mb increases the activities of brain and heart mitochondrial complex iv by 100 and 50 respectively
Báo cáo khoa học: Murine serum nucleases – contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3) doc
... glycosylated in a random manner by NIH-3T3 cells, and in vivo by the exocrine cells of the parotid gland, and furthermore demonstrate that the putative glycosylation site of DNase1l3 is not recognized ... unclear whether this is also true for the in vivo situation The exact concentrations of released and activated enzymes within inflamed tissues, the order of their appearance and the duration of their ... allow the identification of the residual nuclease activity by, for example, the estimation of the molecular mass of the nuclease Therefore, we attempted to establish a DPZ procedure for the identification...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
... values of the native and WT, and the YQ mutant CPU with a synthetic and physiological substrate of CPU There seem to be no major changes in the positioning of the propeptide, as indicated by residual ... x)D]}) to the data, where y is percentage inhibition and x is the molar concentration of the inhibitor, A is locked to 0%, B to 100% , C is the IC50 value and D is the slope of the curve The IC50 value ... mutation T347I The mutants with the most stable activity are achieved by combinations of few conservative mutations, S327C, H355Y and H357Q Can the effects of the mutations reported here and the reasons...
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Báo cáo khoa học: Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates potx
... result of the presence of negatively-charged residues at P2 and P2¢ that are not accommodated within the b2-tryptase active site because of the presence of Asp147 and Asp143 within the S2 and the S2¢ ... reported by Hof et al [1] indicate that the side-chain of Arg41 located on the 30S insertion loop in CG projects from the molecular surface to the east of the active site in accordance with the standard ... of the higher electronegative charge of the O atom of the Ser side-chain compared to that of the sulfur atom in the Cys side-chain; P3¢ Leu for Pro because a Pro is not well accommodated by the...
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Báo cáo khoa học: Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP ppt
... Activation of brain SR requires the presence of GAP2 together with PDZ7 Interestingly, in the absence of additional ATP, the activation induced by the presence of the PDZ4PDZ5-PDZ6-GAP2-PDZ7-end of GRIP ... inspected the catalytic properties of SR in the presence and absence of added ATP In the presence of 100 lm ATP, the enzyme becomes activated but, interestingly, the Vmax for d-serine synthesis increases ... through the direct interaction of the PDZ6 domain of GRIP and the final four amino acids of SR [12] We performed the recombinant expression in E coli and the purification of two larger fragments of...
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brain landscape the coexistence of neuroscience and architecture dec 2008
... beauty of the mind and the beginnings of understanding how the mind comprehends and why the body experiences pain and pleasure We need both Each stands on the brink of understanding the other The ... the design and structure of the brain, but the environment can modulate the function of genes and, ultimately, the structure of our brain Changes in the environment change the brain and therefore ... principal cell of the brain is a neuron, and there are something on the order of 100 billion neurons in the human brain, joined by 100 trillion connections In addition to these neurons, the brain is...
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the mit press the handbook of brain theory and neural networks second edition nov 2002
... pairs The contraction of one member of the pair will then act around a pivot to cause the expansion of the other member of the pair Thus, one set of muscles extends the elbow joint, while another ... environment the inputs to the organism—while the activity of the environment will be responsive in turn to aspects of the current activity of the organism, the outputs of the organism The inputs and ... Gordon and the copy editors and typesetters who transformed the diverse styles of the manuscripts into the style of the Handbook; and to the graduate students who helped so much with the proofreading...
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báo cáo sinh học:" The role of nurses and midwives in polio eradication and measles control activities: a survey in Sudan and Zambia" pdf
... midwives in the expanded programme on immunization Study objectives The objectives of this study were to document the roles, functions and contribution of nurses and midwives in the delivery of routine ... Nurses and midwives are the key health care providers and constitute the largest proportion of the health workforce globally In most countries, they are the first, and often the only, point of contact ... necessary for the process of empowerment [5] Given the pace of change in health systems across the world, the need to develop nurses and midwives who value creativity and innovation and enjoy the challenge...
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Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
... inhibit the expression of monocyte-activating factor at the surface of T lymphocytes, which in turn decreased the activation of monocyte/macrophages, and thus their production of IL-1β and matrix ... inhibition of PGE2 synthesis was observed in the presence In the present study we investigated the effect of the active metabolite of leflunomide – A77 1726 – on the production of IL-1Ra by human ... derived from the same gene [24,25] The exact biological functions of the different IL-1Ra isoforms are still not clear [25–27] The major role of secreted IL-1Ra is to block the effects of IL-1 by...
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Báo cáo khoa học: " Neuropsychological testing and biomarkers in the management of brain metastases" doc
... recall The severity of neurocognitive impairment from brain lesions generally is related to the size of the tumor rather than the number of metastases Meyers et al [58] found that the volume of the ... survivors of brain metastases treated with WBRT [40,41], which is thought to be dependent on the total dose of radiation, the size of the irradiated field, and the fraction size Understanding and ... the presence of S100B in the serum of 38 patients with lung carcinoma, an elevated S100B level was either associated with brain metastases or with the presence of imaging changes suggestive of...
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Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... the loss of Mcl-1 preceded the appearance of morphological and biochemical features of apoptosis and occurred in the absence of changes in the level of Bcl-2 or Bcl-xL In addition, the loss of ... loss of mitochondrial membrane potential, leading (presumably as a result of subsequent release of cytochrome C from mitochondria and activation of procaspase-9) to the cleavage and activation of ... present and 50% of the osteoclasts were rounded and lacked areas of spreading Many of these rounded osteoclasts lacked membrane ruffles or microvilli but contained numerous blebs, indicative of cells...
