bao cao toan van
Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
... reported inhibitors of HCV (see Introduction) include bis-benzimidazole analogues Particularly relevant are the 2,5,6-trihalogeno-1-b-D-ribosylbenzimidazoles reported as potent and selective inhibitors ... antiviral therapies Antiviral Chem Chemother 12, 261–272 Wang, Q.M & Heinz, B.A (2000) Recent advances in prevention and treatment of hepatitis C virus infections Prog Drug Res 55, 1–32 Crotty, ... ribonucleoside ribavirin is an RNA virus mutagen Nat Med 6, 1375–1379, Rosenberg, S (2001) Recent advances in the molecular biology of hepatitis C virus J Mol Biol 313, 451–464 Matusan, A.E., Pryor,...
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Báo cáo y học: "Lymphopenia and autoimmune diseases" pps
... population that keeps them in control In lymphopenia this balance is perturbed and the outgrowth of autoantigen-specific, proinflammatory T cells is facilitated by the depletion of the regulatory T-cell ... activators of the immune system, such as mycobacterial cell wall constituents (e.g complete Freud’s adjuvant), protected NOD mice from developing diabetes, indicating a correlation between increased T-cell ... numbers because of infusions of syngeneic excess T cells or immunization with complete Freud’s adjuvant The authors assessed cell surface receptors to distinguish between conventionally activated...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... Leukoc Biol 2003, 74:471-478 59 Liu Z, Geboes K, Hellings P, Maerten P, Heremans H, Vandenberghe P, Boon L, van Kooten P, Rutgeerts P, Ceuppens JL: B7 interactions with CD28 and CTLA-4 control ... regulatory T cells for therapeutic benefit With continued efforts, a better understanding and more advanced techniques will emerge Human systemic lupus erythematosus (SLE) patients and murine models ... immunological abnormalities The most pervasive of these include the generation of pathogenic autoantibodies In this regard, 98% of human SLE patients possess antinuclear antibodies and 50 to...
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Báo cáo y học: "Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report" doc
... treatment and its risk including development of autoantibodies, and autoimmune diseases needs to be balanced against its benefits The development of autoantibodies and lupus-like features in patients ... ascites with liver decompensation led to repeated paracentesis In HIV, the risk of developing autoantibodies and autoimmune disease depends on the time in the disease course and may be stratified ... both contribute to dysregulation of immune responses and favour autoimmunity HIV can increase autoantibodies through non-specific stimulation of B-cells [8] and viral and mammalian DNA can trigger...
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autoimmunity and autoimmune diseases
... autotoxicus“ Normal process – eliminate self antigens (aggrieved or inappropriate) autoreactiveT-cells autoantibodies Self tolerance lack of immune responsiveness to an individual´s own tissue antigens ... hypersensitivity Antibody (IgM or IgG) directed mainly to cellular antigens (e g on ERYTROCITE) or surface autoantigens can cause damage through - opsonization - lysis by complement - antibody dependent cellular ... molecules are strongly expressed on B cells and synovial lining cells It is thought that the autoantigen is presented to T cells at this site and that AutoAbs production results in immune complex...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"
... reported lower with initial levels of HCV RNA >600,000 IU/ml, male gender, high body weight, and advanced liver fibrosis (11-17) Recent studies have also shown a poorer response to treatment associated ... the groups and deciding among the investigators clinical importance From the data, clinically relevant cut-offs determined by the investigators were as follows: for weight loss (more than kilograms.), ... infected with genotype 1, 16% with genotype and 28% with genotype Clinical characteristics, relevant laboratory data and liver biopsy results of all patients are shown in Table The major risk...
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Báo cáo y học: "Hepatitis C Virus (HCV) Infection and Hepatic Steatosis"
... trigger severe advancement of fibrosis in patients with genotype infections [32] Overall, steatosis, whether metabolic or HCV induced, worsens the sequence of events leading to advanced fibrosis...
