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Design, optimization and structure activity relationship study of CD2 derived peptides for immunomodulation
... CHAPTER PEPTIDE DESIGN AND OPTIMIZATION STRATEGY 38 2.1 Peptide design strategy 39 2.1.1 Design of parent peptides from CD2 ligand binding epitopes 39 2.1.2 Design of parent peptides from CD2 ... cIN 115 5.3.1.3 Conformation of peptide cQT and cIN 120 5.3.1.4 SAR of cAQ series and cIL series peptides 123 5.3.2 SAR study of rCD2 derived peptides 5.3.2.1 CD analysis of cVL series and cEL ... Peptide-based drug design for immunomodulation 28 1.4.1 β-turn as drug design target 29 1.4.2 Peptide design from protein interaction interfaces 31 1.4.3 Design from CD2 epitopes for modulation of CD2-CD58...
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The application of ANFIS prediction models for thermal error compensation on CNC machine tools
... method is used for constructing the proposed models 2.2 Extraction of the initial fuzzy model In order to start the modelling process, an initial fuzzy model has to be derived This model is required ... model One of the difficult issues in thermal error modelling is the selection of appropriate locations for the temperature sensors, which is a key factor in the accuracy of the thermal error model ... Therefore, the influence ranking from the independent variables to the dependent variable can be known by comparing the model values of b2 ∼bN To obtain robust models, all the influence weighting of...
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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt
... argued that the Vertical Track as an instantiation of the integration reform represents an arena for potential expansive transformation However, in order for integration to have an impact on the ... Introduction Does integration of school and child care institutions possess a potential for transformation of the pedagogy1 in school and how might the vision and goal of integration be defined? What ... out for use when needed This “banking” (Freire, Haug borrows the concept of code from Basil Bernstein and states that “characteristic for a code is that it contains principles or guidelines for...
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Tài liệu Báo cáo " DETERMINING FLOW ENERGY AND EROSION COEFFICIENT FOR CLASSIFICATION OF POTENTIAL EROSION IN BINH DINH PROVINCE " ppt
... product of them is the value of erosion potential for all pixels of the four basins Table K values of main soil groups and classification by erosive characteristics Symbology Number of profiles ... Table - The results of calculating average values of the factors participated in flow energy analysis and average values of Y for river basins are shown in tables and VNU Journal of Science, Earth ... numerical value of the flow energy Y and the erodability factor K in the following formula: M = K×Y , (1) The erodability factor K is determined by the quantity of grain force M* defined by the...
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Báo cáo khoa học: "Probabilistic Integration of Partial Lexical Information for Noise Robust Haptic Voice Recognition" doc
... = M , insertions and deletions have to be taken into consideration: P (li = |wi ) = Cdel and P (li |wi = ) = Cins where represents an empty token Cdel and Cins denote the deletion and insertion ... where A, L, P and H denote the WFST representation of the acoustic model, language model, PLI model and haptic model respectively Mohri et al (2002) has shown that Hidden Markov Models (HMMs) and ... provide crucial information that can significantly improve the efficiency and robustness of speech recognition For instance, the number of letters entered can be used to constrain the number of words...
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Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
... absence of ester synthase activity In recombinant yeast, the concentration of Adxp, but not of Adrp, controls SCC activity Fig The final levels of accumulated steroids are independent of Datf2 ... coding for the mature Adrp (preceded by a methionine codon) by sequences coding for the mature form of cytochrome CYP11A1 (preceded by a methionine codon) pV13SCC expresses the mature form of CYP11A1 ... Igs against the following organelle marker proteins: 3-PGK for cytosol, Pma1p for the PM, the 40-kDa protein for the ER and porin for mitochondria The distribution of heterologous proteins was...
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Báo cáo khoa học: Identification of preferred substrate sequences for transglutaminase 1 – development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin pot
... effect on the reactivity of the peptide Assessment of the K5 sequence for reactivity and specificity in the peptide form To assess the reactivity and specificity of K5 in the peptide form, biotinylated ... specifically detects endogenous TGase activity We also compared the reactivity of FITC-pepK5 and FITC-cadaverine, which has been used previously for detection of in situ TGase activity, over a range of ... Reaction time (min) 30 Fig Analysis of the reactivity of the K5 peptide with casein in the presence of TGases The time-dependent incorporation of biotinylated peptides (pepK5, pepK5QN and pepT26)...
