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Tài liệu New York Times - Looking Back At The Crash Of 1929Pdf doc

... final stages. This point of view is also substantiated by the slight rally at the close and the confidence which the steel directors place in the situation by augmenting their dividend. In ... announcement the institutions participating in the group, together with other leading banks of the city, had agreed upon a reduction of margin requirements to 25 per cent of the market price of the ... Fear Waningbanking institutions in reducing margin requirements upon security loans. This move was announced at midday at the time of the first meeting of the banking group. According to the announcement...

Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"

Danh mục: Y học thưởng thức

... of in vitro and in vivo experiments have proved that GJ may be involved in the injury or dis-ease induced activation of vessel wall cells. It is indi-cated that the expression of Cx43 in the ... with PBS, the sections were incubated with secondary antibody conjugated to horseradish pe-roxidase (Histofine simple-stain kit, Nichivei, Japan) for 30 min. The sections were visualized with ... while lumens were smaller in the high fat diet group than in the normal group. Vessel wall is in the condition of rugosity and the yellow athero-matous plaques were found in the lumens of high...

LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS

Danh mục: Tin học văn phòng

... globally, while maintaining the fast convergence rateCHOICES OF STEPSIZE I • Minimization Rule: αkis such thatf(xk+ αkdk) = minα≥0f(xk+ αdk).• Limited Minimization Rule: Min over α ∈ ... Sensitivity− Duality• Computation by iterative algorithms− Iterative descent− Approximation methods− Dual and primal-dual methodsLOCAL AND GLOBAL MINIMAf(x)xStrict LocalMinimumLocal Minima ... set of global minimaα = 0There is no global minimumα > 0, β < 0There is no global minimumIllustration of the isocost surfaces of the quadratic costfunction f : 2→given byf(x,...

Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx

Danh mục: Báo cáo khoa học

... of mutations on catalytic activity The catalytic activity of E1 mutants was investigated usingthree different assays: the DCPIP assay, which measures E1activity bymonitoring the reduction ofDCPIP ... at the C-terminal end (Fig. 2).Choice of mutations The importance of the loop region in the a-subunit of the B. stearothermophilus E1p component was highlighted by itssusceptibility to limited ... was inactivated.Binding of E1 to the peripheral subunit-bindingdomain of E2 The E1 component of the PDH complex of B. stearother-mophilus is bound to the E2 core mainly by interaction of itsTable...

Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc

Danh mục: Cao đẳng - Đại học

... es-tablishing mathematical facts.What is interesting is that a mathematical statement of fact is a free-standing entity with intrinsic merit and value. But a proof is a device of communication. The ... relations with siblings. This is an entirely diﬀerent kind of proof from the kind treated in the present book. It is in the spirit of this book in the sense that it is a “device for convincing ... gainsay that particular mathematicalfact.It should not be thought that the generation of mathematical proofs ismechanical. Far from it. A mathematician discovers ideas intuitively—justlike...

Báo cáo " Sequence stratigraphy of Quatemary depositions on the land and at the continental shelf of Vietnam " pot

Danh mục: Báo cáo khoa học

...

Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc

Danh mục: Báo cáo khoa học

... evidence in support of binding of ATP to the ligand-free hGK, resulting in a change of protein conformation. The MD simulations indicatethat the binding triggers molecular motion of the ﬂexi-ble ... steady-state kineticanalyses are also compatible with conformational con-trol of GK catalytic activity by the binding of (Mg)ATP, with possible implications for kinetic coo-perativity with respect ... mellitus, and GCK congenital hyper-insulinism of infancy [6–11]. Some of the mutationsgreatly reduce the binding afﬁnity of MgATP2)[11,12], which is compatible with a direct interaction of these...

RESULTS BRIEFING SESSION: THE FIRST-HALF OF THE FISCAL YEAR ENDING MARCH 31,2009 pptx

Danh mục: Tài chính doanh nghiệp

... changes. The forward -looking statements regarding earnings contained in these materials were valid at the time these materials were drafted. SQUARE ENIX GROUP assumes no obligation to update or revise ... strategy61807,000Second -Half Operating IncomeFirst- Half Operating IncomeSoul Eater(Millions of yen)5,1575,4265,2106,1805,0006,000First- Half Operating IncomeFirst -Half Net Sales©Atsushi Ohkubo3,5694,4713 ... forward -looking statements, including forecasts or projections, whether as a result of new information, subsequent events or gpjqotherwise. The financial information presented in this...

