hardware requirements for in vivo nuclear magnetic resonance studies of neural metabolism
báo cáo khoa học: "BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer" ppsx
... cancer of mm in diameter and IVIS imaging system and Magnetic Resonance Imaging, investigated the feasibility of as-prepared nanoprobes for non-invasive in vivo targeted dual modal imaging of gastric ... Department of Bio-nano Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of ... FMNPs Potential mechanism of targeting imaging In recent years, molecular imaging technologies have been used for real-time and non-invasive imaging of in Wang et al Journal of Nanobiotechnology 2011,...
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Báo cáo khoa học: "Proton nuclear magnetic resonance spectroscopy based investigation on propylene glycol toxicosis in a Holstein cow" potx
... NMR spectroscopy, which in principle enables detection of all hydrogen-containing molecules, has turned into a commonly applied technique for metabolic profiling of biofluids, among other to ... concentrate containing profollowing intake and andof arterial blood developed dyspnea pylene glycol clinical force feeding with concentrate containdid propylene(circle) (triangles)tocow that in two cows ... containing clinical reaction feeding with taining did following (circle) 2) force (triangles) in two cows dyspnea not show intake andglycol to concentrate conCarbon dioxide pressure (pCO2) of arterial...
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Báo cáo khoa học: A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation docx
... technique for specific labelling of recombinant proteins by means of incorporating a radioactive selenocysteine residue in a C-terminal Sel-tag [18] Der p carrying the Sel-tag had an intact core ... difficult to follow the in vivo clearance and turnover of an allergen after inhalation In this study we used a novel approach for specific labelling of proteins in order to investigate how an airborne ... In vivo tracking of 75 Se-labelled Der p intrinsic biological properties of the allergens may all contribute to their allergenicity [1–4] The intrinsic properties required for evoking an...
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Báo cáo khoa học: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre doc
... three pairs of cysteines in Erv1p are indispensable for in vivo activity The six cysteines of yeast Erv1p can be grouped into three pairs (Fig 1): one pair near the N-terminus of the protein, the ... the importance of the N-terminal domain for dimer-formation Under nonreducing conditions all of the cysteine mutant proteins display only a small amount of monomeric form 1532 G Hofhaus et al (Eur ... evidence for an essential involvement of the N-terminal cysteine pair in the in vivo function A possible function of this N-terminal CXXC motif in Erv1p is suggested by the discovery of a CGC...
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Báo cáo hóa học: " Adenoviruses with an avb integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases" pdf
... Replicating viruses WT -Replicating wild type virus WT-RGD -RGD insertion in HI loop of fiber knob for avb integrin targeting [43] WT-RGDK -Fiber shaft’s KKTK domain mutated to RGDK for avb integrin ... -RGD insertion in HI loop of fiber knob for avb integrin targeting -Fiber shaft’s KKTK domain mutated to GATK for HSPG ablation [21,27] AdTLY -Y477A substitution in DE loop of fiber knob for CAR ... ablation [21] Ad5luc1RGD -RGD insertion in HI loop of fiber knob for avb integrin targeting [42] AdTLRGDK -Fiber shaft’s KKTK domain mutated to RGDK for avb integrin targeting [30] -HSPG ablation via...
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Báo cáo hóa học: " Are quantum dots ready for in vivo imaging in human subjects?" docx
... (alphafetoprotein, a marker for hepatocellular carcinoma cell lines) antibody for in vivo tumor targeting and imaging [174] No in vitro validation of the QD probe was carried out before the in vivo experiments ... success of in vivo targeted imaging of QDs in live animals [37, 45] Future development of improved QD-based biological probes for in vivo optical imaging is promising for both basic science and clinical ... of QD-based research is to eventually translate QDs for use in clinical applications such as in vivo imaging in human subjects Modeling studies have revealed that two spectral windows exist for...
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Nuclear Magnetic Resonance 2 doc
... heteronuclear) coupling – broadening anisotropic chemical shift These can be averaged away over time by spinning at a root of the scaling factor: The result of magic angle spinning (often ... diffuse quickly, leading to narrow isotropic resonances In solids, the fixed orientation of individual crystallites leads to a range of resonance frequencies for anisotropic interactions Solid-state ... relevant information for the spectroscopist Designed to harness a property or properties of the nuclear spin Hamiltonians – – – – J-coupling Chemical shift Quadrupolar coupling Dipolar coupling ...
