fox transcription factors and the cell cycle
Báo cáo y học: "RNA interference pinpoints regulators of cell size and the cell cycle" doc
... of cells in G1, decreased the percentage of cells in G2, increased the percentage of cells undergoing apoptosis and decreased both G1 and G2 cell size It is tempting to speculate that these cells ... regulate cell size Another aim of the screen was to identify genes whose downregulation alters cell size Becuase cells grow as they progress through the cell cycle, dsRNAs that increase the proportion ... on growth or the distribution of cells in the cell cycle These two possibilities could be distinguished by examining the effect of these dsRNAs on cell number Intriguingly, many of these hits for...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... Cremisi CE (2002) The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2 Mol Cell Biol 22, ... expression in the face and limbs In a follow-up study, they found that this conserved cis-acting sequence serves to maintain a level of AP-2a expression that limits the size of the hand plate and the associated ... post-transcriptional processing of the protein [41] Additionally, it is evident that AP-2 transcription factors can indirectly modulate genes by functional interactions with other transcription factors, ...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... propose that the underlying mechanism by which PMLA increases the growth rate and shortens the duration of the cell cycle is the polymer-inherent isosterism of the carboxylates with the array of ... and the stage of the cell cycle determined as described previously [18] The stages could be fairly well predicted by calculation, taking into account the time elapsed after the fusion and the ... on the high PMLA producing yellow plasmodia (Table 1) The greater sizes persisted until the end of the experiment We then tested whether the plasmodial size (growth rate, Fig 2A,C,E) and the...
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Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt
... cyclins E and B, as a function of the cell cycle Western blot analysis of the whole -cell extract and histones from different stages of the cell cycle demonstrated that the overall levels of MLL1 and ... MLL and H3K4 methylations during cell cycle in S phase may not be the same as the marks in other phases of the cell cycle (as shown by immunofluorescence staining and western blotting); rather, ... affected, they are modulated at the promoters of specific genes over different phases of the cell cycle 1630 Results and Discussion Dynamics of MLL1 and its interacting proteins during the cell cycle...
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Báo cáo khoa học: NrpRII mediates contacts between NrpRI and general transcription factors in the archaeon ¨ Methanosarcina mazei Go1 pot
... complex with NrpRII and either of these transcription factors to approximately 20.5% (TBP2) and 36.6% (TFB) Studying potential interactions between MBP–NrpRI and the three TBPs and TFB demonstrated ... knowledge, the first report of interactions between an archaeal repressor and the general archaeal transcription factors TBP and TFB besides the recent documentation of interactions between the transcriptional ... promoters, we studied the binding properties of NrpRII to the general transcription factors – TATA-binding protein (TBP) and the archaeal homolog of the eukaryotic general transcription factor...
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Báo cáo khoa học: The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest pdf
... Rat1/ras cells at the G1 phase of the cell cycle We next examined the effect of HR12 on the distribution of Rat1/ras cells in the cell cycle To resolve the G1, S and G2/M phases, we double-labelled the ... examine whether the effects of HR12 on the cell cycle, cell motility and cell cycle components are mediated exclusively by its effect on Ras, rather than on the farnesylation of other protein(s), ... Rat1/ras cells [[6] and this study) This raises the possibility that the HR12-induced increase in p27Kip1 levels might be the consequence of the induction of cell cell contacts, rather than the outcome...
