histomorphological protein and molecular markers in colorectal cancer current perspectives
Báo cáo sinh học: "Protein kinase CK2a is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes" docx
... in colorectal cancer CK2a protein expression was analyzed in 144 patients (104 with CRC and 40 with colorectal adenoma) Staining for CK2a was nearly negative in all of the normal Page of 11 colorectal ... The human colorectal cancer cell lines LoVo, SW480, HT29, HCT116 and LS174T were maintained in RPMI 1640 (Gibco, Grand Island, NY, USA) supplemented with 10% fetal bovine serum at 37°C in a 5% ... expression in colorectal cancers, adenomas and adjacent normal colorectal mucosa Staining was (A) negative in normal colorectal epithelium cells, (B, C) weak to moderate in the nuclei of colorectal...
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Báo cáo hóa học: " Comparison of T-cell receptor repertoire restriction in blood and tumor tissue of colorectal cancer patients" docx
... antigens and prognosis in colorectal cancer patients J Transl Med 2005, 3:3 Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM: Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal ... carcinoma patients, unaffected colonic mucosa, carcinoma tissue) one has to keep in mind the differences in sample sizes and applied tests The highly significant difference in CD between blood and ... origin, we found a negative correlation between HAC/PBGD and CD (Figure 3) as well as HAC/PBGD and n(F) (not shown) However, separate analysis of the samples originating from blood and originating...
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Báo cáo hóa học: " LEF-1 and TCF4 expression correlate inversely with survival in colorectal cancer" pptx
... TCF4 expression in colorectal cancer To investigate the localisation of LEF-1 and TCF4 in human colorectal cancer, we evaluated the expression of these proteins by immunostaining on tissue microarrays ... The DNA binding proteins and transcription factors TCF4 and LEF-1 are partners of nuclear b-catenin and effectors of the Wnt/b-catenin signalling pathway, which is decisively involved in tumorigenesis ... These surprising findings suggest that TCF4 might be the main binding partner for b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/bcatenin transcriptional...
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Báo cáo sinh học: "Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review" pdf
... Medline and PubMed from January 1998 to January 2010 for original studies on ASI in CRC, Using the following keywords: colorectal OR “colon” OR “rectal” AND cancer OR “carcinoma” AND vaccine ... Many clinical trials have been conducted using active specific immunotherapy (ASI) in CRC, including autologous tumor cell vaccines, define-tumor protein vaccines, monoclonal antibodies and anti-idiotype ... D, Thiel E: Clinical and Immunologic Responses to Active Specific Cancer Vaccines in Human Colorectal Cancer Clin Cancer Res 2006, 12:3064-3069 14 Alejandro R, Jadad MD, DPhil R, Andrew Moore...
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Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot
... basal and 24 hours neuroserpin levels was defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints ... Neuroserpin and brain injury biomarkers We evaluated the relationship between neuroserpin levels and brain injury biomarkers on admission as well as between neuroserpin decrease within the first ... neuroserpin decrease < 70 ng/mL and serum levels of brain injury biomarkers at 24 hours, which remained independent for glutamate, IL-6 and cFn after adjusting for confounding factors Neuroserpin displays...
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Báo cáo sinh học: "A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" ppt
... effect induced by 5-FU in the KIAA0247expressing cells could be crucial in controlling the G2/ M checkpoint and in decreasing the number of cells in G2/M At the same time, reduced levels of cyclins ... Progress and challenges in colorectal cancer screening and surveillance Gastroenterology 2010, 138:2115-2126 Kim MS, Lee J, Sidransky D: DNA methylation markers in colorectal cancer Cancer Metastasis ... determined the expression of the uncharacterized gene, KIAA0247, in human gastrointestinal tissues and colonic cell lines Results indicated that KIAA0247 ubiquitously expresses in gastrointestinal...
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf
... basal and 24 hours neuroserpin levels was defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints ... Neuroserpin and brain injury biomarkers We evaluated the relationship between neuroserpin levels and brain injury biomarkers on admission as well as between neuroserpin decrease within the first ... neuroserpin decrease < 70 ng/mL and serum levels of brain injury biomarkers at 24 hours, which remained independent for glutamate, IL-6 and cFn after adjusting for confounding factors Neuroserpin displays...
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báo cáo hóa học:" A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment" doc
... effect induced by 5-FU in the KIAA0247expressing cells could be crucial in controlling the G2/ M checkpoint and in decreasing the number of cells in G2/M At the same time, reduced levels of cyclins ... Progress and challenges in colorectal cancer screening and surveillance Gastroenterology 2010, 138:2115-2126 Kim MS, Lee J, Sidransky D: DNA methylation markers in colorectal cancer Cancer Metastasis ... determined the expression of the uncharacterized gene, KIAA0247, in human gastrointestinal tissues and colonic cell lines Results indicated that KIAA0247 ubiquitously expresses in gastrointestinal...
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Báo cáo lâm nghiệp: "of morphological characters and molecular markers for the analysis of hybridization in sessile and pedunculate oak" pps
... 419, allowing discrimination between sessile and pedunculate oaks Among these 12 bands, two (F14a and 174g) were present in small frequencies in pedunculate oak and in high frequencies in sessile ... characters were included in the analysis (DFAa) Second, the individuals of the groups ses/ses and ped/ped were considered as principal points, and individuals of the mixed zones ped/ses and ses/ped ... letswaart and Feij, 1989) Interspecific gene flow between sessile and pedunculate oak has been inferred in many studies on the basis of the finding, in natural mixed populations, of trees with intermediate...
