... accountability and promptness of the listing process, including establishment of an independent review of listing decisions[3] Representatives of the multinational brand-name pharmaceutical industry, including ... and weakening of medicines clinical and cost-effectiveness evaluation and/ or reference pricing, necessarily involves a weakening of a nation's social and economic fabric, or the capacity of its ... number of applications that include nonclinical claims concerning price The number and type of proposals aired in the media by government and industry concerning pharmaceutical regulation will...
... trading against superior information and is the component of interest to our investigation Glosten and Milgrom (1985) argue that the adverse selection component should be an increasing function of ... examination of institutional trading activity before and after regulation fair disclosure.” Working Paper, Arizona State University (2002) Wolak, F A “Testing inequality constraints in linear econometric ... respectively) Taken in isolation, the hint of a reduction in price reaction to mandatory announcements is puzzling in that one would expect an increase in information flow at the time of announcement...
... optimizing of an objective function that incorporates fuzzy membership functions of voltage profiles and device cost In consideration of stochastic sag events occurring at the point of common coupling, ... Chapter Modeling of Thyristor Voltage Regulator where the regulation voltage Vd is determined by combinations of various onand “off” switching modes By combination of various onand “off” switch ... find the optimum mitigation scheme: selecting the types of compensation devices, evaluating possible candidate solutions and optimization Before the discussion on optimization of sag mitigation,...
... receding into the background as Macbeth is beginning to take front stage by acting of his own initiative without consulting his Lady In the third scene, the sun is settingand it is getting dark ... Macbeth had convinced Macbeth to murder Duncan, Macbeth here convinces the murderers against Banquo The last speech of Macbeth is in a way similar to the one of Lady Macbeth addressing the evil ... reinforced strongly here "O full of scorpions is my mind, dear wife; / Thou know'st that Banquo and his Fleance lives," Macbeth reveals to Lady Macbeth that the existence of Banquo and his son...
... determinant of VLP morphology These data support prior findings by Noda, Bavari, and Jasenosky [4,5,13], and expand upon these findings by incorporation of NP and VP35 into VLPs Our data demonstrate ... proteins was found to vary Indeed, statistical analysis indicated a significant difference between VLPs containing VP40 alone vs those containing VP40+VP35 Gross inspection of the particles indicated ... study EBOV proteins is transfection and co-expression of plasmids coding for individual viral proteins Using this approach, Bavari et al have demonstrated that co-expression of VP40 and GP yielded...
... plantation in New Zealand [69] and a Pinus taeda plantation with varying water and nutrition amendments in the southern United States [52] Our understanding of the seasonal variation in stand LAI ... range of species and stand conditions [8, 61], few involve concurrent assessment of LAI or total foliage mass and, hence, few models exist for explaining the patterns of variability in retained and ... is based on only a few Pinus species and a narrow range in environmental conditions, so further investigation is required to account for the effect of seasonal dynamics on forest production [62]...
... After induction of paresis, all dogs were examined everyday on motor and sensory functions by postural reaction, superficial pain and deep pain These neurological examinations were continued ... tapered according to clinical signs and complications Cage confinement was applied concurrently Electroacupuncture In groups B and AB, 48 hours after induction of spinal cord compression, electroacupuncture ... reports on the effects of the combination of medications and electroacupuncture The purpose of this study is to investigate the effects of electroacupuncture, corticosteroid, and combination of two...
... homogeneity of the regions of provenance; these findings will lead to the upgrading of some selected stands in the tested category The main limitation to the application of the EC regulations is that ... stands are selected and to control seedlot and seedling purity, from collection to planting tion started in 1973-1975 Since many mixed stands were selected then, complete checking is needed and ... charge of stand selection, thanks to its new version of the handbook on forest reproductive material (CEMAGREF, 1991b) RESULTS CONCLUSION Twenty years of application of the EC regulation has...
... Phalloidin-fluorescein isothiocyanate staining of IVD cells following monolayer (left panel) and alginate (right panel) culture in conditions of glucose-deprivation at day 7, demonstrating that ... were seeded into alginate beads at a low cell density of 106 cells per millilitre and a final alginate concentration of 1.2% The alginate beads were then incubated in combinations of medium supplemented ... those in monolayer Hence, whereas 24% ± 2% of cells in control monolayers were Ki-67-immunopositive, only 3% ± 0.8% of cells were positive in control alginate cultures None of the cells in serum-deprived...
... questionnaires that were not included in the analysis only contained information regarding the category of HCW and the area they worked in, the rest of the questionnaire was not filled inOf the ... than one action Discussion The National HIV HCW Hotline was established in March 2008, in response to the roll-out of ART in the public sector of South Africa, to provide information and decision ... (34%) and/ or interruption or discontinuation (44%) of ART The most common reasons for medicines to be interrupted or discontinued were adverse events (33%), treatment failure (11%) or drug interactions...