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Nuclear Magnetic Resonance 1 pot
... of Nuclear Magnetism”, Oxford, 1961 R R Ernst, G Bodenhausen, and A Wokaun, “Principles of Nuclear Magnetic Resonance in One and Two Dimensions”, Oxford, 1987 C P Slichter, “Principles of Nuclear ... information This involves separation of electronic Hamiltonian from the nuclear spin Hamiltonians NMR is thus “simplified” in that its data can be linked back to “spin systems” Examples of ... Electromagnetic Spectrum NMR, MRI EPR/ESR What is NMR? NMR is an experiment in which the resonance frequencies of nuclear magnetic systems are investigated NMR always employs some form of magnetic...
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báo cáo khoa học: " N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging" pps
... side scattering (SSC) distribution of cell shifted with increasing concentration of the MC-IOPs, which means an increase in granularity with increasing MC-IOPs concentration This finding is important ... macrophases cell lines) Briefly, RAW cells suspensions containing × 104 cell/well in DMEM containing 10% FBS were distributed in a 96well plates, and incubated in a humidified atmosphere containing 5% CO2 ... pattern of MC-IOPs, which is in exact/or in good agreement with the XRD results The ring type SAD pattern consists of a cubic inverse spinal structure of magnetite and it indicates good crystalinity...
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Báo cáo y học: " Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy-a single centre, open-label study" doc
... Measures in Rheumatology Clinical Trials (OMERACT) PsA working group has identified a hierarchy of domains to be included in PsA clinical trials [2], which includes tissue analysis and magnetic resonance ... the single joint MRI synovitis scores with a single joint clinical measure, a more detailed clinical assessment was performed of each patient’s involved knee It was scored in the manner of the ... manually per image, such that staining could be quantified in two areas - the intimal lining (ll) and synovial sublining (sl) layers Analysis was performed using the Qwin analysis system (Leica, Cambridge,...
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Báo cáo y học: " Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usa
... The dotted line indicates a deletion damaged areas of the brain Such cells have the potential to be useful for the treatment of Parkinson's disease, spinal cord injury and other inflammatory ... determinants of feline immunodeficiency virus J Virol 2002, 76:11889-11903 Browning MT, Mustafa F, Schmidt RD, Lew KA, Rizvi TA: Delineation of sequences important for efficient packaging of feline ... of the Gag/Pol coding regions (pSVR∆GP-CMVGFP) and also the generation of a self inactivating (SIN) vector (pSVR∆SIN-CMVGFP) created by additional deletion in the 3' UTR This will be copied into...
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Báo cáo y học: " A remission spectroscopy system for in vivo monitoring of hemoglobin oxygen saturation in murine hepatic sinusoids, in early systemic inflammation" doc
... detected an increasing NAD(P)H autofluorescence representing an intracellular inadequate oxygen supply Both changes are accompanied by increasing markers of liver cell injury Future therapeutic interventions ... Quantification of redox state and cell death was performed off-line by frame-by-frame analysis of the videotaped images using Meta Imaging Series Software (Ver 6.1; Universal Imaging Corp., Downington, ... the bottom side of the glass slide The setup permitted systematic in vivo scanning of the liver sinusoidal HbsO2, without affecting the organ integrity Page of (page number not for citation purposes)...
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Nuclear magnetic resonance spectroscopy (NMR)
... INADEQUAT Phổ cho thấy mối tương quan ngang qua nối nhờ phổ cho biết phân tử cacbon kề bên cacbon Phổ 1D 13C INADEQUAT thường sử dụng khó xác định mối lien hệ 13C, 13 C Ngược lại phổ 2D 13C INAQUAT ... xúc với thiết bị CW hay gắn với máy tính máy FT sau phổ chỉnh sữa in Các khái niệm NMR 2.1 Tần số máy Nếu lượng trạng thái spin thấp, trạng thái m = -1/2 ưu tiên chiếm theo điều kiện tần số Bohr, ... (δ6-δ7) x 500 = (δ7-δ8) x 500 = 7.15 làm tròn với số lẻ J = 7.1 Hz cường độ peak nhóm theo %Int = 1:2:1 + Tại singlet peak chọ làm tín hiệu với δ = 1.9907 làm tròn với hai số lẻ δ = 1.99 ppm + Tại...
