7 signal transducer and activator of transcription stat 3 signaling
Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
... IFN-γ (ng·mL–1) 20 100 200 P -STAT1 STAT1 P -STAT3 STAT3 Discussion – – Pull-down – + + – – + C IFN-γ IL6 + – P -STAT1 P -STAT3 Fig Binding of the STAT3 decoy ODN to STAT3 and STAT1 (A) SW480 cells were ... Grandis JR (2007) Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1 Mol Pharmacol 71, 1 435 –14 43 ... levels of STAT3 and STAT1 in SW480 cells after treatment with different concentrations of IFN-c analysed by western blotting using antiP -STAT1 and anti-P -STAT3 sera (C) Interaction of the STAT3 decoy...
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Báo cáo y học: "Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)" ppt
... of 13 (page number not for citation purposes) and can bind STAT- 1 /STAT- 1 homodimers, STAT- 1 /STAT- 3 heterodimers as well as STAT- 3 /STAT- 3 homodimers [29 ,30 ] Analysis of STAT- 1, STAT- 3, CD40, and ... Activation of the STAT1 pathway in rheumatoid arthritis Ann Rheum Dis 2004, 63: 233 - 239 Nguyen VT, Benveniste EN: Involvement of STAT- 1 and ets family members in interferon-gamma induction of CD40 transcription ... sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity Proc Natl Acad Sci USA 1995, 92 :30 41 -30 45 46 Nissler K, Pohlers...
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Tài liệu Báo cáo khoa học: Hsp105b upregulates hsp70 gene expression through signal transducer and activator of transcription-3 pdf
... human HEK2 93 cells in which STAT3 expression was effectively downregulated by the STAT3 siRNA, and monkey COS-7 cells in which it was not The transfection of STAT3 siRNA decreased STAT3 expression ... Phosphorylated STAT3 (Tyr705) (p -STAT3 ), STAT3 , Hsp105, Hsp70 and a-tubulin were analyzed by western blotting, using the respective antibodies (B) These cells were stained with Hoechst 33 342 (blue), and ... J 33 0, 189–195 Stephanou A, Isenberg DA, Nakajima K & Latchman DS (1999) Signal transducer and activator of transcription- 1 and heat shock factor-1 interact and activate the transcription of...
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Báo cáo khoa học: A novel splicing variant form suppresses the activity of full-length signal transducer and activator of transcription 5A pot
... Rev Mol Cell Biol 3, 651–662 Ihle JN (1996) STATs: signal transducers and activators of transcription Cell 84, 33 1 33 4 Hoey T & Schindler U (1998) STAT structure and function in signaling Curr Opin ... (B) Comparisons of the mouse and human amino acid sequences of STAT5 A_FL, STAT5 A_DE18, and STAT5 Ab The frameshift regions of STAT5 A_DE18 are underlined Shaded letters, bold letters and the open ... activation of PRL-stimulated STAT5 A to 2.2-fold (Fig 7C) The expression of STAT5 A_DE18 suppressed the PRLinduced activity of STAT5 A by 33 % Furthermore, we observed nuclear translocation of STAT5 A_FL...
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Báo cáo khoa học: Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells potx
... STATs: signal transducers and activators of transcription Cell 84, 33 1 33 4 20 Lee PJ, Camhi SL, Chin BY, Alam J & Choi AM (2000) AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1 ... known to activate the JAK -STAT pathway in several cells [9], STAT1 , STAT2 and STAT3 in VSMCs [9, 23, 25,26] and STAT5 in cardiac myocytes [8], whereas the activity of STAT5 is unknown in Ang II-induced ... contains both AP-1- and STAT5 B-binding sequences in the AGT promoter from )545 to 39 bp (Fig 3A), and pcDNA3.1 -STAT5 B and ⁄ or pcDNA3.1-c-Jun expression plasmids Overexpression of STAT5 B or c-Jun alone...
