alzheimer apos s disease ad involves neuronal cell loss and reductions of synaptic density in specific brain regions some of the pathological signatures of ad implicate the process of excitotoxicity for instance glutamate receptors are altere
báo cáo khoa học: "Sheehan’s syndrome with pancytopenia: a case report and review of the literature" ppt
... Discussion The diagnosis of Sheehan s syndrome is determined by the patient s history and physical examination, and confirmed by laboratory tests (hormone levels and hormone stimulation tests ... regarding the hematological disease AM analyzed and interpreted the patient data regarding the endocrinological disease All authors have read and approved the final manuscript Competing interests The ... Acknowledgements For the reprint of the Table and Table 2, permission has been given, after the authors have accepted the terms and conditions on Springer s website Authors’ contributions MF analyzed and interpreted...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... test the latter hypothesis other inhibitors were also applied in the COS-7 cell fluorescence assay, including in particular proteasome and caspase inhibitors The inhibitors lactacystin (0.5 lM and ... DNA constructs into COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected...
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ALZHEIMER’S DISEASE PATHOGENESIS-CORE CONCEPTS, SHIFTING PARADIGMS AND THERAPEUTIC TARGETS pot
... pathogenesis of Alzheimer s disease This book is unusual in that it provides current information within each of the subdisciplines, and therefore will satisfy the needs and interests of both newcomers ... affecting primarily the association areas and finally the primary areas The stages of senile plaques are represented in the top 2.2.4 Other less specific findings include Inclusions and pigments: ... elongated basket around the nucleus The inclusions are basophils to the hematoxylin and eosin and strongly stained with silver stains The inclusions fill the cytoplasm, particularly in the soma and apical...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... 5¢-end of these cDNAs as the adapter sequence was present in each cloned insert and the adapter RNA was added before the reverse transcriptase reaction Several expressed sequence tags (EST) and cDNA ... site selection associated with either the expression of CB1 in the striatum vs the cortex or expression of CB1 in transgenic HD mice To test the hypothesis that expression of mutant huntingtin ... implicated in a number of neurodegenerative diseases including HD and Parkinson disease, and in other neuropsychiatric disorders such as schizophrenia [27] Cannabinoid receptors therefore are important...
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PARKINSON’S DISEASE: National clinical guideline for diagnosis and management in primary and secondary care ppt
... established disease lasting some years varying geographical locations 31 Parkinson s disease some studies are in specialised units and may not reflect the diagnostic accuracy of other units in ... diagnostic studies were found that assessed the accuracy of clinical diagnosis in parkinsonism compared with autopsy.36–38 These studies compared clinical diagnosis, at various stages of disease ... – Parkinson s Disease Society Jacqui Handley (GDG member) Parkinson s Disease Nurse Specialist Dorset County Hospital, Dorchester Parkinson s Disease Nurse Specialist Association John Hindle...
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Báo cáo khoa học: "Characterization and localization of the unique Marek''''s disease virus type 2 ORF873 gene product" ppsx
... studies need for addressing the observations, the MDV2 ORF873 proteins in both of the Sf9 and CEF cells additionally seem to interact with cytoskeletal components such as actin or microtubules However, ... mass of a 108-kDa protein A recombinant baculovirus expressing MDV2 ORF873 protein was constructed and used for the characterization of the protein Interestingly, the apparent molecular mass of ... analysis The results of immunoblot analysis using the anti-ORF873-monospecific polyclonal serum are shown in Fig The molecular mass of a 108-kDa protein was specifically detected in both the rAcORF873-infected...
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Báo cáo khoa học: "ACTH-producing carcinoma of the pituitary with refractory Cushing''''s Disease and hepatic metastases: a case report and review of the literature" pptx
... in 0% of noninvasive adenomas, 15.2% of invasive tumors, and 100% of metastases These data suggest that p53 expression analysis may be a promising avenue for assessing aggressive tumor behavior ... persistent hypercortisolism was shortlived, necessitating bilateral open adrenalectomy for her refractory pituitary Cushing 's disease The rates of cure and recurrence of Cushing 's disease, and the ... production in severe forms of Cushing 's disease, it may lead to Nelson 's syndrome (NS) Originally described by Nelson et al [32] in 1958, NS is defined by the association of a pituitary macroadenoma and...
