folate receptor targeted liposomes for cancer therapy
nanotechnology for cancer therapy, 2007, p.810
... the folate receptor on their cell surface, liposome nanovectors have been developed to target folate receptors.12,13 Using the strategy of biomarker-based targeting, folate receptor targeted liposomes ... Nanotechnology for Cancer Therapy contrast media for detection by magnetic resonance imaging (MRI) are effectively targeted to cancer cells that overexpress the high affinity folate receptor. 34 Gadolinium ... coated with a ligand for one of these receptors such as folate can be used to target to cancer cells.84 q 2006 by Taylor & Francis Group, LLC 30 Nanotechnology for Cancer Therapy Folate has been used...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... sequences for targeted gene therapy in cancer Int J Cancer 2001, 98:645-650 Maxwell IH, Glode LM, Maxwell F: Expression of diphtheria toxin A-chain in mature B-cells: a potential approach to therapy ... regulatory sequences of the H19 gene for the development of DNAbased therapy for human ovarian cancer related ascites The successful development of anti-tumor gene therapy depends on the use of a ... Israel for providing OCAF from patients 16 17 18 19 20 21 22 23 References 10 11 12 13 14 15 NCI: National Cancer Institute [http://www .cancer. gov /cancer topics/types/ovarian] Cannistra SA: Cancer...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... patient Cancer Therapy 2005, 3:249-266 Cooper MJ: Noninfectious gene transfer and expression systems for cancer gene therapy Semin Oncol 1996, 23:172-187 Kouraklis G: Gene therapy for cancer: from ... at very high levels in a broad spectrum of different cancers, therefore we propose a double promoter expression approach for targeted cancer therapy According to this approach patients will be ... ISH was performed on successive slides of TCC tissue for H19 and IGF2-P4 transcripts The intensity of hybridization signal was indicated as (0) for no staining, (+1) for weak, (+2) for moderate...
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Nutraceuticals as new treatment approaches for oral cancer – i
... implanted subcutaneously Some of these studies were performed some years ago, before oral cancer had been differentiated from oropharyngeal cancer We are aware that some of the reviewed studies ... head and neck cancer: lessons from mobile tongue cancer Nat Rev Cancer 2011;11(5):382 Allen M, Louise Jones J Jekyll and Hyde: the role of the microenvironment on the progression of cancer J Pathol ... al Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer Cancer Med 2012;1(2):128–40 Vissink...
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IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE
... cyclophosphamide is still used to treat various recalcitrant forms of cancer When activated, cyclophosphamide forms aldophosphamide that can spontaneously form the toxic phosphoramide mustard, an alkylating ... phenotypes Table 3A: SAR for CB29 analogs .61 Table 3B: SAR for CB29 analogs 62 Table 4: SAR for CB7 analogs 65 Table 5: Refinement statistics for CB29 bound to ALDH3A1 ... were selected for IC50 determination IC50 values were further determined against propionaldehyde oxidation (for ALDH1A1 and ALDH2) or benzaldehyde oxidation (for ALDH3A1) This was performed spectrophotometrically...
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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy
... Methods for analyzing drug interactions 1.2.5 Issues and strategies for combination therapy 1.2.5.1 Practical issues for consideration 1.2.5.2 Mechanistic considerations 1.2.5.3 Strategies for determining ... sebacate}P(MDS-co-CES) have been fabricated and used for the codelivery of various anti -cancer drugs and therapeutic proteins for improved cancer therapy The first part of this thesis focuses on ... antibodies against the death receptors before incubation with TRAIL, Dox-loaded micelle/TRAIL or free Dox+TRAIL formulation for an additional or hours (B) Death receptor (DR4 or DR5)mediated...
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Insights into the mechanism of safingol and its potential to synergize with anti cancer drugs
... prevalent types of cancer occurring in Singaporean men and women (5) 1.1.1 Conventional Treatment for Cancer Today, the mainstays of cancer treatment are surgery, radiotherapy and chemotherapy Surgery ... Introduction 1.1 Overview of Cancer 1.1.1 Conventional Treatment for Cancer 1.1.2 Rationale for Drug Combinations Approaches in Cancer 1.2 The Processes of Cell Death ... Shiau Fui, whom I have known for more than 15 years now Thank you all for i always being there for me and encouraging me through emails Thanks for all the fun and for speaking the same lingo as...
