inhibiting telomerase activity and inducing apoptosis in cancer cells by several natural food co
Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx
... tubulin, and DAPI, to stain kinetochore microtubules and DNA, respectively In an another experiment, nonkinetochore microtubules were depolymerized by incubating the cells in a calcium containing ... to taxol and vinblastine, benomyl also induces apoptosis in HeLa cells, indicating that benomyl may be useful in combination with other potent anticancer drugs for the treatment of cancer Experimental ... spindles Then, the cells were incubated in a CO2 incubator at 37 °C in the absence and presence of different concentrations of benomyl The cells were fixed at the desired time points and stained...
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báo cáo khoa học: " All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein" pdf
... al.: All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein Journal of ... proliferation and induced apoptosis in GIST-T1 cells, suggesting anti -cancer effect of ATRA on GISTs The cell death inducing mechanism by ATRA in cancers has not yet been fully clarified In this report ... after 24-hour incubation Panel B shows the isobologram result of drug combination between ATRA and imatinib This combination resulted in additive effect inducing apoptosis in GIST-T1 cells Thus...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained in a 37°C ... Figure Apoptosis induction by isoproterenol or propranolol in combination with irradiation in BGC-823 and SGC-7901 cells There was an increasing rate of apoptosis in gastric cancer cell lines in ... preventing pancreatic carcinoma by aspirin Cancer 2005, 103:2485-2490 26 Takada Y, Kobayashi Y, Aggarwal BB: Evodiamine abolishes constitutive and inducible NF-κB activation by inhibiting InBa kinase...
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The NR4A orphan nuclear receptors are target genes of the novel drug c1 in cancer cells and potential mediators of drug induced apoptosis
... related apoptosis inducing ligand (TRAIL ) where these ligands bind to specific death domain receptors and induce the formation of the death inducing signaling complex (DISC) (Micheau and Tschopp, ... spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins (Luthi and Martin, 2007; Taylor et ... succession of intermediate pre malignant states into metastatic cancers (Hanahan and Weinberg, 2000) It is becoming increasingly apparent that a large contingent of genes each contributing to varying extent...
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Tài liệu Time trends in leisure time physical activity and physical fitness in elderly people: 20 year followup of the Spanish population national health survey (1987-2006) docx
... manuscript Authors’ information None Competing interests The authors declare that they have no financial competing interests and non-financial competing interests Conflict of interest: The manuscript, ... proportional random selection of primary and secondary sampling units (towns and sections, respectively), with the final units (individuals) being selected by means of random routes and sex- and age-based ... been involved in revising it critically CFP conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... in the antisense orientation in the Construction of cell clones Metabolic labelling and carbohydrate analysis BxPC3 cells and T5AS clone (4.0 · 106 cells) were plated in 25-mm2 flasks containing ... downregulation in colon cancer and N-glycan synthesis [16], the results suggest that b3Gal-T5 may play a protective role in gastrointestinal and pancreatic cells, counteracting the glycosylation ... GlcNAcb1-3Galb14GlcNAcb1-R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas J Biol Chem 276, 3564–3573 Ó FEBS 2003 194 L Mare and M Trinchera (Eur...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt
... glycine, l-alanine, l-proline, l-lysine, l-serine, b-alanine, taurine, sarcosine, dimethylglycine, glycine betaine, trimethylamine N-oxide, and cytidine 2¢-3¢ cyclic monophosphate were also obtained ... alanine, proline, serine, lysine, b-alanine and taurine) that have no significant effects on both DGD° and kcat (b) Class II represents methylamines (sarco- Functional stability and activity by ... (1992) Compatible and counteracting aspects of organic osmolytes in mammalian kidney cells in vivo and in vitro In Water and Life (Somero GN, Osmond CB & Bolis CL eds), pp 19–32 Springer, Berlin...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... RNA-binding-domain protein that is a homologue of the HIV transactivating response RNA-binding protein (TRBP) The functional strand of the miRNA duplex guides the RNA-induced silencing complex ... expression in lung cancer cells in vitro to inhibit colony formation [36] Key downstream targets for let-7 include the human Ras family of proteins, oncogenes that are commonly mutated in many human ... regulated by miR-17–5p and miR20a [42] In turn, E2F1 regulates cell cycle progression by inducing genes mediating DNA replication and cell cycle control [43] Beyond the regulation of key targets contributing...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... irradiation, etoposide and glucocorticoids [10,11] Smac promotes caspase activation by eliminating inhibition of caspases by inhibitor of apoptosis protein (IAP) and is known to be a new and important ... iodination (PI) co- staining and analyzed by flow cytometry Q3 cells were regarded as control cells, whereas Q4 cells were considered as a measure of early apoptosis, Q2 cells were considered as cells at ... Jiang et al The ATP-binding domain of HSP70 is important for the interaction of HSP70 with apoptosis signalregulating kinase (ASK1) and the inhibition of ASK1-induced apoptosis in vitro [28] Furthermore,...
