disorders of the metabolism of amino acids and related compounds
Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... promote the transfer of the p-HB moiety onto PKS15 ⁄ [16,18] To examine the involvement of FadD29 in the biosynthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of an ... knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 in the ... 15–17 Mycocerosic acids OCH3 O 3–5 15–17 Fig Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium...
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Báo cáo y học: " Effects of carbohydrate, branched-chain amino acids, and arginine in recovery period on the subsequent performance in wrestlers" potx
... weeks The same food was provided in the lunch and dinner on the day before, and the breakfast on the day of each trial The lunch and dinner were meal boxes purchased from a local restaurant The ... restore the performance and (2) whether BCAA and arginine could provide additive effect on glucose disposal during the recovery and the performance in the subsequent match Mater ial and methods ... trial) The peak and average power in the matches was similar in the trials After the supplementation, CHO and CHO+AA trial showed significantly higher glucose and insulin, and lower glycerol and...
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Báo cáo khóa học: Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation ppt
... N-myristoylation, and the amino acid requirements at this position were significantly affected by the amino acid at position [25] Therefore, we next determined the effect of the amino acid at position on the amino ... amino acids, and their susceptibility to protein N-myristoylation was evaluated In this case, we chose Thr and Phe to further analyze the effect of the amino acid residue at position on the amino ... Nmyristoylation In the present study, to examine the effect of the combination of amino acids at positions and on protein N-myristoylation, sequential vertical-scanning mutagenesis of the amino acids at...
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Báo cáo khoa học: Assimilation of excess ammonium into amino acids and nitrogen translocation in Arabidopsis thaliana – roles of glutamate synthases and carbamoylphosphate synthetase in leaves ppt
... hybridization of the transcripts As the endogenous photorespiratory ammonium affected the levels of ammonium and amino acids in the GLU1 and GLT mutants (Fig 3), we investigated whether expression of the ... weight) [2,16,17] The high levels of glutamine and glutamate (nitrogen-rich ve-carbon amino acids) and asparagine and aspartate (four-carbon amino acids) (up to 80% of the total amino acids) (Fig 3) ... arginine synthesis in the carB mutant In fact, amino acid synthesis is tightly correlated with amino acid transport under the ne control of the cellular and subcellular expression of the nitrogen...
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Guanidine catalyzed enantioselective mannich reaction towards the synthesis of amino acids
... TOWARDS THE SYNTHESIS OF -AMINO ACIDS PAN YUANHANG (BSc., Zhejiang University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE ... on the direct addition of simple ester and amide remains a challenging problem in organic synthesis The difficulty is due to the relatively high pKa values of the -protons of these carbonyl compounds. 11 ... strategies for the stereoselective synthesis of -amino acids have been reported.16 Amongst these, the most robust and powerful method is attributed to the asymmetric Mannich reaction, of which several...
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Microbial Production of Amino Acids in Japan
... industries After the successful introduction of the technology, various methods were searched for and developed for microbial production of other amino acids Today a whole array of amino acids are produced ... glutamate even in the presence of excess amounts of biotin and suggested that the overproduction of glutamate is caused by the imbalance of the coupling between fatty acid and glutamate synthesis [7] ... interesting to know of the existence of this new lysine decarboxylase in lysineproducing Corynebacterium and to investigate the effects of the deletion of the gene on the amounts of l-lysine production...
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Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... Foreword The dawn of psychogeriatrics in Japan was celebrated with the symposium entitled ‘Psychiatry for the Elderly’ in the frame of the annual meeting of the Japanese Society of Psychiatry and ... psychogeriatrics The success of the 21st Annual Meeting of the Japanese Dementia Study Society and the International Symposium on Neurobiology of Alzheimer’s Disease and Related Disorders in October ... been the main interest of the Department of Psychiatry and Behavioral Proteomics, Preface XI Osaka University Graduate School of Medicine, since the time of Professor Jiro Kaneko and Professor...
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Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
... )70 °C The areas of the gels corresponding to the released strand and to the nonunwound substrate were cut out and 32 P radioactivity counted Alternatively, the films were scanned and the radioactivity ... of 1.5–5.5 lM) of the helicase activities of HCV, WNV and Suv3(D1–159), but not JEV The tetrachlorobenzotriazole TCBT is only a weak inhibitor of the HCV enzyme, and a moderate inhibitor of the ... the interaction of these compounds with RNA and/ or DNA appears to be dependent on the base sequence of the polynucleotide [42] It is intriguing that the potent inhibitor of the HCV and WNV NTPase/helicases,...
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Báo cáo khoa học: Identification of amino acids in antiplasmin involved in its noncovalent ‘lysine-binding-site’-dependent interaction with plasmin pptx
... around the two sites Lys452 and Lys436 In these models, the side chain of the C-terminal lysine residue (K452) seems to be in the near vicinity of the side chain of Phe448 Lys436, on the other hand, ... half-lives of plasmin in these experiments (also before 50% of the plasmin activity was inhibited) Computer model of the C-terminal 40 amino acids in antiplasmin A computer model of the C-terminal 40 amino ... decreased about one order of magnitude The only exception was the variant K436E, for which the reaction rate decreased by only a factor of 2–3 On the other hand, in the absence of 6-aminohexanoic acid,...
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Care of the Patient with Retinal Detachment And Related Peripheral Vitreoretinal Disease docx
... Prognosis and Followup The prognosis for the patient with a retinal break and the need for followup by the optometrist depend on the type and severity of the break The frequency and composition of evaluation ... inflammation of blood vessels Visual acuity The clearness of vision that depends upon the sharpness of focus of the retinal image and the integrity of the retina and visual pathway Visual field The area ... time The further into the vitreous cavity the retina floats, the more elevated it appears during ophthalmoscopy and the greater the number and size of retinal folds in the detachment In longstanding...
