complete the sentence with the correct form of the adjective sebastian es
Tài liệu Supply the correct form of the verbs1 docx
... live in a snake.14. My brother managed to kill the snake just at the time when I were almost exhausted. Supply the correct form of the verbs1. Cats could fly if they (have) wings.2. If Peter ... (not,want) to live in a snake.14. My brother managed to kill the snake just at the time when I (be) almost exhausted. Ifhe (be) a little late, I (kill) by the snake.15. Had I know you were ill, ... snake.14. My brother managed to kill the snake just at the time when I (be) had been almost exhausted. If he (be) had been a little late, I (kill) would have been killed by the snake.15. Had...
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Báo cáo khoa học: The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of b-glucosidase docx
... after indirect immunofluorescence staining, as described inMaterials and methods. In the merged images, yellow denotes the colocalization of the two proteins, indicative of their lysosomal locali-zation. ... c-octyldeoxynojorimycin[33]. As a result of the very low level of GCase activityin the L444P fibroblasts, alternative methods weredeveloped to reduce the amount of IFG in the assay,thereby increasing the overall ... measures of dis-ease (e.g. reduced spleen weight, GC and plasmamarkers) were observed in only one of the 18 patientswho completed the study. The results of this trial pro-vide preliminary proof -of- concept...
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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning mutagenesis of the N-terminus of the V1aR; this revealed that a single residue(Arg46) ... ([R46A]V1aR) are presented in Fig. 2B. The degree of perturbation of second messenger generationwas dictated by the identity of the residue present at position46, with the EC50for AVP-induced ... precursors of oxytocin [1]. The receptors that mediate the effects of thesehormones are G-protein coupled receptors (GPCRs) andinclude the isotocin receptor, the mesotocin receptor, the oxytocin...
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Economic Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU – doc
... limited, representing just 7% of global dairy Overview of the EU dairy sector - 7 - Besides the differences in the number of dairy cows between the MS, the number of dairy cows also varies significantly ... EU-15. This excess supply makes the net trade position of the EU-27 stronger towards the Rest of the World. Within the EU there is a quite heterogeneous picture, since most of NMS and several ... purposes, results remain of a technical nature (i.e. ex-post behaviour of the model to policy changes in the baseline) and are therefore also not further commented in the report. The results of...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... translation suppression.Moreover, phosphorylation of the RS motif modulates the ability of the N protein to form SGs.RS motif deletion induces the N protein to form large RNP complexes The SARS-CoV ... complexes was calculated as 100 · (arbitrary unit of each band in individual lane divided by the unit of the unbound RNA detected in the absence of the N protein). The results are representative of ... La Jolla, CA, USA); the sequences of thesemutants were verified. The cDNAs encoding the N-terminal(residues 1–214) and C-terminal (residues 215–422) domain of the N protein and N-6A and N-14A...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... between the projection of the tilt of the z axis on the xÂ,y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes. The orientation of the ... that the Pe Hb possesses a limited flexibilitythat involves the position of the B-helix, as alreadywitnessed by the facility with which the position of the B-helix and FG corner accommodates perturbations ... are within the uncertainties of the respective determinations (not shown). The tilt of the major magnetic axes is correlated with Fe-CN tilt [8,28,30] (with the negative z axis), and indicates...
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Báo cáo khoa học: Structure of the exceptionally large nonrepetitive carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-82164 doc
... position 2. The substitution positions of all the other monosaccharideswere confirmed by GC-MS data of the methylated productsto be as presented in Scheme 1.Deamination of the products of complete ... correlating with H6 of GlcN and H1 of Ara4N). The residue of Ara4N1P was lost after KOH deacylationand therefore was not present in oligosaccharides 1–3. The NOE spectra of oligosaccharides 2, 3,and7a,bcontained ... lacking the terminal glucose residue. The largest structure of the carbohydrate backbone of the LPS that could be deduced from experimental results consists of 25 monosaccharides (including the previously...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
... Aggregation of the NR1FAD/NADPH domain was much less extensive in the absence of cofactor reduction.Stopped-flow kinetic studiesReduction of the FAD/NADPH domain of NR1 wasinvestigated by ... detail the redoxand electron transfer properties of the component flavin-binding domains of protein NR1. These studies haveenabled us to make detailed comparison with equivalentstudies performed ... determination of the FAD potentials,titrations of the NR1 FAD/NADPH domain were per-formed on samples of identical concentration over smallranges (100–150 mV) of the potential range, moving on to afresh...
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Báo cáo khoa học: Structure of the O-polysaccharide fromProteus myxofaciens Classification of the bacterium into a newProteusO-serogroup pptx
... 2.01–2.10.These data together suggest that the tetrasacchariderepeating unit of the polysaccharide consists of two residues of GlcNAc and one residue each of GalNAc, GlcA andAlaLys. The 1Hand13C ... monosaccharides at d 72.9, 74.8, 61.9, and 62.1,respectively [26], demonstrated the modes of glycosylation of the monosaccharides. The linkage positions were confirmed and the sequence of the monosaccharides ... LPS)[5,6]. The serological specificity of the bacteria is definedby the structure of the O-specific polysaccharide chain(O-antigen) of the lipopolysaccharide. On the basis of the O-antigens, the strains...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... polypeptideYield % of 1-218Fig. 1. Expression of the c ECD variants. (A) Schematic representa-tion of the various c ECD constructs. The drawings depict the poly-peptides with their tags ⁄ epitopes; the additional ... report, we present the expression and charac-terization of the ECDs of the b, c and e subunits of the human muscle AChR. We describe their expressionin a soluble, glycosylated form and in satisfactoryamounts ... results inhigher expression of the mouse muscle a ECD [21]. Totest the effect of these additional epitopes ⁄ tags on the yield of the present proteins, we constructed a set of eight human c ECD variants...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
... in the light of our results. The presence in vitro of a less stabledimer in the mutant PufXD2)7neither affects the photo-synthetic capability of the bacteria nor the efficiency of exchange of ... an inhibitory effecton the formation of the LH1 complex. This result suggeststhat the central core of the PufX protein is responsible of the break in the continuity of the LH1 ring in vivo [14], ... sphaeroides demonstrated the role of the C-terminal amino-acid residues of the LH1 apolypeptide in the organization of the LH1–RC complex[12]. In the present work, we have investigated the possible...
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Review of the Literature Regarding Critical Information Needs of the American Public
... opportunities; and to fully participate in the civic and democratic lives of their communities should they choose. To meet these needs, communities need access to the following eight categories of essential ... specifically addresses the differential access to resources in the city, and the “neighborhood effects” of layers of resource distribution. Urban studies and urban planning address the changing ... each of these literatures for studies that bear on our eight core areas of critical information needs. Rarely, studies spoke directly to these needs per se. More often, the literature addressed...
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Báo cáo sinh học: " Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein" docx
... literature, the present set of experiments confirms that the LLP domains present in the TM portion of the Env protein of HIV-1 form amphipathicα-helical structures in the presence of a 10% POPG: ... http://www.virologyj.com/content/4/1/123Page 5 of 14(page number not for citation purposes)LLP peptides form α-helices in the presence of lipidFigure 2LLP peptides form α-helices in the presence of lipid. Circular dichroism ... compared the Tb3+/DPAfluorescence of the peptide-treated wells to that of wellscontaining the same amount of untreated vesicles and towells containing vesicles that had been lysed with the detergent...
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