4implication of gpergper in the resistance to antiestrogen therapy
Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
... cadmium-inducible genes (≤1.5-fold) are involved in the resistance to cadmium toxicity (although these genes certainly could also be involved in detoxification of other stressors) These cadmium resistance ... from cadmium toxicity The discovery of these novel genes involved in the resistance to cadmium toxicity provides valuable information in understanding the biological function of the transcriptional ... enzyme involved in the biosynthesis of retinoic acid Cadmium has been shown to act synergistically with retinoic acid in the induction of limb-bud malformation in mice [51] The Y46G5A.24 network includes...
- 15
- 336
- 0
Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate resistance ... Collectively, the results indicate that innate resistance to HSV-1 infection is intimately dependent on Stat 1-induced gene expression Discussion The current study was initiated to determine if innate resistance ... dispensable for the innate resistance of mice to HSV-1 infection, further investigation is necessary to determine what role, if any, NK cells play in human resistance to HSV-1 infection Methods...
- 15
- 344
- 0
báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
... and/or professional APCs confer innate resistance to HSV-1 infection via the secretion of IFN-γ at early times p.i The following study was initiated to determine if NK cells provide innate resistance ... Collectively, the results indicate that innate resistance to HSV-1 infection is intimately dependent on Stat 1-induced gene expression Discussion The current study was initiated to determine if innate resistance ... dispensable for the innate resistance of mice to HSV-1 infection, further investigation is necessary to determine what role, if any, NK cells play in human resistance to HSV-1 infection Methods...
- 15
- 296
- 0
A study on teaching oral skills to the first year students at Hanoi University of Industry in the Communicative Approach
... investigates the reality of the teaching oral skills to the first year students in HaUI when the teachers are considered to be applying CLT approach in their teaching The main goal of the research is to ... considering the following issues: - Creating interesting topics because interesting topics motivate the students and create enjoyable atmosphere in the class When they are interested in something, they ... think the researcher wants to read rather than their real feelings Moreover, the number of the subjects is small which may influence the implications of the thesis to some extent The results of...
- 44
- 1,605
- 9
Introduction to The Crisis of Literature in the 1790s
... reproducing the myth of the selfdetermining subject.31 Having stressed the ongoing centrality of Enlightenment thought in the 1790s, I want to insist that I am not interested in rethinking our ... supposed to generate these values, could be contained The emotional intensity of the backlash against the intrusions of these subaltern groups suggests the importance of reading these developments in ... for the possibility of meaningful interventions into existing debates 14 The Crisis of Literature in the 1790s by previously excluded voices But the reaction to the claims of women and working-class...
- 22
- 542
- 0
Tài liệu Báo cáo khoa học: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein ppt
... to detect the binding interactions between the peptides and the Grb4 SH2 domain The affinity of the binding interactions was evaluated by measuring the changes of fluorescence polarization of the ... conformation of the PDZ binding domain of ephrinB2(301–333) is essentially independent of tyrosine phosphorylation within the SH2-binding element of ephrinB2(301–333) On the other hand, tyrosine phosphorylation ... to determine the binding specificity of the Grb4 SH2 in relation to the closest consensus binding sequence of the Src SH2 domain (i.e pYEEI) responded to the addition of the ephrinB2 peptide phosphorylated...
- 12
- 551
- 0
Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... possible to quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated ... protein belonging to the GTPbinding elongation factor family, which promotes the GTPdependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis and the capture of ... Thus, in these high basic proteins it might be that either methylation of the lysine or specific substitutions in the amino acid sequence, increasing the number of basic residues of lysine, arginine...
- 12
- 552
- 0
THE ELEMENTS OF DRAWING IN THREE LETTERS TO BEGINNERS doc
... pencil inside the outline of the letter, retouch it, closing it up to the inked line The straight lines of the outline are all to be ruled,[5] 15 but the curved lines are to be drawn by the eye and ... darkness of ground there is the light of the little pebbles or dust; in the darkness of foliage, the glitter of the leaves; in the darkness of flesh, transparency; in that of a stone, granulation: in ... they took the greatest pains with the circlet of a crown, or the rim of a crystal cup, in the heart of their picture, they would twist their capitals of columns and towers of churches about in...
