Acne Symposium at the World Congress of Dermatology Pari doc

[...]... coding region Association between variation at the locus and acne is not found [44] In conclusion, the pathogenesis of acne is multifactorial and a greater number of genes than those cited above are probably related to the condition Genes affecting keratinization and desquamation are suspected to be involved in the pathogenesis of acne and their correlation to acne is yet to be evaluated Advances in immunogenetic... clinical entities and their therapeutic modification Aetiology of Comedogenesis Comedogenesis is due to the accumulation of corneocytes in the pilosebaceous duct [5] This could be due to hyperproliferation of ductal keratinocytes, inadequate separation of the ductal corneocytes or a combination of both factors [6] There is reasonable evidence to support the hyperproliferation of ductal keratinocytes [7] This... on the understanding of the inflammatory reaction in acne Genes expressed in the sebaceous glands which exhibit polymorphism are of special interest, regardless of their known function Any gene polymorphisms found to be related to acne may provide additional insights into the pathogenesis of this condition Further research is needed to investigate the combined effects of these and other genes Dermatology. .. Burgdorf W, Plewig G: Pathogenesis and treatment of acne in childhood Pediatr Dermatol 1997;14:7–21 2 Katsambas AD, Katoulis AC, Stavropoulos P: Acne neonatorum: A study of 22 cases Int J Dermatol 1999;38:128–130 3 Lucky AW: A review of infantile acne and pediatric acne Dermatology 1998;196:95–97 4 Bekaert C, Song M, Delvigne A: Acne neonatorum and familial hyperandrogenism Dermatology 1998;196:453–454... on the endothelia after subsequent culture Furthermore, preincubation of explants with the SP analogue or with cromolyn sodium, one of the MC inhibitors, abrogated the ability of SP to induce ELAM-1 These findings suggest that SP endogenously released by dermal nerve fibers may be important in the regulation of endothelial-leukocyte interaction via MCs It has been demonstrated that the proinflammatory... alterations of the sebaceous glands in organ culture by several kinds of NPs and nerve growth factor (NGF), the best-characterized member of the neurotrophin family [20] The ultrastructure of the sebaceous glands with medium alone was identical to that of intact sebaceous glands From the exterior aspect to the interior, the sebaceous glands consisted of the germinative, the undifferentiated and the. .. upregulated by SP (in vitro) Taken together, these findings suggest involvement of neurogenic factors including innervation, NPs, neuropeptides-degrading enzymes and neurotrophic factors in the inflammatory process of acne and provide new insight into the possible mechanism of exacerbation of acne from the neurological point of view References 1 Koo JY, Smith LL: Psychologic aspects of acne Pediatr Dermatol... could be the first sign of pubertal maturation and associated with increase in sebum and urinary excretion of androgenic steroids A high frequency of acne was found in a longitudinal study of adolescent boys, where the prevalence and severity of acne correlated well with advanced pubertal maturation [24] A similar study of the same authors in early adolescent girls concluded that acne can be the first... can be the first sign of pubertal maturation; significant elevations of DHEAS correlated well in girls with comedonal and inflammatory acne The most common locations of acne in this group were the midforehead, nose and chin [25] In a longitudinal study of acne and hormonal analysis, Stewart et al [26] concluded that girls with severe acne 26 Dermatology 2003;206:24–28 present a statistically significantly... range of compounds such as vitamin A In acne patients, a higher frequency of CYP1A1 mutation was observed on regulatory sites, and this may impair the biological efficacy of natural retinoids due to their rapid metabolism to inactive compounds This mutation may thus be involved in the pathogenesis of acne in some patients CYP1A1 inducibility is determined by polymorphism in the genes of the aromatic . pleasure to present the Proceedings of the Symposium on Acne held at the 20th World Congress of Dermatology, July 1–5, 2002 in Paris. The topics dis- cussed. for their use, in association to the need of developing strategies to minimize use of anti- biotics in acne therapy, the endocrine aspects of acne and their