... increase iron loss, or decrease iron intake or absorption can produce iron deficiency (Table 98 -2) Table 98 -2 Causes ofIron Deficiency Increased demand for iron and/ or hematopoiesis rapid growth ... red cell morphology and indices are normal Figure 98 -2 Laboratory studies in the evolution ofiron deficiency Measurements of marrow iron stores, serum ferritin, and total iron- binding capacity ... prolonged iron- deficiency anemia, erythroid hyperplasia of the marrow develops, rather than hypoproliferation Causes ofIron Deficiency Conditions that increase demand for iron, increase iron loss,...
... immunoglobulin (CTLA-4Ig; on days and 12) ; (d) CTLA-4Ig (on days 12 and 16) ; and (e) or anti-IL -6 mAb just after the onset of arthritis (on day 8, on days and 12, or days 12 and 16; arrow) The mean ... in macrophages Nature 20 06, 44 3:998-10 02 19 Ruderman EM, Pope RM: Drug Insight: abatacept for the treatment of rheumatoid arthritis Nat Clin Pract Rheumatol 20 06, 2: 6 54- 66 0 20 Kremer JM, Westhovens ... M: Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 costimulatory pathway: requirement for both B7-1 and B7 -2 Eur J Immunol 19 96, 26 :23 20 -23 28 23 Matsumoto I,...
... 30 mm 29 mm 31 mm – 36 mm 30 mm mm Nil 29 mm 30 mm 25 mm 32 mm 20 mm 30 mm 29 mm Nil Nil Nil Nil 28 mm 32 mm 35 mm 24 mm 24 mm 26 mm 27 mm Nil Nil Nil Nil 33 mm 28 mm 24 mm 26 mm 32 mm 26 mm – ... 1 62 0 , 1 46 5, UV (nm); 340 , 40 4 ([Cu (HQ)(MET)]) 4d Yield 1 320 mg, 74. 2% , Anal Calc for C14H16CuN2O3S, C, 47 .25 ; H, 4. 53; N, 7.87; Found: C, 47 . 36; H, 4. 55; N, 7.83; IR (KBr, cmÀ1): 3500, 29 54, ... Found: C, 40 .10; H, 4. 36; N, 7.81; IR (KBr, cmÀ1): 3 741 , 160 0, 1 46 5, UV (nm) 338, 3 82 ([Fe (HQ)(MET)]Cl2H2O) 4b: Yield 41 0 mg, 19.5%, Anal Calc for C14H20ClFeN2O5S, C, 40 .07; H, 4. 80; N, 6. 67; Found:...
... 93 56 93 62 12 Ash DE (20 04) Structure and function of arginases J Nutr 1 34, 27 60 S 27 64 S 13 Morris SM (20 04) Recent advances in arginine metabolism Curr Opin Clin Nutr Metab Care 7, 45 –51 14 Kim ... [9, 24 ] However, the volume of the active site cleft was found to be larger for arginase II Moreover, the D2 32 (Od1)-Mn2+B FEBS Journal 27 2 (20 05) 45 40 45 48 ª 20 05 FEBS Interaction of arginase II ... (19 94) On the evolution of arginases and related enzymes J Mol Evol 39, 101–1 04 FEBS Journal 27 2 (20 05) 45 40 45 48 ª 20 05 FEBS Interaction of arginase II with substrate and manganese ions 21 Ahn...
... P4, P6 and P9 anchoring pockets [N62a/N62a, Y13b/F11b (F11b points towards Y13b superimposed on DR2 and I-Au) and Y26b/Y26b form the P4 pockets; N62a/N62a, V65a/T65a and Y13b/F11b form the P6 ... S 76 N Q77 O R78 O S79 N S79 Oc Y9a N E74b Oe2 N62a Od1 Y61b OH Y66b OH N69a Od1 N69a Od1 ˚ van der Waals contacts ( 4. 5 A cut-off) < Q 74 Y9a, F11b, P13b, T28b, Y62b, E74b K75 F11b, E74b S 76 N62a, ... position 82 of 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 myelin basic protein 73– 86 for recruitment of V beta 8 .2+ T cells and encephalitogenicity in the Lewis rat J Immunol 1 62 , 829 – 8 36 Moscarello,...
... significant similarities to hST6Gal I (X17 24 7 [22 ]) These sequences (GenBank accession numbers AB058780, BC00 866 0, AA3858 52; EST clones and AC108 049 , AC0 169 94, AC005 040 and NT_00 5 42 9; genomic clones) were ... (0. 52) b 0 100 (13. 86) b 1 .4 Asialofetuin Arylglycosides Oligosaccharides 66 83 5.3 8 .2 259 0 6 92 62 3 0 .6 0 .6 0 .4 72 2.5 0.7 87 120 a Rrepresents the remainder of the N-linked oligosaccharide chain ... ST6Gal I using Galb1–4GlcNAc [41 ] Ó FEBS 20 03 Characterization of the human ST6Gal II (Eur J Biochem 27 0) 957 Table Comparison of the acceptor substrate specificity of ST6Gal I and ST6Gal II...
... GST-TFIIS, GST-MCM2( 169 21 2)wt, GSTMCM2( 169 21 2)L192P/R193G, and GST-MCM2( 169 – 21 2)V203E/F204L proteins were expressed in BL21(LysS)DE3 cells and coupled to glutathione Sepharose 4B (Pharmacia) ... Figs and To test this hypothesis, we substituted conserved hydrophilic and hydrophobic residues in GST-MCM2( 169 21 2) as shown in Fig 6A GST, GST-MCM2( 169 21 2)V203E/ F204L, GST-MCM2( 169 21 2)L192P/R193G, ... full-length MCM2(1– 8 92) (lanes and 5), MCM2(1 23 0)V203E/F204L (lanes and 6) , MCM2(1 23 0)L192P/R193G (lanes and 7), and MCM2(1 23 0)wt (lanes and 8) were expressed in 29 3 cells and whole cell...