- 193
- 594
- 0
Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... binding of the inhibitor a-NAPAP to the thrombin active site The effects of pH (5.5–10) on the hydrolysis of d-Phe-PipArg-pNA substrate by both WT and DK9 mutant thrombin and binding of the inhibitor ... thrombin show that the A-chain closely follows the contour of the catalytic B-chain, hinging the two interacting six-stranded barrel-like domains of the B-chain [17] A well-structured network of ... side-chains to the solvent the smaller the intrinsic fluorescence of the enzyme The smaller gain in the intrinsic fluorescence of DK9 upon Na+ concentration (9 vs 18% in WT) may reflect not only the...
- 11
- 553
- 0
Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... clarified in detail and could play a key role in the detoxification processes In this study we examined the role of Bcp2 in order to increase the knowledge of the enzymatic activity involved in the ... Prxs, the largest Prx class, is their second redox-active cysteine, the resolving cysteine (Cys-SR) In typical 2-Cys, Sp at the N terminus and SR at the C terminus of the protein belong to different ... solfataricus Furthermore, we report the cloning, the expression and the characterization of the recombinant protein rBcp2 in order to shed light on its role in the detoxification process and on its...
- 11
- 565
- 0
THE ROLE OF BIODIVERSITY CONSERVATION IN THE TRANSITION TO RURAL SUSTAINABILITY pptx
... achieving real progress on sustainability The intent in organizing the NATO ARW was to bring together a range of disciplinary perspectives with a wide array of experiences in research, policy and institutional ... linked to incentives and monitoring systems The European Environmental Agency is seeking to move in this direction by linking monitoring and reporting systems directly to assessing progress of ... mutual interest in finding ways of maintaining and restoring biodiversity as part of the designing and deciding upon new economic and security structures The western countries must find ways of reducing...
- 353
- 564
- 0
CONFLICTS OF INTEREST IN THE HOLLYWOOD FILM INDUSTRY: COMING TO AMERICA - TALES FROM THE CASTING COUCH, GROSS AND NET, IN A RISKY BUSINESS pdf
... Kroo|zrrg lv d qhw0sur wv frqwudfw/ lq zklfk qhw sur wv lv d frqwudfwxdoo| gh qhg whup/ qrw sur w dv fdofxodwhg dffruglqj wr Jhqhu0 doo| Dffhswhg Dffrxqwlqj Sulqflsohv +JDDS,1 Vhyhudo glvsxwhv kdyh dulvhq ... ryhukhdg fkdujhv/ dqg lwv vkduh ri qhw sur wv1 Hdfk frvw frpsrqhqw kdv vrph pdujlq ri sur w fdofxodwhg lqwr lw1 Wkh vwxglr kdv d srwhqwldo frq lfw ri lqwhuhvw ehfdxvh lw pxvw eh wuxvwhg wr shuirup ... wkh qhjdwlyh frvw1 Wkh euhdn0hyhq srlqw ri wzlfh wkh qhjdwlyh frvw zdv fkrvhq ehfdxvh lw zdv fdofxodwhg wr eh wkh srlqw dw zklfk wkh vwxglr zrxog uhfryhu lwv glvwulexwlrq dqg dgyhuwlvlqj h{shqvhv...
- 32
- 551
- 0
Báo cáo khoa học: Analysis of the contribution of changes in mRNA stability to the changes in steady-state levels of cyclin mRNA in the mammalian cell cycle doc
... inhibition to explain the decay of an mRNA that fluctuates 10-fold in the cycle At present it is unclear what triggers the decrease in the level of the 2.5-kb cyclin B1 mRNA at the M ⁄ G1 transition Mitotic ... amplification of their coding sequences The GAPDH probe template was the EcoRIHindIII fragment of the coding region [30] To detect long transcripts of cyclins A2 and B1, we amplified by PCR the 3¢UTR of ... corresponding to the 1.7-kb transcript in the mouse We show that mouse transcripts differ only in their 3¢UTR, but not the coding regions Therefore, the significance of 3¢UTR differences is unclear They...
- 13
- 338
- 0
Báo cáo hóa học: "The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer" docx
... resection of hepatic lesions None of the patients had undergone either chemotherapy or radiotherapy before the collection of the samples The histopathologic characteristics of the colon carcinoma ... grading The study was conducted in accordance with the Helsinki Declaration and approved by the Ethics Committee of our institution Patients were informed of the investigational nature of the ... Evaluation of risk of liver metastasis in colorectal adenocarcinoma based on the combination of risk factors including CD10 expression: multivariate analysis of clinicopathological and immunohistochemical...
