regulation of bone remodeling by neuropeptides affecting appetite cocaine and amphetamine regulated transcript cart
báo cáo hóa học:" Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Chi Zhang" pptx
... article as: Zhang, Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Journal of Orthopaedic Surgery and Research 2010, 5:37 Page of ... function of Osx are incompletely understood Osteoporosis and Osx Osteoporosis is characterized by reduced bone mass, alterations in the microarchitecture of bone tissue, Zhang Journal of Orthopaedic ... pathway of bone synthesis Conclusions Bone formation is a complex process regulated by multiple factors and pathways; it is clearly shown that Osx is required for the final commitment of osteoblast...
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Báo cáo y học: "Immune regulation of bone loss by Th17 cells" doc
... Osteoclast-independent bone resorption by fibroblast-like cells Arthritis Res Ther 2003, 5:R163-R173 Walker DG: Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and ... Osteoclastic bone resorption by a polarized vacuolar proton pump Science (NY) 1989, 245:855-857 Salo J, Lehenkari P, Mulari M, Metsikko K, Vaananen HK: Removal of osteoclast bone resorption products by ... Nesbitt SA, Horton MA: Trafficking of matrix collagens through bone- resorbing osteoclasts Science (NY) 1997, 276:266-269 Eilon G, Mundy GR: Direct resorption of bone by human breast cancer cells in...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
... early events of innate response to virus infection In a previous study, we used a constitutively active form of IRF-3 (IRF-3 5D) to stimulate transcription of genes in the absence of virus infection ... the regulation of apoptosis [21,22] Thus, the possibility that the antiviral effect of spermine is mediated by induction of apoptosis was analyzed For this purpose, the effect of spermine (50 ... expression of a constitutively active form of IRF-3 This study shows for the first time that ArgII expression is up -regulated in the context of virus infection Previous studies reported the induction of...
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Báo cáo khoa học: Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues pot
... blocked, the INO1 gene, the most highly regulated of a set of genes encoding enzymes of phospholipid biosynthesis, is deregulated (derepressed in the presence of inositol) [8] Using two criteria ... cki1D strain (deregulated level of the INO1 transcript) is twice as high as the PA level in the same strain with introduced wildtype SEC14 (normal, regulated level of the INO1 transcript) Similarly, ... SFH2 gene (deregulated level of the INO1 transcript) as in the same strain in which Pld1p-mediated turnover was abolished with pld1 disruption (normal, regulated level of the INO1 transcript) ...
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Báo cáo khoa học: Regulation of STAT signalling by proteolytic processing Lisa Hendry and Susan John doc
... Negative regulation of STAT signalling Cytokine-induced STAT activation can be inhibited by suppressors of cytokine signalling (SOCS) proteins, whose gene expression is regulated by STAT proteins, ... Upon activation of naı¨ ve T cells by mitogenic stimulation, the expression of truncated Stat5a and Stat5b proteins disappears and is replaced by the expression and activation of the full-length ... of the exact cleavage site on Stat5 will be important in enhancing our understanding of the regulation of Stat5 function by proteolytic cleavage in peripheral T cells Proteolytic regulation of...
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REGULATION OF SRF ACTIVITY BY THE ATP-DEPENDENT CHROMATIN REMODELING ENZYME, CHD8
... regulation of transcription of these genes is also controlled by additional transcription factors In addition to SRFdependent proliferation genes, the lack of SRF affects the expression of smooth ... 90 Curriculum Vitae x LIST OF TABLES Table Changes in apoptotic genes as a result of loss of CHD8 72 xi LIST OF FIGURES Figure Schematic of functional domains of serum response factor (SRF) ... Growth Factor (PDGF) Promotion of proliferation and migration of smooth muscle cells accompanied by the downregulation of smooth muscle markers can be regulated by platelet derived growth factor...
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Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot
... Arosio P (1988) Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site A study of iron uptake and ferro-oxidase activity of human liver, recombinant ... that treatment of RAW 264.7 cells with the NO+ donor, SNP, causes the degradation of IRP2 associated with an increase of ferritin synthesis [20,37] Here, we examined the kinetics of ferritin synthesis ... RNA-binding activity of IRP1 remained largely unaffected (Fig 1B) Surprisingly, the rapid induction of ferritin synthesis by SNP in RAW 264.7 cells occurred much earlier than any decrease of IRP activities...
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REGULATION OF INTEREST RATE BY THE STATE BANK OF VIETNAM (SBV) potx
... on loans on the basis of market capital supply – demand and the creditability of borrowers” Page of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) This ... Liberalization of interest rate From the year Page 18 of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) 1994, Credit limit mechanism was deleted, replacing by other ... Loc MBA Intake 13 CFVG, Hanoi, June 2006 Page of 20 International Finance Regulation of Interest Rate by the State Bank of Vietnam (SBV) THE ROLES OF INTEREST RATE Interest Rate is a key economic...
