determine possible effects of prkag3 gene polymorphisms on meat quality of ban pig
Báo cáo y học: "Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study" pps
... (gene expression) These epigenetic changes generally involve DNA modification such as methylation and acetylation, histone protein modifications, and regulation of gene expression by microRNAs ... suggest that modifications of gene expression and function may be more important [5,6] Such modifications of gene expression are thought to result from gene- environment interactions occurring before ... of all the proteins necessary to create a living organism Nonetheless, epigenetic modifications provide additional instructions on how, where, and when the genetic information will be used (gene...
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Analysis of functional candidate genes related to ubiquitination process for meat quality in commercial pigs
... Aims of the current study The objective of the study was to evaluate the effects of functional candidate genes on meat quality by the identification of polymorphisms in transcribed regions of these ... known function of the particular gene in the ubiquitination process and/or (ii) their genetic positional information of QTL for meat quality traits 1.3 The functions of candidate genes involve ... candidate genes related to the ubiquitination process and its effects on meat quality The previous sections present an overview of the effects of ubiquitin-proteasome system on the degradation of the...
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Application of knowledge discovery and data mining methods in livestock genomics for hypothesis generation and identification of biomarker candidates influencing meat quality traits in pigs
... androstenone in porcine adipose tissues is one of the primary reasons for a meat quality trait known as boar taint Boar taint is often described as an off odor or off taste often noticeable from meat ... overlaying interaction networks with expression profiles of genes, transcripts, proteins or other biological molecules The computational integration of expression profiles and interaction networks have ... interaction data, phylogenetic profiles, expression data, phenotypes and Gene Ontology annotations into a functional relationship network (Wong et al., 2012) This network is used to predict genes...
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Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx
... expression of a protein(s) required for induction of the Timp-1 gene Time course of TSA action upon PMA- and TGF-b1-induced Timp-1 expression The time course of induction of Timp-1 gene expression ... effect on basal expression of Timp-1, only on induced gene expression In conclusion, this is to our knowledge, the only described instance of HDAC inhibitors having opposite effects on the same gene, ... modification of histones, via acetylation, methylation and phosphorylation [15–18] Acetylation by histone acetyltransferases (HATs) occurs on specific lysine residues on the N-terminal tails of histone...
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Báo cáo khoa học: Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR, HR3, E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera ppt
... the effects of 20E both on cell proliferation and morphological changes of IAL-PID2 cells Isolation and characterization of P interpunctella EcR-B1 mRNA Cloning of a PIEcR cDNA frament We wondered ... B1 isoform) of other insect EcRs and a strong degree of identity was confined to the two ends of N-terminal region of the A/B domain Using a B1 isoform-specific probe from the A/B region of PIEcR, ... minimal concentration of 20E required for an induction of PIEcR-B1 mRNA, IAL-PID2 cells were exposed to various concentrations of 20E for 18 h As shown in Fig 5B, a significant induction of PIEcR-B1...
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Báo cáo khoa học: Conformational stability of neuroglobin helix F – possible effects on the folding pathway within the globin family potx
... apo form of the protein (apoNgb) as a result of the formation of an intermolecular disulfide bond The preparation of apoNgb was obtained from the corresponding holoprotein by the removal of heme ... helix F of apoNgb is preserved from proteolysis at pH (P Picotti, unpublished results), suggesting the conservation of its secondary structure in spite of the extreme conditions By contrast, ... calculated at pH 2.1 Additional details are given in Table Figure shows a diagrammatic representation of the superposition of the structure of family conformers at both pH conditions The structures were...