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Báo cáo khoa học: "Does Doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer?" ppt
... apoptosis in colorectal cancer cell lines [13,14] In this study we investigated whether doxycycline works in synergy with cisplatin and oxaliplatin or not in HT 29 colorectal cancer cell line Methods ... activity levels in cells treated with cisplatin and oxaliplatin in combination with doxycycline (p = 0.001 and p = 0.039 respectively) These findings corresponded with the findings obtained in caspase ... mechanism of action involves inhibition of protein synthesis by restricting binding of aminoacyl t-RNA to 30S ribosomes [2] Tetracyclines are believed to interfere the mitochondrial protein synthesis...
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báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx
... transfected into the breast cancer cell lines MDA-MB-231 and MCF-7 Its effect on protein expression of estrogen recepter alpha(ER a ), matrix metalloproteinase 9(MMP-9), cyclinD1, and on cancer cells invasion, ... Bridge Biotechnology, China) Protein bands were detected using ECL detection system (Zhongshan Golden Bridge Biotechnology, China), and b-actin staining served as the internal standard for the membranes ... up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness using Boyden chamber assay mentioned in Albini’s[20]...
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báo cáo khoa học: " Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival" docx
... of deviating skipping -3 -2 -1 Relative amounts of deviating inclusion skewed TIN (sTIN): Preferential exon skipping or inclusion overall TIN (oTIN): High or low total amounts of deviating exon ... scanned image files containing pixel intensity values CEL data files were used as input for preprocessing and alternative splicing detection with the Finding Isoforms using Robust Multichip Analysis ... deviating exon usage as tumors with transcriptome instability (TIN) Tumors showing preferential exon skipping or inclusion - that is, having a skewed distribution in the amounts of deviating skipping...
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Báo cáo sinh học: " Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication)" ppsx
... Reynolds distance and standard errors were computed between the G2 population and lines in G11, and across lines in G11, using the POPULATIONS programme [19] In order to assess the in uence of the ... equivalent to NeV using genotype information from markers in all QTL zones, but estimated values were larger in the control line i.e., 76 for the control line and 51, 65 and 41 for lines 1, and 3, respectively ... from markers in QTL zones were significantly different everywhere except in the control line The value from neutral markers was significantly lower than the one from markers in QTL zones in lines and...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... 10% of all cancer incidence and mortality in 20132 Consistent with trends in developed countries, CRC is the most frequent cancer in Singapore, accounting for 14% to 18% of all cancer incidence ... up-regulated proteins in the metastatic cell line (STMN1 isoforms indicated by red box) Up- and downregulated proteins are represented in red and green respectively 18 Figure 2-2: STMN1 expression increases ... 2005-20093 Colorectal cancers usually begin as non-cancerous polyps in the inner lining of the colon or rectum4 Over many years, adenomatous polyps in the dysplasic colon may develop into pre-neoplastic...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
... that interfacial protein protein interactions between the hinge region of ISP and the extramembranous cd2 helix of cytochrome b are important for maintaining the structure of the hinge region and, ... progressively lost during the assay, or that its integration within the complex was progressively distorted, causing further inhibition of the enzyme activity An altered protein protein interaction between ... shown in pink, and the hinge region of the ISP is shown in white the integration or stability of the ISP within the bc1 complex In order to investigate its effect on the bc1 complex, we introduced...
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Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
... Apoptosis, growth arrest and suppression of invasiveness by CRE-decoy oligonucleotide in ovarian cancer cells: protein kinase A downregulation and cytoplasmic export of CREbinding proteins Mol Cell Biochem ... activity, and showed that CDO alone did not increase the extent of staining However, in cells that had been cocultured with CDO and a cytotoxic drug, staining was significantly increased, indicating ... reduction in cyclin D and E expression Disappointingly, the specific interactions between CDKs and cyclins were not assessed, and the effects of CDO on p21waf1 were not investigated, making direct...
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Clinical and Molecular Advances in Ankylosing Spondylitis Edited by Jacome Bruges-Armas doc
... only marginal involvement of the skin and peripheral joints, others mainly present skin and joint affections with only little back pain In these cases, it is quite easy to diagnose ankylosing spondylitis ... another being the sternoclavicular joint The disc divides each joint into two The lower joint compartment formed by the mandible and the articular disc is involved in rotational 16 Clinical and Molecular ... asking the patient, if and which part of the spine is painful during this examination The disease is caused by chronic inflammation of the spinal joints and entheses, proliferative synovitis and...
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Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot
... chemopreventive agents, including resveratrol [26,27], brassinin [28,29], and deguelin [30,31] Resveratrol is present in grapes, red wine and peanuts, brassinin is from Chinese cabbage, and deguelin is from ... apoptosis in SW480 human colon cancer cells To investigate the effects of IxoA on apoptosis, we 5720 used acridine orange ⁄ ethidium bromide staining and DAPI staining and found a marked increase in ... point, and protein expression was compared between untreated and treated SW480 cells All bands were compared with b-actin bands using densitometric analysis The percentage change for each protein...
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