induction chemotherapy in locally advanced head and neck cancer an evolving concept
Báo cáo khoa học: "Prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities" doc
... heterogeneous or include also initial stage lesions and head and neck tumors [1016] The present study investigates a consecutive series of only localized advanced SCCS of the trunk and extremities, in order ... extremity (shoulder, arm and forearm), 7; lower extremity (thigh and leg) 16; hand 12 and foot The T classification was T3 in 36 cases and T4 in 21 cases 11 patients initially presented with ... significance Other studies reported anatomic sites as high risk for metastasis, but with conflicting results, and including head and neck tumors [7,19,20] The only statistically significant clinical...
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Báo cáo khoa học: "Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer" pot
... charts, and wrote the first draft of the paper GDAP and PC conceived of the study, and participated in its design and coordination and helped to draft the manuscript ATD ran the statistical analyses, ... hyperplasia Int J Cancer 1991, 49:645-649 Magklara A, Scorilas A, Stephan C, Kristiansen GO, Hauptmann S, Jung K, Diamandis EP: Decreased concentrations of prostate-specific antigen and human glandular ... treatment for clinically localized prostate cancer include tumor stages T1 and T3 and a higher tumor Gleason score Author details College of Human Medicine, Michigan State University, East Lansing, MI,...
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Báo cáo khoa học: "Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)" docx
... and SC collected the data SC and SA evaluated the dataset and performed statistical analysis SC, SA, SR, TW Page of and JD wrote and edited the manuscript All authors read and approved the manuscript ... structures In the orbial region very small changes in normal tissue and tumor geometry can have a major impact on organ and nerve function due to the very narrow architecture Thus, imagingdefined stable ... life Patients and Methods Forty consecutive patients with ONSM treated with FSRT between January 1991 and January 2010 at the Department of Radiation Oncology and the Germany Cancer Research...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines Int J Cancer 2002, 99:538-548 Yu M, Yeh J, Van Waes C: Protein kinase ... factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo Cancer Res 1999, 59:3468-3474 Duan J, Friedman J, Nottingham ... microarrays in head and neck cancer research Laryngoscope 2004, 114:241-248 Choi P, Chen C: Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma Cancer...
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Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
... lm recombinant FtGLDH to assays containing matrix 6986 Fig SDS–PAGE with recombinant H-proteins from Flaveria trinervia, Arabidopsis thaliana and Synechocystis, and recombinant P-protein from ... recombinant Synechocystis P-protein is enzymatically active and can be produced in large enough quantities (lane in Fig 1) The enzymatic activities obtained with recombinant plant H-proteins as ... Hence, both natural and artificial N-terminal insertion of two alanyl residues result in higher P-protein activities in vitro, and could increase GDC activity in vivo Results and Discussion The...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... objective response and cancer- specific survival in patients treated by Cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma Clin Cancer Res 2007, 13:3855-3859 ... Cisplatin in Patients with Locally Advanced Head and Neck Cancer J Oncol 2009, 2009:305908 33 Nix PG, Stafford N, Cawkwell L: Expression of XRCC1 and ERCC1 proteins in radioresistant and radiosensitive ... Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer N Engl J Med 2003, 349:2091-2098 Argiris A: Update on chemoradiotherapy for head and neck cancer Curr Opin...
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AUDIT TOGETHER WITH INDEPENDENT AUDITORS* REPORT FOR THE PERIOD JULY potx
... supporting the amounts and disclosures in the financial statements An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating ... Grambling Black and Gold Foundation, Inc Grambling, Louisiana We have audited the accompanying statement of financial position of Grambling Black and Gold Foundation, Inc (the Foundation) as of January ... of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period...
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Báo cáo sinh học: "Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" pot
... Germany) Her3 assessment included manual qualitative interpretation of both membranous and cytoplasmic staining Her2 (membranous) staining and Her3 membranous staining were scored according to ... heterodimerization in development and cancer EMBO J 2000, 19:3159-3167 Hynes N, Lane H: ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 2005, 5:341-354 Schlessinger J: Common and ... Renginfo E, et al: Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... objective response and cancer- specific survival in patients treated by Cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma Clin Cancer Res 2007, 13:3855-3859 ... Cisplatin in Patients with Locally Advanced Head and Neck Cancer J Oncol 2009, 2009:305908 33 Nix PG, Stafford N, Cawkwell L: Expression of XRCC1 and ERCC1 proteins in radioresistant and radiosensitive ... Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer N Engl J Med 2003, 349:2091-2098 Argiris A: Update on chemoradiotherapy for head and neck cancer Curr Opin...
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báo cáo hóa học:" Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" doc
... Germany) Her3 assessment included manual qualitative interpretation of both membranous and cytoplasmic staining Her2 (membranous) staining and Her3 membranous staining were scored according to ... heterodimerization in development and cancer EMBO J 2000, 19:3159-3167 Hynes N, Lane H: ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 2005, 5:341-354 Schlessinger J: Common and ... Renginfo E, et al: Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer...
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Báo cáo hóa học: " Unscented Kalman filter with parameter identifiability analysis for the estimation of multiple parameters in kinetic models" pptx
... where Wim and WiC are the corresponding weights to calculate, respectively, the mean and covariance of the state The transformed mean and covariance are then fed into the standard Kalman filter ... UT [7], a deterministic sampling technique which implements a native nonlinear transformation to derive the mean and covariance of the estimates This transformed mean and covariance are then supplied ... presented in Table and Figure In each case, the mean and standard deviation are calculated for the 97 repetitions, and are used for the comparison Four values are plotted for each parameter in the...
