al combination chemotherapy of alternating etoposide and carboplatin with weekly administration of irinotecan and cisplatin in extensive stage small cell lung cancer anticancer res 2012 oct 32 10 4473 4478
Báo cáo toán học: "Molecular Predictors of EGFR-TKI Sensitivity in Advanced Non–small Cell Lung Cancer" ppsx
... factor receptor and in KRAS are predictive and prognostic indicators in patients with non -small- cell lung cancer treated with chemotherapy alone and in combination with erlotinib J Clin Oncol 2005; ... copies in 90% of cells ≤2 copies in ≥40% of cells, copies in 10% –40% ... in 10% –40% of the cells, ≥4 copies in
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báo cáo khoa học: "Temozolomide and cisplatin in relapsed/refractory acute leukemia" potx
... CBC with differential, chemistry profile and coagulation studies Treatment Cisplatin was administered on day of therapy The dose of cisplatin was escalated from 50 mg/m2 to 100 mg/m2 as in Table ... methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin Clin Cancer Res 1996, 2:735-741 Wang G, Weiss C, Sheng P, Bresnick ... expected and included myelosuppression, nausea, vomiting and (mild) renal and electrolyte abnormalities We chose not to increase temozolomide beyond the dose in our other study and did not escalate cisplatin...
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báo cáo khoa học: "Identification of circulating tumour cells in early stage breast cancer patients using multi marker immunobead RT-PCR" doc
... dilutions of MDAMB453 into normal blood resulted in consistent detection of all RT-PCR markers at a level of 10 cells per ml of blood (Figure 1) In samples containing cell per ml of blood (10 cells ... overall stage of disease and positive expression of markers was examined Positive results were seen in all stages of disease and included a patient considered to have in situ disease Analysis ... to clinical samples and were involved in interpreting the data and reviewing the manuscript MH assisted with the statistical interpretation of the data and reviewed the manuscript AD was responsible...
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Architecture, Economics, And Identity In Romano-British ‘Small Towns’
... Justification for Studying Small Towns Small towns” were a vital link in our understanding o f the rural population in the Empire The exact nature o f small towns and a definition of what exactly the ... addressed in order to create meaningful results The main problems included not only defining the subject sample group of small towns” but also normalizing variable archaeological data coming ... understand the silent majority of the population in the provinces In addition, a comparison between small towns in Roman Britain and on the continent is lacking (Bumham, et al 1997) Examining the...
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báo cáo khoa học: "Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature" pptx
... patient presented again with a right submandibular mass and multiple bilateral lung metastases (Figure 2A) Our patient received combination chemotherapy using doxorubicin 50 mg/m2 and cisplatin 100 ... interpretation of the pathological findings 11 12 13 14 15 16 17 Ivery RH, Churchill L: The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin Am ... responding to combination chemotherapy: case report and review of the literature Journal of Medical Case Reports 2011 5:491 Author details Department of Medical Oncology, National Institute of...
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Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
... target for chemotherapy Indeed, it has been shown that a palindromic trioctamer of this sequence can interfere with CREB binding, and specifically inhibit PKA subunit expression, interfering with the ... highlighting cyclin/CDK interactions in the GEO cell line (i–ii) and the HCT116 cell line (iii–iv) The results of densitometry analyses are given in (A) and (B), and are expressed as a percentage of ... transferred into fresh culture medium containing 10 lM BrdU for 30 mins before fixing with ice-cold 70% (v/v) ethanol and permeabilization in M HCl with 0.5% (v/v) Triton X -100 Samples were washed and incubated...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... fixed with 10% buffered formalin embedded in paraffin and decalcified in 10% EDTA solution Representative blocks of the formalinfixed, paraffin-embedded tissues were cut to mm and deparaffinized with ... to the initiation of treatment The clinicopathological information including age, gender, tumor (T) stage, nodal (N) status, TNM stage, and survival was Page of obtained from the clinical records ... score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation with...
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Báo cáo sinh học: "Combination therapy: the next opportunity and challenge of medicine" ppt
... interest and participatin of individual companies Segregation of products according to market niches and proprietary arguments is limiting the utilization of promising products in combination and ... licensed Clinical trials are often influenced by the financial pressure aimed at demonstrating product effectiveness for licensing rather than systematically designing trials to evaluate the ... low-density lipoprotein cholesterol reduction and goal attainment in a real-world clinical setting Clin Ther 2011, 33:212-24 Sawakhanda RB, Dharmalingam M, Kumar S, Bell D: Triple oral fixed dose diabetes...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... fixed with 10% buffered formalin embedded in paraffin and decalcified in 10% EDTA solution Representative blocks of the formalinfixed, paraffin-embedded tissues were cut to mm and deparaffinized with ... to the initiation of treatment The clinicopathological information including age, gender, tumor (T) stage, nodal (N) status, TNM stage, and survival was Page of obtained from the clinical records ... score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation with...
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báo cáo hóa học:" Combination therapy: the next opportunity and challenge of medicine" potx
... interest and participatin of individual companies Segregation of products according to market niches and proprietary arguments is limiting the utilization of promising products in combination and ... licensed Clinical trials are often influenced by the financial pressure aimed at demonstrating product effectiveness for licensing rather than systematically designing trials to evaluate the ... low-density lipoprotein cholesterol reduction and goal attainment in a real-world clinical setting Clin Ther 2011, 33:212-24 Sawakhanda RB, Dharmalingam M, Kumar S, Bell D: Triple oral fixed dose diabetes...
