building the team based on stage of venture life
6 Secrets to Startup Success
... hundreds of these clients, I’ve noticed a consistent pattern over the years the unrelenting pace and compression of their lives, the politicization of their jobs, and the diminishing light in their ... awareness of how their founding role in the new venture will adversely impact their loved ones and their well-grooved lifestyle At the startup’s inception, they envision a thriving venture and ... employers further fuels startup aspirations The comic strip Dilbert and the hit TV show The Office are only two iconic examples of entertainment products poking fun at the absurdity of corporate life...
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AUTOPHAGY - A DOUBLE-EDGED SWORD CELL SURVIVAL OR DEATH? pptx
... concerning the significance of LIR motifs in additional components of the complex and the contribution of autophagy versus proteasomal degradation to cellular turnover of the kinase These inconsistencies ... complex, and the Atg12 and Atg8/LC3 conjugation systems [6] Upon starvation, inhibition of the protein kinase target of rapamycin (TOR) results in activa‐ tion of the Atg1/ULK complex, which is the most ... and probably also of autolysosomes [41] From the further specific localization of WIPI-1 and WIPI-2 upon the induction of macroau‐ tophagy, conclusions about the membrane origin of WIPI-positive...
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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
... 60% of those will be symptomatic [3] Clinical manifestations of OA of the knee include pain in and around the joint, stiffness of the joint, crepitation on motion and limited joint motion, among ... there are migrations of inflammatory cells in the synovial fluid Adhesion molecule expression on endothelial cells helps in the diapedesis of these cells Therefore, in order to determine whether ... identify mechanisms of actions of Aflapin: Effect on expression of ICAM-1 and MMP3 Adhesion molecule (ICAM-1) expression on endothelial cells: 20,000 Endothelial cell (HDMEC, Lonza Inc., USA) per...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... plot of the Lineweaver–Burk plot for determination of the mode of inhibition at various fluoride concentrations at pH The plots fit the noncompetitive inhibition mode The reaction solution contained ... bases The magnitude of the solvent isotope effect depends of course on the rate-limiting step in the reaction, which could include the protonation or deprotonation steps and ⁄ or the generation of ... calculating DHion, it is assumed that the deprotonation of the zincbound water molecule to the hydroxide nucleophile has a greater effect on the reaction rate than the protonation of the peptide bond nitrogen...
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Báo cáo Y học: Ribosome-associated factor Y adopts a fold resembling a double-stranded RNA binding domain scaffold potx
... to be trans based on the observation of the strong Hia À –Hid NOEs Potential hydrogen bonds were classified based on the identification of slowly exchanging amide protons All hydrogen bond acceptors, ... used to confirm the good quality of the structure Of the residues, 81.4% have backbone conformation in the most favored regions, and most residues in less favorable conformations are from the poorly ... in the range of the middle part of the second a helix Fourth, the part of the b sheet near the C-terminal regions of a helices is shorter in dsRBD, resulting in the a helices extending over the...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
... applicability of this assumption, the first stage was to explore the expression level of each of the mentioned regulatory sequences and then compare it to the combined expression level (from the two ... μg of LucSV40 and either (a) the concentrations indicated (Figure 11) of single-promoter constructs H19-DTA + P4-DTA in combination, or (b) the same amount of H19-DTA-P4-DTA as for one of the ... transfection of the double promoter construct The use of double promoter vectors was previously described [44] as a convenient tool for evaluation of the activity of a gene of interest by monitoring...
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báo cáo hóa học:" Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study" pdf
... continuation of randomization in case one of the patients needed to be excluded within the study period Surgical Protocol All patients received a combination of regional and general anaesthesia ... limb: involved and non-involved and test occasion: pre-surgery, months, months, months and 12 months) and one between factor (subject group: nandrolone and control) In the event of a significant ... interactions for the walking data Nevertheless, whilst the control group demonstrated only minor improvements throughout the testing cycle the nandrolone group improved steadily from weeks to months...
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báo cáo hóa học:" Anabolic steroids after total knee arthroplasty. A double blinded prospective pilot study" pptx
... continuation of randomization in case one of the patients needed to be excluded within the study period Surgical Protocol All patients received a combination of regional and general anaesthesia ... limb: involved and non-involved and test occasion: pre-surgery, months, months, months and 12 months) and one between factor (subject group: nandrolone and control) In the event of a significant ... interactions for the walking data Nevertheless, whilst the control group demonstrated only minor improvements throughout the testing cycle the nandrolone group improved steadily from weeks to months...