Báo cáo khoa học: Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme pot

Danh mục: Báo cáo khoa học

... study, the ﬁrst evidence for the involvement of some amino acidresidues in the catalytic activity of this enzymehas been obtained by site-directed mutagenesis afterin silico docking. Two histidine ... histidine residues (His502 andHis546) in the vicinity of the ﬂavin ring were found tobe strictly required for AAO activity. One of these his-tidines is most likely involved in activation of the alco-hol ... together with their location near the isoalloxazinering of FAD, suggested a contribution to catalysis by alcohol activation,enabling its oxidation by ﬂavin-adenine dinucleotide (FAD). The presenceof...

Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx

Danh mục: Quỹ đầu tư

... UCITS attracted EUR 87 billion during the first half of the year, down from net inflows of EUR 142 billion for the same period in 2010. This reduction reflects the change in investor confidence ... 23 billion during the quarter. Overall, net inflows into UCITS amounted to EUR 48 billion during the first half of 2011, slightly behind the EUR 55 billion recorded in the first half of 2010. ... DDoomm i icc i ill i iaatt i ioonn Eleven countries recorded net inflows into UCITS in the second quarter of 2011, with seven countries reporting net sales in excess of EUR 1 billion...

Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf

Danh mục: Quỹ đầu tư

... countries recorded net inflows into UCITS during the first half of 2012, with five countries attracting net inflows in excess of EUR 5 billion: Ireland (EUR 44 billion), Luxembourg (EUR 31 billion), ... DDoomm i icc i ill i iaatt i ioonn Twelve countries recorded net inflows into UCITS in the second quarter of 2012, with four countries attracting net inflows in excess of EUR 1 billion: ... from equity funds. Of the other large domiciles, the UK attracted net inflows of EUR 800 million, whilst France and Germany registered net outflows of EUR 9 billion and EUR 1 billion respectively....

Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot

Danh mục: Báo cáo khoa học

... dissolvedimmediately in SDS and 2-mercaptoethanol with proteaseand protein phosphatase inhibitors, frozen within 10 s, andthawed in boiling water to minimize postincubation signal-ling modiﬁcations in the ... ter-minally differentiated cells that do not divide further,insulin has the potential for genomic control via amitogenic signalling pathway. This may also be medi-ated by IRS; insulin activation ... Hotamisligil GS, Peraldi P, Budavari A, Ellis R. &White MF (1996) IRS-1-mediated inhibition of insulinreceptor tyrosine kinase activity in TNF-alpha- andobesity-induced insulin resistance....

Báo cáo khoa học: Do N-terminal nucleophile hydrolases indeed have a single amino acid catalytic center? Supporting amino acid residues at the active site of penicillin G acylase pptx

Danh mục: Báo cáo khoa học

... and initial velocities were calculated, taking intoaccount both the consumption of the substrate and the lib-eration of the arylamine with the time. The kinetic experi-ments with each substrate ... feature of the PGA catalytic reaction. It is probably a cumulativeresult of intrinsic amino acid interactions in the activesite of the E. coli enzyme that differentially (de)stabi-lize the structures ... because of the substitution of the oxyanion hole with twowater molecules. The effective stabilization of the oxy-anion is the main driving force of the ﬁrst step of acyl-ation, and dominates all other...

Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx

Danh mục: Báo cáo khoa học

... H4biop-terin, the oxidized cofactor H2biopterin and the catechol-amine inhibitor dopamine. From Fig. 3A it is seen that onpreincubation with saturating concentrations (Fig. 3B) of the biopterin cofactors ... side-chain of Ile25.Discussion The catalytic activity of PAH is regulated by four mainmechanisms, i. e. by substrate (L-Phe) activation, biopterincofactor (H4biopterin/H2biopterin) inhibition, ... different (Table 1) because of the differentpositions and hybridizations of the C6 atom of the pyrazinering in the two redox states [18,20]. This diversity of the side-chain position is likely...