endothelial icam 1 mediated signaling and its role during lymphocyte migration to the cns parenchyma
Báo cáo lâm nghiệp: "Evaluation of changes in the landscape management and its influence on animal migration in the vicinity of the D1 motorway in Central Bohemia" ppsx
... 6,000 0 .1 23:00–24:00 22:00–23:00 21: 00–22:00 20:00– 21: 00 19 :00–20:00 18 :00 19 :00 17 :00 18 :00 16 :00 17 :00 15 :00 16 :00 14 :00 15 :00 13 :00 14 :00 12 :00 13 :00 11 :00 12 :00 9:00 10 :00 10 :00 11 :00 8:00–9:00 ... 23:00–24:00 22:00–23:00 21: 00–22:00 20:00– 21: 00 19 :00–20:00 18 :00 19 :00 17 :00 18 :00 16 :00 17 :00 15 :00 16 :00 14 :00 15 :00 13 :00 14 :00 12 :00 13 :00 11 :00 12 :00 10 :00 11 :00 9:00 10 :00 8:00–9:00 7:00–8:00 ... monitored years 11 –29 km section J FOR SCI., 57, 2 011 (7): 312 –320 Fig Cluster analysis showing changes of polygons in the monitored years in a test section in 11 th–29th km section 19 49 19 74 19 88...
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Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... Methyltransferases 1. 2 .1 DNMT1 DNMT1 variants 1. 2.2 10 1. 2.3 DNMT3a and DNMT3b 11 1. 2.4 1. 3 DNMT2 Cooperation among the DNMTs 12 Roles of DNA Methylation 1. 3 .1 Genomic imprinting 13 1. 3.2 X-chromosome ... UHRF1 18 Transcriptional suppression 19 1. 3.4 iv 1. 4 DNMT1 in the Cell Cycle 1. 4 .1 21 1.4.2 E2F1/RB pathway 23 1. 4.3 p300/CBP co-activator 25 1. 4.4 DNMT1 and DNA replication 27 1. 4.5 DNMT1 and ... PCNA 27 1. 4.6 1. 5 Regulation of DNMT1 expression DNMT1 and p21WAF1 29 Regulation of p21WAF1 Expression 1. 5 .1 p53-dependent trancriptional regulation of p21WAF1 WAF1 31 1.5.2 31 1.5.3 1. 6 p53-independent...
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A novel membrane pool of protein kinase c and its role in mammalian cell signaling
... bound to DNA even in the absence of ligands After the binding of hormones to the receptors, the inhibitory protein complexes bound to the inactive receptors dissociate and the receptors bound to ... receptors: ion-channellinked receptors, G-protein-linked receptors, and enzyme-linked receptors1 1. 1.2 .1. 1 .1 Ion-channel-linked receptors Ion-channel-linked receptors are involved in synaptic signaling ... action of DAG kinase, and further to PI, PIP, and PIP2 PA produced from PC is converted to DAG by the action of phosphomonoesterase 116 ,11 9 ,12 0 On the other hand, the DAG produced from PC hydrolysis...