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nanocarriers as an emerging platform for cancer therapy
... Ligand -targeted therapeutics in anticancer therapy Nat Rev Cancer 2, 750–763 (2002) 17 Pastan, I., Hassan, R., FitzGerald, D. J & Kreitman, R. J Immunotoxin therapy of cancer Nat Rev Cancer ... cells such as breast and tongue cancer4 3 Additionally, based on the same idea, the vitamin folic acid (folate) has also been used for cancer targeting because folate receptors (FRs) are frequently ... necessary for improved therapeutic efficacy of antibody -targeted liposomal drugs Cancer Res 62, 7190–7194 (2002) 20 Allen, T. M Long-circulating (sterically stabilized) liposomes for targeted...
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Nutrition and cancer: A review of the evidence for an anti-cancer diet pptx
... effects for women undergoing radiation therapy for carcinomas of the uterine cervix [175], for patients undergoing radiation therapy for head and neck cancers [176], and for colorectal cancer ... polyp Folate may be more important for rapidly dividing tissue, like the colonic mucosa Therefore, the cancer risk associated with low folate intake is probably higher for colon cancer than for ... = 0.04 folate = ↓colon cancer (ORmen = 0.40, P-trend = 0.03; ↑alcohol, folate = ↑colon cancer (ORmen = 2.67 folate intake = ↓colon cancer in women with family history (OR = 0.48) folate =...
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Báo cáo khoa học: Serum autoantibodies as biomarkers for early cancer detection docx
... prostate-specific antigen for prostate cancer, cancer antigen CA19-9 for gastrointestinal cancer and CA-125 for ovarian cancer, lack sufficient specificity and sensitivity for use in early cancer diagnosis ... to develop novel vaccines for targeted immunotherapy against cancer Based on the autoantibody profile of the cancer patient, individualized anti -cancer vaccine immunotherapy can be developed from ... for such treatment, for example, HER2 ⁄ neu for breast carcinoma, CD20 for B-cell lymphoma, vascular endothelial growth factor for renal cell carcinoma, and epidermal growth factor receptor for...
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Báo cáo khoa học: Natural polyphenols as proteasome modulators and their role as anti-cancer compounds doc
... resistance in human tumour cells Therefore, it seems to be an attractive target for a combined chemopreventative ⁄ chemotherapeutic approach, which seems ideal for cancer therapy In particular, because ... activity for cancer prevention and treatment Curr Protein Pept Sci 9, 227–239 Orlowski RZ & Kuhn DJ (2008) Proteasome inhibitors in cancer therapy: lessons from the first decade Clin Cancer Res ... National Cancer Institute, http://www .cancer. gov) Polyphenols Source Curcumin Turmeric Turmeric Clinical trial phase Type of cancer Combined with Phase Phase Phase Phase Phase Metastatic colon cancer...
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báo cáo hóa học:" Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer" docx
... advanced, inoperable disease and are, therefore, candidates for palliative chemotherapy The role of chemotherapy as an integral part of the treatment of lung cancer has grown significantly, especially ... P: Estimating the world cancer burden: Globocan 2000 Int J Cancer 2001, 94:153-156 Non-small Cell Lung Cancer Collaborative Group: Chemotherapy in non small cell lung cancer: a meta-analysis ... other than lung cancer, with the exception of non melanoma skin cancer or curatively treated carcinoma in situ of the uterine cervix; previous chemotherapy in an adjuvant setting or for metastatic...
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Báo cáo sinh học: "Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" pot
... prospect for generating anti -cancer chimeric T cells for use in cancer immunotherapy The target selected in the current work was CEA, a tumor-selective antigen Several possible mechanisms for tumor ... colorectal cancer The WHO Collaborating Centre for the Prevention of Colorectal Cancer Bull World Health Organ 1990, 68:377-385 American Cancer Society.: Cancer Facts and Figures 2004 In American Cancer ... cancer Thus, this vector has potential for redirection of human PBLs to chimeric anti-tumor T cells, forming basis for immunotherapy of many different human cancers Mouse cells and human lymphocytes...