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báo cáo hóa học:" Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft" pptx
... Crystallization and preliminary crystallographic studies of the single-chain variable fragment of antibody chA21 in complex with an N-terminal fragment of Zhang et al Journal of Ovarian Research ... the combination of chA21 and trastuzumab induced a further inhibition of VEGF protein expression (Fig 3B) Enhanced suppression of HUVECs proliferation and migration by combination of chA21 with ... potency on inhibiting the AKT It may partly explain our findings that the combination of chA21 with trastuzumab could synergistically enhance the in vitro and in vivo anti-angiogenesis effects In conclusion,...
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báo cáo hóa học:" Effectiveness and Safety of Generic Fixed-Dose Combination of Tenofovir/Emtricitabine/Efavirenz in HIV-1-Infected Patients in Western India" doc
... was defined as occurrence of a new or paradoxical worsening of an existing clinical condition (infectious or noninfectious) within months of initiation of ART Toxicity was graded according the ... Suleiman JM, et al. : The safety and efficacy of tenofovir DF in combination with lamivudine and efavirenz through years in antiretroviral-naive HIV-1-infected patients HIV Clin Trials 2007, 8:164-172 ... HIV infection in adults and adolescents in resource limited settings: towards universal access [www.who.int] Accessed October 17, 2007 Mathaiss AA, Hinkle J, Menning M, et al. : Bioequivalence of...
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Báo cáo toán học: "ntersecting families in the alternating group and direct product of symmetric groups" potx
... Furthermore, if equality holds in (1), then for any independent set I of cardinality α(Γ ) in Γ2 , φ−1 (I) is an independent set of cardinality α(Γ1 ) in Γ1 Intersecting families in the alternating group ... for all ≤ i ≤ q This is also a special case of a more general problem of determining independent sets of maximal size in tensor product of regular graphs, see [3] and [9] for recent interests in ... sets of maximal size in Kneser-type graphs, European Journal of Combinatorics 25 (2004), 657–673 [9] B Larose and C Tardif, Projectivity and independent sets in powers of graphs, Journal of Graph...
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Báo cáo khoa học: "Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Productivity in Mice" pdf
... the removal of microorganisms and neutralize toxins [11] Serum immunoglobulin E is an immunoglobulin of major importance in mechanisms against parasites and in the immunopathogenesis of allergic ... of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Production in Mice 107 In this experiment, all the 1.5% CLA feeding groups ... blood collection, the end of the duodenum and the cranial part of the cecum were tied and both ends were cut One end of the small intestine was at the stand and a conical tube was placed at the...
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Báo cáo y học: "Innovative combination strategy to enhance effect and diminish adverse effects of glucocorticoids: another promise" pot
... pudding is in the eating Comparative clinical trials of long duration with adequate numbers of patients and regular assessments of predefined beneficial effects and adverse effects in a standardized ... with inflammatory and immunosuppressive activity and with adverse effects, respectively For instance, hypopituitarypituitary-adrenal axis suppression and increased risk of infection are linked ... Szechinski J, Alten R: Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised...
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Báo cáo y học: "Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study" ppt
... symmetrical, oligoarticular, axial and/ or distal interphalangeal joint involvement without the presence of rheumatoid factor [11] Histological features of PsA synovial tissue include infiltration ... http://arthritis-research.com/content/6/4/R326 Figure Representative pictures of immunohistochemical stainings Pictures represent the expression of von Willebrand Factor (vWF), αvβ3 integrin, vascular stainings ... therapy with low-dose infliximab in combination with stable methotrexate therapy confers improvement in clinical signs and symptoms of psoriasis and PsA Decreased cell infiltration in both skin and...
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Báo cáo khoa học: "The combination effect of sodium butyrate and 5-Aza-2''''-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines" pot
... demethylation of the RASSF1α gene and reexpression of mRNA was increased more with a combination of 5-aza-DC and SB compared to using 5-aza-DC alone In our experiment, the combined effect of 5-azaDC and ... (Gibco, Invitrogen Corp., San Diego, California, USA) combined with 10% fetal bovine serum and 1% penicillin/streptomycin using a humidified cultivator that maintained 37°C and 5% CO2 The normal cell ... combined with 10% fetal bovine serum and 1% penicillin/streptomycin Bisulfate modification and methylation-specific PCR After being treated with 5-Aza-2'-deoxycytidin and sodium butyrate, and...
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Báo cáo khoa học: "Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro" ppsx
... (Gibco, Grand Island, NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained in a 37°C ... statistically significant Analysis of the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic ... combined radiation and chemotherapy improves disease-free survival (DFS) and overall survival (OS) in resected adenocarcinoma of the stomach and gastroesophageal junction: Update of the results of...
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Báo cáo khoa học: " The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay" pptx
... Depending on the schedule of administration, the frequencies of grade 3-4 diarrhea were 3% and 7% for infusional and bolus regimens, respectively, in a randomized trial [21] For oxaliplatin as single ... observed for 5-FU and oxaliplatin alone in the present study is in concordance with clinical experience Whether the combination of both drugs synergistically leads to considerable increase in bowel toxicity ... http://www.ro-journal.com/content/4/1/61 Increasing doses of oxaliplatin resulted in an essentially linear decrease in the number of surviving crypts in the dose range from to 10 mg/kg (Fig 2B) Chemoradiation - single fraction...
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Báo cáo y học: " A meta-analysis of gemcitabine containing chemotherapy for locally advanced and metastatic pancreatic adenocarcinoma" ppsx
... gemcitabine with gemcitabine plus fluoropyrimidine Both oral capecitabine and infused 5-fluorouracil (5-FU) were evaluated in combination with gemcitabine in a variety of dosing schedules in these ... survival percentages for the gemcitabine and combination groups were 42% and 62%, respectively Combination therapy with gemcitabine and cisplatin was associated with a higher resection rate and ... most of these trials showed negative results In the present analysis, nine trials including 3, 342 patients evaluated gemcitabine combined with targeted therapy (Table 3) Although the results of...
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