... contributions GSvB and JR produced cultures of DRG neurones and established the co -culture system They also carried out the labelling of neurones MH, CR and RB induced the antigen-induced arthritis and produced ... produced the cultures of FLS cells, carried out the ELISA study and collaborated in establishing the co -culture system HGS was involved in planning the study andthe preparation ofthe manuscript ... addition of either PGE2 [43] or IL-6 [46] to theculture medium, we measured the concentration of PGE2 and IL-6 in the Page of 12 (page number not for citation purposes) Arthritis Research & Therapy...
... nucleotides 10 and 11 ofthe guide strand [Hammond et al., 2000; Elbashir et al., 2001] The identity of both the guide strand and passenger strand is determined by the thermodynamic stability ofthe 5’ ... Next, 25µL ofthe cocktail was then transferred into the individual well ofthe 96-well plate ofthe PCR array, andthe recommended thermal cycling profile was run on the Applied Biosystems™ ABI ... inhibitors The released RNA will then be bound to the membrane at the base ofthe spin column The efficiency ofthe binding was further enhanced by the presence of carrier RNA, buffering conditions and...
... consultation with the Director of 20 the Office of Research on Women’s Health and with the 21 advisory council for the Institute 22 ‘‘(b) RESEARCH, TRAINING, AND INFORMATION AND 23 EDUCATION.— ... INSTITUTE OFENVIRONMENTAL HEALTH SCIENCES; AWARDS FOR DEVELOP- MENT PLINARY RESEARCH CENTERS REGARDING WOMEN’S HEALTH AND DISEASE PREVEN- TION AND OPERATION OF MULTIDISCI- Subpart 12 of part C of title ... multidisci16 plinary research on environmentalfactorsthat may be re17 lated to the development of women’s health conditions (as 18 defined in section 486) The Director ofthe Institute shall 19 carry...
... cases of cancer in the UK (approximately 134 000 new cases in 2010), and about 50% of all cancer deaths Most of these cases of cancer (excluding a few thousand due to the natural background of ionising ... appearing in the articles and advertisements herein are the responsibility ofthe contributor or advertiser concerned Accordingly, Cancer Research UK, the publishers, the editorial committee and their ... clearly identified in the print and online contents ofthe journal with a BJC OPEN logo Each paper will also carry the BJC OPEN logo and details ofthe precise terms ofthe licence that applies to...
... mass may be one ofthe determinants that mediate the association between excess body mass and joint abnormalities, such as the reduction in cartilage volume andthe presence of cartilage defects ... over the course ofthe study Assessment of physical activity is further complicated by the different features of physical activity, including the type, intensity, frequency and duration, thatcan ... examined the relationship between obesity and knee OA and found that joint alignment mediated the effect of obesity on knee OA These studies not only highlight the effect of knee alignment on the...
... order to obtain the was merged with the reproductive file mentioned previously registration number ofthe sire ofthe cow and birth date ofthe cow As a consequence of this process, the new data ... because the value of Rg depends on the quality ofthe data set However, great differences were not observed Our point of view is in favor ofthe results obtained through the EBV, ofthe sire, ... including age and herd-year-season of calving (natural trimester); s is as vector of random sire effects and e is a vector of random residuals, and X and Z are incidence matrices The following...
... Axes of two-dimensional plots are derived from (A) PC-1 and PC-2, (B) PC-1 and PC-3 These factors were chosen for the best visualization of field and genotype separation and include 50% ofthe ... perception and texture In the first case, approaches that allow modulation ofthe expression of genes involved in sugar and acid biosynthesis should be designed In the second case, candidate genes ... components were obtained that explained approximately 80.3% ofthe variability in the dataset The first two factors explained about 38% ofthe variation in the data, with the first component alone...
... The study protocol was approved by the Departmental Ethics Committee ofthe University Children's Hospital and by the Government Ethics Committee ofthe State of Berne, Switzerland Parts ofthe ... interpretation of data and manuscript revision UF took part in the interpretation of data and revised the draft SG performed the CF mutation screening, took part in the interpretation of data (especially ... combinations of infection The impact of different types of infection on progression of lung function is shown in Figure Age andthe most frequent types of infection were taken as fixed effects and the...
... and characterizing environmental risk factors for atopy (including onset and length of period of exposure) make these studies a challenge Very high numbers of affected and unaffected subjects ... polymorphisms in candidate genes for asthma/atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate ... expected by chance, linkage ofthe particular marker and disease can be assumed, indicating thatthe chromosomal region containing the genetic marker also contains a gene that contributes to disease...
