cytokines and chemokines in immune cell traffic across the blood brain barrier
báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and Its ... and trafficking of HIV-1-infected immune cells across the BBB [8] HIV-1 infection of brain endothelial cells (BECs) is not a productive infection [9] and penetration of HIV-1 is independent of the ... diffusing from the luminal to abluminal (influx) chamber and was calculated from the initial level of radioactivity in the loading chamber and final level of radioactivity in the collecting chamber:...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... predominantly affects the meninges surrounding the brain and the spinal cord is called meningitis The infection of the brain tissue is called encephalitis If both brain and meninges are affected, the ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited ... the drug can INTRODUCTION reaches the sites of infection in the body, and how quickly the body can eliminate the drug During the clinical application, the biggest obstacle in the antibiotic therapy...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the ... pathways and ameliorates the inflammatory response of immune cells [76] At a molecular level, MSH-α decreases the intracellular production of proinflammatory cytokines and chemokines by inhibiting ... Production of the cytokines interleukin and by murine brain microvessel endothelium and smooth muscle pericytes J Neuroimmunol 1993, 47:23-34 53 Reyes TM, Fabry Z, Coe CL: Brain endothelial cell production...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... right) There was a small amount of extravasation of rhodamine B Gd-G5 and rhodamine B Gd-G8 dendrimer across the normal bloodbrain barrier beginning approximately hour following intravenous infusion, ... designing nanoparticles that are effective at traversing the pores of the blood- brain tumor barrier and accumulating within individual glioma cells Methods PAMAM dendrimer functionalization and ... defective BBTB of the smallest gliomas within the size range of brain tumors in our study (Figure 3B) In the case of the largest RG-2 gliomas within the size range of brain tumors in our study, Gd-G7...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... ONE: INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier ... 2.2 BRAIN CANCER AND OTHER BRAIN DISEASES A brain tumor is a mass of unnecessary cells growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain ... With these two functions of the blood brain barrier, the brain capillaries allow the passage of oxygen and other essential chemicals and shield the brain from toxins in the circulatory system and...
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Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps
... [8,9] Therefore, both chemokines and In the present investigation, we have determined levels of cytokines and chemokines in BAL fluids (BALF) in an early SSc cohort Furthermore, we analyzed controls ... inflammatory protein-1β (MIP1β or CCL4) may play a role in SSc, as the overexpression of these chemokines has been detected in SSc-related lung disease [6,7] In addition to chemokines, cytokines ... reflect disease progress and the pathogenic mechanisms present in SSc-ILD The role of chemokines and cytokines as markers reflecting disease severity and predicting outcome in SSc-related lung disease...
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Báo cáo khoa học: Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma ppt
... RCC cells to the lack of calbindin protective function The protection from apoptosis despite the lack of calbindin could be explained by the decrease in TRPC4, or by retention of the Ca2+-binding ... + +++ ++ In contrast, HNK and RCC cell lines differed in their ability to induce angiogenesis Conditioned media (CM) from P769 and other RCC cell lines were potently angiogenic in rat and mouse ... of such inhibitors in angiogenic tumors impedes their progression: these include angiostatin, endostatin, tumstatin, PEDF, SPARC (secreted protein, acidic and rich in cysteine), tissue inhibitor...
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Báo cáo khoa học: Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds potx
... selenoureas and selenoamides using three cell lines, HaCaT, HEL, and HEp-2, and PMNs, by the microtiter tetrazolium method [41–43] The cytotoxicities of the compounds in each cell line are shown in Fig ... shows the red fluorescent phallodin staining (F-actin) and the blue fluorescence of the nuclei Green fluorescence marks the p47phox translocated from the cytosol to the cell membrane After incubation, ... cytotoxicity against some human cell lines, such as human keratinocytes (HaCaT cells), human embryo lung fibroblast cells (HEL cells), human nasopharyngeal carcinoma cells (HEp-2 cells) and PMNs in vitro...
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Báo cáo sinh học: "Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations" pdf
... stimulating the growth of one cell line in our panel, and the antagonistic effects of the combination of metformin and vemurafenib in several cell lines, the combination of vemurafenib and metformin ... melanoma cells to each drug alone, both drugs were combined in constant ratios to each other Among the 11 BRAFV600E mutant cell lines, in cell lines the combination was antagonistic and in cell lines ... Conversely, the effects on pACC were mainly derived from single agent metformin, where in most cell lines the increases in pACC were noted concordantly with single agent metformin and the combination...
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Báo cáo khoa học: "The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer" doc
... parameters in the examined samples were measured in sera obtained from blood drawn in the fasting state, clotted (15 min, room temperature) and centrifuged (15 min, 1000 g) The serum samples were then ... of pro-inflammatory cytokines, cytokins, APRP, adiponectin, ghrelin and leptin leves have not been explained yet We suggested that adiponectin, ghrelin and leptin are tightly regulated the energy ... lymph node involvement in esophageal squamous cell carcinoma The concentrations of circulating IL-6 and midkine, independently of the patients weight status, and with Il-1, Il-8 and VEGF in cachectic...