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Distribution of betaine gaba transporter BGT 1 in excitotoxic brain injury and its role in osmoregulation in the brain
... dissected the role of BGT -1 in osmoregulation in the brain Further studies are necessary to study the 15 mechanism by which betaine induces BGT -1 expression and the effects of BGT -1 inhibitors on ... BGT -1 results from a 31 hyperosmolarity-induced increase in the transcription of BGT -1 gene and the resulting increase in BGT -1 synthesis 3 .1. 5 .1 Tonicity-responsive enhancer (TonE) Following the ... al., 19 81; Wilcken and Wilcken, 19 97; Walter et al., 19 98) Within the kidney, the production of betaine from choline occurs in proximal tubule (Wirthensohn and Guder, 19 82; Miller et al., 19 96) and...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... 767 15 0 934 IB: -v-KIND E F CD2 -1 CD2 -1- 1 634 CD2 -1- 2 667 CD2 -1- 3 7 01 CD2 -1- 4 CD2 -1- 5 735 CD2 -1- 6 702 CD2 -1- 7 668 CD2 -1- 8 635 CD2 -1- 6 -1 702 CD2 -1- 6-2 CD2 -1- 6-3 Interaction PD Input GST CD2 -1- 1 ... specific to HMWMAP2, but not to LMW-MAP2, which lacks the CD [14 ] Although the functional property of the CD, the FEBS Journal 278 (2 011 ) 16 51 16 61 ª 2 011 The Authors Journal compilation ª 2 011 FEBS ... CD2 -1- 1 CD2 -1- 2 CD2 -1- 3 CD2 -1- 4 CD2 -1 767 250 15 0 PD 734 Input GST CD2 -1- 5 CD2 -1- 6 CD2 -1- 7 CD2 -1- 8 CD2 -1 600 734 744 755 250 PD Input GST CD2 -1- 6 -1 CD2 -1- 6-2 CD2 -1- 6-3 CD2 -1 C 250 15 0 IB: -v-KIND...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx
... Furthermore, the overexpression of TJ proteins such as claudin -1 and claudin-4 induces apoptosis and suppresses metastatic potencies [10 ,11 ] Occludin has also been reported to induce apoptosis and ... (IP3), which binds to the IP3 receptor (IP3R) located on the endoplasmic reticulum (ER), thereby releasing calcium into the cytoplasm [20, 21] When calcium concentrations in the cytoplasm increase, ... BAX and Apaf -1 increased, and that of the antiapoptotic gene Bcl-2 decreased OccDE9overexpressing cells, on the other hand, did not show any alteration in the expression of these genes 314 8 Using...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... · 10 10 1. 0 · 10 10 28 21. 11 8.0 · 10 10 7.6 · 10 9 2953.4 nsd – – nsd – – 6 .1 · 10 8 1. 4 · 10 8 5760. 01 1.8 · 10 8 1. 1 · 10 8 13 065.2 nsd – – kcal/mole of injectant dichroweb online software [29,30] There ... glycine molecules to copper, corresponding to the CuGly2 complex results in K1 ¼ 4.0 · 10 5 m )1 and K2 ¼ 1. 7 · 10 4 m )1 with b2 ¼ 6.8 · 10 9 m )1 (data not shown) in agreement with the pH adjusted ... D160– D164 10 Turk V & Bode W (19 91) The cystatins: protein inhibitors of cysteine proteinases FEBS Lett 285, 213 – 219 11 Turk V, Turk B & Turk D (20 01) Lysosomal cysteine proteinases: facts and...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx
... (Fig 1) whilst 3-hydroxyisovaleric acid is produced via the enzymatic hydration of 3-methylcro- 2.3 .1. 168 1. 8 .1. 4 1. 3.99 .10 6.4 .1. 4 4.2 .1. 18 4 .1. 3.4 tonyl-CoA (crotonase, EC 4.2 .1. 17) (Fig 1) [2] ... applied to the HPLC-system the same picture appears Thus, it seems, that the fronting, the shoulder and the tailing is due to acetyl-CoA and not due to any other compound (B) The peaks 3, 4, and ... 3-Hydroxy-3-methylglutaryl-CoA lyase 2.6 .1. 42 1. 2.4.4 BCAT1 BCKDHA BCKDHB DBT DLD IVD MCCC1 AUH HMGCL 11 3520 608348 248 611 248 610 246900 607036 609 010 250950 246450 3-Methylglutaric acid is synthesized by the action of...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... residues (AsPPase numbering: E -12 5, K -13 3, E -13 5, R -15 5, Y -17 0, D -19 2, D -19 4, D -19 7, D-224, D-229, K-2 31, Y-269 and K-270) (Fig 1) , which have been reported previously to be evolutionarily well conserved ... found to be closer to those of the highly purified and crystallized E coli (2000 lmol PiÆmin )1 mg )1 [50]), yeast (655 lmol PiÆmin )1 mg )1 [ 51] ), rat liver 600– 700 lmol PiÆmin )1 mg )1 [36]) and bovine ... protozoa [44] These results prompted us to investigate the role of PPase enzymes in the development and molting process of A suum larvae and to test whether this could be targeted by inhibitors...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... multifunctional proteins 410 1 Molecular characterization of ANKHD1 splice variant 10 11 12 13 14 15 16 17 18 involved in many cellular pathways Folia Histochem Cytobiol 40, 239–249 Bork P (19 93) Hundreds ... caspase-independent mitochondrial pathway Cell Death Differ 9, 12 12– 12 19 25 Gaynor EM & Chen IS (20 01) Analysis of apoptosis induced by HIV -1 Vpr and examination of the possible role of the hHR23A protein ... important roles in cell signaling during cell proliferation, apoptosis, and cell survival upon stress [14 16 ] Despite the fact that a homolog of dMASK is present in the human genome, neither its function...
