histogenesis and biology of extragonadal germ cell tumors
Báo cáo khoa học: Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA ppt
... clonal expansion of T-cells bearing human Vb3, Vb12, Vb17 and Vb19 [20] Others showed proliferation of human T-cells bearing Vb1, Vb2, Vb3, Vb5.2, Vb12, Vb15 and Vb17 domains and found differences ... pathologies and because of the potential use of the toxins as biological weapons Alteration of their MHC and TCR binding capacity by site directed mutagenesis could be useful in the development of vaccines ... hVb2.1hCb2 and hVb1hCb2 (genes kindly provided by U Utz and R P Sekaly, University of Montreal, Canada), were cloned between the NdeI and EcoRI restriction sites of the pET17b expression vector and...
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Báo cáo khoa học: A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea docx
... of FtsZ occurred spontaneously at urea concentrations > 0.6 m and > 1.25 m in the absence and presence of 0.6 m TMAO, respectively Furthermore, the standard free energy changes of unfolding of ... increasing concentration of urea in the absence and presence of TMAO The Dm values for the urea-induced unfolding of FtsZ were found to be 1.8 and 3.6 m in the absence and presence of TMAO, respectively ... absence and presence of 0.8 m TMAO, respectively Electron microscopy analysis of the FtsZ assembly reaction showed the formation of thicker and larger bundles of FtsZ protofilaments in the presence of...
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the genetics and biology of sex determination - novartis foundation
... Capel Department of Cell Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA Brian Charlesworth Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh ... Zarkower Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street, SE, Minneapolis, MN 55455, USA The Genetics and Biology of Sex Determination: ... di¡erentiation of Sertoli cells rather than follicle cells (Palmer & Burgoyne 1991) Cell marking and BrdUlabelling experiments have shown that cells of this lineage originate, at least in part and conceivably...
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Báo cáo hóa học: "Programmed cell death-1 (PD-1) at the heart of heterologous prime-boost vaccines and regulation of CD8+ T cell immunity" doc
... subsides, a minor subset of T cells down-regulate PD-1 and become memory cells, while the larger pool of effector cells extinguishes through a range of mechanisms leading to cellular apoptosis Conversely, ... properties of nonreplicating vectors and biological response modifiers by direct intra-nodal administration of plasmid and peptide [19,41] We showed that the sequence and the route of administration of ... robust expansion of epitope-specific CD8+ T cells (on the order of 1/2 - 1/10 specific T cells/total CD8+ T cells), reversing the order of the vectors resulted in a limited overall T cell expansion...
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báo cáo hóa học:" The detection, treatment, and biology of epithelial ovarian cancer" pdf
... cells, most NKT cells, and a subset of CD4 + T cells [105] When NKG2D binds to its ligands, it induces the cytotoxic activation and proliferation of the immune cell However, MICA and MICB can be ... epithelial cells of ewes: prospective regulatory mechanisms of repair/survival and apoptosis Biol Reprod 2001, 65:1417-1424 Dubeau L: The cell of origin of ovarian epithelial tumors and the ovarian ... diagnosis and treatment of EOC The significant advances made in the molecular understanding of EOC, development of murine models and novel proteomicsbased technologies, and the use of immune-based...
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Báo cáo khoa học: " SCLC extensive disease – treatment guidance by extent or/and biology of response?" pptx
... and cross sectional imaging was not routinely demanded but performed in case of defined key symptoms However, treatment of occult brain metastasis by PCI cannot be finally ruled out Despite of ... supplemented by biology of response Surely, randomized trials are essential to evaluate this proposed procedure Furthermore, the significance of potential confounders like treatment of asymptomatic ... S, Dagovic A, Aleksandrovic J, Radosavljevic-Asic G: Role of radiation therapy in the combined-modality treatment of patients with extensive disease small -cell lung cancer: A randomized study J...
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báo cáo khoa học: " Simultaneous measurement of sensor-protein dynamics and motility of a single cell by on-chip microcultivation system" pps
... time course of the motility and the localization of the aspartate receptor protein (Tar) for several cell generations We also report cellular responses caused by the addition and removal of the aspartate ... single cell observation, image analysis and drafted the manuscript DS and IK prepared Tar-GFP vector and discussed this study KY conceived of the study, and participated in its design and coordination ... frequency and the protein-localization dynamics When the cell divided into two daughter cells, one of these two daughter cells was picked up by optical tweezers, transported to the axle area and was...