- 9
- 828
- 0
Báo cáo hóa học: " Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients" docx
... consisted of three five-minute periods of tourniquet insufflation on the upper thigh of the operative limb, interrupted by five minute periods of reperfusion The pressure to which the tourniquet was insufflated ... limb at the initiation of surgery and at hour of ischaemia to coincide with the muscle sampling Blood was then obtained 30 min, hour and 24 hours following tourniquet release to investigate the effect ... Accordingly, we sought to investigate the effect of IPC in patients undergoing total knee arthroplasty The primary objective of this study was to investigate the genomic response induced by IPC in...
- 11
- 616
- 0
báo cáo hóa học:" The value of SPECT in the detection of stress injury to the pars interarticularis in patients with low back pain" doc
... for pars stress injury, it is highly suggestive of some type of derangement of the posterior elements of the spine [16] Imaging studies used to evaluate patients with low back pain include: radiographs, ... therapy emphasizing hamstring stretching and core strengthening The length of activity restriction, use of bracing and type of rehabilitation programs varies, reflecting a lack of consensus among ... skeletal scintigraphy, CT and MRI all play an important role in imaging patients with back pain Planar bone scintigraphy has a long history in the diagnosis of patients with suspected injury of the...
- 6
- 447
- 0
Báo cáo hóa học: " The prevalence of polypharmacy in elderly attenders to an emergency department - a problem with a need for an effective solution" doc
... close level of monitoring of therapeutic anticoagulation in dedicated anticoagulation clinics in the hospital, and of wider awareness of the potential for drug interactions with warfarin • Hospital ... warfarin is used in a significant number of elderly patients, we were unable to find any drug combinations leading to potential adverse interaction with warfarin usage This may be because of the ... years or over attending the ED: medication in the minors (ambulatory care area) was recognised to be an issue, usually in patients with minor injuries requiring a relatively brief intervention, who...
- 3
- 340
- 0
Báo cáo hóa học: " Research Article Removing the Influence of Shimmer in the Calculation of Harmonics-To-Noise Ratios Using Ensemble-Averages in Voice Signals" docx
... generated using a rising time of 0.33T0 and a falling time of 0.09T0 ; the values which resulted in the most naturalsounding synthesis in [23] The shimmer was controlled by changing the value of each ... signal, of the decaying tails of previous pulses This summation of tails adds differences to the pulses, interpreted as noise in the model and causing a reduction in the calculated HNR as the introduced ... different to the values used in the synthesis The results for the different methods facing both noise types are shown in Figure 1, and the discussion below is first centered in the AWGN and later in the...
- 7
- 243
- 0
Báo cáo nghiên cứu nông nghiệp " Increasing the capacity of the Food Crops Research Institute to enhance the Production and Management of Potatoes in the Red River Delta " pot
... Performance indicators Outputs Performance Indicators ♦ Survey of crops in the first year will achieve the i) Publication of survey results of objective of training FCRI staff to identify the major factors ... leading to low yields of 10-12 tonnes/ha The FCRI estimated there is the potential to grow 400,000 of potatoes in the RRD should yields prove economical Ultimately the profitability of growing ... technology to extend storage and Performance Performance indicators rating Crop Survey to train Publication of FCRI staff in survey results of identifying the crops in the RRD major factors limiting...
- 12
- 508
- 0
Báo cáo nghiên cứu khoa học: " AN APPROACH TO THREE CLASSICAL TESTS OF THE GENERAL THEORY OF RELATIVITY IN THE VECTOR MODEL FOR GRAVITATIONAL FIELD" docx
... at each point with its etalons into measured results with the standard etalon is the synchronizing of the rulers and the clocks as the synchronizing of clocks in the special theory of relativity ... General Theory Of Relativity), library of University of Natural Sciences, Ho Chi Minh city in Vietnamese, (1999) [8] A.Einstein, The Meaning of Relativity, Princeton University Press, Princeton, ... 2007 We see that in non-inertial frames of reference, the length of a line segment depends upon the region of space it is located in The length of the same line segment differs at points with different...
- 7
- 461
- 1
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25