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Solar and Space Physics and Its Role in Space Exploration doc
... dedicated to the furtherance of science and technology and to their use for the general welfare Upon the authority of the charter granted to it by the Congress in 18 63, the Academy has a mandate ... broadly and that include exploration to understand the origin and evolution of the universe, the formation of planets and planetary systems, the origin and extent of life, and the environment and ... (From The Sun to the Earth and Beyond, p .1 ) Space is far from empty an often gusty solar wind flows from the Sun through interplanetary space, forming the heliosphere (see Figure 1. 1 and Box 1. 1)...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... corresponds to TbPEX5 (first lane), band to TbPEX14-N,H (last lane), band to the complex formed by the two proteins (lane 3), and bands and correspond to noncomplexed TbPEX5 and TbPEX14-N,H, respectively ... e.g TbPEX5 or other T brucei peroxins still to be identified and characterized (e.g PEX13, PEX7) 10 11 12 13 14 15 16 17 Acknowledgements This research was supported by grants from the Belgian Fonds ... cells clearly shows the involvement of PEX14 in the targeting of PTS -1, PTS-2 and I-PTS proteins to the glycosome To further analyse the effect of the destruction of PEX14 mRNA on the parasite, we...
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báo cáo hóa học:"Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells" pdf
... CEACAMs CEACAM1 and CEACAM6 have been reported to present selectin ligands to CD62E (ELAM -1, E-selectin) on endothelial cells [23], and appear to be involved in angiogenesis [9 ,16 ,28 ,10 0] A role for ... of the Sixth International Workshop and Conference on Human Leukocyte Differentiation Antigens and included the following CD66 mAbs: B13.9 (IgG1) (CD66b), C 112 28.2C (IgG1) (CD66c), Bu -10 4 (IgG1) ... desensitized the cells to further stimulation by the CD66ae mAb and the CD66c mAb, but not by CD66b, CD66de, or CD63 mAbs (Fig 1, panel C) Finally, desensitization to the CD66ae and CD66de mAbs left the...
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Báo cáo hóa học: "ZnSe nanotrenches: formation mechanism and its role as a 1D template" potx
... along the [ 011 ] and [ 011 ] directions, with the top surface terminated at (11 1)A and ¯ (11 1) B, respectively These schematic drawings are ¯¯ ¯ applicable to the views along the [ 011 ] and [ 011 ] directions ... < 011 > direction although there are four < 011 > directions on the surface of a (10 0)-oriented substrate of zinc-blended structure [16 ] This is because the [ 011 ]/ ¯¯ ¯ ¯ [ 011 ] and the [ 011 ]/[ 011 ] ... eV/atom) [19 ] is lower than that of Au-Se (-0 .15 eV/atom) [20] This study further reveals that the contact interfaces between the AuZnδ droplet and the ZnSe ¯¯ lattice are {11 1}A and {11 1}B planes...
