macular pigment carotenoids and their roles in human eye health and diseases
Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, the FYRC domain and the ... different signaling pathways, Role of MLL in human malignancies for example, protein kinase C, protein kinase A, RAS ⁄ RAF, WNT-, phosphatidylinositol 3-kinase and Hedgehog, and thus affects ... protein-binding platform for several other proteins to initiate a fundamental cellular process P-TEFb binds to the N-terminal portion of AF4, whereas the C-terminal portion of AF4 confers binding...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing ... aB-Crystallin R120 corresponds to aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases...
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The chemical components of detergents and their roles in the washing process
... present in hard water and in soils, thus allowing surfactants to function correctly Phosphates prevent these ions combining with surfactants and rendering these inactive They also condense to increase ... and magnesium incrustations on fabrics and on the washing machine’s heating elements - stabilise alkalinity at the correct level throughout the washing process thus giving good soil removal and ... redissolve calcium and magnesium compounds present in the washing machine from previous washes, thus reactivating any remaining detergents and improving detergent performance No other single chemical...
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Cloning and characterization of diamine oxidase and glutamate decarboxylase genes of mustard (brassica juncea) and their roles in shoot morphogenesis in vitro
... Lai Lai and Dr Yu Hao, for their help and encouragement during my staying in Singapore Their presence has created an enjoyable and productive working environment and made my staying in Singapore ... in siliques and rosette leaves, lower in flower and cauline leaves and lowest in stem and root (Soyka and Heyer, 1999) Unlike ADC1, ADC2 transcript was accumulated predominantly in siliques and ... lines of AtGAD-AS, AtGAD-S and AttGAD plants 214 xvii Summary There is accumulating evidence showing that polyamines (PAs), including putrescine (Put), spermidine (Spd) and spermine (Spm), and...
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The ancient origin of NF kb ikb and thioredoxin and their roles in immune response
... is involved in the dimerization, DNA-binding and interaction with the inhibitory IκB (inhibitor of NF-κB) proteins The difference is that RelA, RelB and c-Rel have an activation domain in their ... dual and opposing roles in the regulation of NF-κB in the nucleus and cytoplasm In the cytoplasm, TRX interferes with the signals to IκB kinases, and blocks the degradation of IκB, thus maintaining ... kinase; IL-1β, interleukin-1β; iNOS, inducible nitric oxide synthase; LT, lymphotoxin; MCP-1, monocyte chemotactic protein-1; MIP-1α, macrophage inflammatory protein-1α; NIK, NF−κB-inducing kinase;...
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siRNA, miRNA and their possible roles in molecular therapy of chronic human hepatitis b virus infection and hepatocellular carcinoma
... protein = HBV polymerase; L = large surface proteins; M= middle surface proteins; S = small surface proteins; TP: terminal protein During HBV infection in human, virus particles are present in ... 60-70% of the incidences of HCC in Europe, 50-60% in North America and 70% in Japan In contrast, in the less developed countries, such as in Asia (except Japan) and Africa, HBV infection is the ... of development and/ or progression of HCC still remain unclear and current approaches for screening and treatment of HCC remain disappointing In the next section, I will review the incidences of...
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Tài liệu Báo cáo khoa học: Role for nectin-1 in herpes simplex virus 1 entry and spread in human retinal pigment epithelial cells docx
... changes in the cytoskeleton that may occur during the initial h window of infection We infected RPE cells with K26GFP [27], and stained cells for F-actin, using phalloidin at 30 and h postinfection, ... time points and stained for F-actin (red) The GFP intensity (representing virus production) increased significantly over time, as seen pictorially in Fig 3A–E and in graphical form in Fig 3F Infection ... boxed regions in (b) and (e) are highlighted in (c) and (f) Arrows and arrowheads in (c) and (f) indicate the association of HSV-1 GFP particles with actin-stained rhodamine phalloidin (g, h) Effect...
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Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells ppt
... remnants are able to induce foam cell formation in human monocyte-derived macrophages (HMDM) [21] and in human and murine macrophage cell lines [22–24], and that, in striking contrast to LDL, ... containing 70% trilinolein, 2% cholesterol, 5% cholesteryl ester and 25% phospholipids, in Tricine buffer (20 mM, pH 7.4) containing 0.9% NaCl, followed by density-gradient centrifugation and binding ... cells THP-1 monocytes were maintained in suspension in RPMI1640 containing 10% fetal bovine serum, mM glutamine, 100 UÆmL)1 penicillin, 100 mgÆmL)1 streptomycin and 50 mM 2-mercaptoethanol (culture...
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Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot
... HO-1 in human RPE cell lines In contrast to interferon-c, hypoxia induced the expression levels of HO-1 mRNA in D407 cells and exerted no or only marginal effects in ARPE-19 cells (Fig 2) In D407 ... expression by interferon-c in the RPE cell lines It has been reported that HO-1 expression was induced by oxidative stress in two human RPE cell lines, D407 and ARPE-19 [21,25], indicating that these ... the HO-1 gene in mice [47] and in cultured human lung cancer cells [27] The expression levels of HO-1 and Bach1 mRNAs are inversely regulated by interferon-c in both RPE cell lines In contrast,...
