carbon nanowires synthesized by the thermal evaporation method
... room temperature to adjust the pore diameter and remove the barrier layer at the bottom of nanoholes 2.2 Synthesis of SiC nanowires The preparation apparatus for synthesis of SiC nanowires is a conventional ... [23] of SiC, the emission peak for b-SiC nanowires is obviously shifted to the blue The emergence of the peak with a blueshift is due to the existence of oxygen defects in the amorphous layer, the ... The SiO2 sheath could be easily removed by etching in hydrofluoric acid (HF) The thickness of the SiO2 sheath could be controlled by changing the etching time Fig also shows that the spacing of...
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx
... between the mAhR model and the FixL template is the relative position of the helical connector that moves closer to the b sheet, thus reducing the size of the binding cavity entrance (Fig 3) The ... one hand, the availability of the three structures indicates that the position of the helical connector can differ On the other, the closer functional homology between FixL and AhR, the secondary ... central helix, highlighting the importance of this region and the ¯anking loops as the critical regulatory region of the PAS domain family [16], with the remainder of the PAS fold serving as a...
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The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America pot
... included in the spectrum of the initial antibiotic choice or that subsequently display resistance to the initial agent by means of induction of resistance mechanisms, mutation, or selection of a small ... tests performed, and the goals of the investigators CAP in children in the United States, the focus of these guidelines, is defined simply as the presence of signs and symptoms of pneumonia in a ... from the organizations represented on the expert panel These guidelines have been endorsed by the AAP, the American College of Emergency Physicians, the American Society of Microbiology, the American...
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Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... deletion of OXA1 decreased the rate of formation of all aminoglycerophospholipids The rate of PtdSer synthesis decreased to 80%, the rate of PtdEtn formation to 70% and that of PtdCho synthesis ... formation by Psd1p This process includes synthesis of PtdSer in the endoplasmic reticulum by the PtdSer synthase Pss1p and translocation of PtdSer to the site of Psd1p-catalyzed decarboxylation in the ... translocation of the 50 kDa intermediate to the IMM, appears to be directly affected by Oxa1p, the whole process of Psd1p assembly into the IMM occurs more slowly in the mutant than in the wild-type The...
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measurement of metalcarbon nanotube contact resistance by adjusting contact length using laser ablation
... micrographs, the original contact length was measured to be ∼12.6 μm The resistance plotted is the total resistance which includes both the contact resistance and the MWCNT resistance of the μm section of ... plot of equation (9) to illustrate the effect of the parameters rCNT and rc on the predicted resistance as the contact length to a CNT is reduced (a) The variation in the total resistance of a ... contact resistance per unit length of 1.0 k μm As the length of one of the contacts is shortened, the total resistance increases in a characteristic way according to the specified value of rCNT , the...
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Báo cáo hóa học: " The use of RNA-dependent RNA polymerase for the taxonomic assignment of Picorna-like viruses (order Picornavirales) infecting Apis mellifera L. populations" pptx
... separated the family Picornaviridae from the others The amino acid Glycine (G) was nonetheless found to be conserved amongst all of the members With the exception of the genus Ilfavirus, all members of ... validated the use of the RdRp as a taxonomic marker for the classification of the order Picornavirales and, to an extent, for the viruses infecting the honeybee The evidence supports the assignment of ... affect the prediction of cause and effect The data presented here provides further foundations for understanding the ecology of these viruses and the interactions they have with their hosts, therefore...
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Báo cáo hóa học: " Research Article Space-Varying Iterative Restoration of Diffuse Optical Tomograms Reconstructed by the Photon Average Trajectories Method" ppt
... that by choosing the optimal values of the time-gating delay of receivers, the length of the middle segment of the broken PAT may be greatly longer than the first and the end ones Moreover, the ... solution of the time -dependent diffusion equation for the instantaneous point source with the use of the FEM method The time-gating delays of the receivers were chosen so that the lengths of the outer ... reconstructed by FBP The results of their restoration by unpreconditioned MRNSD are given on the right of Figure You can see that there are distortions of the inhomogeneity forms in the cases of 10%-...
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Báo cáo lâm nghiệp: "Seasonal changes of plant hydraulics, water relations and growth of Aesculus hippocastanum seedlings infested by the leafminer Cameraria ohridella" ppt
... Raimondo et al of horse chestnut seedlings either infested by the leaf miner or protected from the parasite attacks The final aim of the present study was to evaluate the risk of mortality in ... indicated by the relative constancy of root hydraulic resistance (Rroot) A detailed analysis of seasonal changes of the hydraulic resistance of different shoot compartments revealed that the reduction ... to controls We not know the physiological basis for the presence or the absence of borderline effects of mines on the photosynthetic apparatus of still green parts of the leaf blade We note,...
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Báo cáo lâm nghiệp: "Discrimination of coated carbide tools wear by the features extracted from parallel force and noise level" potx
... along the edge of the disk (work material) with depth of cut of mm The disk was fed down into the corner of the cutting edge in the speed of 0.05 mm/rev When the cutting tools finished one pass of ... cutting angle of –5° and clearance angle of 5°, was placed on the three component forces of dynamometer that was held on the table of the NC machine Turning was performed by the corner of the cutting ... same in the rate of the increase (Tab IV) The TiN/AlN coated tool would be more abrupt in the increase of the noise level compared to the others However, the regression coefficients for the parallel...
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báo cáo khoa học: " Insight into the early steps of root hair formation revealed by the procuste1 cellulose synthase mutant of Arabidopsis thaliana" doc
... to the expression pattern or activity of one of the other CesA proteins or other important factors cannot be ruled out However, alteration of the cellulose composition of the cell wall is not the ... hydrate:glycerol:H2O 8:3:1 and the relative root hair position determined by dividing the trichoblast cell length by the distance from the basal cell wall of the trichoblast to the basal wall of the root hair ... [4,5] The formation of double hairs by a proportion of prc1-1 epidermal cells (Fig 2E) indicates that the control of the site of hair initiation is affected To test this, the position of hair...
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The common errors in using some skinds of nouns in english made by the eleventh grade student at nguyen trai hight school, thai binh
... question about their level of English, about 30.00 % of them said that they were rather good at English 40.50% of them said that they were bad at English Based on the questions in the survey questionnaire, ... Most of students know the meaning of the word “people”; however, they not know the meaning of “peoples” There are only 10 students who made correct answers for choosing the meaning of “peoples” The ... kinds of nouns were found In the third step, the percentage of each type of errors was calculated and shown in a bar chart by the following smaller steps: The total number of questions of each...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008