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Báo cáo y học: " Extragonadal germ cell tumor presenting in a woman with systemic lupus erythematosus: a case report" ppt
... JP, Horwich A: Extragonadal germ cell tumors Comprehensive Textbook of Genitourinary Oncology New York: Lippincott Williams and WilkinsVogelzang NJ, Scardino PT, Shipley WU, Doffey DS , 2000 ... Journal of Medical Case Reports 2010, 4:97 http://www.jmedicalcasereports.com/content/4/1/97 Page of References Takeda S, Miyoshi S, Ohta M, Minami , Masaoka M, Matsuda H: Primary germ cell tumors ... hormones and systemic lupus erythematosus: review and meta-analysis Arthritis Rheum 2003, 48:2100 doi:10.1186/1752-1947-4-97 Cite this article as: Shahrir et al.: Extragonadal germ cell tumor...
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Báo cáo y học: " The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation" ppt
... limited intercellular coupling Numerical Simulations HCP and SCP β -cell clusters of different sizes with number of β-cells nβ ranging from 1–343, number of inter β -cell couplings of each β -cell nc ... d, and f) on the gc-nc plane λ, and bursting period Tb plotted for a HCP-323 β -cell cluster (a, c and e) and Figure burster cells fb, synchronization index Fraction of Fraction of burster cells ... affects the cell- cell communication and the synchronization of cell oscillation [28,50] Reduced amount of gap junctions Page of 13 (page number not for citation purposes) Theoretical Biology and Medical...
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Analysis and design of power electronic cell for modular power electronic systems AC DC operation
... electronics The philosophy of UPEC cell is to design a standard PEBB cell, which is capable of implementing different kind of operation modes This thesis studies the effect of input and output filter ... of basic UPEC cell: AC/DC operation Topology of basic UPEC cell: DC/AC operation Topology of soft-switching UPEC cell: DC/DC operation 2 2.1 2.2 2.3 2.4 2.5 2.6 Dataflow graph of ... 1.6: Topology of soft-switching UPEC cell: DC/DC operation 1.4 Scope of Thesis The main focus of this thesis is to look into design of UPEC cell for AC/DC operation Since the idea of UPEC requires...
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Analysis and design of power electronic cell for modular power electronic systems DC AC converter configurations
... units Standardization of cells and their connectivity will lead to reduction of engineering costs in power electronic systems Once standardized and produced in large numbers, the cost of this cells ... programming flow chart and the comparison of simulated and experimental results of the cell Chapter and Chapter form control part of the thesis These two chapters analyze the possibilities of building the ... switching frequency and prevent reduction in the size and cost of passive components and limit the bandwidth of control loops For IGBTs, the turn-off loss is dominant because the turn-off current switching...
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Expression and roles of microRNAs in cell cycle
... Synchronisation of HuH7 and HepG2 cells 40 4.2 Total RNA extraction and mature miRNA expression profiling 43 4.3 Effects of miRNA on cell proliferation 52 4.3.1 Determination of concentration of miRNA ... 24 3.2 Cell culture 25 3.3 Synchronisation of cells 25 3.4 Cell cycle analysis 26 3.5 RNA extraction and quantitation 26 3.6 Mature miRNA expression profiling 27 3.7 Effects of miRNAs on cell proliferation ... transfection of miRNA mimics and inhibitors in (A) HuH7 and (B) HepG2 cells 56 Figure 4.8 Transfection of mimic miR-193a and mimic miR-210 delays HuH7 cell cycle progression 58 Figure 4.9 Expression of...
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Expression and roles of microRNAs in cell cycle
... Synchronisation of HuH7 and HepG2 cells 40 4.2 Total RNA extraction and mature miRNA expression profiling 43 4.3 Effects of miRNA on cell proliferation 52 4.3.1 Determination of concentration of miRNA ... 24 3.2 Cell culture 25 3.3 Synchronisation of cells 25 3.4 Cell cycle analysis 26 3.5 RNA extraction and quantitation 26 3.6 Mature miRNA expression profiling 27 3.7 Effects of miRNAs on cell proliferation ... transfection of miRNA mimics and inhibitors in (A) HuH7 and (B) HepG2 cells 56 Figure 4.8 Transfection of mimic miR-193a and mimic miR-210 delays HuH7 cell cycle progression 58 Figure 4.9 Expression of...
