... the presence of cytokines.Natural ligands of ICAM- 1and LFA-1 are expressedon the surface of T and B lymphocytes, natural killercells, monocytes, macrophages and granulocytes [33], and interaction ... activates monocytes and macrophages to produce cytokines such as tumor necrosis factor- a and interleukins IL-1b and IL-6. These cytokines appear to be responsible for the neurotoxicityobserved ... inflammatory cytokines. ICAM-1 con-tributes to multiple processes seen in central nervous system inflammatorydisease, for example migration of leukocytes to inflammatory sites, and adhesion of polymorphonuclear...
... class and the gender divisionof labor in the household.The basic objective of this chapter, then, is to explore empirically therelationship between class and the gendered domestic divisionof labor. More ... men and women.Rather, the amount of housework done by husbands should be viewedas at least in part an outcome of a process of contestation, con¯ict and bargaining.The class location of husbands ... reports of the husbands themselves,both because women are generally likely to have a more accurate view of the totalamount of housework done in a household and because men may be prone to exaggerate...
... effectiveness of Ethernet transport and services. One area currently underconsideration is how to fully utilize fiber build-outs to continue to offer revenue-generatingservices such as voice, andto add ... offering cost-effective and easy -to- manageEthernet and TDM-based services that allow for the full utilization of fiber networks.The LoopStar 711 offers the complete suite of LoopStar 700 software, ... Suite of Ethernet and TDM Services to Cost-Effectively Utilize Fiber NetworksCarriers and enterprises are looking for inexpensive ways to utilize their infrastructures to takeadvantage of the...
... between commander, gunner, and loader, which may lead to direct control by the tank commander and potential reduction of errors during the heat of combat; APPLICATIONS OF ROBOTICS AND ARTIFICIAL ... how to capture and deploy knowledge and duties of the operations, intelligence, logistics, and fire-support officers into operations, intelligence, logistics, and fire-support expert systems to ... these officers; ã how to automate screening messages and establishing priorities to reduce information overload; ã how to integrate the operations of the expert systems to support the command;...
... absence of tunicamycin. Drugtreatments resulted in the accumulation of forms of the mutant proteins that were of lower apparentmolecular mass andof similar size to the unglycosy-lated form of ... antigenbinding and presentation to CD8+cytolytic T cells.In HFE, the proximity of the two a helices and thepresence of amino acid side chains that project intothe groove appear to prevent peptide ... end of an a-helical region of theHFE a1 domain (V100 and W103A) as being of par-ticular importance for TfR1 interactions [16,17,20].The effect of HFE binding to TfR1 is to lower theaffinity of...
... gastriccancer. To test this hypothesis, the expression of Akt and PrPCwas examined by immunohistochemistry and confocal microscope in human gastric cancer cases and cell lines. Expression of total and ... and increasing release of these drugs (ADR and VCR) [5].PrPC-mediated multidrug resistance (MDR) wasthought to be related to upregulation of P-glycoprotein(P-gp) [6] and inhibition of apoptosis [6–9]; ... at varioussteps in the cytotoxic activity of the drug, from adecrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance. Oftenseveral different mechanisms...
... thought to be the sameLys185, is required to donate a proton to the C3 car-bonyl group of the keto-intermediate to facilitatedecarboxylation. Both a base and an acid are neededin the tautomerization ... tautomerization of the enediol intermediate to yield the ketone ribulose 5-phosphate product, withthe acid (Glu192) required to donate a proton to C1 of the enediol intermediate and the base (the ... per se. To better understand why these analogues have highaffinity andto help in rational drug design, we under-took a thermodynamic characterization of substrate and analogue binding to T. brucei...
... approach to natural lan-guage based on the understanding that the major-ity of sentences in the English language can bematched to one of ten patterns. Each of these pat-terns has a set of slots. ... position of a word to be filledby a multiple-word phrase or an entire subclause,with its own pattern and set of slots. To understand these relationships better, a stan-dardized system of sentence ... parser (from herein referred to as the Stanford parser) was developed and com-pared to two other systems: MINIPAR, describedin (Lin, 1998), and the Link parser of (Sleator and Temperley, 1993), which...
... muscle and fat cells. To gain some insight intothis issue we subsequently monitored the effects of a number of inhibitors that target PI3K, the MAP kinase pathway,p38 MAP kinase and mTOR on ... establish the importance of GSK3 in theacute regulation of glucose transport in terms of itsregulatory control of GS in muscle and fat cells we haveinvestigated the effects of Li and the anilinomaleimide, ... thebinding of insulin to its receptor and activation of thereceptor kinase, which tyrosine phosphorylates intracellulartarget substrates, in particular insulin receptor substrate 1(IRS-1) and its...
... fluorescentcoloration of M. cavernosa and L. hemprichii is due to GFP-like proteins and not caused by a fluorescentphycoerythrin. The contribution of mcavRFP, EosFP and lhemOFP to the total content of soluble ... chromatography(data not shown) [20]. The spectral properties of thered form of cjarRFP are surprisingly similar to those of EosFP and other known representatives of green -to- red photoconvertible ... analysis of the purified green -to- red photoconvertingproteins cjarRFP, lhemOFP, mcavRFP and EosFP. Both green (G) and red states (R) of the proteins were separated by SDS ⁄ PAGE.(A) Photoconversion...
... index it, and rank it basedon words and phrases and other factors. To achieve high rankings, pay attention not only to the words and phrases, butalso to other search engine optimization factors ... will make sense to them too. And hey, if your releases generate a story about your organization, wonderful! Don’t forget to link to it from your site and to purchase the online and print reprint ... also create your own RSS feeds of your news stories on your site. Use a standard off-the-shelfRSS feed generator so that interested visitors will be able to subscribe to your press release feed...
... concomitant intoxication of thepatient [7,35,51]. Moreover, binding of drugs to FA2reduces the affinity of FA7 and increases the affinity of FA1 ligands. Eventually, FA6 ligands are expected to affect ... 10)4m solution to a final concen-tration of 1.0 · 10)4m.Automatic flexible ligand-docking simulation to HSAwas performed using autodock 3.0 and the graphical userinterface autodocktools [54–56,68]. ... drug solubilization and distribution, a too tightan interaction negatively affects the distribution to sites of action and dramatically increases the total con-centration of the administered...
... concentrations,[B]0 and [A]0, in order to determine k2. However, only b and the ratio of [B]0 to [A]0 are needed in order to make the plot. Tools of the Trade 1 and substitution ... = 0.075 M. Tools of the Trade 23the "cage effect" which sometimes is used in photochemistry to control thelifetime of the immediate products of photochemically ... for k,[A] into Eq. (1.24) givesThis equation can be rearranged and integrated over the limits [B] = [B]0 to [B] and t = 0 to t to obtainTherefore, a plot of In ([B]e...