... (Group 3) and 18 WKY (Group 4) were randomly divided into three groups (6 rats per group): (1) ischemia with PZH treatment, (2) ischemia control and (3) sham operation control In the ischemia ... Groups 3A, 3B and 3C), WKY (i.e Groups 4A, 4B and 4C) and SHRsp (i.e Groups 5A and 5B) rats after ligation (with and without PZH treatment) or sham operation The WKY (F = 7.55, P = 0.005) and SHR (F ... assay results in SHR and WKY Cell death assay results in (1A) hippocampus and (1B) cerebellum samples from sham operation, ischemiaandischemia with PZH treatment groups of WKY and SHR two weeks...
... statistical analysis and drafted the manuscript RR participated in the study design and coordination and helped to draft the manuscript JR, JW, MF, AF, YR and OG helped to perform the study and draft the ... compromise between dissociated cell cultures and models using intact living animals as most neuronal and glial cells survive [27] and their cytoarchitecture and connective organisation are well preserved ... site and possibly at multiple other discrete sites of the GABAA receptor [49] The activation of GABA receptors has been shown to be neuroprotective in in vitro and in vivo ischemia models and...
... in paraffin blocks, and sections were stained with hematoxyline and eosin ANs and L3 roots were evaluated The numbers of the normal and degenerated axons were determined, and the ANs were evaluated ... appearance of the normal rabbit NR and ANs is shown in Figure Figure shows a histopathological representation of an NR and AN on the nonplegic side, and Figure shows a NR and AN on the plegic side The ... necrosis, neuronal and axonal degeneration in the DRG and sciatic nerves (SNs), and volume reduction in the AN on the plegic sides Discussion The peripheral nerves are supplied by ANs and innervated...
... neurodevelopmental disability and economic outcomes during mid-childhood Child Care Health Dev 2013; 39: 345–57 Bassan H: Intracranial hemorrhage in the preterm infant: understanding it, preventing it ... outcomes This is not in the least surprising if one thinks of how effective regular hand hygiene training and team training are in preventing infection, for example (10) A return to scientific ... of medicine at the Pediatric Hospital, Justus Liebig University Gießen and head of the Department of General Pediatrics and Neonatology No conflict of interest exists Translated from the original...
... people with and without stroke or health experts [8]) including the type and range of tool used; timing of elicitation between the event and the assessment; differences in age and gender; and the ... utility loss varied by age and time since stroke and ranged between 0.025 and 0.514 Our summary QoL weight estimate at 12 months was 0.19 and at years 0.25 (adjusted for age and population size) These ... as DALYs and QALYs for simplicity) per case ranged from Table 2: Quality Adjusted Life Years lost according to stroke subtype and gender Ischemic stroke Males N= 14 139 Intracerebral Hemorrhage...
... evaluation and participated in the study design and coordination EU performed the statistical analysis MR and MM participated in the experiments and data evaluation HA and GZ conceived of the study, and ... depending on the duration of the ischemiaand reperfusion period, just like in cardiomyocytes subjected to cardioplegia and reperfusion The longer the cardioplegia and reperfusion periods lasted ... cardioplegic -ischemia and reperfusion according to our routine cardioplegia regimen The impact on apoptosis was investigated selectively after ischemia or reperfusion analysing cytosolic calcium changes and...
... treatment but subject to ischemiaand reperfusion) and GdCl3 (treated and subject to ischemiaand reperfusion) groups Infarct size was also measured using this protocol and serves as a positive control ... myocardium or serum during ischemiaand reperfusion Rats were either treated with vehicle or GdCl3 either before 30 ischemiaand 120 reperfusion or a Sham procedure (Ischemia) and (Reperfusion) in ... time period that correlates with Ischemiaand Reperfusion in the Control and GdCl3 groups IL-8/CINC-1 was measured from the serum at 30 ischemiaand 120 reperfusion and from the tissue at 120 reperfusion...
... patients (30 and 36, or 29% and 37%, respectively, in AOX and placebo groups; P = 0.11); it was most frequent in the cardiac patients (P < 0.0001) and least frequent in SAH (2 in AOX and in placebo) ... Richling B: Extracerebral organ dysfunction and neurologic outcome after aneurysmal subarachnoid hemorrhage Crit Care Med 1999, 27:505-514 37 Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski ... leukocytes, and platelets were determined daily for clinical purposes, and aspartate amino transferase, alanine amino transferase, and urate were determined three times weekly using standard clinical...
... study was to examine how ischemia, with or without IPC and IPO, affects the expression of HIF-1a and the target genes VEGF and TGF-b1, in rodent liver Methods The surgical and experimental protocols ... Pharma, Birkerød, Denmark) and mg/kg Midazolam s.c (Dormicum, La Roche, Basel, Switzerland) and placed on a heated pad A midline laparotomy was performed and total hepatic ischemia was accomplished ... of ischemia IPC, IPC + 30 of ischemia IPO, 30 ischemia + IPO IPC+IPO, IPC + 30 of ischemia + IPO * indicates p ≤ 0.01 compared to group IRI ¤ indicates p = 0.065 compared to group IRI liver ischemia...
