lymphatic vessels in health and disease
Tài liệu Translational Vascular Medicine docx
... Alpha-smooth muscle actin Cytoskeletal contractile protein Aminopeptidase A + N Zinc-dependent peptidase Desmin Intermediate filament protein predominantly expressed in muscle cells Nestin Intermediate ... (IL-1ra) and soluble TNF receptors exert potent anti -in ammatory effects and are used clinically in the treatment of systemic in ammatory diseases including autoinflammatory disorders [17] and rheumatoid ... Complications in Human Disease (2008) and Advances in Vascular Medicine (2010), both also published by Springer, have dealt with other key and developing areas of basic science and its clinical applications...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... ferritin expression in nonpermeabilized (thin lines, – saponin) and permeabilized cells (thick lines, + saponin) cells cultured without and with iron as indicated (D) Perls’ staining of cytospins ... without and with iron Thin lines represent background staining with mouse Igs (B) Histograms show background staining with no antibody (thin lines) or with rabbit Igs (thick lines) as first step in ... found altered in keratinocytes from psoriatic lesions [47], in the gastrointestinal tract of certain in ammatory diseases [48,49], and in primary biliary cirrhosis [50] Whether iron and ⁄ or lipid...
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Báo cáo khoa học: Tyrosine nitration in the human leucocyte antigen-Gbinding domain of the Ig-like transcript 2 protein ppt
... 90 kDa Loading control was performed using an antibody against b-actin, which produced a band at 42 kDa The data indicate the intensity of the HLA-G band related to the b-actin band and are representative ... ILT2 nitration in the binding domain Fig (A) Amino acid sequence coverage and sites of nitration of SIN-1-treated rhILT2-Fc, obtained by LC-MS ⁄ MS analysis Protein was nitrated with SIN-1, subjected ... lysis) These results indicate that NO maintains, or even increases, ILT2mediated suppression in NKL cells After HLA-G binding, immunoreceptor tyrosinebased inhibitory motifs in the cytoplasmic...
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Báo cáo khoa học: Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum potx
... original activity (–) F, D, FD indicate inactivation reactions containing FeCl3, dithiothreitol and both, respectively FDP and FDaP indicate inactivation reactions containing FD + rPf1-Cys-Prx and ... percentage of the original activity (–) HG indicates inactivation reactions containing FP and GSH HGP and HGaP indicate inactivation reactions containing HG + rPf1-Cys-Prx and HG + autoclaved rPf1-Cys-Prx, ... against inactivation was observed and the initial GS activity was maintained (116.5 ± 7.3% of the initial activity) The protective effect was abolished when the recombinant protein was heat-inactivated...
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Báo cáo khoa học: "AMBIGUITY RESOLUTION IN THE HUMAN SYNTACTIC PARSER: AN EXPERIMENTAL STUDY" ppt
... there would be a delay in beginning analysis, and then another delay as a result of abandonment When analysis is begun again following abandonment, i t can proceed according to any of the above ... considered so far Instead of the parser, after making a single or parallel analysis of an ambiguity, maintaining the analysis/es as further input is received, one can imagine i t just dropping whatever ... points Many of these f i l l e r s also contained ungrammaticalities, of various sorts and in various locations in the sentence.) A wide variety of ambiguities were tested, including those investigated...
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Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot
... domains The N-terminal domain adopts an expanded Rossmann fold, and provides the residues for binding the coenzyme The C-terminal domain has a largely a-helical structure, and serves mainly in ... concentrations of inhibitor The observed inhibition was, in each case, best described by competitive binding of coenzyme and adenine nucleotide Inhibition constants (KiEI) were obtained from nonlinear ts ... random binding of NAD+ and Man-ol1P [29] It is reasonable to assume that random binding of reactants by AfM1PDH and AfM2DH occurs in rapid equilibrium, and the absence of curvature in LineweaverBurk...
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Báo cáo khoa học: A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP docx
... sarcomas and lymphomas in females and of carcinomas in males [2] It would thus be interesting to determine if heterozygous mice carrying the L225A point mutation in the CtBP-binding domain, Hic1+ ... a PDZ domain-containing protein [22,23] In contrast, CtBP2 is mainly nuclear, due to a specific N-terminal 20 amino acid region containing Lys residues acetylated by P300 [24,24a] Finally, CtBP1 ... canonical CtBP-interacting domain (CID) containing a PxDLSxK ⁄ R motif found in virtually all CtBP-interacting proteins [11,14,20] The vertebrate genomes contain two different genes, CtBP1 and CtBP2,...
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Báo cáo khoa học: Human-blind probes and primers for dengue virus identification Exhaustive analysis of subsequences present in the human and 83 dengue genome sequences doc
... n-mers having a subsequence belonging to one file and the remaining sequence in another file were not included in our calculations All calculations on the human genome utilized both the original and ... properties of short subsequences in microbial identification In Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences (Valafar ... s is in order to determine whether it is, in fact, the optimal solution For instance, a particular set may exceed the minimum values required of a, b and c and, in fact, have values A, B and G,...
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Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf
... carcinoma cell line, QGY-7703, was kindly provided by D Lu (Dept of Neurology, Stanford University, Palo Alto, CA, USA) The cells were maintained in RPMI-1640 containing 10% heat-inactivated bovine ... tBid and Bax by combined treatment of TRAIL and etoposide; these results are shown in Fig 4C The protein levels of both tBid and Bax increased with the incubation time, and these results are in ... such as procaspase-9 and caspase-3, by binding to the inhibitor of apoptosis proteins and thus disrupts linkage of the caspase–inhibitor of apoptosis proteins complex during apoptosis [48–50]...