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Báo cáo khoa học: ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature potx
... indicating a defect of the DNA degradation ⁄ repair process in mutants How or whether the RecD-dependent helicase ⁄ nuclease activity of RecBCD complex is related to the ATPase activity of the altered ... Summary of the properties of wild-type and mutant RecD proteins Biochemical activities of the wild-type protein (RecDHis) were taken as 100% for evaluation of the activities of the mutated proteins ... The Vmax values for ATPase activity of RecDHis at 25 and °C were 72 and 21 lmol ATPÆs)1, respectively, which were considered to be 100% for relative activity of the mutant proteins at the respective...
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Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... CT of gene - CT of the average of endogenous controls for that sample (delta CT) Gene expression values were calculated as: delta CT of gene minus delta CT of calibrator (delta delta CT) Data ... Sequence Detector (Sequence Detector Software v2.2.2) using universal thermal cycling conditions of 50°C for minutes, 95°C for 10 minutes, followed by 40 cycles of 95°C for 15 seconds and 60°C for ... isolation, description of custom TLDA and assay of RNA concentration for monkey studies RNA isolation was performed as described above for the human blood assay The pilot work for the assay was performed...
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Báo cáo hóa học: " Synthesis and highly visible-induced photocatalytic activity of CNT-CdSe composite for methylene blue solution" pdf
... reflectance spectra of CdSe and CNTCdSe composite Figure Degradation of MB under visible light irradiation for the CNT-CdSe composite with different amount activity toward the photodegradation of MB solution ... However, for the × 10-4 mol/L and MB concentration, only about 10% was degraded after 240 Therefore, it seems that the photodegradation efficiency of the MB photocatalyzed by the CNT-CdSe composite decreased ... Figure Dependence of the MB concentration of the CNTCdSe composite (0.05 g) under visible light irradiation 30 60 90 120 150 180 210 240 Irradiation time under visible light (min) Figure Degradation...
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A Development of Novel Integral Method for Prediction of Distorted Inlet Flow Propagation_2 docx
... monotonous function of inlet incident angle only The increment of distorted region size at outlet, ξ ( x = 10 ) , will decrease with the increasing of inlet incident angle before about θ = 25° ... region will decrease with the decreasing of inlet distortion level With the increase of inlet flow angle, the peak point of outlet size of distorted region will move forward along α ( ) axes (Figure ... distortion level, the radius of curvature of outlet size of distorted region tends to be increased whatever the inlet size of distorted region is 92 Chapter A Development of Novel Integral Method...
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Báo cáo khoa học: " Use of flow cytometry to develop and characterize a set of monoclonal antibodies specific for rabbit leukocyte differentiation molecules" ppsx
... identify mAbs for research in rabbits As part of our continued effort to develop mAbs critical to our research efforts in ruminants, we have developed a flow cytometric approach for initial identification ... differences in the frequency of leukocyte subsets The age of the rabbits varied from six months to about two years Preparation of leukocytes for flow cytometry Because of the tendency for T lymphocytes ... performed with live cells immediately after labeling For further analysis of the pattern of expression of mAbdefined LDM, cells were obtained from thymus, spleen, and appendix at the time of...
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Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... Heissmeyer et al reported, however, that IKK-dependent degradation of NF-κB1 is independent of NF-κB1 processing [32], so that changes in the total amount of p50 and p52 may be controlled by a different ... reversible, the inhibition of the proteases responsible for cartilage degradation is an important part of therapy While potent inhibitors of MMP enzymatic activity have been developed, their use has ... (IL-1RAcP), causing conformational changes in multiple receptor-bound proteins (MyD88, IRAK, TRAF6, TAB2; see Figure for definition) This results in recruitment and activation of transforming-growth-factor-κ-activated...