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Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx
... Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner A B Fig Processing of APP to form Ab peptides (A) Schematic diagram of the alternative processing pathways of APP ... full details) (B) Sites of cleavage of APP by b- and c-secretases to form Ab peptides The sites of the juxtamembrane and intramembrane cleavages of transmembrane APP by b- and c-secretases, respectively, ... Modulation of oligomeric state and hence activity of the enzyme Modulation of protein–protein interactions affecting localization and ⁄ or activity Modulation of lipid environment of the enzyme...
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EVOLUTION OF THE MOLECULAR BIOLOGY OF BRAIN TUMORS AND THE THERAPEUTIC IMPLICATIONS pdf
... higher cellular density and a notable presence of atypia and mitotic cells Grade IV tumors are the most malignant and also the most frequent gliomas and include glioblastoma and gliosarcoma These tumors ... of communication to other cell cell junctions and to cellsubstratum junctions Cadherin cluster forms a transmembrane core of adherens junctions at sites of the cell cell contacts During tumor ... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications nectin is almost absent but it is effective in the microenvironment of glioma cells, which coexpress large amounts of...
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Báo cáo sinh học: " Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" doc
... there are also reports of the presence of replicating virus in blood cells (peripheral blood mononuclear cells) and in the small and large intestine [11,16] Alternative modes of transmission, such ... Progress in cell biology of SARS-CoV: Signaling pathways Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular ... infected Vero E6 cells and expression of this protein alone was shown to induce apoptosis in cell culture [35,36] This raises the question of how apoptosis of SARS-CoV infected cells is balanced...
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báo cáo hóa học:" Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" pot
... there are also reports of the presence of replicating virus in blood cells (peripheral blood mononuclear cells) and in the small and large intestine [11,16] Alternative modes of transmission, such ... Progress in cell biology of SARS-CoV: Signaling pathways Successful viral replication depends upon the ability of the virus to subvert cellular processes to their advantage and counteract cellular ... infected Vero E6 cells and expression of this protein alone was shown to induce apoptosis in cell culture [35,36] This raises the question of how apoptosis of SARS-CoV infected cells is balanced...
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Báo cáo khoa học: "Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors" ppt
... seminomas and Sertoli cell tumors filled the lumens or sheets of the affected seminiferous tubules These cells replaced the normal lining of spermatogenic and Sertoli cells Large and irregular cellular ... and canine Canine seminomas and Sertoli cell tumors testicular tumors In the current seminoma series, inhibin-alpha was observed in the cytoplasm of tumors cell in 45% of the cases Vimentin and ... (data not shown) Seminomas consisted of aggregates of germ cells that Table Frequency of expression of the antigen in canine seminomas (n = 20) and Sertoli cell tumors (n = 15)* Antibody PLAP AFP...
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Báo cáo khoa học: " SemiIntensity modulated radiotherapy (IMRT) in benign giant cell tumors – a single institution case series and a short review of the literatur" docx
... reported the development of sarcoma in of 47 (4%) patients and Mnaymneh et al [23] even in of 25 (8%) patients after surgery The appearance of malignant giant cell tumors of bone or malignant foci ... mainstay of treatment of giant cell tumors of the bone is complete surgical excision Especially in patients with extremity tumors, this treatment results in high local control rates of more than ... through improved understanding of the molecular mechanisms in the development of giant cell tumors As they are rich in stromal cells that express RANKL, a key mediator of osteoclast activation...
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báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx
... each cell line and sample Expression level of each Bcl-2 family protein was determined by scanning band density using "AlphaEaseFC" software and normalized to density of the β-actin band of same ... induction of apoptosis in the cell lines and in the fresh cases studied (R2 = 0.9682 and 0.9653 after 48 and 72 h of exposure to TW-37, respectively, Figure 2C) Effect of TW-37 on growth of established ... samples of patients with CLL Caspase activation, PARP cleavage and DNA fragmentation Exposure of WSU-FSCCL cells to TW-37 induced activation of caspase and caspase activity and PARP cleavage Page of...
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