breast cancer screening and prevention options in brca1 and brca2 mutation carriers
European guidelines for quality assurance in breast cancer screening and diagnosis pot
... irregular’ screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... irregular’ screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... Pagina 26 EPIDEMIOLOGICAL GUIDELINES FOR QUALITY ASSURANCE IN BREAST CANCER SCREENING Table 11: Screening policy* Age group targeted Screening test* • Initial screening* • Subsequent screening* ...
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Factors infl uencing the risk of breast cancer – established and emerging ppt
... briefing will outline: The established risk factors for breast cancer, and The current thinking regarding the involvement of certain chemical exposures in breast cancer, and in particular, the ... smoke and breast cancer is clearly defined In the meantime, not smoking has other clear health benefits BREAST CANCER Factors in uencing the risk of breast cancer – established and emerging Other ... for breast cancer include radiotherapy treatment for Hodgkins lymphoma40,41, having dense breasts42, being taller than average 43 and having certain kinds of noncancerous breast disease44 In addition,...
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Breast cancer incidence and case fatality among 4.7 million women in relation to social and ethnic background: a population-based cohort study pdf
... Jensen and colleagues emphasizing the importance of early breast cancer detection in Sweden on decreasing breast cancer mortality [58] Our findings of higher breast cancer survival by increasing ... national breast cancer screening in the Netherlands 1997-2008 Eur J Cancer Prev 2010, 19:195-198 Page 13 of 13 62 Coughlin SS, Wilson KM: Breast and cervical cancer screening among migrant and seasonal ... diagnosed after age 50 or in 2001 to 2007 had higher breast cancer case fatality compared with corresponding native Swedes Our findings of increasing incidence [37-39] and improving survival [40] over...
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Báo cáo toán học: " Breast cancer screening in France: results of the EDIFICE survey" ppsx
... performing or not breast cancer screening 109 Int J Med Sci 2008, 110 Figure 3: Date of breast cancer screening implementation and observed screening rate Figure 4: Organized Breast cancer screening ... perceptions on screening methods, level of screening counselling, type of screening tests recommended, perception of obstacles to screening, and patients' expectations about cancer screening according to ... available cancer screening procedures (through organized programs or individual initiatives) and general practitioners’ (GPs) behaviour towards cancer screening [3] The EDIFICE results pertaining to breast...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ... design and coordination and helped to draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... BG: BRCA1/ BRCA2 germline mutations in locally recurrent breast cancer patients after lumpectomy and radiation therapy: implications for breast- conserving management in patients with BRCA1/ BRCA2...
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báo cáo khoa học: " Implementing academic detailing for breast cancer screening in underserved communities" pps
... that support breast cancer screening (e.g., computerized systems for tracking and reminding patients about regular screening tests) The subscale was developed and tested in previous prevention ... Nursing or other office staff and the delivery of preventive servicese Involving nursing or other office staff in tracking and prompting preventive care Involving nursing or other office staff in ... to breast cancer screening, it is more likely that advocacy groups active during the intervention period [39] and national controversies, including the evidence both in support of and contesting...
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báo cáo khoa học: " Implementing academic detailing for breast cancer screening in underserved communities" pptx
... that support breast cancer screening (e.g., computerized systems for tracking and reminding patients about regular screening tests) The subscale was developed and tested in previous prevention ... Nursing or other office staff and the delivery of preventive servicese Involving nursing or other office staff in tracking and prompting preventive care Involving nursing or other office staff in ... to breast cancer screening, it is more likely that advocacy groups active during the intervention period [39] and national controversies, including the evidence both in support of and contesting...
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Early and locally advanced breast cancer: diagnosis and treatment pdf
... found in Western Europe, including England, Scotland and Wales amongst people diagnosed in the early 1990s (Coleman, 2003) There are inequalities in survival for most cancers, including breast cancer, ... accompanied by a levelling off in incidence and a marked increase in survival This has been jointly attributed to the introduction of national screening and by improvements in treatment arising from the ... evidence • distilling and synthesising the evidence and writing recommendations • agreeing the recommendations • structuring and writing the guideline • updating the guideline The Guideline Development...
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Early and locally advanced breast cancer - Diagnosis and treatment pdf
... early invasive breast cancer and a high risk of local recurrence, following breast conserving surgery with clear margins and whole breast radiotherapy NICE clinical guideline 80 – Early and locally ... (2008) Cancer incidence in Wales Cardiff: Welsh Cancer Intelligence and Surveillance Unit NICE clinical guideline 80 – Early and locally advanced breast cancer Patient-centred care This guideline ... following breast screening or after presentation to a GP, diagnosis in the breast clinic is made by triple assessment (clinical assessment, mammography and/ or ultrasound imaging, and core biopsy and/ or...
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Báo cáo sinh học: "A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples" doc
... samples (including both healthy and baseline breast cancer patient volunteers) to obtain protein identification for peptide peaks of interest Thus in our platform, specific peaks of interest ... and stored under standard operating procedures in a clinical trial-like protocol Samples from healthy volunteers and breast cancer patient volunteers are included Follow up samples from the breast ... proteins and containing 697 proteins, was recently described [27] Our results confidently identify 306 of the proteins in this plasma protein reference set (44%) This indicates that protein identification...
