dissecting odorants by the pathways they take to the brain
Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc
... the inhibitors as well as to the packing constraints of the environment The larger and wider the features of the ligands that compete with the occluding loop for binding to the active site, the ... (V47–Q51) fills the S1¢ site with V48 In addition to this hydrophobic interaction, the loop is fastened to the cathepsin B surface by the hydrogen bond between the stefin A A49 amide and cathepsin B ... clearly exposed the relevance of the occluding loop for the exopeptidase activity [11], they not explain the mechanisms of endopeptidase activity, nor the inhibition of the enzyme by their endogenous...
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Tài liệu REPORT BY THE DIRECTOR-GENERAL ON THE UNITED NATIONS DECADE OF EDUCATION FOR SUSTAINABLE DEVELOPMENT: INTERNATIONAL IMPLEMENTATION SCHEME AND UNESCO’S CONTRIBUTION TO THE IMPLEMENTATION OF THE DECADE doc
... will largely affect the success of national responses to the DESD The most crucial element to the Decade’s success is the scope of the human resources brought together, including these enthusiastic ... response Stakeholders of all kinds have the right to take part in the Decade from the initial stages of visioning to implementation The organizers of the Decade, whether appointed by a government ... Invites the Director-General to take all necessary measures to further ensure UNESCO’s response to United Nations General Assembly resolutions 57/254, 58/219 and 59/237; Further invites the Director-General...
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Tài liệu The History of England from the First Invasion by the Romans to the Accession of King George the Fifth Volume 8 docx
... conception They divided their time between military duties and prayer; they sang psalms as they advanced to the charge; they called on the name of the Lord, while they were slaying their enemies The ... induce them to aspire to office, and commands and honours, to form cabals against their competitors, and to distract the attention of the monarch by their importunity or their complaints They contained ... induced them to withdraw, the royalists to their first position on the hills, and the parliamentarians to the village of Keynton From the conflicting statements of the parties, it is impossible to...
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Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... recognition of the receptor by the snake venom This illustrates the dual mechanism of the complex, with one subunit, namely GPVI, responsible for binding to the ligand, and the other subunit, the FcR ... cells to that induced by cross-linking of the T cell antigen receptor, despite the absence of the c-chain A possible explanation for this is provided by the observation that the CD3 chain of the ... mutations of these amino acids have revealed the importance of the arginine residue in the transmembrane domain of the immunoglobulin receptor However, the cytoplasmic domain of these FcRs is...
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21st Century Welfare: Presented to Parliament by the Secretary of State for Work and Pensions by Command of Her Majesty pptx
... awarded by HM Revenue & Customs are taken into account as income by the Local Authority in assessing Housing Benefit The system gives with the one hand, only to take away with the other In short, the ... and families to move into f work and to increase the amount of work they do, by improving the rewards from work at low earnings, and helping them keep more of their earnings as they work harder; ... move into work have understandable concerns about how they will support their families during the transition They ask themselves: “Will the in-work benefits kick in quickly enough to fill the gap...
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Báo cáo khoa học: DNA-binding characteristics of the regulator SenR in response to phosphorylation by the sensor histidine autokinase SenS from Streptomyces reticuli doc
... SenS–SenR influences the transcription of the furS– cpeB operon encoding the redox regulator FurS and Response regulator SenR the catalase-peroxidase CpeB, and the hbpS gene for the secreted HbpS, ... Taken together, the presented data show clearly that SenS is a histidine autokinase SenSc phosphorylates and dephosphorylates SenR As SenR was predicted to be the cognate RR of the SK SenS, the ... up-hbpS verified the specificity of the SenR–up-hbpS1 interaction (Fig 5C, third box from left) Taken together, these data revealed that SenR binds specifically to up-furS1 and up-hbpS1, and the phosphorylation...
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... binding to the target (e.g [13,16,17]) Binding to the target can increase the Ca2+-binding affinity to CaM further [17,18] In addition, subsequent binding of Ca2+ to the N-lobe then induces further ... of the CaM constructs bound to the peptide in the absence of Ca2+ For the TMR-labeled peptide C2, EF-hand mutations and increased the KD by about a factor of seven (to 1560 ± 190 nm compared to ... exposure to BODIPY FL-hCaM Dark spots indicate CaM binding The top frame marks the spots encompassing residues 1–205, the bottom frame the C-terminal residues 480–962 (B) Topology of the hEAG1...