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Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase pdf
... of individual heme propionates [23,24] and of Y280 [25] was previously studied employing this technique in combination with site-directed mutants and isotopic labeling Here mutants of E78II in ... heme a and heme a3, if it is taken into account that our measurements were carried out in the absence of NO acting as a trapping ligand for reduced heme a3 [27] Proton-pumping activity Fig Kinetics ... to A and Q, revealing clear defects in their catalytic properties The activity in the A and Q mutants was diminished considerably, namely to 43 and 10% (E coli bo3) and to and 14% (R sphaeroides...
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Báo cáo sinh học: " PET kinetics of radiolabeled antidepressant, [N-methyl-11C]mirtazapine, in the human brain" ppt
... intermediate binding potential in the thalamus, and low binding potentials in the striatum, hypothalamus, and brainstem Thereafter, we initiated PET studies with arterial sampling in humans and ... estimating the binding potential of [N-methyl-11C]mirtazapine in the living human brain Methods: Distribution volumes of [N-methyl-11C]mirtazapine in brain regions were estimated using single- and ... Figure 3) Since the binding of [N-methyl-11C]mirtazapine may be relatively slow in some brain regions, methods C and D may have underestimated the distribution volumes and binding potentials in such...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx
... minced in DMEM containing 10% FBS supplemented with 100 U/mL penicillin and 100 μg/mL streptomycin The cell suspension containing small tissue pieces was plated in a 10 cm-culture dish and incubated ... monocyte-like cells and MNCs in GCTs CD68, an intracellular glycoprotein, was expressed in monocyte lineage cells, including OPCs and OCs [20] Therefore, it is possible that the infiltrating MNCs and monocyte-like ... using 3-amino-9-ethylcarbazole in N,N-dimethylformamide To examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining;...
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báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx
... minced in DMEM containing 10% FBS supplemented with 100 U/mL penicillin and 100 μg/mL streptomycin The cell suspension containing small tissue pieces was plated in a 10 cm-culture dish and incubated ... monocyte-like cells and MNCs in GCTs CD68, an intracellular glycoprotein, was expressed in monocyte lineage cells, including OPCs and OCs [20] Therefore, it is possible that the infiltrating MNCs and monocyte-like ... using 3-amino-9-ethylcarbazole in N,N-dimethylformamide To examine the pY-Flt-1 and pY-FAK levels in GCT samples, the staining intensity of each specimen was scored as follows: (weak staining;...
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Báo cáo hóa học: " Research Article Robust Object Categorization and Segmentation Motivated by Visual Contexts in the Human Visual System" docx
... of learning and inference will be explained in the next sections Cup instances Surface marking reduction by intermediate blurring Repeatable part Surface marking part Figure 13: Large intraclass ... codebook and category-related background codebook In addition, each UCB contains all possible link information to CCB This link information is useful for bottom-up inference Details of modeling and ... In general, objects not exist in a white background Instead, objects exist in certain places, such as cars in a street, hair driers in a bathroom, and drills in a workshop Therefore, object and...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... JK, JP, and LN and KN aiding in obtaining biopsy and blood samples NR and LH were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final ... interferon-inducible protein 10 (IP10); leptin; monocyte chemotactic protein-3 (MCP3); monokine induced by gamma interferon (MIG); macrophage inflammatory protein alpha (MIP-1a); macrophage inflammatory ... 8-fold increase in the bFGF levels in EoE subjects as compared to HC subjects and a 4-fold increase compared to GERD; b)There was a 6-fold increase in eotaxin-3 comparing EoE subjects to HC and...
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Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps
... RA synovium into tissue microcompartments and fluid The finding that the proportion and percentage of chemokine binding sites on macrophages increases in the inflamed intima of RA and non-RA synovia ... thickening and some infiltration of mononuclear cells, although not as severe as in RA samples, and noninflamed sites showed a normal intimal layer and no leukocyte infiltrates Chemokine binding ... tissue (c) CXCL8 binding to macrophages in a lymphocyte-rich infiltrate in rheumatoid synovium (d) CCL3 (macrophage inflammatory protein-1α) binding to macrophages in the inflamed intimal layer of...
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Báo cáo y học: "A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation" potx
... studies indicating a role for platelets and the 5-HT system in the onset of or in the maintenance of Table Genotype and allele distribution of the C+1354T single nucleotide polymorphism in patients ... competing interests 452His or the 452His/452Tyr phenotype Serotonin-induced platelet aggregation 452His/ in subjects with the or the 452His/452Tyr phenotype Fold increase of serotonin (5HT)-induced ... 5-HT-induced platelet aggregation Indeed, Hazelwood and Sanders-Bush also described a reduced intracellular signalling capacity in murine fibroblasts expressing the His452Tyr substitution after...
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Báo cáo y học: " NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitid" pot
... meningitidis and N lactamica strains (encoding proteins displaying at least 50% amino acid identity over at least 80% of their length and are, in addition, in synteny and/ or BBHs) and absent in ... transformation of an aliquot of the in vitro transposition reaction in DH5α and selection on plates containing kanamycin (cassette in the mini-transposon) and spectinomycin (cassette in the target vector), ... of the remaining CDSs in Z2491 using the criteria set for strain 8013 and transferred this annotation to the remaining genomes using the same cutoff This was then done iteratively in the order...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
... across non-coding exons (NCEs), coding exons, and flanking introns according to their relative positions within the transcript All exons and introns were partitioned into ten bins and the average ... (NRC) was obtained for each bin of all corresponding exons and introns ICEs (initial coding exons) and LCEs (last coding exons) are broken into the UTR (light blue or light green) and coding region ... cannot be maintained in AT-rich sequences This phenomenon might explain, in part, the nucleosome-favoring signals encoded in CGI sequences Reflecting this reciprocal tendency of in vivo and predicted...
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