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Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx
... versican and nfatc1 were mainly respectively expressed in the myocardium and endocardium at the AV junction of the heart in both DMSO-treated 48- and 72-hpf embryos (Figure 2C) Ectopic expressions of ... in b-lapachone-treated 52- and 72-hpf embryos (Figure 1C-J) Severe pericardial and yolk edema accompanied by the linear arrangement of the heart chambers and a lack of blood circulation were observed ... Both the endothelium and erythrocytes are regulated by oxidative stress Oxidative stress was shown to regulate the growth, survival, and apoptosis of vascular smooth muscle and endothelial cells...
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Báo cáo y học: " Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs" potx
... after day 10 The rectal temperature of the deceased pigs of the coinfected group reached 41°C, and in of the pigs the temperature reached 41.5°C, and the number of neurologic symptoms in these pigs ... in the sequence alignment Sun Page of Guanli, Li Linxi and Xiang Hua participated in the design of the study and performed the statistical analysis Cai Xuehui and Lei Liancheng conceived of the ... group contained PRRSV in the brain The lungs of HP-PRRSV-infected and coinfected pigs contained similar amount of PRRSV RNA; however, the amount of PRRSV RNA in the brain of coinfected pigs was...
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Báo cáo y học: "Infra-red thermometry: the reliability of tympanic and temporal artery readings for predicting brain temperature after severe traumatic brain injur" pot
... explained by the fact that during the 'sweep' across the forehead (followed by the 'behind the ear' tap over the mastoid) the temporal artery thermometer records the 'peak' temperature value of the ... were provided by 353 temperature 'triplets': brain and tympanic membrane readings, and brain and temporal artery readings The temperature measurements were made by one member of the research team ... infra-red heat energy from the skin overlying the course of the temporal artery [11] The technique is quick; the instrument is easy to clean and is relatively inexpensive The aim of the study was to determine...
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Báo cáo y học: "The relation between the incidence of hypernatremia and mortality in patients with severe traumatic brain injury" pptx
... for the purpose of study data collection The Ethical Committee of the Parma University Medical School approved the study and waived the need for written informed consent by patients' next of kin ... week of stay The nine missing daily Na measurements were replaced by the value of the previous day of the ICU stay The use of DDAVP, which we took as a surrogate marker for the presence of CDI, ... mmol/l) Altogether, 15.9% of the follow-up days were complicated by hypernatremia – occurring at least once in 51.5% of the patients for 31.0% of the duration of their stay in the ICU, even though...
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The relationship of psychological and personality factors to post concussive symptoms (PCS) in mild traumatic brain injury (MTBI) patients
... linked to the duration of PCS experienced and the interaction of the MTBI afflicted individual with the demands of daily life 14 CHAPTER 3: INJURY AND NON-INJURY FACTORS IN PCS AND PPCS The pathophysiology ... differences in age and level of education between the patient group and control group The sample profile of the population and injury profile of the patients were obtained through descriptive statistics ... write down the answering scheme and reply accordingly when the questions were asked For the BDI-II, they had to listen and respond to the questions asked by the assessor At the end of the assessment,...
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An investigation into the attitudes of teachers and students at the hanoi college of industrial economics towards speaki
... understand well about the teachers’ attitudes towards the speaking skill lessons, the 37 researcher asked the teachers about their opinions about the contents of the topics, the activities and the ... positive and negative attitudes towards the speaking skills in the textbook According to them the topics and activities in the textbook are interesting but not suitable with the level of the first ... students and teachers to choose In term of the activities, they supposed that the speaking activities of the book were not abundant and motivating enough in learning a new skill but they could...
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Guidelines for the determination of brain death in infants and children
... in irreversible coma Coma and apnea must coexist to diagnose brain death Determination of brain death by neurologic examination should be performed in the setting of normal age-appropriate physiologic ... with brain death All aspects of the clinical examination, including the apnea test, or ancillary studies must be appropriately documented 4 References Guidelines for the Determination of Brain ... Infants and Children:An Update of the 1987 Task Force Recommendations— Executive Summary Thomas A Nakagawa, MD, FAAP, FCCM 2.Report of Special Task Force Guidelines for determination of brain death...
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Managing activities of teaching and learning the specialized subjects in the vacatinal schools in viet nam under the ministry of trade and industry
... as the input of the study The researcher then proceeded to the assessment of the current status of the management of teaching and learning activities, evaluation of the current status of the ... on the management of teaching and learning activities Process •Assessment of the current status of the management of teaching and learning activities •Evaluation of the current status of the ... include the management and coordination of the activities of the organization of pedagogy in schools such as the professional activity andthe hours, management of a team of teachers - the support...
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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System
... receipt of data in an IPC message In the first case, the source of the data is considered trusted (either the default pager, or a data manager known to the requestor) Use of the data received in ... access to the array and, if other clients had already referenced the data of the array, the physical memory cache of the array would be directly accessible to the client with no further message ... structure records the memory object and offset into the object, along with the access permitted to that page by the data manager Reference and modification information provided by the hardware is...
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The graphs below show the numbers of male and female workers in 1975 and 1995 in several employment sectors of the republic of Freedonia
... and 250 000 women worked in the communications sector Twenty years later, though the number of men remained unchanged, the number of women rose to 550 000 A similar situation was seen in the wholesale ... 450 000 by 1995 The number of men grew only marginally from 425 000 to 480 000 over the same period In defence, the number of men declined from 225 000 to 200 000, while the number of women rose ... wholesale and retail trade sector, where the number of women rose from about 550 000 in 1975 to almost 800 000 two decades later The number of men in this sector remained stable over the period,...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008