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Báo cáo y học: "Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines" ppsx
... hepatocytes and Kupffer cells respond by producing TNF and other cytokines [52] Likewise, spleen, brain and bone marrow cells also produce cytokines following i.p exposure to LPS [52-54] Whether these cells ... of cytokines and chemokines was induced to high levels, with mean pixel densities within 75% of the positive controls included with the array kit The coordinates on the array of these cytokines ... attributed to the ability of TMP to interfere with the binding of Sp1 to DNA TMP has been found to arrest the growth of certain tumor-derived cell lines in the G2 phase of the cell cycle by inhibiting...
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Role of hodgkin and reed sternberg cell derived lymphotoxin alpha in t cell recruitment into the microenvironment of hodgkin lymphoma lesions
... better understand the cell- cell signaling pathways between the HRS cells and the nonmalignant reactive and stroma cells in lymphatic tissues Findings so far pointed out immune cells in the microenvironment ... secreted cytokines and chemokines Surrounding the HRS cell are cell types representative of the nonmaglinant cells attracted by these molecules The cells in the microenvironment can, in turn, ... and IL-13 Cytokines produced by THelper2 cells can activate mast cells and eosinophils, thereby eradicating helminths and other extracellular parasites (O'Garra and Arai, 2000) In addition, these...
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The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 1
... Src family kinases Note that: the SH4 domain of SFKs is for membrane targeting; the SH3 domain for binding to proline-rich containing proteins; the SH2 domain for binding to tyrosine-phosphorylated ... Ras-guanine nucleotide releasing protein Src family kinases Src-homology Src-homology SH2 domain -containing transforming protein C SH2-containing inositol 5’-phosphatase-1 SH2-domain containing ... domains allow protein-protein interactions The role of paxillin superfamily adaptor proteins, in particular paxillin and Hic-5, is well established in growth factor and integrin mediated signaling...
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The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 2
... together, the data in Fig support the finding that LPXN interacts with Lyn and that the interaction likely occurs in the plasma membrane of B cells and is induced upon BCR activation Leupaxin Interacts ... signaling proteins such as the tyrosine kinase Btk and the adaptor protein BLNK (37–39) LPXN is known to contain 11 tyrosine residues Therefore, to determine whether LPXN is involved in BCR signaling, ... BJAB cells and appeared to peak at the 5- and 15-min time points before returning to the basal level at the 30-min time point Conversely, immunoprecipitating total cellular phosphotyrosine proteins...
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The expression of CD44s in squamous cell carcinoma of the oral tongue and association with clinicopathological factors and survival outcomes
... glycosaminoglycan-associating proteins, increasing the capacity of these ligands to interact with their receptors, thereby lowing the threshold for signal transduction The binding of such ligands, including osteopontin ... a cancer on the decline in the developed world, a rising incidence suggests a continuing increase in the absolute numbers of cases to be treated in the coming decades.3 In India, incidence rates ... membrane and influences CD44-mediated signal transduction The cytoplasmic partner molecules of CD44 are the cytoskeleton proteins ankyrin and ezrin, radixin and moesin (ERM proteins) These proteins...
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The graphs below show the numbers of male and female workers in 1975 and 1995 in several employment sectors of the republic of Freedonia
... made gains in both the finance/banking industries and in the defence-related public sector Whereas some 125 000 women worked in finance and banking institutions in 1975, the number increased to ... answer: The two decades between 1975 and 1995 brought significant changes in the representation of women in Freedonia's work force, according to the graphs In 1975, for example, some 300 000 men and ... worked in the communications sector Twenty years later, though the number of men remained unchanged, the number of women rose to 550 000 A similar situation was seen in the wholesale and retail...
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Health Care Quality and Disparities in Women: Selected Findings From the 2010 National Healthcare Quality and Disparities Reports potx
... quality and progress on reducing disparities with respect to certain services, geographic areas, and populations, including: • Cancer screening and management of diabetes • States in the central ... quartile In all years, Asian/Pacific Islanders had higher rates than Whites 3 l The achievable benchmark could be attained overall and by most racial/ethnic and income groups in about years Whites and ... quality and access are suboptimal, especially for minority and low-income groups Information about health care delivery and systems are presented in the chapters about Patient Safety, Timeliness,...
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Boom and Bust in Australian Screen Policy: 10BA, the Film Finance Corporation and Hollywood‘s ‗Race to the Bottom‘ ppt
... evasion scandals and the rising cost of the 10BA provision led to the winding back of the 10BA subsidy from 1988 With the taxpayer as the overwhelming funder of Australian production, the production ... Entertainment in 1989, and Matsushita Electric Industrial Company‘s $USD6.9 billion deal for MCA in 1990 - shook up the industry and foreshadowed the mid-1990s merger waves in media, finance and investment ... mandate as a new screen funding institution, the FFC operated from the beginning in an environment of conceptual continuity with past government screen policies With the demise of the 10BA financing...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... clarify the mechanisms underlying the efficacy of endocannabinoid-bases therapies In this report, we have addressed the role of AEA in regulating 1) VCAM-1 expression in brain endothelial cells infected ... of staining intensity (Figure 3D) The increased anandamide tone limits microglial activation in mice infected with Theiler’s virus The intracranial injection of Theiler’s virus induced an increase ... is elevated on blood vessels and in reactive astrocytes distributed closely around them suggests the synthesis of AEA by brain endothelium in MS [43] In other models of brain injury 2-AG has...
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