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Báo cáo khoa học: Distinguishing between different pathways of bilayer disruption by the related antimicrobial peptides cecropin B, B1 and B3 pptx
... surfactant Polysorbate 20 The purpose of the surfactant is to reduce sample loss caused by the adsorption of hydrophobic molecules to the surfaces of the flow system of the BIAcore instrument Peptides ... disrupt cell membranes, and thereby kill their targets, by associating with the membrane lipids [21] The mechanism of bilayer disruption by cecropin A was recently shown to occur via an ion channel ... on the endotherm, and higher concentrations (50 lM) were required to obtain multiple peaks similar to the endotherms obtained with CB or CB1, suggesting that CB3 binds less efficiently to the...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... interaction Although the three b-amino acid substitutions in position of SP are tolerated by the NK-1 receptor, the substitution of the flexible Gly by the even more flexible HGly causes a 30- to 40-fold ... affinities and the nonvarying response of these agonists could be explained by the number of receptors to be occupied by these agonists to get activation of the second messenger cascade as reported ... behaviour in their affinity for the NK-1m binding and their potency to stimulate PLC (Fig 4B) Whatever the affinity measured for the NK-1m binding site for these agonists (from pM to 0.54 nM), the corresponding...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... result of the presence of the N-terminal domain of the protein that slightly differs from that adopted by its C-terminal moiety The only amino acid residue belonging to Ure2p which exposure to the ... within the same area in the 3D structure of Ure2p Thus, the binding of Ssa1p to the region centered on lysine 339 could abolish the acquisition by Ure2p of an assembly competent state The results ... the present study provide a rationale for the inhibition of Ure2p assembly by Ssa1p and underline the key role of the C-terminal domain of Ure2p in assembly into fibrils [25–28] The results, together...
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Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf
... could to some extent mimic the role of Fru(1,6)P2 in the allosteric binding sites, thereby stabilizing the tetrameric active form when the preferred activator is absent This seems to be the case ... encoded by the ldhB gene, and the activation of this gene was explained by the site-specific, oriented integration of an IS905-like element in the intergenic region upstream of the ldhB gene, thereby ... with the sequence analysis of the ldhB gene in strain FI9078, led to the conclusion that lactate production in strain FI9078 was mediated by the enzyme encoded by the ldhB gene As expected, the...
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Báo cáo khoa học: Enzymatic oxidation of NADP+ to its 4-oxo derivative is a side-reaction displayed only by the adrenodoxin reductase type of ferredoxin-NADP+ reductases potx
... prompted us to propose the hypothetical mechanism for the FprA-catalyzed NADPO formation reaction depicted in Fig NADP+ oxidation is initiated by water addition to the electron-poor C4 atom of the nicotinamide ... 7.7) and after adjusting the pH to c by the addition of HCl Monitoring of the time-course of NADPO formation catalyzed by various enzymes The enzymatic conversion of NADP+ to NADPO was studied in ... 15.6 mm)1Æcm)1 for NADPO To monitor the reaction in the absence of molecular oxygen as the oxidant, c 20 lm FprA in the same buffer as above, either in the absence or in the presence of 140 lm...
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REPORT ON OBSERVATIONS OF PCAOB INSPECTORS RELATED TO AUDIT RISK AREAS AFFECTED BY THE ECONOMIC CRISIS pot
... they relate to audit risks posed by the ongoing effects of the economic crisis and any future similar events The Board's statutory mission is to protect the interests of investors and to further ... available to the auditors with respect to these items Second, the audit committee might wish to discuss with the issuer's auditor the auditor's assessment of audit risk in the areas discussed in the ... market sectors and the broader economy, the inspection staff continued to discuss the issues with firms, monitored how firms were adjusting their 2007 and 2008 audit plans to respond to the risks,...
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Báo cáo khoa học: "DEVOTED TO THE TRANSLATION OF LANGUAGES BY THE AID OF MACHINES" pot
... related problems There are plans to form shortly a working committee of HAS, for the purpose of theoretically co-ordinating all of the Hungarian work in MT and mathematical linguistics György Szépe ... linguists of different institutions The Center plans to form an official MT group in 1964 3) Debrecen Group for Mathematical and Applied Linguistics Director: Ferenc Papp This group conducts ... Hungarian and Russian texts Also, they are investigating linguistic aids for foreign language teaching, and are doing preparatory work for Czech-Hungarian MT, and theoretical work on models Papp...
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Báo cáo khoa học: Binding of activated Factor XII to endothelial cells affects its inactivation by the C1-esterase inhibitor pptx
... FXIIa to the inactivator as illustrated in Fig 3A; (b) the second mechanism assumes that the inactivator binds to FXIIa, while still bound to the cell surface (Fig 3B) To analyse which of these ... cell-bound FXIIa (A) The C1-INH disturbs the binding of FXIIa to HUVEC by binding to soluble FXIIa (B) The C1-INH binds to receptor bound FXIIa analogously for the inactivation of FXIIa in the medium (2.3)4.3 ... was confirmed by analysing the effect of C1-INH on the kinetics of FXIIa binding to the cells by determining the S-2302 amidolytic activity of the bound FXIIa In the absence of C1-INH the activity...
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Public health functions to be exercised by the NHS Commissioning Board docx
... their population Public health functions to be exercised by the NHS Commissioning Board • to ensure that these systems take into account and support future changes to services (e.g a change to ... Act 2006 ( the 2006 Act”) as amended by the Health and Social Care Act 2012 This service specification is to be applied by the NHS CB in accordance with the 2013-14 agreement An update to this service ... level, and prior to April 2013, commissioned by PCTs They take a variety of forms from a spreadsheet with manual entry processes, to a more advanced database relying on many automated inputs and...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25