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Báo cáo hóa học: " A New MAC Protocol with Pseudo-TDMA Behavior for Supporting Quality of Service in 802.11 Wireless LANs" docx
... service, and network management Ioannis Papapanagiotou has been studying in the Electrical and Computer Engineering School of University of Patras, Greece, since 2001, and he is currently in his ... number of contending stations, basic and handshaking access, and the several access classes Every terminal is assumed to demand all four classes of access In case of saturation analysis, it is ... states In state 2, it refrains from transmission for as long as an Fd counter runs An interrupt from the timer leads to state where low AIFS and CW guarantee channel access Certain issues remain...
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Báo cáo hóa học: " ITERATIVE SCHEMES WITH SOME CONTROL CONDITIONS FOR A FAMILY OF FINITE NONEXPANSIVE MAPPINGS IN BANACH SPACES" docx
... Hyperbolic Geometry, and Nonexpansive Mappings, Monographs and Textbooks in Pure and Applied Mathematics, vol 83, Marcel Dekker, New York, 1984 B Halpern, Fixed points of nonexpanding maps, Bull Amer ... Appl Nonlinear Anal 12 (2005), no 2, 27–34 F Deutsch and I Yamada, Minimizing certain convex functions over the intersection of the fixed point sets of nonexpansive mappings, Numer Funct Anal Optim ... a mapping T : D → E is firmly nonexpansive if and only if Tx − T y ≤ (1 − t)(x − y) + t(Tx − T y) (3.19) for each x and y in D and t ∈ [0,1] It is clear that every firmly nonexpansive mapping is...
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báo cáo khoa học: "Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature" ppsx
... Maggiore M, Gabrielli F, Migliano E, Pagan M, Concolino F, Ruatti P: Lymphatic mapping and sentinel node identification in squamous cell carcinoma and melanoma of the head and neck Tumori 2002, 88:S39-41 ... perineal squamous cell carcinoma: H&E staining at 2X (A) and 40X (B) Sentinel lymph node biopsy: H&E at 10X (C) and immunostaining with pancytokeratin at 10X (D) showing no evidence of occult ... skin cancers There is ongoing research to identify novel tumor biomarkers to define cancer prognosis and promote individualized therapies Conclusions We conclude that SLN biopsy remains an investigational...
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Báo cáo khoa học: "Large volume unresectable locally advanced nonsmall cell lung cancer: acute toxicity and initial outcome results with rapid arc" potx
... in solid tumor European Organization for Research and Treatment of Cancer, National Cancer Institute of the United State, National Cancer Institute of Canada J Natl Cancer Inst 2000, 92:205-216 ... after an intensive validation at planning level, compared to IMRT or other approaches, in a series of studies including brain tumours, prostate, head and neck, mesothelioma, cervix uteri and other ... MU/Gy, Dose Rate, Gantry speed, Collimator angle, beam-on and treatment time); beam-on and treatment times are defined without inclusion of patient positioning and imaging procedures and were scored...
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Báo cáo khoa học: "Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy" pdf
... preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial EORTC Head and Neck Cancer Cooperative Group J Natl Cancer Inst ... chemoradiotherapy versus induction docetaxel, cisplatin and fluorouracil (TPF) followed by concomitant chemoradiotherapy in locally advanced head and neck cancer: a phase II randomized study Ann Oncol 2010, ... G, Tran BN, Dempsey JF: Determination and delineation of nodal target volumes for head- and- neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT Int...
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Báo cáo khoa học: "Parotid gland-recovery after radiotherapy in the head and neck region: 36 months follow-up of a prospective clinical study" pdf
... after 24 and 36 months was in group I 66% and 74%, in group II 56% and 49%, and in group III 31% and 24%, respectively Multiple linear regression analyses revealed that the parotid gland dose and ... Determination of the parotid gland doses The planning target volumes and both parotid glands, the mandible, and the larynx were outlined on the transversal slices of the planning CT-scans The planning ... parotids, and thus on the saliva flow and recovery of parotid gland Keywords head and neck cancer; irradiation, saliva; hyposalivation; parotid gland sparing; recovery Background Sparing salivary glands...
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Báo cáo khoa học: "Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions" ppsx
... alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal ... administered in anal cancer clinical trials Data on the biologic effects and clinical outcomes of such low doses are lacking Historically, anal cancers were treated with surgical therapy involving ... with a complete response and negative biopsy findings (16) Radiotherapy and concurrent FU and MMC is the current standard of care and allows many patients to avoid having a colostomy Several prospective...
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Báo cáo khoa học: " Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans" ppsx
... OAR sparing between IMRT and conventional 3D plans Incorporation of IMRT in phase or in phase and significantly reduced the volume of bladder and genitalia/ perineum receiving ≥ 30 Gy and ≥ 40 ... prescribed dose) and doses to OAR were minimized Statistical Analysis The mean percentage volume of bladder, genitalia/perineum, and small bowel receiving more than 30 and 40 Gy (V30 and V40) were ... diagnostic CT scan, MRI and endoscopic ultrasound in all patients The clinical target volume (CTV1) consisted of the GTV expanded by a three-dimensional cm margin, the anal canal, and the draining lymphatic...
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Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps
... was involved in the interpretation of the data, and drafting of this article IO was involved in the conception and design of this project, analysis and interpretation of the data, and critiquing ... was involved in the conception and design of this project, analysis and interpretation of the data, and drafting of this article SA was involved in the design of this project, data acquisition and ... acquisition and analysis, interpretation of the data, and critiquing of drafts of this article BB was involved in the design of this project, analysis and interpretation of the data, and critiquing of...
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