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báo cáo khoa học: " Integration of molecular biology tools for identifying promoters and genes abundantly expressed in flowers of Oncidium Gower Ramsey" pps
... Different lengths of OnExpansin promoter-GUS constructs were transformed into A thaliana With the exception of the 133 bp transformants, GUS activity was detected in flowers and minimal activity was ... of the promoter The blue box denotes the putative floral-related transcription binding site provide suitable information for identifying the relationship between flower-related genes and tandem ... 12 of 14 Figure Strategy for identification of BAC clones containing genes of interest Genes of interest or partial Oncidium sequences were used for the BAC library screening Primers were designed...
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Báo cáo y học: " In vitro evaluation of marine-microorganism extracts for anti-viral activity" pot
... analysis of the study as well as provided useful technical input for assay protocols RB provided the extracts that were made previously for another study, as well as provided necessary information ... studies provide the greatest amount of information However, high concentrations of marine extracts may be toxic to cell cultures To address this, a set of experimental tests was performed to determine ... assess these marine extracts for antiviral activity, a set of experimental tests were performed to determine the safe and effective dose of these extracts to be used for each cell culture system...
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Báo cáo y học: "A proposed adaptation of the European Foundation for Quality Management Excellence Model to physical activity programmes for the elderly - development of a quality self-assessment tool using a modified Delphi process" ppt
... adaptation of the European Foundation for Quality Management Excellence Model to physical activity programmes for the elderly – development of a quality self-assessment tool using a modified Delphi ... Physical Activity, Health and Leisure, Faculty of Sports, University of Porto, Porto, Portugal Department of Information Systems, University of Minho, Guimarães, Portugal Department of Physical ... contexts of PA programmes for the elderly in order to support its continuous improvement is, therefore, crucial Thus, the aim of this study was to develop a selfassessment tool for PA programmes for...
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Báo cáo y học: "Mediators of physical activity change in a behavioral modification program for type 2 diabetes patients" docx
... point, independent of baseline activity [36] A similar measure of residualized change in psychosocial correlates (except for coping with relapse, for which Van Dyck et al International Journal of Behavioral ... between the independent (the intervention) and the dependent variable (change in physical activity behaviors) before and after adjustment for the mediator (change in psychosocial variables) For each ... recommendations of King and colleagues [9], we tried to gain a wider understanding of Page 11 of 13 mediators across different physical activity domains in the present study As mentioned before, most...
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Epigenetic control of neuronal activity dependent gene transcription as a basis for long term memory formation
... implications in the development of novel therapeutics for disorders of learning and memory 2.II Introduction Activity- dependent gene transcription, a pre-requisite for memory formation, is a highly ... paraformaldehyde, 0.1% glutaraldehyde for minutes, and then washed for a total of 10 times in PBS STORM imaging buffer containing Cysteamine (Sigma) titrated with HCl to pH 7.4 and a cocktail of ... Classifications of memory II Molecular Mechanisms of Long-Term Memory Formation A Overview: plasticity and activity B Epigenetics as a mechanism of activity- dependent gene expression...
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Investigation and integration of piezoresistive silicon nanowires for MEMS applications
... limitation, a considerable effort is devoted to the design and fabrication of MEMS testing platform By using the MEMS testing platform, characterization of SiNWs under a large range of tensile strain ... feeling of the surgeon; thus the force or pressure feedback of the passing guidewire is extremely difficult to quantify Besides, quantitative information of force or pressure feedback of the passing ... sensor Inset shows the SEM picture of a μm SiNW after metal deposition 40 Figure 2.7: (a) 2.5 µm of PECVD SiNx deposition for passivation; (b) backside release and front side cantilever...
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Developing chemical biology approaches for the activity based investigations of reversible protein phosphorylation mediating enzymes
... dialdehyde 6.4 pH-dependence of the labeling of Abl by the dialdehyde 138 138 xxvii 6.5 Effect of β-mercaptoethanol (BME) on the three-component reaction of Abl kinase with the dialdehyde ... 45 (b) Determination of kobs of the phosphopeptides for reaction with PTP1B 45 2.9 Comparison of relative activity of the 10 probes against PTP1B as Determined from quantitative analysis of the ... approaches developed towards betterunderstanding and manipulations of some important members in these two classes of proteins In Chapter 2, the design and development of a panel of peptide-based ActivityBased...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25