at the current state of technology
LECTURE SLIDES ON NONLINEAR PROGRAMMING BASED ON LECTURES GIVEN AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MASS DIMITRI P. BERTSEKAS
... Application Contexts• Characterization Issue• Computation Issue• Duality• OrganizationCOMPUTATION PROBLEM• Iterative descent• Approximation• Role of convergence analysis• Role of rate of ... convergence of steep-est descentx0x1x2f(x) = c1f(x) = c3 < c2f(x) = c2 < c1...Quadratic Approximation of f at x0Quadratic Approximation of f at x1Fast convergence of New-ton’s ... Zero slope at a localminimum x∗∇f(x∗)=0• 2nd order condition: Nonnegative curvature at a local minimum x∗∇2f(x∗): Positive Semidefinite• There may exist points that satisfy the 1st and2nd...
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Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
... the suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of ... for the treatment of pathological frenulum, keratoses, angiomas and telangiectases. 2. PATIENTS AND METHODS The treatment with the 980nm Diode Laser was proposed to a group of 15 patients ... during treatment or during the healing period. All the patients were followed up at 1, 4, and 8 weeks from the procedure. 3. RESULTS At the 4-week follow-up the cases of keratosis, had...
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"
... connections. The present study aimed to detect the expression of Cx40 and Cx43 in the artery at early stage of high fat diet induced atherosclerosis and to investigate the effects of AT1 antagonist ... reduced by treatment. RT-PCR and Western blot assay showed that the mRNA and protein expression of Cx40 and Cx43 were elevated in the neointimal area at the early stage of atherosclerosis. The mRNA ... involved in the injury or dis-ease induced activation of vessel wall cells. It is indi-cated that the expression of Cx43 in the smooth mus-cle cells was markedly elevated at the early stage of coronary...
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The 2011 State of Inbound Marketing
... that allow customers to find them. The State of Inbound Marketing report shows that businesses that more aggressively practice this are capturing leads more effectively. Given the digital nature ... from the following social media / blog channels? THE STATE OF INBOUND MARKETING HubSpot.com 8 A more granular view of the data shows that: Marketers are allocating ... a series of questions related to their business‘ marketing programs the results they have seen. Most of the questions fell within three categories: - Marketing budget and sources of leads,...
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Tài liệu Báo cáo khoa học: Salt-induced formation of the A-state of ferricytochrome c – effect of the anion charge on protein structure docx
... the charge, the lower is the anion concentration required to stabilize the A -state [11]. Subsequent studies have shown that the tertiary conformation of the A -state is modulatedby the type of ... 35% that of the native state, consistent with het-erogeneity of the A -state. On the basis of earlier data(relative to monovalent anions) [18], a mixture betweenMet80–Fe(III)–His18 coordinated ... progresscurve of Fig. 9B is expected to refer: (a) for the fastphase, to the sulfate-induced destabilization of the HSacid-denatured form, with further formation of the LS(IHH) A -state; (b) for the...
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Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... affecting the ability of E1 to catalyse the reductive acetylation of the tethered lipoyldomain in the assembled PDH complex. It should be notedthat Tyr281 and Arg282 are located at the mouth of the funnel-shaped ... site of E1, at the bottom of which lies the ThDP cofactor some 20–25 A˚from the protein ÔsurfaceÕ[14]. Thus it may be that these mutations are affecting the efficacy of the recognition of the ... any of the mutations in E1a (Fig. 4).Therefore, any effects of the mutations on the catalyticactivities of the PDH complex must be due to direct effectson the reactions catalysed by E1. The...
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Tài liệu The Proof is in the Pudding - A Look at the Changing Nature of Mathematical Proof doc
... we are able to acquaint the reader with the culture of mathematics: who mathematicians are, what they care about, andwhat they do. We also give indications of why mathematics is important, andwhy ... bullet-proof fashion that willstand the test of time. The second, and for the working mathematician the most important, aspect of proof is that the proof of a new theorem explainswhy the result ... convincing another mathe-matician that a given statement (the theorem) is true. Thus a proof can takemany different forms. The most traditional form of mathematical proof isthat it is a tightly...
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Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... following the change in ellipticity at 222 nm at a constant heating rate of 40 °CÆh)1. The midpoint of the transition (Tm) was deter-mined from the first derivative of the smoothed denatur-ation ... Mg2+), sat-urating amounts of Glc were used. In the case of the severely inactivating mutation T228M [9,20], an ATP con-centration of 10 mm was used. For determination of Hillcoefficients of WT ... hyper-insulinism of infancy [6–11]. Some of the mutationsgreatly reduce the binding affinity of MgATP2)[11,12], which is compatible with a direct interaction of these residues with the nucleotide at the...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... models, which indicatethat the approach may be applicable to the treatment of a wide range of human cancers. This minireview summarizes the available data on thesecompounds and the challenges posed ... senescence,and ultimately apoptosis. The catalytic subunit of telo-merase (hTERT in humans) has reverse transcriptaseenzymatic activity and synthesizes TTAGGG repeatson to the end of the 3¢ single-stranded ... quadruplexformation at the single-strand overhang may itself be aDNA damage signal, producing responses analogousto those of other mediators of telomere damage [12]. The biological function of induced...
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The 2011 State of Inbound Marketing docx
... rank the services that they use as ―critical,‖ ―important,‖ or ―useful.‖ The results indicate: A whopping 27% of users rated their company blog as “critical” to their business. 85% of users ... that allow customers to find them. The State of Inbound Marketing report shows that businesses that more aggressively practice this are capturing leads more effectively. Given the digital nature ... that ChannelCustomer Acquisition by Channelby IndustryLinkedInTwitterFacebookBlog THE STATE OF INBOUND MARKETING HubSpot.com 18 Respondent Profiles The State of...
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Báo cáo khoa học: Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme pot
... are situated at similar distancesfrom the hydroxyl of the docked substrate, they couldcooperate in facilitating the hydride transfer from sub-strate to FAD. The decrease of activity of the AAOH502A ... modulating the catalyticrate of the enzyme. Finaly, L315 affects the enzyme kcat, although it is notlocated in the near vicinity of the cofactor. The present study provides the first evidence for the ... glycoprotein of 70 kDa with dissociableflavin-adenine dinucleotide (FAD) as cofactor thatcatalyzes the oxidation of a variety of aromatic andaliphatic polyunsaturated alcohols to their corres-ponding...
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Báo cáo khoa học: Modulation of nitric oxide-mediated metal release from metallothionein by the redox state of glutathione in vitro doc
... thiscoexpression of counteracting proteins, we investigated the role of the glutathione redox state in vitro because the oxi-dation state of thiols is involved in the metal binding in Cd-Sor Zn-S clusters ... increased the cadmium release by nitric oxide. The decay occurs in the first 10 min after the addition of NO as observed bymonitoring the CD at the maximum of the charge transferband at 260 nm ... to samples of 20 lMCd5Zn2-MT2 togive final ratios as indicated at the bottom of Fig. 2. The normalized amounts of zinc and cadmium in the MT2fraction, taking into consideration the dilution...
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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... incubation.When the insulin-responsiveness of the cells wasexamined at different concentrations of insulin, wefound that insulin enhanced the phosphorylation of PKB at lower concentrations ... degree of phos-phorylation of the insulin receptor and IRS1 wasrequired to increase the phosphorylation of ERK1 ⁄ 2(Figs 1C and 5).Our findings indicate that the collagenase treatmentto isolate ... been the subject of intensive research for many years. Yet, wedon’t know the details of the molecular dysregulationin the target cells of the hormone. Studies of cells frompatients with the...
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