... accompanied by decreases in Glu and GABA on the ipsilateral side (Table 2) Effects of ischemia- hypoxia and ischemia- hyperoxia in the occipital cortex Both ischemia- hypoxia and ischemia- hyperoxia induced ... subjected to ischemia- hypoxia and ischemia- hyperoxia procedures Induction of hypoxia and hyperoxia against the background of ischemia After the ischemic injury, the rats of the young and aged subgroups, ... overall modest and variably different However, Table 6: Effects of ischemia- hypoxia and ischemia- hyperoxia in the hippocampus of aged rats Ischemia- hypoxia Metabolite Control Right Ischemia- hyperoxia...
... diagnosis of cerebralischemiaand those with artificial heart valves were excluded Complete clinical neurological examination, electrocardiogram, and sonographic examination of the extra- and intracranial ... between PFO and cryptogenic stroke has repeatedly been shown However, most studies included only small numbers of patients and thus did not allow to adjust the analysis for gender and age The ... for simultaneous insonation of both middle cerebral arteries (MCA) using simultaneous 64-point FFT and bigate technique An intensity threshold of = 11 dB and a time window of 20 seconds after the...
... H, and Battaglia FC: Hypernatremia and intracranial hemorrhage in neonates, N Engl J Med 291:6, 1974 Wigglesworth JS, Keith IH, Girling DJ, and Slade SA: Hyaline membrane disease, alkali, and ... Brown JK, and Maehin GA: Hyaline membrane disease, alkaline buffer treatment, andcerebral intraventric- ular hemorrhage, Lancet 1:117, 1976 Corbet AJ, Adams JM, Kenny JD, Kennedy J, and Rudolph ... solutions and IVH (P < 0.05) Sodium bicarbonate infusions andcerebralhemorrhage 835 Table I Clinical characteristics of infants with and without IVH IVH ] No of infants Birth Weight (gm) Mean...
... in defective endothelial cell junctions and intracerebral hemorrhage in the fish, reminiscent of both the slow, unpredictable blood leak and the frank hemorrhage associated with CCMs [30] The ... patients with sporadic CCM and those with familial CCM People with an inherited form of CCM have a larger number of lesions and more frequent sequellae, such as seizure andhemorrhage These features ... CCM is to understand the basic processes that have been disrupted, resulting in the vascular malformation Between observational and genetic studies in humans and biochemical and cellular studies...
... Health and Quality of Life Outcomes 2008, 6:109 Background Children and adolescents with cerebral palsy (CP) have permanent and non-progressive development disorders In spite of medical treatment and ... analyzed and assisted in interpretation of the results and formatted the manuscript CHMS and CARF conceived the idea, assisted in interpretation of the results and commented on drafts ACF and RRHA ... collection and assisted in interpretation of the results VOR and CHAR assisted in analyzing and interpreting the results RMCP analyzed and assisted in interpreting the data All authors read and approved...
... information and working memory capacity As a consequence, age differences emerge when demanding storage and processing of information are simultaneously required [21] Paper and pencil tests and ecological ... impairment, due to cerebral lesions, can influence Virtual Maze performance; and 3) to compare healthy subjects and patient performances Carelli et al Journal of NeuroEngineering and Rehabilitation ... age group A and she performed well in both tasks Page of 10 Results Healthy subjects All subjects succeeded in completing the P&P mazes Mean values and standard deviation (S.D.) of P&P and VR maze...
... He showed aphasia, motor impairment, and poor scores in fluency and verbal tests After a year of drug therapy (antihypertensive and antiaggregating agents) and logopedic therapy, this subject ... motor control and reaching tasks, and increased his AAT (Aachener Aphasie Test) score from 52/60 to 56/60 Measurement protocol We applied TCD and NIRS during baseline conditions and during CO2 ... filter, with ripple in the stop band, cutoff frequency equal to 50 mHz and at least 30 dB of discrimination) and set the initial concentrations equal to zero The O2Hb and CO2Hb concentration signals...
... Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia Brain Pathol 2000, 10:95-112 Iadecola C, Alexander M: Cerebralischemiaand inflammation ... in transient ischemia [12] In the model of transient focal ischemia, the time window of nimesulide's neuroprotection extends over a 24 h period [12], and in other models of cerebral ischemia, the ... intraluminal occluder had entered the anterior cerebral artery and occluded the origin of the anterior cerebral artery, the middle cerebral artery (MCA) and posterior communicating arteries [27] After...
... captured and processed in Adobe Photoshop 7.0 (Adobe Systems, CA) and were adjusted by using the brightness and contrast level and unmasking tools to enhance image clarity Maintenance of cell lines and ... stroke and their effects on infarct size andcerebral blood flow: A systematic review Free Radical Biology and Medicine 2005, 39:412-425 Brash AR: Lipoxygenases: Occurrence, Functions, Catalysis, and ... rat model of focal cerebral IR BW-B 70C demonstrated a neuroprotective role through inhibition of both 5-LOX and NF-κB It is a potent and a selective inhibitor of 5-LOX in vitro and in vivo with...