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Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective doc
... 142 Foods and drinks Wholegrain and refined cereals and their products Foods containing dietary fibre Glycaemic index and load Aflatoxins Micronutrients and other bioactive compounds and cancer ... endemic in high-income countries, and are in general increasing in middle- and low-income countries: cancers of the lung, colon and rectum, breast, and prostate Information on the trends and projections ... recorded cases in the USA in recent years, although the incidence in several high-income countries has declined since the 1990s Prostate cancer incidence is increasing rapidly in low-income countries,...
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Báo cáo khoa học: Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells ppt
... MCF-7 cells were incubated either separately with curcumin, paclitaxel and vinblastine or in combination with curcumin and vinblastine or paclitaxel for one cell cycle The combination index was ... with vinblastine in inhibiting MCF-7 cell proliferation Curcumin affected the localization of the kinesin protein Eg5 Because curcumin produced monopolar spindles in MCF-7 cells, we examined the ... curcumin for and h and then stained with PI DNA content of the cells was quantified by flow cytometry Nocodazole and curcumin treatment activated Mad2 (B) and BubR1 (C) in MCF-7 cells MCF-7 cells...
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... mutant proteins used in these experiments The DCaM-DK mutant lacks 47 amino acid residues (proline 277 to leucine 323) containing the calmodulin-binding domain In the K42A-DK mutant, a lysine residue ... 42 in the kinase domain (asterisk) is replaced by an alanine The DD-DK construct contains the death domain and the serine-rich tail (aspartic acid 1299 to arginine 1430) All expressed proteins ... Ca2+/calmodulin-independent DAP kinase activity was slightly stimulated by 1.4- and 1.3-fold by exposure to 10 lM C2- and C8-ceramide, and greater activity was seen with increasing concentrations...
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Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx
... Tumor protein D52 in prostate cancer R Ummanni et al Results A protein profiling study on prostate biopsies identified differentially expressed proteins in cancer containing several proteins that ... treatment strategies to increase survival, PCA is the most common type of cancer found in men in Western countries and is the leading cancer death, next to lung and colorectal cancer In the present study, ... [37] Usually, integrins avb3 and avb5 are involved in cell migration and attachment to the extracellular matrix proteins: vitronectin, fibronectin, fibrinogen, laminin, osteopontin, amongst others...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... Wnt/βcatenin and cadherin pathway genes including N-cadherin and P-cadherin but low E-cadherin protein expression This finding demonstrated the highgrade serous ovarian cancer contained messenchymal ... targets in cancer are also included Chapters in “Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer present comprehensive and expert ... genes in the uncontrolled behavior of cancer cells Studying the functional roles of genes in cancer cells has deepened our understanding not only the cancer cells as well as normal cells Since...
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Báo cáo khoa học: Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells docx
... others providing evidence of antisense technology inducing apoptosis [35], involving GSH depletion [36], and sensitizing cancer cells to chemotherapy [37] In several cases, the findings in this work ... is excluded from viable cells and commonly used for identifying dead cells as a counterstain in multicolor fluorescent techniques [22] After staining, cells were maintained on ice until analysis ... fragmentation in cells undergoing apoptosis induced by 100 nM MTX, indicating that this antineoplastic molecule also causes cell death by apoptosis Similar DNA fragmentation was observed in cells treated...
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Updates in the Understanding and Management of Thyroid Cancer Edited by Thomas J. Fahey doc
... high survival for this cancer in EUROCARE-2 Denmark, Germany, The Netherlands, Updates in the Understanding and Management of Thyroid Cancer England, Scotland, Wales and the countries of Eastern ... carcinoma and a high ratio of papillary to follicular carcinomas As in many other regions and countries, the incidence of thyroid cancer is increasing and this trend is primarily caused by an increase ... Changes in clinical presentation, management and outcome in 1348 patients with differentiated thyroid carcinoma: experience in a single institute in Hong Kong, 1960-2000 Clinical Oncology (Royal College...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... RAGE in Cancer and Inflammation Inflammatory state, disease or cancer Effect of RAGE/HMGB1 Colon cancer Co- expression of RAGE and HMGB1 leads to enhanced migration and invasion by colon cancer ... dominant-negative phenotype and blocks signaling Soluble RAGE can act as an extracellular "decoy receptor", antagonizing flRAGE and other receptors by binding DAMPs and other ligands and inhibiting ... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... HLA-A24-binding assay and CTL induction from PBMCs HK, ES and NM contributed to collecting patients' samples with the informed consent YT, TT and NS contributed to the design and coordination ... minutes The cells were then suspended with mL of PBS containing 1% formaldehyde, and analyzed by FACScan (Becton Dickinson, Mountain View, CA) Binding affinity was evaluated by comparing mean fluorescence ... http://www.translational-medicine.com/content/7/1/103 normal essential tissues such as adult liver and pancreas by immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... TX) and were cultured in serum-free keratinocyte Page of 10 medium (Invitrogen Corporation, Carlsbad, CA) Cells were cultured at 37°C in a humidified incubator containing 5% CO2 Chemicals and ... LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), and ... K-ras and protein kinase C iota Cancer Res 2008, 68:7403-7408 Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B: Inhibiting JNK dephosphorylation and induction of apoptosis by a novel anticancer...
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