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báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt
... F1-041006-26099) The one modification to this questionnaire consisted of asking the patient to evaluate the two-week period prior to the examination The original answers obtained to the questions in the SF-36 ... [3,4] The first was the sum of all eight health concept scores; the second, known as the physical health component, was the sum of the physical components (role limitations due to personal problems, ... recommended substance on the evening of the randomization day and the last dose on the morning of the day of the evaluation In addition, patients continued taking stable doses of previously prescribed drugs...
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Báo cáo hóa học: " Fano-Rashba effect in thermoelectricity of a double quantum dot molecular junction" pptx
... In this study, the phonon thermal conductance of the junction, which is typically limited by the QDs-electrode contact, has been ignored in the case of the poor link for phonon transport Results ... The last feature is that one spin component of Seebeck effects can be tuned while the other spin component is retained The behind reason is that the behavior of the spin-dependent transmission ... Acknowledgements The authors thank the support of the National Natural Science Foundation of China (NSFC) under Grants No 61106126, and the Science Foundation of the Education Committee of Jiangsu...
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Báo cáo hóa học: " Research Article Hierarchical Convergence of a Double-Net Algorithm for Equilibrium Problems and Variational Inequality Problems" ppt
... norm, as t → The proof is complete Proof By Conclusions 1–4, the proof of Theorem 3.1 is completed 3.44 x∗ This is sufficient to 14 Fixed Point Theory and Applications Then 1.12 reduces to the following: ... needed in the argument of the subsequent sections Lemma 2.2 see 32 Let H be a real Hilbert space Let the mapping A : H → H be α-inverse strongly monotone, and let λ > be a constant Then, one has ... to the fixed point problem Find x ∈ C such that x projFix T · P x, 1.4 where projFix T stands for the metric projection on the closed convex set Fix T By using the definition of the normal cone...
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báo cáo hóa học:" Research Article ´ ¨ Sharp Constants of Brezis-Gallouet-Wainger Type Inequalities with a Double Logarithmic Term on Bounded Domains in Besov and Triebel-Lizorkin Spaces" pdf
... proposition above, the sharp constants for λ1 and λ2 in 1.7 are independent of the choice of the equivalent norms of the auxiliary space X Ω On the other hand, note that these sharp constants ... describe the organization of the present paper In Section 2, we introduce some notation of function spaces and state embedding theorems Section is devoted to proving the negative assertions of Theorems ... Section describes the affirmative assertions of Theorems 1.5 and 1.7 Section concerns the affirmative assertion of Theorem 1.9 In the appendix, we prove elementary calculus which we stated in Section...
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Báo cáo sinh học: " Research Article A Double S-Shaped Bifurcation Curve for a Reaction-Diffusion Model with Nonlinear Boundary Conditions" doc
... Value Problems in u The boundary condition 1.2 arises naturally in applications and has been studied by the authors of 1–4 , among others, in particular in the context of population dynamics Here ... 0, there exists a unique ρ0 > such that if ρ ≥ ρ0 then H ρ, ≥ and if ρ < ρ0 then H ρ, < In the second case, β ∈ 4, ∞ , the shape of H ρ, changes from that of the first case with the addition of ... bifurcates into the separate cases To conclude the section, we present the computational results for 1.10 by combining the solutions of 1.11 in Section 3.1 and 1.12 in Section 3.3 Theorem 3.6 For...