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Báo cáo khoa học: "Mac-1-mediated Uptake and Killing of Bordetella bronchiseptica by Porcine Alveolar Macrophages" pptx
... 2.32 2.26 1. 12 1. 55 0% -2.59% - 51. 7% -33.2% MOPC- 21 MHM23 TMG6-5 MHM23+TMG6-5 12 700±2200 15 700±3600 11 150±3950 19 050±4650 360±70 290±70 18 5 11 5 19 0±70 2.83 1. 85 1. 66 1. 00 0% -34.6% - 41. 3% -64.7% ... 10 200 18 00 10 750 17 50 11 900 12 00 10 600 13 00 217 0±360 216 5 15 5 15 15±35 785±95 21. 27 20 .14 12 .73 7. 41 0% -5. 31% -40.2% -65.2% Bacterial invasion assays were performed to measure binding and uptake of ... 17 500±2000 14 000 12 00 17 950±2450 235±65 420 11 0 410 16 0 445±65 1. 51 2.40 2.93 2.48 0% +58.9% +94.0% +64.2% MOPC- 21 MHM23 TMG6-5 MHM23+TMG6-5 29950 19 50 317 00 11 00 49900 12 00 3 610 0±4000 695±55 715 ±45...
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Báo cáo y học: "ignal 3 and its role in autoimmunity" pot
... inflammatory arthritis [14 -16 ] This highlights the critical role of IL-1ra in the constitutive maintenance of peripheral tolerance, and in counterbalancing the proinflammatory effects of IL -1 and ... signals on failure of mechanisms of central tolerance in the thymus Competing interests None declared References 5.* 10 11 12 13 .* 14 15 16 Delon J, Stoll S, Germain RN: Imaging of T-cell interactions ... factors, such as infectious or toxic signals, may reset the signal threshold Together, the genetically determined settings of the T-cell response mechanism and the environmental exposure history,...
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Báo cáo y học: "Circadian rhythm and its role in malignancy" docx
... 95 96 97 98 99 10 0 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice J Biochem 2009, 14 5:289-297 Hua H, ... are synthesized in the cytoplasm and they associate before entering the nucleus In the nucleus, CRYs repress the activity of CLOCK and BMAL1 and in this way, they negatively feedback on their ... (EC) The decreased Per1 expression in EC is partly due to inactivation of the Per1 gene by DNA methylation of the promoter and partly due to other factors This downregulation of the Per1 gene...
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Báo cáo y học: " Beyond the first 25 years: The International AIDS Society and its role in the global response to AIDS" pps
... society, and the IAS is looking at ways to strategically expand its role in this area in order to strengthen the capacity of the HIV workforce The IAS has been increasingly involved in policy and ... linkages and dialogue, and to strengthen the focus on youth – began to be implemented in the planning for the XVI International AIDS Conference (AIDS 2006) in Toronto and will be implemented ... research can be rapidly applied to practice The IAS is committed to continuously improving the conferences and strengthening their role beyond three or five-day events to become part of an ongoing...
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Báo cáo y học: "Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release" pps
... Institutes of Health grants R 01 GM053008 and R 01 GM057468 (PW) Available online http://ccforum.com/content /12 /4/R100 References 10 11 12 13 14 15 16 17 18 19 20 21 22 Bernard GR, Vincent JL, ... Nat Med 2004, 10 :12 16 -12 21 Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock: a review of laboratory models and a proposal J Surg Res 19 80, 29 :18 9-2 01 Yang S, Cioffi WG, Bland KI, Chaudry ... inflammatory cytokines and hepatocellular dysfunction during early sepsis J Surg Res 19 99, 83 :15 1 -15 7 Yang S, Zhou M, Fowler DE, Wang P: Mechanisms of the beneficial effect of adrenomedullin and...
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MECHANISM OF TISSUE TRANSGLUTAMINASE UPREGULATION AND ITS ROLE IN OVARIAN CANCER METASTASIS
... loops bind and activate 13 the receptor-coupled G-proteins They are classified into subtypes: α1A, α1B, and α1D based on molecular structure, function, and signaling (Graham et al 19 96) 1- AR activates ... About 21, 990 women were diagnosed with and 15 ,460 women died of OC in 2 011 (www.cancer.gov) The lethality of OC is mainly due to the inability to detect the disease at an early stage, and the lack ... (Grenard et al 20 01) All TGase encoding genes are closely related and have similar sequence and gene structure The genes for FXIIIA (F13A1) and TG1 (TGM1) consist of 15 exons and 14 introns, whereas...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25