... fusion in Ws and dir1-1, respectively Examination of these lines indicated that the DIR1 promoter region initiated expression of GUS and DIR1:GUS in seedlings, roots and floral tissues andin ... LTP2 family In vitro, DIR1 can bind two monoacylated phospholipids and contains two proline-rich SH3 domains SH3 domains participate in protein-protein interactions in numerous proteins [23] Lascombe ... reduction in GUS activity observed in Figure 1A Intense staining occurred in the midvein and Page of 16 secondary veins in mock-inoculated or untreated leaves of both the DIR1pro:GUS-11 and DIR1pro:DIR1-GUS29...
... vet scand vol 42 no 1, 2001 Max score Effect of eradication of lice on cattle hides 101 Table Effect of eradication of lice on the frequency of light flecks and spots in different regions of the ... anatomical regions Following the eradication of lice, there were significant reductions in frequency of light flecks and spots in all anatomical regions examined on the cattle hides (Table 2) Accordingly, ... 186 British Leather Confederation, Northampton, 1990 Chalmers K, Charleston WAG: Cattle lice in New Zealand: observations on the biology and ecology of Damalinia bovis and Linognathus vituli N...
... elimination capacity of both systems for bilirubin fractions and bile acids and found superior removal of bilirubin (especially of the unconjugated fraction) by Prometheus but similar removal of ... effects of hemoconcentration on albumin and albumin-bound solutes Failure to account for this will lead to an underestimation of PlCl PlCl corrected for the effect of hemoconcentration was determined ... acquired, analyzed, and interpreted the data, drafted the manuscript, and was involved in revising the manuscript PK made substantial contributions to the conception and design of the clinical study,...
... factors in addition to shock and organ dysfunction, however, may cause the prolonged elevation of CRP (for example, higher risk of secondary infection or difficult elimination of present infection in ... novel sight of inflammatory markers and pointed out the need for considering these findings in designing studies comparing the usefulness of the markers 10 11 12 13 14 Competing interests The ... CRP and PCT blood levels at the same time points Similar findings, in the context of time and different stimuli resulting in PCT elevation, may be apparent from other studies [25,26] In designing...
... http://chiromt.com/content/19/1/17 spine care practitioner model would be helpful in reducing the burden on these practitioners Standardization of care: Inconsistent clinical decision-making, unnecessary ordering ... use of imaging and appropriate communication of findings may also help avoid the iatrogenic disability that can arise as a result of the medicalization of imaging findings that are of questionable ... Authors’ contributions DRM originally conceived of the conceptual basis of the paper and wrote the initial manuscript BDJ, ICP, SMP and MJS then made individual contributions to various sections of...
... illustrated in only a few cases of real livestock populations [14] However, simulations [17] have indicated that, when introduction of selection on a major gene leads to less intense selection on production ... Evolution of the average coefficient of inbreeding of the young candidate elite rams per birth year Figure shows the evolution of inbreeding between 1992 and 2004 Both the average coefficient of inbreeding ... based on pedigree information (average coefficients of relationship and numbers of ancestors contributing for a cumulative contribution of 50%), usually more sensitive to recent selection events, indicated...
... data consisted of twin calving records on 680 calvings in 216 Maine Anjou cows from a total 11 herds involved in the nucleus of the high twinning selection programme set up in that breed In both ... (1990), only 18% of cows with a twin calving had a second or latter twin set; Foulley et al (1990) using records on twinning of Charolais and Maine Anjou cows prior to purchase in farms, and after ... animals and genetic and environmental effects on twinning rate J Animal Sci 68, 1867-1876 Johansson I, Lindhé B, Pirchner F (1974) Causes of variation in the frequency of monozygous and dizygous twinning...
... identified a clear association between arsenic exposure and the increased incidence of cancer in the internal organs of individuals who chronically consume arsenic-contaminated drinking water (Anetor et ... activation of signaling pathways responsible for regulating cellular proliferation and growth Conversely, high levels of ROS generation can lead to DNA damage, resulting in genomic instability (Weinberg ... compounds, contaminated drinking water is the predominant source of acute and chronic arsenic exposure globally (Gebel, 2001) It has been found that millions of people are at risk of drinking water contaminated...
... finalized in 1996 II.1.1 ISO 14000 - Introduction After the success of the ISO 9000 seriesof quality standards, the International Standards Organization is nearing completion and publication ... solved by increasing public participation in pollution monitoring andin the preparation of local environmental protection plans Such participation has been of crucial importance in the industrialized ... In Vietnam, the Office for Standardization, Metrology, and Quality Control is the pioneer in environmental protectionand considered as the main state’s body responsible for providing guidelines,...
... candidate facts Candidate facts Validation of patterns Occurrences of extraction patterns Validation of candidate facts Validated candidate facts Validated extraction patterns Scoring and ranking Scored ... the set of words that occurred within a small window of w in a large corpus The context window of an instance of w consists of the closest non-stopword on each side of w and the stopwords in between ... D Lin 1998 Automatic retrieval and clustering of similar words In Proceedings of the 17th International Conference on Computational Linguistics and the 36th Annual Meeting of the Association...