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Báo cáo y học: "Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle" doc
... during the initial stages of the cell cycle and confirm the notion of functional specificity for the H-Ras and N-Ras isoform proteins Materials and methods Cell culture Cell lines from the appropriate ... of the cell cycle, the absence of N-Ras was quantitatively more disruptive for the first transcriptional wave linked to G0/G1 transition, and the absence of H-Ras affected more potently the transcriptional ... primary cell metabolism, signal transduction, cell development and differentiation and cell adhesion (Figure 4) In particular, the categories of primary cell metabolism and cell development and differentiation...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... Acknowledgements The author's own publications therein cited are, in part, financially supported by the Anonymous Trust (Scotland), the National Institute for Biological Standards and Control (England), the ... hemorrhage, Shenkar and Abraham examined in vivo the activation of these nuclear transcriptional factors among intraparenchymal lung mononuclear cells obtained in the immediate posthemorrhage period ... changes in the physiologic processes of many tissues and activates inflammatory cascades that include the activation of stress transcriptional factors and the upregulation of cytokine synthesis This...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... cytokines have the ability to suppress inflammatory processes via the inhibition of NF-κB, which can interact with other transcription factors, and these interactions thereby lead to greater transcriptional ... Acknowledgements The author's own publications therein cited are, in part, financially supported by the Anonymous Trust (Scotland), the National Institute for Biological Standards and Control (England), the ... organ damage through the rapid and exaggerated production of nitric oxide and prostaglandins Furthermore, in a novel study by Shoshani and colleagues, the identification and cloning of a HIF-1-responsive...
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Báo cáo y học: " Single cell studies of the cell cycle and some models" pps
... interferometry and then placed it in the cycle by following it as it moved about until it divided The difference in timing between the measurement and cell division gave the timing in the cycle A second ... quarters of the cycle but rather two linear segments with a rate change point (RCP) between them The position of the RCP showed a large cell- to -cell variation An important moral here is that these ... showed the plateau in growth during the last quarter of the cycle This distinction between single cells and synchronous cultures does of course depend on the frequency and accuracy of the data...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... reporter assays, the roles of the transcription factors E2F1 and Sp1, and the transcriptional coactivator p300 in the regulation of DNMT1 expression were investigated Transcription from the human DNMT1 ... RESULTS AND DISCUSSION Regulation of DNMT1 expression in the Cell Cycle 3.1.1 Inverse relationship between DNMT1 and p21WAF1 in the 63 cell cycle 3.1.1.1 3.1.1.2 DNMT1 expression in the cell cycle ... facilitate cell cycle arrest governed by p53 as well as enhance the apoptotic activity of E2F1, the levels of p53 and E2F1 in cells may have a profound impact on cell cycle progression Other than transcriptional...
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Tài liệu Báo cáo khoa học: Dimer asymmetry and the catalytic cycle of alkaline phosphatase from Escherichia coli doc
... affinity of the subunits for the substrate (KS1 and KS2) and for Pi (KI1 and KI2), presented in Table and Table 2, respectively, are independent of the Zn2+ ion concentration In order to support the ... constants KI1 and KI2, describing the affinity for Pi, differ less than constants KS1 and KS2 Therefore, the dimer with the substrate bound to the high affinity subunit (21) is more stable than the dimer ... subunits and If the ligand concentration is higher than that of the substrate, the conformational change occurs more often, enhancing the overall reaction velocity The catalytic path A, active in the...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... transcription factors regulated the expression of the aV integrin in mouse melanoma cells [54] and the a5 integrin in human glioma cells [55] These factors have also been shown to regulate the expression ... plasmid The assays were carried out in triplicate, and the error bars indicate the standard deviation Fig Nucleotide sequence of the 5¢-flanking region of the mouse a3 integrin gene Major and minor transcription ... Carcinoma cells (5 · 105 cells) were seeded in a 35-mm dish and cultured for 20 h The cells were then transfected with the mixture of the plasmid construct in pGL3 vector (3.0 lg) and pRSV-b-Gal...
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Tài liệu Báo cáo Y học: Evolution of the enzymes of the citric acid cycle and the glyoxylate cycle of higher plants pdf
... localized in the cytosol [32,33] Here we investigate the evolution of the enzymes of the pyruvate dehydrogenase (PDH) complex, the tricarboxylic acid cycle, and the glyoxylate cycle by examining the individual ... into the origin of its individual enzymes However, the study of the enzymes of the tricarboxylic acid cycle necessarily also entails the study of the several enzymes involved in the glyoxylate cycle ... a-proteobacterial, homologues (MDH, CS and aconitase in the tricarboxylic acid cycle, and all of the enzymes of the glyoxylate cycle There are two general patterns among the Ôeubacterial but not speci®cally...