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Báo cáo hóa học: " Research Article A Double Inequality for Gamma Function" pot
... function,” Computers & Mathematics with Applications, vol 49, no 2-3, pp 389–406, 2005 10 H Alzer, On Ramanujan’s double inequality for the gamma function,” The Bulletin of the London Mathematical ... and monotonicity for the ratio of gamma functions,” Taiwanese Journal of Mathematics, vol 7, no 2, pp 239–247, 2003 12 H Alzer, On a gamma function inequality of Gautschi,” Proceedings of the ... differentiable function If f x > and 2f x xf x > or
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THIẾT KẾ HỆ THỐNG SẤY DẦU FO DÙNG CHO LÒ HƠI BẰNG THIẾT BỊ TRAO ĐỔI NHIỆT ỐNG LỒNG ỐNG SỬ DỤNG NĂNG LƯỢNG MẶT TRỜI DESIGNING A SYSTEM FOR DRYING BOILER FUEL OIL WITH A DOUBLE TUBE HEAT EXCHANGER DEVICE USING SOLAR ENGERGY pptx
... có nhiều collector bố trí thành dãy Qua tính tóan, kiểm tra so sánh, việc chọn panel có dạng song song để hấp thụ lượng xạ mặt trời hiệu Tấm hấp thu gắn vào ống hấp thụ cách đan xen dải nhỏ; Một ... Bảng Xác định lượng dầu thơ ( FO) tiêu thụ theo cơng suất hiệu suất lò NHIỆT TRỊ CỦA DẦU FO: 9800Kcal/Kg KHỐI LƯỢNG RIÊNG: 0,991Kg/m3 ; NHIỆT LƯỢNG TRONG KG HƠI: 663 Kcal ĐỘ NHỚT ĐỘNG HỌC: 180cSt( ... 15, 18 đóng lại, van 13, 17, 19, 23 mở nước dàn lượng mặt trời gia nhiệt cho tank lớn để dự trữ Trong trường hợp nhiệt độ mơi trường khơng đủ để gia nhiệt cho dàn trao đổi nhiệt ống lồng ống, lúc...
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Báo cáo y học: "Reproducibility and sensitivity to change of various methods to measure joint space width in osteoarthritis of the hip: a double reading of three different radiographic views taken with a three-year interval" pot
... dependent on the precision of the readers than on the radiographic view selected Although the three views examined in the present study offered comparable precision in the assessment of JSW, either ... a reduction of the number of patients required It would certainly permit a shorter duration of the trial (e.g two years instead of three) The present study shows that the precision of the measure ... progressors based on the pelvic view alone Using the pelvic or hip AP view, or combining one of them and the oblique view to assess structural modification in hip OA remains an option, depending on the...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
... function The pain, stiffness and function subscales of the WOMAC were converted to a to 100 normalized units (NU) scale [23] The pain subscale was the average of the first five questions of WOMAC ... completed the questionnaires, and partly due to the consumption of ibuprophen as rescue medication by more patients in the placebo group during the study Interestingly, at the end of the study ... effect of the test compound in OA patients Taken together, these observations further demonstrate that 5-Loxin® is potentially safe in the treatment of OA in humans Conclusion In summary, the present...
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Báo cáo y học: " Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind" potx
... throughout the operation for the next hours after termination of the cardiopulmonary bypass In group B, a solution of normal saline was administered in the same dose, way, and duration Both solutions ... infused at an infusion rate of 22 ml/h Neither the surgeon nor the anesthetist or any other in the operating room except from this nurse did know the kind of infused solution, in each patient ... observed in the number of patients requiring additive infusion of epinephrine While in the group of vasopressin only pts (20%) required additional infusion of epinephrine, in the group of placebo...
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Báo cáo y học: " A double shunt technique for the prevention of ischaemia of a congenital, solitary, pelvic kidn" pps
... bifurcation and the other from the proximal portion of the right common iliac artery (yellow arrows) Page of Figure The first shunt The axillofemoral shunt consisting of two 22 Fr femoral cannulas connected ... interposed, and the procedure was carried out without further difficulty The selection of the graft size was based upon the wide width of the aortic bifurcation The total time of renal ischaemia ... administration of antibiotics, allowing discharge on the ninth postoperative day There was no rise in renal retention values and no deterioration of the existing hypertension during 24 months of follow-up...
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Báo cáo y học: "Appearance of a double bubble in achalasia cardia: a case report" docx
... the double bubble after successful dilatation of the lower esophageal sphincter Red arrows indicate the presence of air in the colon Note the haustrations Black arrow indicates the presence of ... bubble in the gastric region adjacent to the previous one This phenomenon is an anticipated one Careful examination of the first air bubble, which was seen even before the dilatation was done, showed ... are seen in the colon This led us to the conclusion that the air bubble which was present before dilatation was indeed a colonic air bubble in the splenic flexure Therefore, the second air bubble,...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25