clinical trial update for nonviral vectors in cancer gene therapy
Báo cáo khoa học: "Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia" doc
... implantation in a controlled clinical trial of CHD The treatment effect for gold bead implantation is given in the blinded trial versus the open treatment trial Pain signs of canine hip dysplasia ... regarding gold bead implantation for their dog in a clinical controlled therapy trial of 80 dogs with canine hip dysplasia The two opinions of the owner were requested at the end of the month trial ... performing a double blind trial, in which neither patient or owner nor physician or veterinarian are aware of which treatment the patient or animal is receiving The first study to include blinding...
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Báo cáo y học: " Bedside adherence to clinical practice guidelines for enteral nutrition in critically ill patients receiving mechanical ventilation: a prospective, multi-centre, observational study" doc
... in 19 ICUs in France (see acknowledgements for complete list of participating centers) In early 2008, the Clinical and Epidemiology Research Commission (CERC) of the French-speaking Society for ... receiving mechanical ventilation and without contraindication to initiation of enteral nutrition (e.g., gastrointestinal bleeding, ileus, suspected perforation, abdominal surgery, prone positioning) ... especially the gastrointestinal tract status (vomiting, diarrhea, or abdominal pain or distension) Our study was not designed to evaluate gastrointestinal tolerance to enteral feeding, because such...
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Báo cáo sinh học: " Clostridial spores as live ''''Trojan horse'''' vectors for cancer gene therapy: comparison with viral delivery systems" pptx
... trailed in the clinic setting for various cancers, accounting for 66.6% of all gene therapy trials in humans [2] This has reflected the fact that cancer has become the leading causes of death in Western ... not triggered in normal cells containing wt-p53 following gene transfer Based on these preclinical studies a number of p53 gene repair clinical trials have been initiated These trials have used ... fragments, but in case the foreign gene is integrated in the host chromosome there is in fact unlimited capacity for insertion of therapeutic genes, forecasting the promising future for the development...
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Báo cáo Y học: In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors pdf
... shown in Fig The packaging system contains the self-inactivating transducing constructs (sin) obtained Fig Diagram of lentiviral vector carrying the human IDUA cDNA Gene transfer vector includes ... subcloned into plasmid pRRLsinPPT.CMV.WPRE after double digestion of this vector with MscI and MluI to obtain the self inactivating (sin) gene transfer construct PRRLsinPPT.CMV IDUA.WPRE The packaging ... cross-correction of co-incubated, untransduced cells Lentiviral vectors have been shown to effectively transduce genes into a range of both dividing and nondividing cell types, including neurons, retinal cells,...
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Báo cáo y học: " Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy" pps
... against other invading pathogens and succumbs to opportunistic infections There is a great deal of progress in the area of stem cell gene therapy for AIDS [12] A primary goal of many ongoing ... control for 30 minutes at 4C before staining with the respective cell surface marker antibodies Isotype control staining was used to determine background levels FACS analysis was performed on ... consistent in replicative experiments The transgene GFP expression was also maintained during the differentiation of hES cells into mature macrophages GFP expression in Page of 11 (page number not for...
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Human pluripotent stem cell derived cellular vehicles for cancer gene therapy
... gene therapy strategy for clinical trials (Michael Edelstein, 2012) Figure 1.1 Percentage of each gene therapy strategy for clinical trials (Michael Edelstein, 2012) 1.1.2 Gene carriers for cancer ... undergo clinical trial in 1998, carries two mutations in the viral E1B-55kDa gene (Kirn, 2001) The E1b-55kDa protein is responsible for binding and inactivating p53 in infected cells and required for ... Chapter Introduction 1.1 Gene therapy in cancer treatment 1.1.1 Gene therapy strategies for cancer treatment 1.1.1.1 Suicide gene therapy 2 1.1.1.1.1 Herpes Simplex Virus Thymidine Kinase/Ganciclovir...