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Báo cáo y học: "Identification and characterization of the carboxy-terminal region of Sip-1, a novel autoantigen in Behçet''''s disease" docx
... boxy-terminal subunit of Sip1 (anti-Sip1 C-ter) antibodies in patients with Behçet 's disease (BD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), vasculitis, inflammatory bowel disease ... process involves apoptosis need further investigations Apoptosis of endothelial cells may be initially induced by inflammation or oxidative stress caused by intrinsic or extrinsic factors In this ... C-ter in patients with distinct autoimmune diseases characterized by the presence of serum anti-endothelial cell antibodies such as BD, systemic lupus erythematosus (SLE), systemic sclerosis (SSc),...
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Báo cáo khoa học: " Neoadjuvant radiotherapy of primary irresectable unicentric Castleman’s disease: a case report and review of the literature" pps
... radiotherapy was a possible strategy This case illustrates that this hypothesis was successful and should be considered as a strategy in case of irresectable unicentric disease The question remains which ... no systemic symptoms, since most reports describe unicentric CD as a slowly progressive disease, which does not metastasize In the case where a recurrence of residual disease is found, a resection ... However, CD is associated with other disorders such as HIV infection, POEMS syndrome, amyloidosis, renal insufficiency and increased risk of lymphoma [5,9-11] Therefore specific systemic therapy related...
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Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons ppsx
... number of candidates for disease susceptibility genes Results Majority of the genes associated with familial Parkinson s disease are expressed within mesDA neurons, the population of neurons which ... during the course of the disease, the dopaminergic neurons of substantia nigra pars compacta in the midbrain Despite being the most prominent pathological feature of PD, the reasons underlying specific ... Parkinson s disease, caused by the loss of function mutations in the PD genes, is due to hindrance to functions of the wild-type forms and that the proper expression of the genes within mesDA...
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Báo cáo y học: " Systemic Epstein-Barr-virus-positive T cell lymphoproliferative childhood disease in a 22-year-old Caucasian man: A case report and review of the literature" docx
... mononucleosis; NOS = not otherwise specified; TCR = T cell receptor; VAHS = virus-associated hemophagocytic syndrome description of rare disorders is essential for improving current knowledge and possibly ... relapse of rectal bleeding and died soon after with cerebral manifestations Discussion Systemic EBV+ T cell LPD of childhood is a rare disorder characterized by an aggressive disease course and ... dismal prognosis [5] As death unfortunately often Page of occurs within a few weeks, and at present there is no specific treatment, a prompt diagnosis is necessary Our case report highlights the...
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báo cáo khoa học: "Budd-Chiari syndrome in a 25-year-old woman with Behçet’s disease: a case report and review of the literature" pps
... pathergy test Evidence in countries where Behçet s disease is prevalent suggests that this disease should be included among the diagnostic possibilities in cases of Budd-Chiari syndrome because the ... disease In countries where the prevalence of Behçet s disease is high, such as Turkey and others in the Middle and Far East, evidence suggests that this disease should be included among the diagnostic ... public hospital with the following complaints: ascites, dyspnea after exercise, and the development of veins and edema in the abdominal wall and swelling in the legs Five years earlier, she had developed...
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Báo cáo khoa hoc:" Small cell carcinoma arising in Barrett''''s esophagus: a case report and review of the literature" pptx
... because of the paucity of cases and the lack of large studies, chemotherapy remains the treatment of choice given the systemic nature of the disease [1,2] Since small cell carcinoma of the esophagus ... (Figure 1) of the tumor cells was positive for chromogranin and neuron -specific enolase (NSE) A diagnosis of primary small cell carcinoma of the distal third of the esophagus arising from dysplastic ... rare case of primary small cell carcinoma of the distal third of the esophagus arising from dysplastic Barrett 's mucosa is presented and the relevant literature is reviewed Figure esophagus Initial...