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báo cáo hóa học:" Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis" doc
... associations have centered on the caffeine content of coffee [26] In fact, caffeine has a variety of pharmacological actions and cellular responses Coffee is one of the most widely consumed psychoactive ... the size of 200 – 1000 bp (Fig 5) stimulation of the central nervous system and cardiac muscle, increased urinary output, and relaxation of smooth muscle [23] The effects of coffee on bone metabolism ... and diluted in phosphate buffered solution (Sigma, St Louis, MO, USA) In the first part of this study, the effects of various concentrations of caffeine on bone cell activities were evaluated by...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc
... housekeeping gene was used as reference for the relative quantification of the gene of interest, which was expressed as the ratio of ‘concentration of the target’ to ‘concentration of b-actin’ ... effect of time on RANKL mRNA expression inhibited by different concentrations of alpha-CGRP was found In particle concentrations of 1:500 RANKL mRNA expression was significantly decreased by all concentrations ... concentrations of 1:100 and 1:500 (Figure 1D) In cell-particle concentrations of 1:100 OPG mRNA-expression significantly increased after 72 hours (P < 0.05) In cell-particle concentrations of...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot
... housekeeping gene was used as reference for the relative quantification of the gene of interest, which was expressed as the ratio of ‘concentration of the target’ to ‘concentration of b-actin’ ... effect of time on RANKL mRNA expression inhibited by different concentrations of alpha-CGRP was found In particle concentrations of 1:500 RANKL mRNA expression was significantly decreased by all concentrations ... concentrations of 1:100 and 1:500 (Figure 1D) In cell-particle concentrations of 1:100 OPG mRNA-expression significantly increased after 72 hours (P < 0.05) In cell-particle concentrations of...
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Báo cáo toán học: " Effects of internal low-dose irradiation from 131 I on gene expression in normal tissues in Balb/c mice" ppt
... regulation of cell adhesion Negative regulation of enzyme activity Positive regulation of actin filament polymerization Protection from natural killer cell mediated cytotoxicity Regulation of hormone ... Digestion Kidney medulla-lung Cell migration Cell-matrix adhesion Cellular defense response Positive regulation of angiogenesis Positive regulation of neurotransmitter secretion Regulation of locomotion ... Inflammatory response Negative regulation of gluconeogenesis Negative regulation of lipoprotein lipase activity Positive regulation of fatty acid metabolism Positive regulation of signal transduction Kidney...
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Báo cáo hóa học: " The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study" pptx
... magnitude of plasma volume expansion, dilution of hemoglobin (Hb) concentration was assessed hour after the fluid administration Laboratory protocol One milliliter of blood was added to ml of M guanidine ... Haren has no conflicts of interest to disclose Dr Pickkers has no conflicts of interest to disclose Mr Cursons has no conflicts of interest to disclose Prof Sleigh has no conflicts of interest ... limitations Septic shock patients are not a homogenous population, and the expression of inflammatory mediators is highly variable and not only dependent on the source of sepsis but also on the genetic...
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Báo cáo hóa học: " Effects of paraoxonase activity and gene polymorphism on coronary vasomotion" pot
... role of HDL has been extensively studied and is known as one of the strongest protectors against coronary artery disease [1] Consequently, the influence of PON1 polymorphism as a main component of ... HOMOZYGOTES −RR Figure Effect of paraoxonase genotype on paraoxonase activity and myocardial blood flow parameters Effect of paraoxonase genotype on (a) paraoxonase activity, (b) response to cold pressor ... the same conditions but for 28 cycles only Fragments obtained were 500 bp long for the PON1-192 polymorphism, 384 bp long for the PON1-55 wild type, and 282 and 102 bp long for the PON1-55 mutant...
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Báo cáo hóa học: " Differential Gene Expression to Investigate the Effects of Low-level Electrochemical Currents on Bacillus subtilis" doc
... indicated Cell density of the biofilms was calculated from the CFU data Figure Effects of ampicillin on biofilms of B subtilis 1500 Biofilms were treated with varying concentrations of ampicillin and ... To better understand the mechanism of bacterial control by ECs, we conducted a systematic study of the effects of weak ECs on the planktonic and biofilm cells of the model Gram-positive bacterium ... gene (mrgA) The genes for arsenic/antimony resistance (arsBCR, yqcK) were also up-regulated (although less than two fold) Effects of DC treatments on biofilms To determine the effect of DCs on...
