23 aging reactive nitrogen species and myocardial apoptosis induced by ischemia reperfusion injury
Báo cáo y học: "CXC-chemokine regulation and neutrophil trafficking in hepatic ischemia-reperfusion injury in P-selectin/ICAM-1 deficient mice" docx
... liver injury following hepatic ischemia/ reperfusion in the rat Hepatology 1996, 23: 506 Jaeschke H, Farhood A: Neutrophil and Kupffer cell -induced oxidant stress and ischemia- reperfusion injury ... subjected to 90 minutes of ischemia followed by and 15 h of reperfusion respectively; (D and F) P/I null mouse subjected to 90 minutes of ischemia followed by and 15 h of reperfusion, respectively ... null and wild-type mice were subjected to 90 minutes of warm liver ischemia followed by various periods of reperfusion Hepatic I/R caused significant hepatocellular injury at and 15 h of reperfusion...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... respiration by correlating the uncoupling effect induced by these molecules with the level and function of UCP2 and free radical production in macrophages We find that MDP induces reactive oxygen and nitrogen ... effect of MDP on ROS and reactive nitrogen species production by murine peritoneal macrophages + n + /An PI Fig The percentage of viable, dead and apoptotic cells in treated and untreated cells ... Stimulation of peritoneal macrophages by MDP increased cellular ROS and reactive nitrogen species (RNS) production The increased production of reactive species was apparent after h of stimulation...
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báo cáo khoa học: " Reactive oxygen species and transcript analysis upon excess light treatment in wild-type Arabidopsis thaliana vs a photosensitive mutant lacking zeaxanthin and lutein" pps
... affected by 1O2 and O3 , whereas there is negative correlation between the genes modulated by 1O2 and those modulated by H2O2 (Table 6) This antagonistic transcriptional regulation mediated by O and ... species and reactive nitrogen species by angiosperm stigmas and pollen: potential signalling crosstalk? New Phytologist 2006, 172:221-228 43 Potocky M, Jones MA, Bezvoda R, Smirnoff N, Zarsky V: Reactive ... -80°C Ascorbate and glutathione were extracted and assayed following the method developed by Queval and Noctor [119] ATP and ADP were assayed as previously described [120] Amino acids and sugars were...
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báo cáo khoa học: " Differential patterns of reactive oxygen species and antioxidative mechanisms during atrazine injury and sucrose-induced tolerance in Arabidopsis thaliana plantlets" ppsx
... of At1g69880 and At2g17420 TRX genes, which are induced by sucrose and by sucrose plus atrazine, in sucrose -induced tolerance Conclusion Parallel and integrative analysis therefore revealed correlated ... sucrose plus atrazine, with At3g06730 being repressed by atrazine, and At5g06690 being induced by atrazine, whereas the presence of sucrose and atrazine resulted in a return to baseline levels ... Correlatively, the situation of sucrose -induced tolerance was characterised by the lifting of atrazine repression, in the case of APX1 and sAPX, or by the induction by sucrose-atrazine combination,...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... agonist -induced apoptosis [26,27] In the present study, we investigated PPARc agonist -induced adipocyte apoptosis by using 3T3-L1 adipocytes and rat primary adipocytes Adipocyte apoptosis could be induced ... Y Xiao et al Apoptosis induced by TZDs in 3T3-L1 adipocyte A B C D F E G Fig Akt-1 reduction in troglitazone (Tro) -induced adipocyte apoptosis (A) Akt-1 and pAkt-1 in troglitazone -induced 3T3-L1 ... FEBS Y Xiao et al Apoptosis induced by TZDs in 3T3-L1 adipocyte A C D B E F G Fig Inhibition of troglitazone (Tro) -induced 3T3-L1 adipocyte apoptosis by Bcl-2 overexpression and the caspase-3...
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Báo cáo sinh học: " Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome" pptx
... with empty vector and cells treated by 50 µM cisplatin for 16 hr were set as (-) and (+) controls Transfected cells were collected at 24 hr and 48 hr after incubation and analyzed by Apoalert™ annexin-V ... Bcl2-homology domain (BH3) in HBx and HBSP which cast light on how the HBV viral proteins are involved in apoptosis at molecular level [7,8] The apoptosis induced by the viral proteins might help ... effect by HBV genome A, B, and C Flow cytometry analysis of apoptotic effect by HBV genome A, B, and C HepG2 cells were transiently transfected with HBV genome A, B, and C and incubated for 24 h...