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Báo cáo khoa học: "In vitro and in vivo gene therapy with CMV vector-mediated presumed dog b-nerve growth factor in pyridoxine-induced neuropathy dogs" pot
... Mata M, Fink DJ In vivo gene therapy for pyridoxine-induced neuropathy by herpes simplex virus-mediated Presumed dog β-NGF gene therapy in vitro and in vivo 373 gene transfer of neurotrophin-3 Ann ... determine the effect of the cytomegalovirus (CMV) vector-mediated gene transfer of the pdβ-NGF in vitro and gene therapy using recombinant pdβ-NGF plasmid in the dog model, having pyridoxine-induced ... nuclei and eosinophilic cytoplasm (arrows) in a few neurons in the gene therapy group H&E stain, ×200 disrupted with vacuolation in the positive control group (Fig 3B) In the gene therapy group,...
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Báo cáo sinh học: "Long term physiologic modification using rAAV in utero gene-therapy" doc
... flanked by viral inverted terminal repeats which are 145 bases in length and form a T-type configuration [10] Interestingly, rAAV vectors only need the inverted terminal repeats in cis for replication, ... expressed using the host cell's machinery [16] This feature is important in gene therapy because it could allow for a single injection of a therapeutic gene without the need for re-administrations ... Glorioso JC, Naldini L: Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics Nat Med 2001, 7:33-40 Bueler H: Adeno-associated viral vectors for gene transfer...
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COMPARISON OF CYTOSINE DEAMINASE 5 FLUOROCYTOSINE VERSUS HERPES SIMPLEX VIRUS THYMIDINE KINASE GANCICLOVIR ENZYME PRODRUG SYSTEMS IN GLIOBLASTOMA GENE THERAPY
... promising new cancer therapy approach, gene therapy is a technique which involves introduction or removal of genes within cells to treat diseases Since the first clinical trial involving human gene ... (Merilainen et al., 2005) HSVtk gene therapy has gone through clinical trial and the phase I 11 clinical trial protocols have been conducted The first clinical trial was performed by Klatzmann in ... Gene/ Prodrug System Used in Gene Therapy Gene therapy is one of the most promising new frontiers in medical therapeutic intervention, especially in tumor therapy Currently used applications in...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
... patient to play in standing or in sitting position to improve balance control in both conditions In standing position the patients are required to maintain their soles on the WBB In sitting position, ... three main goals in mind: obtaining a valid and adaptive system for the balance rehabilitation of the patients, achieving a system that reinforces the motivation of the patients during the rehabilitative ... control trials [8], they demonstrate the feasibility of the application of VR technology in this clinical field In regard to standing balance, systems based on force platforms are particularly interesting,...
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Báo cáo y học: "Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy" pptx
... myelin proteins involved in the maintenance of myelin multilamellar structure, such as myelin protein zero and peripheral myelin protein 22 These actions may result in the protection and regeneration ... myelin proteins [36,37] and/or indirectly to regulate myelin formation by influencing gene expression in neurons and may promote neuroregeneration by several different actions by reducing inflammation, ... finger-wrist; M4 ring fringerwrist) and ulnar (U4 ring finger-wrist) nerves are determined The difference between U4-M4 SCV is also calculated Skin temperature was maintained > 32°C with an infrared...
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Báo cáo y học: " Treatment of forefoot problems in older people: study protocol for a randomised clinical trial comparing podiatric treatment to standardised shoe advi" potx
... recruitment) Finally, all people visiting the general practice (for any reason) will be informed about the study by putting up posters in the waiting area of the GP clinics inviting patients to ... entrance examination will be made available to the expert panel Sample size There are no evidence-based estimates for clinically important change in assessing forefoot pain or for Page of clinically ... between interventions for chronic foot pain In a previous study it was estimated that a reduction of approximately two points on an 11point pain intensity numerical rating scale represents a clinically...
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báo cáo khoa học: " IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT): Cluster randomised controlled trial study protocol" pps
... is expected for patient participants included in this trial [38] It is common in trials assessing the effectiveness of interventions aimed at increasing the uptake of evidence in clinical practice ... 54 55 56 57 58 59 60 61 62 King DW, Hazelwood M: Quantifying Gains in Data Quality for Sampling Plans Used in Clinical Trial Monitoring Drug Inf J 2003, 37:135-141 King DW, Lashley R: A quantifiable ... to their practice being included in the trial Individual GPs will be excluded if they work at more than one of the general practices included in the trial Patients attending enrolled practices...