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Tài liệu Chapter 7: Dimerization, oligomerization and polymerization of alkenes and alkynes pptx
... Wienheim, 1996, p 33 3 50 E Drent, P H M Budzelaar, Chem Rev 1996, 96, 6 63 51 A Sen, Acc Chem Res 19 93, 26, 30 3 52 W Reppe, A Magin, USP 577 208,1951 to BASF; C A 1952, 46, 61 43 53 Z Jiang, A Sen, ... dissociation from and and the rate of this exchange is probably the lowest step of the overall reaction.The hydroxy ligand facilitates the dissociation of and this leads to a slow catalysis of ethene ... organic phase of the monomer and the products to cause substantial metal leaching [17] Dimerization, oligomerization and polymerization of alkenes and alkynes 2 43 Telomerization of butadiene...
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Báo cáo hóa học: " A Genetic Programming Method for the Identification of Signal Peptides and Prediction of Their Cleavage Sites David Lennartsson" pot
... subsidiary of Swedish telecom Dr Nordin is a Cofounder of Dacapo AB, a Swedish consulting and research company specialised in the stateof-the-art information technology, and an Inventor of the patented ... children (a ) and (b ) will be a combination of the parents (a) and (b) genomes Recombination works by letting the crossover operator exchange two random parts of the genomes 4 .3 Selection and genetic ... recombination and 15% probability of mutation The best performing individual was 2 73 instructions long and had formed through 38 3 genetic operations The whole run took about three days on standard PC...
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Báo cáo y học: "Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura" ppsx
... 7 .3 32 PCE8085 2R 12,2 53, 766 12,255 ,30 2 1, 537 CG109 53 - 235 40 CG10950 -36 25 13 15 10 7.2 33 PCE8086 3L 20,612,647 20,614,0 73 1,427 kni +1254 CG 132 53 + 236 63 11 17 12 7.2 34 PCE8087 2R 3, 391, 037 3, 391,561 ... -6950 8 13 4.8 36 PCE 833 2 3R 2,725 ,37 6 2,726,195 820 Antp +32 344 Antp +32 344 11 4.8 4.7 37 PCE 833 8 3R 3, 987,824 3, 989, 532 1,709 grn +17647 grn +17647 13 38 PCE 834 8 3L 18,966,181 18,967 ,38 0 1,200 ... 1,2 73 CG12680 +32 240 ovo -17051 10 4 .3 56 PCE8444 3L 18 ,33 0,7 63 18 ,33 2,045 1,2 83 grim -77470 rpr +15 237 10 4 .3 57 PCE8450 3L 5,141, 131 5,141,7 93 6 63 CG324 23 +2971 CG10677 - 438 11 4 .3 58 PCE8458 3L...
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Báo cáo y học: "Coding region structural heterogeneity and turnover of transcription start sites contribute to divergence in expression between duplicate genes" docx
... http://genomebiology.com/2009/10/1/R10 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 Genome Biology 2009, hensive analysis of transcriptional promoter structure and function in 1% of the human genome ... 0 .39 1 (0 .31 1) 1.292 (1.501) 0.0 53 (0.026) -0.157 (NS) 3' similar 23 0 .30 2 (0 .31 1) 1 .36 5 (1.610) 0 .34 6 (0.249) 0.019 (NS) Neither 5' nor 3' similar 520 0.551 (0.456) 1.565 (1.658) 0.126 (0.0 63) ... included: Tandem, TSS, and interaction terms between Structure and Tandem, between TSS and Tandem, and between KA/KS ratio and Cis (Table 2) Our computation of the relative contribution of the variability...
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algorithms for representation and discovery of transcription factor binding sites
... 35 3. 3 Basic Motif Finding Framework 36 3. 3.1 Similarity scores 36 3. 3.2 Integer linear programming formulation 37 3. 3 .3 Graph ... Motif Finding 3. 1 30 Introduction 30 3. 1.1 Previous approaches 30 3. 1.2 Combinatorial optimization framework 32 3. 2 Broad Problem ... pairwise correlations 20 2.2 .3 2 .3 vii 2 .3. 3 24 2 .3. 4 2.4 Importance of per-position information content Statistical significance of method comparisons 25 Discussion...