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Báo cáo khoa học: cGMP and glutathione-conjugate transport in human erythrocytes The roles of the multidrug resistance-associated proteins, MRP1, MRP4 and MRP5 pot
... indomethacin, methotrexate and E217bG was 77.3 ± 5.2 pmolÆmg)1 The control uptake for the remaining drugs was 136.5 ± pmolÆ mg)1 Compound GSH Vincristine + mM GSH Calcein + mM GSH Indomethacin ... Methotrexate and E217bG were found to inhibit the cGMP uptake in human erythrocyte vesicles with E217bG at 65 lM inhibiting about 90% and methotrexate inhibiting about 75% at 275 lM and completely ... The L23/R and MOR/R sublines were maintained in the presence of 0.2 lgÆmL)1 and 0.4 lgÆmL)1 doxorubicin, respectively The cells were kept in drug-free medium for at least 48 h before use in experiments...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
... component C4b-binding protein is upregulated in inflammation, and binds and inactivates protein S Protein S is an endogenous coagulation inhibitor that enhances the activity of APC as an inhibitor ... walls off the injured site and contains the inevitable microbial contamination that occurs following a breach in the integument of this marine animal The basic elements of clotting and inflammation ... structural and functional similarities All TLRs express a series of leucine-rich repeats in their ectodomain, a transmembrane domain, and an intracellular domain that bears striking homology to the intracellular...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 1
... exhibiting trans-acting transcriptional cooperativity with DLX homeodomain proteins and increasing Dlx5/6 enhancer activity in a neural stem cell line (Feng et al., 2006) In the developing ventral ... morphogenetic protein (BMP) antagonists such as chordin, noggin and cereberus BMP4 is pivotal in neural induction, as it inhibits cells from forming neural tissue (Finley et al., 1999) Therefore, inhibition ... converts midbrain into hindbrain, while in the caudal diencephalon, FGF8 induces an ectopic isthmic organizer which converts the surrounding diencephalon into midbrain tissue The difference in activity...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 3
... target 226 lincRNAs expressed in mESCs, and the authors identified 26 lincRNAs that resulted in loss of Nanog and Oct4 expression upon lincRNA knockdown, indicating that lincRNAs maintain the pluripotent ... lncRNAs using anti-SUZ12, anti-SOX2 and anti-OCT4, respectively lncRNA_ES1 and lncRNA_ES2 were enriched in the SUZ12 RIP and SOX2 RIP, indicating interaction * and ** indicate p-values of < 0.05 and ... transcription start sites, and thick black bars indicate exons Binding site locations were obtained from ChIP-seq data in (Chia et al., 2010) The proximity of OCT4 and NANOG binding sites indicate the possibility...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 4
... expressed in the midbrain and prospective dopamine neurons Rmst transcript was detected by in situ hybridization in the mouse embryonic brain (A, B) Rmst as detected in both thr roof plate (RP) and ... expressed in human dopamine neurons, compared to the hESCs and NPCs from which the neurons were derived from In Chapter VII, the indispensable role of RMST in human neurogenesis was confirmed in vitro, ... of RMST (pRMST), confirming that REST binds upstream of RMST in the human neural stem cell line (Figure 8.5) Since transcription factor binding events may not result in target gene regulation,...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 5
... is a RNAbinding protein and probably binds directly to RMST SOX2 and hnRNPA2B1 may interact via protein-protein interactions The transcription factor SOX2 may then bind to target chromatin regions ... system, and very few human lncRNAs have been studied with such extent In this thesis, I focused on examining lncRNAs involved in the pluripotency maintenance of human embryonic stem cells (hESCs), and ... B., Liu, M., and Shi, T (2011) Comparative analysis of human protein-coding and noncoding RNAs between brain and 10 mixed cell lines by RNA-Seq PLoS One 6, e28318 Chen, M., Zhang, J., and Manley,...
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Kogan.Page.Managing.Projects.in.Human.Resources.Training.and.Developement.Apr.2006.eBook-DDU.pdf
... perspectives in complex settings Moreover, everyone in the setting who should normally be included in shaping and focusing the project is likely to be very busy and concerned with meeting immediate demands ... became apparent that printing organizations that failed to invest in developing the capacity and capability to work with digital printing would have difficulty in surviving Printing organizations ... computers the training could take too long to meet the needs of their organizations In addition, there was growing demand for training in digital media as the structure of the printing industry changed...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of the gut mucosa to endotoxins [43, 44] These factors are involved in ethanol-induced ... Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma derived ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray...
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3D Videocommunication Algorithms concepts and real time systems in human centred communication
... paintings had been a well-known phenomenon since Roman times, and such paintings would create the illusion of, for instance, walls containing a window to the outside world or a ceiling containing ... rendering Image cube trajectory Institute of Electrical and Electronics Engineers Internet Engineering Task Force Interaural intensity difference Interaural level difference Infrared light-emitting ... multidisciplinary perspective that integrates media design and engineering, multisensory perception, and social psychology Add to this the increasingly social nature of interfaces and the increase in...
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- mutations their transition rates and involvements in human and animal disorders
- participants in the project and their roles under the contract
- receptors—muscle spindles and golgi tendon organs—and their roles in muscle control
- the response of animals to disturbance and their roles in patch generation
- ancient roles in dna replication and genomic stability lead to distinct roles in human disease
- βs and their roles in the regulation of neuron survival
- polymers their activities and half lives in human plasma
- noninvasive assessment of carotenoids in the human eye and skin
- their roles in the coping process
- receptors—roles in human disease and as drug targets
- 1b tnfa and their receptors in human ivd
- their roles in renewal
- 29 soosan g lorne bt 2005 organization of stem cell and their progeny in human epidermis journal of invest dermatol vol 124 367 372
- mvat apos s and mvau apos s dna organisation mode and their roles in vivo
- associational commissural connections of the dentate gyrus in the experimental mice at 2 months after pise and their roles in epileptogensis
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