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Banks’ regulatory capital buffer and the business cycle: evidence for German savings and cooperative banks pot
... GAP>0, and zero otherwise Then, we interact the dummy variable with the output gap and one minus the dummy variable with the output gap and include both interaction terms in the regression Thus, the ... savings and particularly the cooperative bank sector (Deutsche Bundesbank 2003) The dummy variable is unity for the acquirer in the year of the merger and zero otherwise The expected sign of the ... states the hypotheses to be tested, and describes the methodology Second, it defines the measures of the variables of interest, banks’ capital buffers and the business cycle Third, it defines the...
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REAL WAGES AND THE BUSINESS CYCLE: ACCOUNTING FOR WORKER AND FIRM HETEROGENEITY potx
... Wage Cushion and the Business Cycle Here we examine the extent to which contractual wages, on the one hand, and firm-specific wage arrangements, in the form of the wage cushion, on the other, are ... retain the last two estimates of α and use the three data points to adjust the trajectory of the estimates for the fixed effects The estimation routines for the OLS coefficients, standard errors, and ... in Stata and discussed in Guimarães and Portugal (2009) Estimation of the standard error associated with the cycle variable Estimation of the standard error associated with the variable cyclet...
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Báo cáo khoa học: Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells pot
... HeLa cells were incubated with nocodazole Cells detached from the bottle by shaking were collected and named mitotic (M) cells Residual cells were collected and named G2 cells These cells and ... growing cells and cells synchronized at the G2 and M phase was examined (Fig 4) Because the MCM proteins, including MCM4, are almost exclusively detached from chromatin in the G2 and M phase, they ... HeLa cells Changes in the phosphorylation level during the cell cycle and the nuclear localization of phosphorylated MCM4 suggest that MCM4 phosphorylated at these sites has several distinct and...
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Báo cáo khoa học: Hepatocyte-specific interplay of transcription factors at the far-upstream enhancer of the carbamoylphosphate synthetase gene upon glucocorticoid induction doc
... accessibility to transcription factors and the sequence in which the transcription factors bind play a role Furthermore, it remains unclear whether accessory factors have to bind first to the GRU, thereby ... on the lower strand FoxA binding resulted in protection of the guanines at positions 347 and 351 on the upper strand, and protection at position 352 on the lower strand These footprints in the ... liver-enriched factors FoxA and C ⁄ EBP, they differ in their recruitment of these common transcription factors Although it is still unclear what determines these differences in the assembly of the transcription...
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Báo cáo Y học: Molecular interactions between nuclear factor kB (NF-kB) transcription factors and a PNA– DNA chimera mimicking NF-kB binding sites doc
... 2001 of the DNA strands causes a distortion in the double strand The rigid junction between the PNA and the DNA at the 50 end of the DNA might play an important role in the conformation of the chimeric ... to the DNA transcription factor complex Finally, the comparison of the relative orientation of the two subunits, both in the solid-state structures and in the MD average models, reveals that the ... Raji cells, and processed as described for the experiments shown in Fig 4A The obtained data confirm that the double stranded PDP– PDP chimera inhibits the binding of protein factors to the 32P-end-labelled...
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Báo cáo khoa học: Collective behavior in gene regulation: The cell is an oscillator, the cell cycle a developmental process doc
... between the TRAC and the cell cycle The release of H2S by a significant fraction of the cells in the fermenter ensures that no cells in the fermenter will be able to respire We have suggested that the ... products of the reaction used to represent the cell cycle in each of the cells In this case, the attractor used to represent each cell was the Rossler attractor and each cell ran the identical ... of yeast as a stochastic tissue The details of the cellular dynamics that lead to the emergence of redox and TRAC oscillations and the gating of cells into cell- cycle stages are still not completely...
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