... alpha-Galac-tosidase A deficient mice: a model of Fabry disease.Proc Natl Acad Sci USA 94 , 2540–2544.8 Chiba Y, Sakuraba H, Kotani M, Kase R, KobayashiK, Takeuchi M, Ogasawara S, Maruyama Y, ... to the treatment of Fabrydisease. Although the efficacy may not, as yet, be as dramatic as ERT, inhibition of MDR1 may provemost beneficial as an adjunct, rather than alternativeto ERT. It is ... ofchloroform ⁄ methanol (2 : 1 v ⁄ v) per 100 lL of plasma and then partitioned against 1 ⁄ 5 volume of water. The lowerphase was dried under a stream of nitrogen gas and then the residue was dissolved...
... sequence aaATGCa to aaTTCCa (core bases shown in uppercase letters)centered at )123 within Prm3 was performed using the mutator primers Kin175 (5Â-CACCAGAGCTACTTACACTGAATTCCAGAATAATCACAAGCAAATC-3Â; ... lysed and prepared for luciferase assays as described above.HEK293 and HEL cell supernatants were assayed forboth firefly and renilla luciferase activity using the DualLuciferase Assay SystemTM, ... HEL92.1.7 (A and B) and HEK293 (C and D) cells. Firefly and renilla luciferase activity was assayed 48 h post-transfection; results are presented as mean firefly relative to renilla luciferase activity,expressed...
... Regulation affects solvency and liquidity with the financial institution. Diamond and Rajan (2000) show that bank capitalaffects bank safety, the bank’s ability to refinance, andthe bank’s ability ... Critical Assessment The mainstream of financial innovations in the past decades was centeredaround risk: risk asa threat, asthe possibility of a loss, but also as anopportunity for profit. ... of thesetheories is that the corporate enterprise is not treated asa “black box”, a uniform entity, as was the case in the traditional micro-economic theory of the firm. It is regarded as a...
... and applications that are really intuitive and easy to use. We did a giant customer service application, last year, andit was so easy to use that there were practically no training costs. It ... Dick and Harry basketball team that was out there. No, I’m pretty sure they were selective, playing only against other NBA teams, and at some special events, and on a schedule that allowed them ... you’ve been in a really abusive workplace, with emotional abuse, verbal abuse, sexual harassment, discrimination, etc., then you really need to seek therapy as soon as possible. (And maybe legal...
... Dudevantfamily was greatly respected. They hada chateau at Guillery in Gascony. Casimir had been well brought up and had good manners. Aurore might as well marry him as any other young man. Itwould ... she was obliged to go elsewhere for it, andit was from another man that guidance and encouragement came. A husband should bethe head and, I do not hesitate to say, the master. Life is a ceaseless ... with Hippolyte Chatiron, and it seems that the intoxication peculiar to the natives of Berry takes a heavy andnota gay form. He had alsotaken to other bad habits, away from home at first, and...
... rate was around 5 percent. Today though, economists in the structural camp argue that the natural rate has risen substantially, largely because of the labor market mismatches I described. The ... overall has been well-contained. Taking a long view, over the past 15 years, the overall inflation rate has averaged almost exactly 2 percent, which is the Fed’s target rate of inflation. The ... improvement. As I said earlier, the news from the labor market has been heartening. The jobless rate has fallen about three-quarters of a percentage point since August and is now at its lowest level...
... representative of the German-speaking academic world, and inparticular the Prussian Academy of Sciences, but above all asa pupil and affectionate admirer that I stand at the grave of the greatest and ... into the open and into many parts of the world, as anexponent not only of pacifism but also of world- disarmament andthe cause ofJewry. To a man of such views, as passionately held as they were ... from the sorrows and agitations of the world around him. Himself familiar from early years with the handicap of poverty and with some of the worst forms of man's inhumanity to man, he has...
... theory has suffered in the past from a failure to state clearly its assumptions” to a high tech corporation would notbe far-fetched. In failing to state the assumptions behindtheir organization ... MANAGER: I agree with that comment. Also I’ll be the first one to admit that we don’t have a product strategy. If we look at the number of products we make, they are all over. Eachof them seem ... divides the worldviews of a marketer on one hand and of the rest of the company on the other. It has to do with the concept of the cost. The subtleties around this largely ignored concept, as far as...
... nóng ẩm quanh năm. Độ ẩm trung bình hằng năm từ 80 – 90 %. Thời tiết hai m a m a, nắng. M a m a kéo dài từ tháng tư đến tháng mười. Lượng m a dồi dào, 90% lượng m a tập trung vào m a m a. ĐBSCL ... thông qua các tài liệu có được c a các tác giả đi trước, qua thực tiễn lời ăn tiếng nói hằng ngày c a người dân đ a phương, luận văn nhằm tìm hiểu về định danh từ vựng c a PNNB, đ a ra những ... niệm “sự cố định (hay gắn) cho một kí hiệu ngôn ngữ một khái niệm – biểu niệm (signifikat) phản -47- đ a lí tự nhiên Nam Bộ mà chúng ta đang quan niệm hiện nay. Đây cũng là quan điểm trong việc...