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Báo cáo sinh học: " G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells" pot
... cycle arrest and cell apoptosis by 3b protein expression Induction of cell cycle arrest and cell apoptosis by 3b protein expression p3b/EGFP-N1 plasmid was transfected into COS-7 cells, and the DNA ... in EGFP positive and negative cells were measured by flow cytometry It was revealed that the percentages in apoptosis and necrosis were both lower and comparable in the positive and negative pEGFP-N1 ... collected and resuspended in binding buffer containing Annexin V-PE and 7-AAD, and then processed for flow cytometry analysis On the left row, EGFP positive cells were gated The middle and right...
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Báo cáo hóa học: " Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome" docx
... with empty vector and cells treated by 50 µM cisplatin for 16 hr were set as (-) and (+) controls Transfected cells were collected at 24 hr and 48 hr after incubation and analyzed by Apoalert™ annexin-V ... Bcl2-homology domain (BH3) in HBx and HBSP which cast light on how the HBV viral proteins are involved in apoptosis at molecular level [7,8] The apoptosis induced by the viral proteins might help ... effect by HBV genome A, B, and C Flow cytometry analysis of apoptotic effect by HBV genome A, B, and C HepG2 cells were transiently transfected with HBV genome A, B, and C and incubated for 24 h...
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báo cáo hóa học:" G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells" pot
... cycle arrest and cell apoptosis by 3b protein expression Induction of cell cycle arrest and cell apoptosis by 3b protein expression p3b/EGFP-N1 plasmid was transfected into COS-7 cells, and the DNA ... in EGFP positive and negative cells were measured by flow cytometry It was revealed that the percentages in apoptosis and necrosis were both lower and comparable in the positive and negative pEGFP-N1 ... collected and resuspended in binding buffer containing Annexin V-PE and 7-AAD, and then processed for flow cytometry analysis On the left row, EGFP positive cells were gated The middle and right...
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Species and Varieties, Their Origin by Mutation, by Hugo DeVries docx
... GUTENBERG EBOOK SPECIES AND VARIETIES *** Produced by Dave Gowan Species and Varieties Their Origin by Mutation Lectures delivered at the University of California By Hugo DeVries ... IX Crossing of species and varieties 247 Balanced and unbalanced, or species and variety crosses Constant hybrids of Oenothera muricata and O biennis Aegilops, Medicago, brambles and other instances ... conception of a species has been chiefly based on the definition given by Linnaeus His species comprised subspecies and varieties, which were in their turn, supposed to have evolved from species by the...
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Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... inhibited the AG147 8induced JNK activation and also AG1478 -induced apoptosis These results indicate that there is a link between the decreased MKP-1 activity and AG147 8induced apoptosis: MKP-1 expression ... for the AG1478 -induced apoptosis in PC-9 cells Stress stimuli that induce apoptosis, including UV- and c-irradiation, heat shock, protein synthesis inhibitors, DNA-damaging agents and the proinflammatory ... al JNK activation is critical for AG1478 -induced apoptosis A A B B C Fig Effect of AG1478 on phosphorylation of MKK4 and MKK7, and expression of MKP-1 and MKP-2 A, PC-9 cells were treated with...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... cells, and TAM1 cells from apoptosis induced by ADR EGF sup3748 pressed ADR -induced cytotoxicity in both TMK-1 and Puro2 cells, but not in the two dominant-negative mutant cells, TAM1 and TAM2 ... suppress apoptosis by modulating the process of apoptosis [11–14] Thus, we determined the effect of EGF on the levels of key antiapoptotic (i.e Bcl-2 and Bcl-XL) and proapoptotic (i.e Bad and Bax) ... rescue TMK-1 cells from apoptosis induced by the DNAdamaging agent ADR Pretreatment of the cells with 10 or 100 ngÆmL)1 EGF for 48 h markedly suppressed the cell death induced by 10 or 20 lm ADR,...
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Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
... supported by the Endocore Research Trust, the Maurice and Phyllis Paykel Trust, and the New Zealand Lottery Grants Board, and by Programme Grants from the New Zealand Health Research Council to GC and ... expression and phosphorylation of ATF-2 by p38 kinase during hA-evoked b-cell 3782 Fig Effects of MAPK inhibitors on hA -induced apoptosis and activation of caspase-3 Cultured RINm5F and CM cells ... protects thymocytes from apoptosis mediated by CD95 and CD3 Nature 385, 350–353 Wisdom R, Johnson R, S & Moore C (1999) c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms...