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Tài liệu Báo cáo Y học: A novel meta-cleavage dioxygenase that cleaves a carboxyl-groupsubstituted 2-aminophenol Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d doc
... 19 Mesbah, M., Premachandran, U & Whitman, W.B (1989) Precise measurement of the G + C content of deoxyribonucleic acid by 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 high-performance liquid ... lmol of 4-amino -3- hydroxybenzoic acid and 0.90 ± 0.08 lmol of O2 were consumed and 1.1 ± 0.02 lmol of 2,5-pyridinedicarboxylic acid was formed, which indicated a molar ratio of 4-amino -3- hydroxybenzoic ... steps of the metabolism of 4-amino -3- hydroxybenzoic acid 4-Amino -3- hydroxybenzoate 2 ,3- dioxygenase contained 1.9 mol Fe2+ per mol of enzyme Addition of Fe2+ increased the enzyme activity and chelating...
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Integrated Assessment of Health and Sustainability of Agroecosystems - Chapter 3 potx
... production and agroforestry Tour of fields Livestock production Tour of pens and sheds Marketing End of tour of fields, pens, and sheds End of tour of fields, pens, and sheds Beginning of discussion ... susceptibility to all kinds of diseases 3. 3 .3 Problem Analysis and Action Planning 3. 3 .3. 1 Problem Identification, Ranking, and Analyses A summary of problems and concern as ranked by participants ... Health and Sustainability of Agroecosystems (4) develop suites of indicators of health and sustainability, and (5) monitor progress, assess health and sustainability, and evaluate the status of the...
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Báo cáo hóa học: " Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia" docx
... 38 8280 38 8887 38 9520 39 0192 39 130 0 39 1 933 V-599 38 4119 38 4584 38 4826 38 5 233 38 6891 38 6990 38 70 23 387124 38 7129 38 7 130 38 7 131 38 71 73 388446 39 17 13 391771 39 2 438 39 3084 39 3198 39 32 73 3 932 82 39 3492 ... EU0 034 94 EU0 034 95 EU0 034 96 EU0 034 97 EU0 034 98 EU0 034 99 EU0 035 11 EU0 035 14 EU0 035 13 EU0 035 09 EU0 034 83 EU0 035 04 EU0 034 87 EU0 035 07 EU0 034 88 EU0 034 89 EU0 034 90 EU0 034 91 EU0 034 92 EU0 034 93 EU0 035 03 EU0 034 84 ... L11 432 AF317645 M 931 30 AB111085 AF147457 AY67 637 0 AY67 636 8 AY67 635 9 AF 533 079 AY 135 419 AY145715 AY145716 AY 338 4 93 AY145 730 AY145726 AY145718 AY1457 23 AY496872 AB111080 L11424 AY09 933 6 AY09 933 7...
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The preparation and use of compost - Part 3 pptx
... decompose (twigs, stalks) 10 cm of material which is easy to decompose (green and fresh) cm of animal manure (if available) A thin layer of soil from the surface of arable land to obtain the micro-organisms ... the boma to save effort moving the manure and used bedding Figure 10: A boma and compost site (Source: KIOF and HDRA) Like on the drawing, a trench of 30 cm in depth is dug out behind the boma ... next to the trench The bottom of the trench is loosened and a layer of dry vegetation is put on the bottom Then a layer of about 10 cm manure and bedding is thrown out of the boma into the trench...
