creactive protein structure synthesis and function

... 2,3 and 4, lower band). The levels of mutant and wild-type MCPIP mRNAs were higher when these vectors were co-transfected with a vector overexpress- ing IL-1b (Fig. 5, lanes 3 and 4, upper bands). ... correct regions in protein models using structural, alignment, and consensus information. Protein Sci 15, 900–913. 6 Kurowski MA & Bujnicki JM (2003) GeneSilico protein structure prediction ... appear- ance of functional proteins. As reported by Kaspar and Gehrke [18] and Dinarello [19], stimulation of macrophages by mild stimulants (such as C5a comple- ment or some modified proteins) leads...

Ngày tải lên: 18/02/2014, 14:20

... preimmune and post-third inoculation sera against a M. tuberculosis sonicate (lanes 1, 2 and 5) and a membrane frac- tion (lanes 3 and 4). Lanes 1 and 3, absence of recognition of M. tuberculosis proteins ... subunit-based, multiepitope, anti-TB vaccine candidate. Rv2560 is a proline- and glycine-rich transmembrane protein, and may thus be classified as a simple sequence protein (SSP). This type of sequence ... for U937 proteins specifically cross-linked with radiolabelled peptide 11024. Lanes 1 and 2, U937 cells; lanes 3 and 4, HepG2 cells; lanes 1 and 3, total radiolabelled peptide binding; lanes 2 and...

Ngày tải lên: 18/02/2014, 16:20

... 1. Conclusions In the last few years, the study of the synthesis and function of RPs has both expanded our knowledge S. Caldarola et al. Ribosomal protein synthesis FEBS Journal 276 (2009) 3199–3210 ª ... 2009 FEBS REVIEW ARTICLE Synthesis and function of ribosomal proteins – fading models and new perspectives Sara Caldarola, Maria Chiara De Stefano, Francesco Amaldi and Fabrizio Loreni Department ... Novel ubiquitin fusion proteins: ribosomal protein P1 and actin. J Mol Biol 328, 771–778. 54 Kirschner LS & Stratakis CA (2000) Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of...

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... FEBS Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain Jinhong ... is a putative protein protein interaction module. Four KIND-containing proteins, Spir-2 (actin-nuclear factor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very-KIND ... compilation ª 2011 FEBS 1655 Introduction Protein protein interactions play important roles in the molecular recognition and functional modulation between proteins in many signal transduction path- ways...

Ngày tải lên: 14/02/2014, 19:20

... dublin TLP and zebrafish TLP are found in the flex- ible portions of strands B and C that protrude towards the solvent and in the conformation of the long loop connecting strands D and E [17]. ... between the loops joining stands G and H with the loops joining strands A and B, mak- ing the transthyretin tetramer a ‘dimer of dimers.’ Recently, the first crystal structures of TLP from various ... transthyretin-related protein family. Eur J Biochem 270, 518–532. 11 Hennebry SC, Wright HM, Likic V & Richardson SJ (2006a) Structural and functional evolution of transthy- retin and transthyretin-like proteins....

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... TET family proteins in the control of DNA methylation and genome function. CG islands can also be targets for dysregulation in diseased states whereby they can become hypermethy- lated and maintained ... required for function in either T cells or mast cells. Shown below are the positions that nucleo- somes and GATA-2 occupy in unstimulated T cells and mast cells [85]. Active chromatin and DNase ... exist within CG islands which are characterized by their very high CG content and have an intrinsic resistance to DNA meth- ylation. CG-island promoters tend to be constitutively and ⁄ or ubiquitously...

Ngày tải lên: 14/02/2014, 18:20

... HPRT and hypoxanthine. (C) PRTFDC1 and guanine. (D) HPRT and guanine. Table 2. K m and V max values for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 filter paper assay and ... [39] and ESPript [40]. Superposi- tions used in the text and figures were made using the ssm superposition algorithm in coot [33,41]. The coordinates and structure factors are published in the Protein ... Environment, Agricultural Sciences and Spatial Planning (to L.W. and S.E.), the Swedish Research Council (to H.E. and P.N.) and the Swedish Cancer Foundation (to H.E. and P.N.). The Structural Genomics...

Ngày tải lên: 15/02/2014, 01:20

... from Koehl, 1995). BODY SIZE AND SUSPENSION FEEDING 21 Body Size The Structure and Function of Aquatic Ecosystems Edited by ALAN G. HILDREW School of Biological and Chemical Sciences, Queen Mary, ... SIZE AND SUSPENSION FEEDING 19 Body Size: The Structure and Function of Aquatic Ecosystems Ecologists have long struggled to predict features of ecological systems, such as the numbers and diversity ... important, and (ii) to compare freshwater and marine ecosystems. In Body Size: The Structure and Function of Aquatic Ecosystems, both those questions of scale and comparison among systems are very...

Ngày tải lên: 17/02/2014, 19:20

... (B) The DHAP binding site with crucial protein residues and solvent molecules engaged in ligand recognition and stabilization are drawn as balls -and- sticks and spheres, respectively. The major ... ACMSD upon ligand bind- ing. The image was obtained by optimal superposition of the hA- CMSD:DHAP and PfACMSD:ligand-free structures. Protein residues are colored in white for hACMSD and in green ... Zn 2+ ion and the coordinated solvent molecule are shown as magenta and cyan spheres, respectively. The strictly con- served protein residues forming the metal coordinative sphere and the ligand molecule...

Ngày tải lên: 18/02/2014, 06:20

... coordinates and structure factors of the crystal structures described in this study have been submitted to the Protein Data Bank, and the structures have been assigned the accession codes 2v4n and 2v4o ... survival protein SurE with metal ion and AMP. J Mol Biol 371, 123–136. 11 Mura C, Katz JE, Clarke SG & Eisenberg D (2003) Structure and function of an archaeal homolog of survival protein ... 2. Structure of the C2-SurE tetramer. The A to D subunits are represented by pink, cyan, blue and yellow, respectively. The tetra- meric interactions are between the subunits A and C, and B and...

Ngày tải lên: 18/02/2014, 14:20