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BREAST CANCER – CURRENT AND ALTERNATIVE THERAPEUTIC MODALITIES pdf
... HER2-overexpressing breast cancer Role of p27 and cdk2 in HER2-overexpressing breast cancer Trastuzumab induces G1 arrest by several mechanisms including increased expression of cyclin-dependent kinase inhibitor ... site binds hydroxyapatite in bones The CD44 interacts through the C-terminal of OPN OPN is involved in maintaining calcium homeostasis via its calcium binding site OPN upon binding with integrins ... OPN, integrin linked kinase (ILK), uPA and MMP-2 in murine mammary epithelial cancer cells was observed by blocking v3 integrin (Mi et al, 2006) OPN can interact with various integrins and the...
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BREAST CANCER – CURRENT AND ALTERNATIVE THERAPEUTIC MODALITIES pptx
... HER2-overexpressing breast cancer Role of p27 and cdk2 in HER2-overexpressing breast cancer Trastuzumab induces G1 arrest by several mechanisms including increased expression of cyclin-dependent kinase inhibitor ... site binds hydroxyapatite in bones The CD44 interacts through the C-terminal of OPN OPN is involved in maintaining calcium homeostasis via its calcium binding site OPN upon binding with integrins ... OPN, integrin linked kinase (ILK), uPA and MMP-2 in murine mammary epithelial cancer cells was observed by blocking v3 integrin (Mi et al, 2006) OPN can interact with various integrins and the...
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Báo cáo khoa học: "Reirradiation of recurrent breast cancer with and without concurrent chemotherapy" ppt
... Background Increasing numbers of breast cancer patients are treated with breast conserving surgery followed by systemic therapy and radiotherapy Failure rates after breast conserving therapy (BCT) increase ... stage and recurrence site are given in table Retreatment and statistical methods Resection was incomplete or undefined (R1 or Rx) in 7/ 29 One patient had inoperable axillary and upper mediastinal ... number; IMC: internal mammary chain; LN: lymph nodes Clinical characteristics of recurrent breast carcinoma patients treated with reirradiation The initial and recurrence TNM staging and site of...
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báo cáo khoa học: "Effects of ulinastatin and docetaxel on breast cancer invasion and expression of uPA, uPAR and ERK" docx
... Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Breast Cancer Res 2007, 9(1):R14 Nguyen DH, Hussaini IM, Gonias SL: Binding of urokinase-type ... binding to integrin a5b1 [3,16] Therefore, uPA-uPAR and ERK can activate each other through different pathways and form a positive feedback loop, thereby maintaining high proliferating and invasive ... proliferation and tumor growth of breast cancer cell was inhibited Combined treatment of ulinastatin plus docetaxel is more effective in anti-tumor invasion Therefore, the role of ulinastatin in the...
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BETWEEN TWO WORLDS: AN EXPLORATION OF PRIVACY MANAGEMENT ISSUES ARISING FOR FIRST-YEAR COLLEGE STUDENTS DEALING WITH A MOTHER‟S BREAST CANCER DIAGNOSIS AND TREATMENT
... fitting framework for analyzing the motivations, spoken and unspoken rules, and methods used in revealing or concealing information in each family who has faced breast cancer and the first year of ... navigate revealing and concealing this delicate information in their new environment Interface of Privacy Transitions in College and Parental Diagnosis of Breast Cancer The transition during the first ... Bell and Dr Gail Gráinne Whitchurch who took me under their wings from the beginning and who continually pour themselves into their students to help them succeed and grow in and out of the classroom...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
... transmembrane domain, and an intracellular domain that contains a catalytic tyrosine kinase domain and a carboxyl terminal tail Numerous sites of tyrosine phosphorylation within the tyrosine kinase and carboxyl ... frequent cancers affecting Singapore women, 2003-2007 Breast cancer is the top cancer type affecting the women in Singapore Data extracted from Singapore Cancer Registry, Interim Report: Trends in Cancer ... Chapter Introduction CHAPTER INTRODUCTION 1.1 Breast cancer 1.1.1 Incidence of breast cancer Breast cancer is the second leading cause of cancer deaths in women today after lung cancer and is...
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Breast cancer incidence after hormonal infertilitytreatment in Sweden: a cohort study
... disorders, ovulation induction, and incidence of breast cancer Arch Intern Med 2006;166:2484-9 16 Burkman RT, Tang MT, Malone KE, et al Infertility drugs and the risk of breast cancer: findings from the ... potential to increase estrogen and ultimately, progesterone in normal ovulating women, resulting in a possible increased risk of breast cancer One study found this increased risk confined to users ... reduction in tumor incidence and number of tumors, leading to the authors’ implication of a protective role in mammary carcinogenesis and a hormonal approach to the prevention of breast cancer. 35 In...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... of truncated BRCA1 or induce apoptosis in a cell line expressing mutated BRCA1 The data in Figs and suggest that TRAIL can alter BRCA1 localization and induce apoptosis in breast cancer cells ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia-induced changes in BRCA1...
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