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Chapter 004. Screening and Prevention of Disease (Kỳ 3) pot
... Men > 35 Every 235 Every Every Every 1 3 height and weight Cholesterol years Women > 45 years Diabetes >45 or earlier, 33 8 if there are additional years risk factors Pap smearb Within years of onset ... 65; Periodically 31 8 >60 at risk Abdominal aortic Men aneurysm who (ultrasound) have 65–75 Once ever smoked Alcohol use >18 Periodically 35 6 Vision, hearing >65 Periodically 22, 30 Adult 116, 117 ... onset of sexual years 78 activity or 21–65 Chlamydia Women 18–25 Every 1–2 169 Every 1–2 78, 86 years Mammographya Women > 40 years Colorectal >50 78, 87 cancera fecal occult Every year blood and/ or...
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Chapter 075. Evaluation and Management of Obesity (Part 3) pptx
... Lung, and Blood Institute: Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report Washington, DC, US Department of Health and ... change and also serves as a basis for further dialogue Obesity: Treatment The Goal of Therapy The primary goal of treatment is to improve obesity-related comorbid conditions and reduce the risk of ... 27– 29.9 With 35 With 35 – 39 .9 ≥4 + + + + + + With + comorbiditie comorbiditie s s Pharmacothera py 30 With comorbiditie s Surgery comorbiditie s Source: From National Heart, Lung, and Blood Institute,...
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schaum s easy outline of principles of economics based on schaum s outline of theory and problems of principl phần 3 doc
... is producing beyond its full-employment level of output Solved Problem 3. 3 Use aggregate demand and aggregate supply curves AD and AS in Figure 3- 3 to answer the following questions: a Is the ... output of a given quantity of resources; (2) the quantity of economic resources increases; or (3) the cost of resources declines Changes in Aggregate Output The effect of changes in aggregate demand ... for aggregate supply and aggregate demand curves ASЈ and ADЈ in Figure 3- 1 Increased government spending shifts the aggregate demand curve outward to ADЉ, and the point of equilibrium changes...
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THE LINGUISTICS, NEUROLOGY, AND POLITICS OF PHONICS - PART 3 potx
... support of career and technical education in high schools and colleges, and adult basic education and English language acquisition" (U.S Department of Education, Office of Vocational and Adult ... cature of science, because it reduces science to a method And the mirror image of this reductionism is the elevation of method itself to a status above that of understanding the phenomenon of reading ... linguistic science, and how our under standing of written language bears on our understanding of reading The main questions that arise here have to with the nature of alphabetic writ ing and its role...
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MODERN MORPHOLOGICAL TECHNIQUES AND THE EVOLUTIONARY BIOLOGY AND TAXONOMY OF SEPSIDAE (DIPTERA) 3
... sequences of ca 778 bp from 50 specimens (GenBank accession numbers EU 435 804, EU 435 807, EU 435 808, EU 435 818, GQ354410, GQ388 730 – GQ388774) The parsimony analysis found 125 trees with a length of 211 ... York and Athens, GA Etymology The specific name first given by Melander and Spuler in their original description of the species (Melander and Spuler 1917), derived from the combination of the ... posterior on median and subapex, dorsal on basal 2 /3 and apex, anterior on apex, anterioventral on basal 2 /3 and ventral on apex Hind femur with anteriodorsal on basal 2 /3 and posterioventral...
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Expression pattern and functions of dihydropyrimindase like 3 in the rodent microglia
... 32 2.2.1 Materials 32 2.2.2 Procedure 32 2.2 .3 Preparation of frozen sections 33 2 .3 Cell culture 33 2 .3. 1 Primary microglial culture 33 ... phagocytosis and proliferation of microglia 68 3. 5.1 Knockdown of Dpysl3 alters the structure of F-actin organization 68 3. 5.2 Knockdown of Dpysl3 inhibits migration of microglia 69 3. 5 .3 Knockdown ... microglia 62 3. 2.1 In LPS injected rat brains 62 3. 2 .3 Activated microglial cultures 63 3 .3 Distribution of Dpysl3 in activated BV-2 microglia 64 3. 4 Dpysl3 regulates the...
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