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Báo cáo y học: "Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Dual Infection"
... Za Zhi 1999 ;20:141-143 Zarski JP, Bohn B, Bastie A, Pawlotsky JM, Baud M, Bost-Bezeaux F, Tran van Nhieu J, et al Characteristics of patients with dual infection by hepatitis B and C viruses ... Hepatology 1998;28:231236 De Maria N, Colantoni A, Friedlander L, Leandro G, Idilman R, Harig J, Van Thiel DH The impact of previous HBV infection on the course of chronic hepatitis C Am J Gastroenterol ... hepatitis C liver disease N Engl J Med 1999;341:22-26 Brotman B, Prince AM, Huima T, Richardson L, van den Ende MC, Pfeifer U Interference between non-A, non-B and hepatitis B virus infection in...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
... in synthesis of the viral genome Data presented in this report provide a basis to test the relevance of sequences and ⁄ or structures implicated in this step of viral RNA replication in the infected ... mediated by an internal ribosome-binding site J Virol 67, 3338–3344 Rijnbrand R, Bredenbeek P, Van Der Straaten T, Whetter L, Inchauspe G, Lemon S & Spaan W (1995) Almost the entire 5¢ non-translated...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C ppt
... Evans, Assistant Professor, Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Drexel Institute of Biotechnology and Viral Research, Doylestown, Pennsylvania ... infected persons are not aware that they have been infected until symptoms of advanced liver disease appear Advanced liver cancer has a 5-year survival rate of below 5% (American Cancer Society, ... INTRODUCTION 20 Lavanchy, 2008) In most populations in Africa, North America, South America, Europe, and Southeast Asia, the prevalence in the general population is less than 3% (Lavanchy, 2008)...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C doc
... Evans, Assistant Professor, Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Drexel Institute of Biotechnology and Viral Research, Doylestown, Pennsylvania ... infected persons are not aware that they have been infected until symptoms of advanced liver disease appear Advanced liver cancer has a 5-year survival rate of below 5% (American Cancer Society, ... (Lavanchy, 2009) Unsafe mass immunization has led to exceedingly high HCV prevalence in some areas, such as Egypt, where 14–20% of the population has HCV antibodies (Frank et al., 2000; Lavanchy,...
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Diagnosis, Management, and Treatment of Hepatitis C: An Update docx
... injury, it identifies features useful in the decision to embark on therapy, and it may reveal advanced fibrosis or cirrhosis that necessitates surveillance for hepatocellular carcinoma (HCC) and/or ... responsible for their ultimate demise74-76 However, treatment is advised for those with more advanced fibrosis stage Ն3 (Table 7) It must be noted, however, that while information obtained from ... being considered, taking into account the estimated duration of infection and other indices of advancing liver disease (e.g., the platelet count), the viral genotype, and the patient’s willingness...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
... that were still insulin-containing 3.2 Pathogenic autoantigen in type diabetes The major autoantigens in Type (DM), identified by circulating autoantibodies, are glutamic acid decarboxylase (GAD), ... J Immunol 178, 2212-2220 Vanderlugt, C L and Miller, S D (2002) Epitope spreading in immune-mediated diseases: implications for immunotherapy Nat Rev Immunol 2, 85-95 Vanderlugt, C L., Neville, ... type in insulin-deficient islets Human T1D Involvement in CD4+ CD8+ the NOD mouse autoantibodies T cells T cells autoantigen Expression Subcellular location Insulin β-cell, thymus secretory granule...
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Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C pdf
... Evans Assistant Professor, Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Drexel Institute of Biotechnology and Viral Research, Doylestown, Pennsylvania...
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Báo cáo sinh học: " Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus " docx
... possibility that interferon resistance phenotype seen in the replicon cells is due to certain growth advantage as compared to sensitive cells, growth rate of nine different replicon cells were over one ... were obtained from the laboratory of James Wilson, Wistar Institute of Human Gene Therapy, Pensylvania, grown in Dulbecco's Modified Eagle's Medium (D-MEM), supplemented with 10% fetal bovine serum ... uniting discordant conclusions Antiviral Therapy 2004, 9:275-286 Nousbaum J, Polyak SJ, Ray SC, Sullivan DG, Larson AM, Carithers RL, Gretch DR: Prospective characterization of full-length hepatitis...
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Báo cáo sinh học: " Hepatitis B virus and hepatitis C virus in pregnant Sudanese women" pot
... http://www.virologyj.com/content/4/1/104 mangers and health planners, so as to initiate the relevant vaccine and screening packages in the antenatal care clinics While, much data exist about the ... visit were approached to participate in the study A fixed questionnaire was applied to gather relevant socio-demographic characteristics of these women (age, education, gestational age, parity, ... J Epidemiol 2001, 30:872-877 Nacro B, Dao B, Dahourou H, Hien F, Charpentier-Gautier L, Meda N, Van de Perre P, Cartoux M, Mandelbrot L, Dabis F: HBs antigen carrier state in pregnant women in...
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Báo cáo sinh học: " The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell" docx
... be infected Replication of HCV in liver cells is generally very low, which may be clinically relevant Page of (page number not for citation purposes) Virology Journal 2007, 4:106 Since HCV, HIV-1, ... However, these effects may be variable due to a number of factors that affect replication This has relevance to viral protein production that may induce or produce pathology How the viruses interact ... antiretroviral therapy and HIV disease progression in the HIV-NAT cohort Aids 2004, 18(8):1169-1177 Sullivan PS, Hanson DL, Teshale EH, Wotring LL, Brooks JT: Effect of hepatitis C infection on progression...
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