... cutoff of L1.5, and verified with Tukey‟s method (Tukey, 1977) These outliers fell outside of values 1.5 times the interquartile range below the first quartile (25th percentile) and above the ... explored and explanations were attempted by controlling for the available variables in the database Another important aim ofthe study was to identify maternal factorsthat significantly affect ... previously, many factorscan directly affectthe well-being ofthe infant even at developmental stage while in mother's womb Therefore variables with regards to maternal factorsthat were collected...
... cutoff of L1.5, and verified with Tukey‟s method (Tukey, 1977) These outliers fell outside of values 1.5 times the interquartile range below the first quartile (25th percentile) and above the ... explored and explanations were attempted by controlling for the available variables in the database Another important aim ofthe study was to identify maternal factorsthat significantly affect ... previously, many factorscan directly affectthe well-being ofthe infant even at developmental stage while in mother's womb Therefore variables with regards to maternal factorsthat were collected...
... related to alcohol and drugs The fallers reported that they were under the influence of substances (alcohol/drugs) that may have affected their balance in 9% ofthe falls The average (median) ... reported by 46 participants (52%) The number of falls ranged from to 5, with 31% of participants falling once and 21% falling more than once (Fig 3) Ofthe participants that reported a fall, the average ... entered the following as examples of ‘other causes of falls’ (15% ofthe falls): pestering someone next to me, trying to pick up a document off the printer, pushing a car out ofthe snow, and jumping...
... another For instance, one ofthe primary factorsthat threatened adherence to model fidelity was the conflict between requirements ofthe funders ofthe sites andthe fidelity requirements ofthe ... related to the implementation outcomes These include factors such as the available workforce, the geographic size of their catchment area, andthe degree to which the infrastructure of their host ... describe here thefactorsthat are either contributors or obstacles to the successful first year start-up, organized by the three start-up outcomes that varied across sites All ofthe sites were...
... infer the plans ofthe questioner (Q) So R is the observer, and Q the actor Building on the analysis of plans as mental phenomena, we can say that, if R believes that she has inferred Q's plan, there ... thatthe plan she has inferred is invalid, s The type of any invalidities, defined in terms ofthe clauses of (PI) that contain the discrepant beliefs, can be shown to influence the content of ... true if and only if the act of G doing a at t is ezecutable, andthe relation G E N ( a , / / , G , t ) is true if and only if the act of G doing a at t generates the act of G doing// at t The function...
... with the basic goals ofthe Directive (see above), with Article and Annex II ofthe Espoo Convention or with the special requirements of other EU environmental norms (see namely Article 6.4 ofthe ... right ofthe public to participate in the screening and scoping procedures and enable the public to legally challenge the screening decision b) Necessity to assess the entirety ofthe project and ... Labem city andthe edge ofthe SPA Meanwhile, development consent for another section was issued which led the highway to the borders ofthe SPA from the other side Necessary changes: The Directive...
... angiostatic factorsThe aim ofthe present study was to analyze whether a decrease ofthe angiogenic factors VEGF and bFGF and an increase ofthe angiostatic factor endostatin contribute to the impaired ... capacity andthe presence of teleangiectasias and other skin ulcers was found Discussion The process of angiogenesis appears to be largely impaired in SSc following the profound disarrangement ofthe ... might, on the other hand, contribute to the progression and severity of SSc Tissue edema ofthe distal extremities in particular, resulting in ‘puffy digits’, is a typical feature ofthe early...
... receptor is not physiological, and second, the delineation ofhuman lymphocytes into Th1 and Th2 subsets is considerably less precise than thatofthe mouse The consequences upon CD26 of activation ... resorption of both cartilage and bone The damaged synovial cells themselves release cellular components that mimic wound healing, leading to the further recruitment of immune cells The predisposing factors, ... were significantly reduced as the arthritis developed [55] The severity ofthe induced arthritis was significantly increased in CD26-/- knockout mice, but in the complete absence of CD26/DPPIV,...
... assays and participated in the design ofthe study LF coordinated blood and milk sample collection and processing, and participated in the design ofthe study MR participated in the design ofthe ... similar age distribution at the start ofthe study at 8, 14, 26 and 54 days of age Infants classified as late transmission ranged from 7– 54 days of age at the start ofthe study All females continued ... profile of rapid disease progression in SIV-infected macaques has been reported and characterized by others [34-36] From these observations it can be hypothesized thatthe same host responses that...
... potential risks for the development ofthe aquaculture enterprises Therefore, the identification offactors affecting the competitive advantage ofthe aquaculture enterprises in the northern region ... analyze the relationship offactors affecting the competitiveness of aquaculture SMEs in the north of Vietnam Identify and measure how these factorsaffectthe performance of aquaculture SMEs To formulate ... to improve the competitiveness of aquaculture enterprises in the North of Vietnam Significance of study The results of this study are the picture ofthe factual situation ofthe Small and Medium...