... compilation ª 2011 FEBS 1655Introduction Protein protein interactions play important roles inthe molecular recognition and functional modulationbetween proteins in many signal transduction path-ways ... FEBSInteraction between very-KIND Ras guanine exchangefactor and microtubule-associated protein 2, and its rolein dendrite growth – structureandfunction of the secondkinase noncatalytic C-lobe domainJinhong ... is a putative protein protein interaction module. Four KIND-containing proteins, Spir-2 (actin-nuclearfactor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very-KIND...
... dublin TLP and zebrafish TLP are found in the flex-ible portions of strands B and C that protrude towardsthe solvent and in the conformation of the long loopconnecting strands D and E [17]. ... eight-stranded b-sandwich (strandsA-H) with each sheet adopting a greek-key topology. Atwo-turn a-helix usually (with the exception of chickentransthyretin) exists between strands E and F in ... between the loops joining standsG and H with the loops joining strands A and B, mak-ing the transthyretin tetramer a ‘dimer of dimers.’Recently, the first crystal structures of TLP fromvarious...
... compilation ª 2011 FEBS206 Ansari KI, Mishra BP & Mandal SS (2008) Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Biochim Bio-phys Acta 1779, 66–73.207 ... TET family proteins in thecontrol of DNA methylation and genome function. CG islands can also be targets for dysregulation indiseased states whereby they can become hypermethy-lated and maintained ... cooperative binding, and creates an accessi-ble environment that also enables Sp1 and Runx1binding [85,86,233]. Both NFAT and AP-1 have thepotential to recruit the HATs CBP and p300 whichmay...
... from Koehl, 1995).BODY SIZE AND SUSPENSION FEEDING 21Body SizeThe Structureand Function of Aquatic EcosystemsEdited byALAN G. HILDREWSchool of Biological and Chemical Sciences, Queen Mary, ... SIZE AND SUSPENSION FEEDING 19Body Size: The StructureandFunction of Aquatic EcosystemsEcologists have long struggled to predict features of ecological systems, such asthe numbers and diversity ... important, and (ii) to compare freshwater and marine ecosystems. In Body Size: The StructureandFunction of Aquatic Ecosystems,both those questions of scale and comparison among systems are very...
... Tecnologia).References1. Davies, D.R. (1990) The structureandfunction of the asparticproteinases. Annu. Rev. Biophys. Biophys. Chem. 19, 189–215.2. Dunn, B.M. (2002) Structureand mechanism of the pepsin-likefamily ... (Eur. J. Biochem. 271) 2069REVIEW ARTICLE Structure andfunction of plant aspartic proteinasesIsaura Simo˜es and Carlos FaroDepartamento de Biologia Molecular e Biotecnologia, Centro de Neurocieˆncias ... 274,28724–28729.11. Laloi, M., McCarthy, J., Morandi, O., Gysler, C. & Bucheli, P.(2002) Molecularand biochemical characterisation of two asparticproteinases TcAP1 and TcAP2 from Theobroma cacao seeds.Planta...
... investigation and understanding of their structure- activity relationships,may start to provide a rational way to develop additionalpharmacological tools for the elucidation of nAChR structure and function. Ó ... pentameric quaternary structure of this protein (Fig. 1) and have provided valuableinformation about the channel architecture and dimensions.A deeper insight into the molecular structure, in particularthe ... formation of the hydrophilic pore. ACh binding protein has structural and functional homology to the extracellular ligandbinding domain of the nAChR, and likewise assembles into pentamers.2306...
... insectsThe structureandfunction of b-helical antifreeze proteinsSteffen P. Graether and Brian D. SykesCIHR Group in ProteinStructureand Function, Department of Biochemistry andProtein Engineering ... [31,32,36] and their three-dimensional structures were determined [34,37–40]. Insubsequent sections, we describe the structureand dynamicsof each protein, and present a comparison of s bwAFP and TmAFPwitheachotherandwithproteinsthathaveasimilar ... and TmAFPwitheachotherandwithproteinsthathaveasimilar fold. Structure of sbwAFP and TmAFPThe structure of sbwAFP has been determined by X-raycrystallography to 2.5 A˚ and by NMR at both 30 °Cand5 °C...
... finger protein Ynr046w,a component of the yeast eRF1 methyl-transferase (A), and the minidomain(residues 329–372) of human eRF1 in theopen (B) and closed (C) forms.NMR structureandfunction ... three antiparallel strands (1, 2 and 7) and strand 6, which is parallel to strand 2. b-Strands arelocated between the four a-helices (a1, 278–294; a2,305–313; a4, 374–381; and a5, 397–405), with ... the protein gives asmaller rmsd of 1.58 ± 0.06 A˚. Figure 6 shows a com-parison of the structure of the protein core (resi-dues 277–328 and 373–413) in solution and in the solidstate, and...