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Báo cáo khoa học: "Effects of Benzo[a]pyrene, 2-Bromopropane, Phenol and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Proinflammatory Cytokines Gene Expression by Mice Spleen Cells" doc
... Elmer) A 100㎕ of final reaction volume contained 20㎕ from the reverse transcription reaction, 63.5 ㎕ of H2O, 0.5㎕ of 5U/㎕ DNA Tag polymerase, 6㎕ of 25mM MgCl2, 8l of 10×PCR buffer, 1㎕ of each primer ... value of β-actin Results are representative of three separate experiments F ig Effect of pollutants on cytokines gene expression Based on the Figure 4, the relative inductions of cytokines genes ... expression [3, 18, 21] It is generally assumed that anti-CD3 can stimulate the production of IL-2 by T cells and in turn promote IFNγ production [9] The production of IFN γ is generally considered...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" pdf
... position +3483 of the gene (+1 being at the beginning of exon instead of exon 2) SNP2 is a C/T polymorphism that constitutes a noncoding mutation, probably at position -1486 of the promoting region ... position -851 of the gene (+1 being at the beginning of exon instead of exon 2) The primers used for PCR amplification of SNP1 and SNP2 PCR are presented in Table PCR conditions will be supplied on ... population on average The polymorphisms tested in our study were selected based on frequency and on feasibility of tests; neither their location in exons or introns nor the nature of the polymorphisms...
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Báo cáo y học: "No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis" ppt
... position +3483 of the gene (+1 being at the beginning of exon instead of exon 2) SNP2 is a C/T polymorphism that constitutes a noncoding mutation, probably at position -1486 of the promoting region ... position -851 of the gene (+1 being at the beginning of exon instead of exon 2) The primers used for PCR amplification of SNP1 and SNP2 PCR are presented in Table PCR conditions will be supplied on ... population on average The polymorphisms tested in our study were selected based on frequency and on feasibility of tests; neither their location in exons or introns nor the nature of the polymorphisms...
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Báo cáo y học: " Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults" ppt
... in CYP2B6 gene, but not CYP3A4 gene polymorphism, gave the significant effects on plasma drug levels Only small effects of rifampicin on efavirenz and nevirapine plasma concentration were observed ... efavirenz concentrations is strongly influenced by CYP2B6-516TT genotype by the finding of significantly higher plasma efavirenz concentration at weeks and 12 of ART and month after rifampicin discontinuation ... a definite conclusion on the effect of CYP3A4 variations In this study, the frequency of CYP2B6-G516T among 124 Thai adults was 8.9%, which was close to that of our recent study on 237 HIV-infected...
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Báo cáo y học: "Toxic effects of methoxychlor on the episodic prolactin secretory pattern: Possible mediated effects of nitric oxide production" pdf
... subcutaneous (sc) injections of MTX at a dose of 25 mg/kg/day for one month MTX was dissolved in sesame oil at a concentration of 17.5 mg/mL The other two groups of animals (control and L-NAME treated) ... dopamine concentration, the comparison of values was done by oneway analysis of variance (ANOVA) Finally, to test the existence of an interaction between MTX and TRH, two ways analysis of variance ... variability of the assay, series of plasma of 10 replicates at different concentrations of the prolactin standard curve were run Coefficients of variation were 8.6, 6.4, 5.7 or 4.7 % of 1.5, 6.25,...
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báo cáo khoa học: " Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro" pptx
... which is strongly influenced by post-translational modifications of histones like methylation is now generally recognized as an important factor in the regulation of gene expression [19,20] The ... combination of different modifications and the incorporation of different histone variants which have distinct roles in gene regulation, have led to the proposition of a regulatory histone code ... JMJD2B constitutes a key component of the estrogen signaling pathway and the establishment of local epigenetic state and chromatin structure required for proper induction of ER responsive genes...
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báo cáo khoa học: " Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells" pdf
... with control group at each time point Effects of DNMT1 silencing on gene demethylation and mRNA expression level in Hela cell Methylation status and mRNA expression level of seven repressive genes ... CpG island hypermethylation of tumor suppressor genes Rhee et al Figure Effects of DNMT1 silencing on gene methylation and mRNA expression of seven tumor suppressor genes in Siha cells assayed ... Xu G, et al: Regulation of DNA methylation on the expression of the FHIT gene contributes to cervical carcinoma cell tumorigenesis Oncology reports 2006, 16(3):625-629 14 Banno K, Yanokura M,...
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