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Health Risks from Dioxin and Related Compounds Evaluation of the EPA Reassessment potx
... illustration of the effect of the selection of the point of departure and of the mathematical model used to extrapolate below the point of departure on the risk estimate Note that the 5% response ... S-1 Conceptual illustration of the effect of the selection of the point of departure and of the mathematical model used to extrapolate below the point of departure on the risk estimate, 5, 15 1-1 ... assess the toxicity of each of the compounds and various mixtures of them in the environment TCDD, other dioxins, and DLCs have been regulated extensively worldwide In the early 1980s, the U.S...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 1) doc
... small area of specialized epithelium in the dorsal posterior recess of the nasal cavity These neurons project axons to the olfactory bulb of the brain, a small ovoid structure that rests on the cribriform ... Physiology of Smell The olfactory epithelium is located in the superior part of the nasal cavities and is highly variable in its distribution between individuals Over time the olfactory epithelium ... is the perception of odor by the nose Taste is the perception of salty, sweet, sour, or bitter by the tongue Related sensations during eating such as somatic sensations of coolness, warmth, and...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 2) ppt
... subjective distortion of taste and smell, which may become more severe as the disease progresses The loss of taste and smell may play an important role in the development and progression of HIV-associated ... craniopharyngiomas, suprasellar meningiomas, and aneurysms of the anterior part of the circle of Willis extend forward and damage olfactory structures These tumors and hamartomas may also induce seizures ... Perversion of the sense of smell may occur as a transient phase in the recovery process Viral infections can destroy the olfactory neuroepithelium, which is then replaced by respiratory epithelium...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 3) pdf
... fossa, and sinus anatomy Biopsy of the olfactory epithelium is possible However, given the widespread degeneration of the olfactory epithelium and intercalation of respiratory epithelium in the ... fractures of the anterior cranial fossa Bone abnormalities are best seen with CT MRI is the most sensitive method to visualize olfactory bulbs, ventricles, and other soft tissue of the brain ... side of the nose Nasal resistance can also be measured with anterior rhinomanometry for each side of the nose CT or MRI of the head is required to rule out paranasal sinusitis; neoplasms of the...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 4) pdf
... tongue; at the junction of the dorsum and the base of the tongue; and in the palate, epiglottis, larynx, and esophagus Figure 30-2 Taste A The taste buds of the anterior two-thirds of the tongue ... and vagal nerves The chorda tympani branch of the facial nerve subserves taste from the anterior two-thirds of the tongue The posterior third of the tongue is supplied by the lingual branch of ... branch of the superior laryngeal nerve of the vagus nerve contains the taste afferents from the larynx, including the epiglottis and esophagus The central connections of the nerves terminate in the...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 5) pptx
... Radiation therapy Sensory Gustatory Losses Renal disease Aging Stroke and other CNS respiratory tract disorders Candidiasis Trauma Drugs (antithyroid and antineoplastic) Upper Endocrine disorders ... to the oral cavity and pharynx; viral infections; endocrine disorders; neoplasms; and aging Neural gustatory losses occur with neoplasms, trauma, and surgical procedures in which the gustatory ... Radiation therapy Viral infections herpes viruses) (especially with A side effect of medication is the single most common cause of taste dysfunction in clinical practice Xerostomia, regardless of the...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 6) pot
... juncture of the chorda tympani branch with the facial nerve in the mastoid Disorders of the Sense of Taste: Treatment Treatment of gustatory disorders is limited No effective therapies exist for the ... cells in the inner ear Sound waves enter the external auditory canal and set the tympanic membrane in motion, which in turn moves the malleus, incus, and stapes of the middle ear Movement of the footplate ... footplate of the stapes causes pressure changes in the fluid-filled inner ear eliciting a traveling wave in the basilar membrane of the cochlea The tympanic membrane and the ossicular chain in the...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 7) pps
... to particular phases of the cycle of the sound wave Intensity is encoded by the amount of neural activity in individual neurons, the number of neurons that are active, and the specific neurons ... explains the exquisite sensitivity and frequency selectivity of the cochlea Beginning in the cochlea, the frequency specificity is maintained at each point of the central auditory pathway: dorsal and ... The inner and outer hair cells of the organ of Corti have different innervation patterns, but both are mechanoreceptors The afferent innervation relates principally to the inner hair cells, and...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 8) ppsx
... mitochondrial disorders [mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS); myoclonic epilepsy and ragged red fibers (MERRF); progressive ... type II MITF Transcription factor SLUG Transcription factor EDNRB Endothelin-B receptor EDN3 Endothelin-B WS type IV receptor ligand SOX10 Transcription factor Note: BOR, syndrome.[newpage] branchio-oto-renal ... Cell-cell interactions Pendred syndrome SLC26A4 Chloride/iodide transporter Treacher Collins TCOF1 Nucleolar-cytoplasmic transport Usher syndrome MYO7A Cytoskeletal protein USH1C Unknown CDH23...
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Chapter 030. Disorders of Smell, Taste, and Hearing (Part 9) pdf
... from obstruction of the external auditory canal by cerumen, debris, and foreign bodies; swelling of the lining of the canal; atresia or neoplasms of the canal; perforations of the tympanic membrane; ... implantation and invasion, immigration and invasion through a perforation, and metaplasia following chronic infection and irritation On examination, there is often a perforation of the tympanic ... quinine and its synthetic analogues, aminoglycoside antibiotics, loop diuretics such as furosemide and ethacrynic acid, and cancer chemotherapeutic agents such as cisplatin), fractures of the temporal...
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