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báo cáo hóa học:" Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro" docx
... prospect for generating anti -cancer chimeric T cells for use in cancer immunotherapy The target selected in the current work was CEA, a tumor-selective antigen Several possible mechanisms for tumor ... colorectal cancer The WHO Collaborating Centre for the Prevention of Colorectal Cancer Bull World Health Organ 1990, 68:377-385 American Cancer Society.: Cancer Facts and Figures 2004 In American Cancer ... cancer Thus, this vector has potential for redirection of human PBLs to chimeric anti-tumor T cells, forming basis for immunotherapy of many different human cancers Mouse cells and human lymphocytes...
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Báo cáo hóa học: "Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol" potx
... CLE before the first 12 h, the release rate of the two formulations was comparable thereafter Overall, quick release rate for mixed micelles might produce a favorable pharmacological effect for ... micelles and CLE, separation of the two phases was performed using ultracentrifugation Ultracentrifugation was performed at 10,000 rpm (14000 g) for 20 Amicon ultra centrifugal filter units (Amicon ... presented in Figure Time for righting reflex recovery was 7.17 ± 2.75 and 7.29 ± 1.25 min, for mixed micelles and CLE, respectively On average, both groups of animals given propofol formulations recover...
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Báo cáo hóa học: " Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen" pdf
... side effects of anticancer drugs during cancer therapy Overall, ethaselen-loaded polymeric micelle possessed improved antitumor activity and reduced toxic side effects of anticancer drug than ethaselen-HP-b-CD ... results suggested that polymeric micelles might be an effective drug delivery system for ethaselen for cancer chemotherapy Nevertheless, the micelles could still be improved, especially with respect ... and ethaselen-HP-b-CD in H22 human liver cancer cell bearing mice model (" Æ s, n = 10) x Formulation Dose (mg/kg) Body weight (g) Tumor weight (g) Before administration Inhibition rate (%) –...
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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc
... S, Schiff R: Crosstalk between Estrogen Receptor and Growth Factor Receptor Pathways as a Cause for Endocrine Therapy Resistance in Breast Cancer Clinical Cancer Research 2005, 112:865s-870s Legault-Poisson ... immunocytochemically localized estrogen receptors in human breast cancer Cancer Res 1990, 5012:3545-3550 British Breast Group: Assessment of response to treatment in advanced breast cancer Lancet 1974, 2:38-39 ... Assessment of response to therapy in advanced breast cancer: a project of the Programme on Clinical Oncology of the International Union Against Cancer, Geneva, Switzerland Cancer 1977, 393:1289-1294...
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Báo cáo y học: "tromal Vascular Fraction Transplantation as an Alternative Therapy for Ischemic Heart Failure: Anti-inflammatory Role" doc
... examined with the use of fluorescence microscopy for PKH26 dye The sections were stained for hematoxylin and eosin Immunohistochemistry was performed for asarcomeric actin, von Willebrand factor ... Kit (Applied Biosystems, Foster City, CA, USA) was performed for cDNA synthesis The cycling parameters were 25°C for 10 minutes and 37°C for hours Page of 10 Real time RT-PCR analyses were used ... were washed in PBS for times, labeled with a fluorescent dye using PKH26, before suspended in 0.1 mL of culture medium (without serum) at a concentration of × 10 /mL cells for transplantation...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
... mTOR inhibitors in cancer therapy J Hematol Oncol 2009, 2:45 Cang S, Lu Q, Ma Y, Liu DL: Clinical advances in hypomethylating agents for epigenetic therapy of cancer Current Cancer Drug Target ... deacetylases are required for androgen receptor function in hormonesensitive and castrate-resistant prostate cancer Cancer Res 2009, 69:958-966 111 Beardsley EK, Chi KN: Systemic therapy after first-line ... chemotherapy Patients with platinum resistant epithelial ovarian cancer (EOC) have low response rates to conventional chemotherapy too Belinostat demonstrates anti-tumor activity in ovarian cancer...
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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... Mizushima N: Methods for monitoring autophagy Int J Biochem Cell Biol 2004, 36:2491-2502 35 Turcotte S, Giaccia AJ: Targeting cancer cells through autophagy for anticancer therapy Curr Opin Cell ... Coughlin SS, Ekwueme DU: Breast cancer as a global health concern Cancer Epidemiol 2009, 33:315-318 Kostova I: Platinum complexes as anticancer agents Recent Pat Anticancer Drug Discov 2006, 1:1-22 ... paclitaxel [14], and cisplatin [15] have high potential for chemotherapy Among the magnetic particles, maghemite (g-Fe2 O ) is suitable for clinical applications due to its magnetic properties...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25