... two proteinprotein interfaces. (B) One proteinprotein interface generated by two-fold NCS. (C) Other proteinprotein inter-faces also generated by two-fold NCS.R. Valverde et al. Structureand ... the proteinprotein interaction.ABFig. 12. Schematic representation of proteinprotein surfaces offree and RNA-bound Nova-2 crystals. The schematic in (A) and (B)is based on the proteinprotein ... ligand stacking with eachother. Coordinates from Protein Data Bankentry 1J5K were used in (A) and (B), and coordinates from Protein Data Bank entry2ASB were used in (C). Structure and function...
... GlcNAc kinase are labeledwith a star.Ó FEBS 2002 Structureandfunction of GlcNAc kinase (Eur. J. Biochem. 269) 4215 Structure andfunction ofN-acetylglucosamine kinaseIdentification of two ... with regard to a-helices and theb-sheets. Three-dimensional modelling was performed usingtheRASMOLsoftware.RESULTSConstruction of cysteine mutants and functional expression inE. coliBL21In ... numberof functionally relevant cysteines was quantified to two, and dithiol-modifying reagents predicted a structural vicinity ofthese cysteines. The amino acid sequences of murine and human GlcNAc...
... 40,000 Linear double-stranded DNAM13 phage 6,400 Closed-circular single-stranded DNAMS2 phage 3,600 Linear single-stranded RNA Human 6,000,000,000 Linear double-stranded DNAFruit fly 270,000,000 ... Closed-circular double-stranded DNABacillus subtilis 4,200,000 Closed-circular double-stranded DNAF plasmid 95,000 Closed-circular double-stranded DNAλ phage 48,500 Linear double-stranded DNAT7 phage ... chromosomes.A single chromosome contains thousands of genes, each encoding a protein. All of an organism’s chromosomes make up the genome.Humans have 46 chromosomes.The human genome has about 3 billion...
... fiber of DNA with proteins attachedproteins attachedChromatin – all of the cell’s DNA and the Chromatin – all of the cell’s DNA and the associated proteinsassociated proteins Why Are ... NucleusNucleus Structure StructureNuclear envelopeNuclear envelope•Two Phospholipid bilayers with protein Two Phospholipid bilayers with protein lined poreslined poresEach pore is a ring of 8 proteins ... received from the ERSorts, tags and packages fully processed proteins and lipids in Sorts, tags and packages fully processed proteins and lipids in vesiclesvesicles Endomembrane System Endomembrane...
... packages and distributes proteins and lipids from ERdistributes proteins and lipids from ERFunctions of Functions of Eukaryotic Cell Eukaryotic Cell FeaturesFeatures Structure Structure ... CELLSCELLS Structure andFunction Structure and Function Cell = smallest unit of lifeCell = smallest unit of lifeFunctions of Eukaryotic Cell FeaturesFunctions of Eukaryotic Cell Features Structure ... detoxification3.3.Transport of proteins from RERTransport of proteins from RERRERRERSERSERFunctions of EukaryoticFunctions of Eukaryotic Cell Features Cell Features Structure Structure Function( s) Function( s)Cilia...
... buffer, pH 7.0, and its UVspectra were recorded between 250 and 190 nm. Molecular modelling Structure manipulations and analysis were performed usingthePYMOLsoftware [41].Results and DiscussionSynthesis ... of maize GST I and otherenzymesMaize G ST I w as cloned into a pQE70 expression vector toyield the pQEGST expression plasmid as described byLabrou et al. [14]. Expressionand purification ... lutathioneS-transferases: enzymes with multiple functions in s ickness and inhealth. Trends Pharmacol S ci 5, 193–198.4. Marrs, K.A. (1996) The functions and regulation of glutathioneS-transferases...
... mitochondrial structureand function. Materials and methodsMaterialsDiS-C3(5) and cyclosporin A (CsA) were kindly providedby Hayashibara Biochemical Laboratories, Inc. (Okayama,Japan) and Novartis ... 2004 Effects of DiS-C on mitochondrial structureandfunction (Eur. J. Biochem. 271) 3577Multiple effects of DiS-C3(5) on mitochondrial structureand function Takenori Yamamoto1,2, Aiko Tachikawa1,2, ... found DiS-C3(5) to show multipleeffects on the mitochondrial structureand function, effectsdependent on both its concentration and the Pistatus.11AcknowledgementsThis work was supported...