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Báo cáo khoa học: Pathways involved in testicular germ cell apoptosis induced by H2O2 in vitro doc
... H2O2 induced testicular germ cell apoptosis Western blots showing expression of (A) (intrinsic) caspase-9 and cytochrome c and (C) (extrinsic) caspase-8, FasL and Fas, which are supported by RT-PCR ... dependent and independent events in apoptosis induced by hydrogen peroxide Exp Cell Res 257, 82–88 15 Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W & Schmitz ML (1999) Hydrogen peroxideinduced apoptosis ... biomolecule in testicular germ cell apoptosis, although Fig A proposed model depicting the pathways of H2O2 -induced germ cell apoptosis The metazoan apoptosis model as proposed by Hengartner [10] has now...
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Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
... activation of this stress -induced kinase was seen by as early as after exposure (two-fold), followed by a slight increase up to (2.25-fold) and reached control levels by 60 (Figs and 2) Effect on JNK ... reduce aberrant signaling and cellular activities that may ultimately lead to SEB -induced lethal shock Our goal was to evaluate multiple signaling cascades induced by SEB and target pathway interconnector ... was visible by as early as min, showed maximum activity after (2.8-fold) and finally returned to control levels by 60 (Figs and 2) Effect on p38kinase Human PBMCs were treated with SEB and the activation...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... groups and 3, and significantly lower in group than in group at 24 h and 72 h after IR injury On the other hand, this protein expression was markedly lower in group than in groups and 3, and notably ... elicited by IR injury and ADMSC treatment contributed to further anti-inflammatory and anti-oxidative effects after IR -induced renal injury in this study Findings from Immunofluorescent and IHC ... NQO1, GR, and GPx, three anti-oxidative indicators, were remarkably lower in group than in groups and 3, and notably lower in Figure Histopathological scoring of ischemia- reperfusion (IR)-induced...
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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt
... PEP-1-SOD1 and PEP-1-CAT cooperatively protected heart against ischemia- reperfusion injury by removing OFR Ischemia- reperfusion injury induces myocardial apoptosis [28,29] OFR produced during the reperfusion ... CK-MB, cTnT and myocardial MDA levels caused by myocardial ischemia- reperfusion injury However, combination of PEP-1-SOD1 and PEP-1-CAT resulted in a greater reduction of CK, CK-MB, cTnT and MDA, ... evaluated by Flow cytometry Transduction of PEP-1-SOD1 and/ or PEP-1-CAT in rat myocardium and ischemia- reperfusion injury To observe whether transduced PEP-1-SOD1 and PEP-1CAT protect myocardial ischemia- reperfusion...
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báo cáo hóa học: " A pilot study on pupillary and cardiovascular changes induced by stereoscopic video movies" pptx
... Beat-to-beat mean pressure and heart rate were interpolated by a cubic spline function and were re-sampled every 0.469 sec to yield corresponding beat-to-beat data, denoted by BP and HR, respectively ... brightness of movies, and other causes should be sought By comparing properties of three movies (Material and Methods, presentation of motion pictures), changes in the CR might be induced by accumulation ... both by sympathetic and parasympathetic activities [13] Pupil is constricted by increased contraction of the pupillary constrictor muscle, which is innervated by parasympathetic short ciliary and...
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báo cáo hóa học: " Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat" potx
... deficits and motor impairment induced by pMCAO (assessed by the neurological score and accelerating rotarod test), it is important to emphasize the fact that these parameters were maximal by 12 ... Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia Brain Pathol 2000, 10:95-112 Iadecola C, Alexander M: Cerebral ischemia and inflammation ... infarct size continues to increase between 12 and 24–48 h of ischemia (Fig 1A), the neurological deficits and motor impairment reached their maximum by 12 h, and the animals did not showed any further...
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báo cáo hóa học: " Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid" pdf
... mouse colony maintenance and assays These studies were supported in part by the Institute for the Study of Aging (DMW) and by NIH grants R37 AG13939 (LVE), R01 AG20243 (LVE), and P01 AG21184 (LVE, ... inflammatory and neural markers Hippocampal soluble extracts were prepared by dounce and sonication in a Hepes buffer containing a protease inhibitor cocktail followed by centrifugation and collection ... antagonist We induced AD-relevant neuroinflammation and neuronal damage by intracerebroventricular (ICV) infusion of human Aβ1–42 in a mouse experimental model previously developed by us [4,5], and determined...
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