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Báo cáo khoa học: "Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum" pot
... most of previous in vivo studies was done for one week or less [11] Feeding mice with LABs in long period is necessary for the evaluation of cellular immunity by probiotics By feeding of LABs before ... chemically induced tumor [28] In our experiment, increased CD8+ T cell subset was observed in long-term feeding groups with a profound change of other immune cells, indicating feeding of preparation of ... F9-bearing mice During administration of cytoplasmic fraction of LABs for wks, F9 was inoculated into mice at wks Though the body weight of mice before tumor inoculation were same in all groups,...
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Báo cáo khoa học: "In vivo morphological and antigenic characteristics of Photobacterium damselae subsp. piscicida" doc
... bacteria maintained in vitro in 300 kDa dialysis tubing (HMW bag), Lane 5: concentrated ECP of bacteria shown in Lane 4, Lane 6: bacteria maintained in vivo in 25 kDa dialysis tubing (LMW bag), ... ECP of bacteria shown in Lane 1, Lane 3: bacteria maintained in vitro in 300 kDa dialysis tubing (HMW bag), Lane 4: concentrated ECP of bacteria shown in Lane 3, Lane 5: bacteria maintained in vivo ... ECP of bacteria shown in Lane 4, Lane 4: bacteria maintained in vivo in 25 kDa dialysis tubing (LMW bag), Lane 5: concentrated ECP of bacteria shown in Lane 6, Lane 6: bacteria maintained in vitro...
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Báo cáo y học: "Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic change" pps
... the study based on certain clinical variables: being female, having a high body mass index (BMI), experiencing a higher level of pain and stiffness, and having reduced joint mobility Fast disease ... contraindication to the use of MRI Further exclusion factors included patients' history of past or present gastrointestinal ulceration, their receipt of an intraarticular corticoid injection in ... Whitehead J: Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee LINK Study Group Longitudinal investigation of nonsteroidal antiinflammatory drugs in knee osteoarthritis...
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báo cáo khoa học: " Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes" ppsx
... following antagomir treatment (Figure S4C in Additional file 1), confirming the suitability of antibodies against them for in vivo profiling In contrast, analysis of CDC42 and PTBP1 proteins in ... Bucks, UK) by applying a current of 400 mA for to 1.5 hours For chemical cross-linking [46] the membrane was incubated at 55ºC for hours in a cross-linking solution consisting of ml RNase free ... all human microarray studies examining insulin resistance in skeletal muscle paint a remarkably similar picture - one of no striking change in protein coding mRNA abundance In the Patti et al study...
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Báo cáo y học: "Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells" pdf
... hyperoxic-induced lung injury is multifactorial, and that the elimination of one factor in the network of factors activated in the post-initiation phases often can not avoid lung injury in response ... signal of p65, the DNA binding subunit mainly responsible for the strong gene-inductory potential of NFκB Thus, only the activated form of NF-κB was measured The semiquantitative estimation of NF-κB ... apoptosis was found in TIIcells upon hyperoxia in vivo for 48 hrs No significant apoptosis was found in TIIcells upon hyperoxia in vivo for 48 hrs Lung tissue of normoxic rats (left) and of hyperoxic...
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Báo cáo y học: "Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure" pps
... estimation of ICP and to define thresholds for diagnosing intracranial hypertension In our institution, brain MRI studies are performed for research purposes during the acute phase of traumatic brain injury ... density/T2-weighted turbo spin-echo is a conventional sequence, lasting less than minutes, which forms part of most routine clinical MRI studies ONSD measurement could provide important clinical information on ... studied Seven of them had two MRI studies during the acute phase of TBI, resulting in 45 scans with ICP monitoring ONSD and OND measurements were possible for both sides in 97% in TBI patients...
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