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Báo cáo y học: "Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia" potx
... scale that consists of a semi-structured interview administered by a trained clinician and provides information on symptoms and functioning during the preceding weeks Each item is scored Page of ... treatment In this instance, the later time point was chosen because for many of the patients in this study, weeks represented the interval between injections, and was therefore the earliest point at ... baseline-to-Week 12 improvement across all functional subdomains of the Schizophrenia Objective Functioning Instrument, a validated functional measure including subdomains of living situation, instrumental...
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báo cáo khoa học:" Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial" pot
... Group Figure Illustrates marked increase in levels of CIC in precancer (OSMF/L) and cancer groups Illustrates marked increase in levels of CIC in precancer (OSMF/L) and cancer groups as comapred to ... immunological response leading to inflammation and tissue injury [22] High levels of copper in areca nut, a major etiological factor in OSMF plays an initiating role in stimulation of fibrogenesis by up regulation ... Leukoplakia rationale for diagnosis and prognosis of its clinical subtypes or "phases" Quintessence Int 1994, 25:133-140 Chen J, Eisenberg E: Changing trends in oral cancer in United States 1935–1985...
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báo cáo khoa học:"The WRITTEN-HEART study (expressive writing for heart healing): rationale and design of a randomized controlled clinical trial of expressive writing in coronary patients referred to residential cardiac rehabilitation" docx
... [11] confirms the breath of current interest in the expressive writing paradigm and invites to look forward at the many remaining frontiers in Expressive Writing research One of the boundary conditions ... and clinical researchers who, beginning in the 90s and going on until nowadays, have started to use the expressive writing procedure with their patients and to examine its effects empirically in ... consist in four 20-minute writing sessions that will occur during the hospital stay within a 2-week period and that will be scheduled twice a week for each participant Writing instructions for the...
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Báo cáo y học: "Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough" potx
... antagonists-2 trials Th2 cytokine inhibitor-1 trial Theophylline-1 trial Nedocromil sodium-2 trials Chronic Bronchitis N = trials, 731 subjects Epinastine-1 trial Ipratropium bromide-1 trial Theophylline-1 ... Theophylline-1 trial Iodinised glycerol-2 trials Low dose Nacetylcysteine-1 trial Budenoside-1 trial COPD N = trials, 8013 subjects Fenspiridine-1 trial Fluticasone-1 trial Formoterol-1 trial Neltenexine-3 ... Neltenexine-3 trials Helicidine-1 trial Oxtriphylline-1 trial High dose N-acetylcysteine-1 trial Salbutamol/Iprapropium bromide-1 trial Iprapropium bromide-1 trial Budenoside-1 trial Codeine-1 trial...
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Báo cáo y học: "Neuro Emotional Technique for the treatment of trigger point sensitivity in chronic neck pain sufferers: A controlled clinical trial" ppsx
... trigger points However, more extensive and clinically relevant outcome measures will be required for use in the interpretation of the effectiveness of this intervention in neck pain in the clinical ... reliability for the identification of trigger points Reeves et al [19] demonstrated a moderate degree of intra and inter examiner reliability in determining the location of trigger points In older ... explanation, the point of maximum tenderness was determined and marked with indelible ink Once marked, the pressure threshold was determined using a control point in a non- painful muscle in an unrelated...
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International Clinical Practice Guidelines for theTreatment of Acute Uncomplicated Cystitis andPyelonephritis in Women: A 2010 Update by theInfectious Diseases Society of America and theEuropean Society for Microbiology andInfectious Diseases
... met criteria for inclusion in the analyses The types of studies included randomized clinical trials and open label clinical trials Expert reviews were also incorporated into the final grade recommendation ... See text for details d Data on blactams data cited are derived from clinical trials examining second and third generation cephalosporins and amoxicillin-clavulanate See text for details Clinical ... once-daily oral fluoroquinolone, including ciprofloxacin (1000 mg extended release for days)or levofloxacin (750 mg for days), is an appropriate choice for therapy in patients not requiring hospitalization...
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