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Báo cáo y học: " Extramammary Paget''''s disease of the penis: a case report and review of the literature" pot
... Immunohistochemical stain of a resected specimen showing occasional cells near the margin Immunohistochemical stain of a resected specimen showing occasional cells near the margin appendage origin Secondary ... classification based on the origin of the Paget 's cells has been proposed by Wilkinson and Brown [3] They classified vulval Paget 's disease (PD) into two broad groups – primary (of cutaneous origin) ... Photograph of the penile lesion Photograph of the penile lesion Figure H&E stain of the resected specimen showing a clear margin H&E stain of the resected specimen showing a clear margin Discussion...
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Báo cáo khoa học: " The construction and characterization of the bi-directional promoter between pp38 gene and 1.8-kb mRNA transcripts of Marek''''s disease viruses" doc
... S, Hirai K: Identification of Marek 's disease virus -specific antigens in Marek 's disease lymphoblastoid cell lines using monoclonal antibody against virus -specific phosphorylated polypeptides ... attenuated and polyvalent vaccines against highly virulent strains of Marek 's disease virus Avian Pathol 1982, 11:49-62 Cui Z, Wei P, Ding J: Molecular comparisons of Marek 's disease virus strains of ... = 5) The CAT expression levels were presented in concentrations (pg/mL) of the lysates prepared as in Materials and Methods The statistics analysis was made between each pairs For each sample,...
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Dual functions of AP 1 in neuronal cell death and differentiation
... Also, in neurodegenerative diseases, such as Alzheimer s, Parkinson s or Huntington s, nerve cell loss occurs slowly It has been established that caspase activity is involved in the processes ... JunB inhibits G1 to S phase progression by inducing p16 and repressing cyclin D1 JunD inhibits S phase entry and increases the numbers of resting cells by modulating the Ras/p53 pathways (Jochum ... of this type is independent of caspases and DNA fragmentation was rarely seen In many tissues, autophagy is a means of reducing cell mass prior to apoptosis It can also be used in situation in...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... variably in other lineages [41] The expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen ... PPP1R3F in chromosome and for stat6 in chromosome 23 Subsequently, the DNA surrounding these genes was retrieved ( 300 000 bp) for further analysis using various sequence software programs Using ... expression data suggest that these genes are involved in the fish immune response, and that there is a relationship between the expression of these transcription factors and the cytokine genes known...
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Tài liệu Báo cáo khoa học: Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition pdf
... wild-type cells (Fig 1A) Protein expression of HSS in the three cell lines (untransfected cells, vector-transfected cells, and HSS-expressing cells) was detected using western blot As shown in Fig ... rate in HSS-expressing cells was decreased by about 30% as compared with vector-transfected cells and mutant HSS-expressing cells Similarly, CCCP-induced apoptosis was also inhibited by CsA Effect ... impairment of the PTP rHSS and mutant rHSS (Cys62 fi Ser, Cys65 fi Ser) were expressed in and purified from prokaryotic cells The resulting protein had a molecular mass of 15 kDa, as determined using SDS...
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Tài liệu Báo cáo khoa học: Cell surface heparan sulfate proteoglycans Target and partners of the basic ®broblast growth factor in rat Sertoli cells pptx
... indicated that the synthesis of cell surface HSPG and FSH-stimulated estradiol synthesis are inversely correlated This suggests a potential role for these Ó FEBS 2002 HSPG, target and partners of bFGF ... suggest a possible involvement of cell HSPG in the agerelated increase in Sertoli cell phosphodiesterase activity and in the concomitent loss of steroidogenic response to FSH These data and our ... FSH-stimulated estradiol synthesis was not observed (Table 3) In conclusion, bFGF requires cell surface HSPG for the inhibition of steroidogenesis in developing Sertoli cells Cell surface HSPG are bFGF...
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Bad Bank(s) and Recapitalization of the Banking Sector docx
... address numerous challenges First, the transparent removal of troubled assets is necessary in order to ensure that the rescued bank has real prospects for a fresh start Second, the costs of the ... cost and the corresponding writedown of assets will create transparency, avoid the high expense of pricing distressed assets, and will insure that shareholders are the first ones to bear the cost ... all distressed assets in the banking sector are deposited in a single bad bank If one bad bank were established for each of the three main pillars of the German banking industry – i.e for the credit...
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