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Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx
... Down-regulation of telomerase activity by induction of differentiation of HL-60 cells has been reported [24,25] To understand the role of each telomerase subunit in enzyme activity, we used downregulation of ... activity, we used downregulation of telomerase by inducing differentiation of HL-60 cells, and up-regulation of telomerase by stimulating proliferation of peripheral blood mononuclear cells (PBMC) ... addition of 100 lL of tetramethylbenzidine substrate solution to each well Ten later, the reactions were stopped by the addition of 100 lL M HCl to each well Colorimetric signals were determined by...
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Molecular Regulation of Endocytosis Edited by Brian Ceresa pot
... to the absence of the VID22 gene is rescued by the addition of purified Cpr1p in vitro or by overexpressing Cpr1p in vivo As such, the Cpr1p protein, whose levels are regulated by Vid22p, directly ... sequestered in the lumen of Vid vesicles [44] Addition of 2% Triton X-100 to permeabilize the Vid vesicle membrane resulted in digestion of FBPase by proteinase K Thus, a portion of FBPase is sequestered ... indicative of an impaired production of the Vid vesicles At present, the mechanism by which UBC1 is involved in the biogenesis of Vid vesicles has not been elucidated Moreover, the formation of multi-ubiquitin...
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Báo cáo khoa học: Submembraneous microtubule cytoskeleton: regulation of microtubule assembly by heterotrimeric G proteins pptx
... [57,58], Ga ⁄ tubulin Agonist GPCR Gαβγ α Gα Activation of GTPase of tubulin by Gα, and inhibition of MT assembly Gβγ Loss of GTP cap on MT end by Gα promotes catastrophy in di and increase i MT dynamics ... Effect GDPTubulin Effectors Promotion of MT assembly by Gβγ GTP-Tubulin γ-Tub Fig Model for the regulation of microtubule (MT) assembly by a and bc subunits of G proteins Based on in vitro results ... new understanding of the mechanism of action of the anti-mitotic ⁄ anti-cancer drugs and allow for the development of new drugs that might be more effective in the treatment of cancer c-Tubulin–Gbc...
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Báo cáo khoa học: Regulation of ascidian Rel by its alternative splice variant pdf
... Ministry of Education, Science, Sports, Culture, and Technology of Japan References Fig Effect of Ci-IjB on transcriptional activity of As-rel1 Transcriptional activity of As-rel1 in the presence of ... members hitherto reported Interaction of Ci-IjB with As-rel1 and As-rel2 Fig Effect of As-rel2 on transcriptional activity of As-rel1 Transcriptional activities of As-rel1 and As-rel2, transiently ... amounts of transfected DNA were kept constant (1.5 lg) by adding an empty vector (pBIND or pCI-neo-Flag vector) The level of activity was normalized on the basis of the level of activity of control...
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Báo cáo sinh học: " Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc
... terminal repeat (LTR) comprised of a single copy of transcriptional enhancer followed 25-bp downstream by a 21-bp sequence triplicated in tandem The sequence and position of the 21-bp triplication ... Figure 1of the U3 region promoter (Pro) boxes) and transcriptional of the FeLV-945 LTR, indicating the transcriptional enhancer (hatched box), 21-bp triplication (open Diagram Diagram of the U3 ... expression of the firefly luciferase gene was driven by the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element Reporter gene constructs were introduced by lipid-mediated...
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báo cáo hóa học:" Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR" doc
... terminal repeat (LTR) comprised of a single copy of transcriptional enhancer followed 25-bp downstream by a 21-bp sequence triplicated in tandem The sequence and position of the 21-bp triplication ... Figure 1of the U3 region promoter (Pro) boxes) and transcriptional of the FeLV-945 LTR, indicating the transcriptional enhancer (hatched box), 21-bp triplication (open Diagram Diagram of the U3 ... expression of the firefly luciferase gene was driven by the U3 region of an FeLV LTR containing one, two or three copies of the 21-bp element Reporter gene constructs were introduced by lipid-mediated...
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Báo cáo y học: " Regulation of Sox9 activity by crosstalk with nuclear factor-κB and retinoic acid receptors" pptx
... directly regulated by binding of membrane-permeable agonists An example of such an agonist is all-trans retinoic acid (atRA), a metabolite of vitamin A, that is bound preferentially by the α, ... were analyzed by densitometry using Kodak Digital Science software (Eastman Kodak, Rochester, NY, USA) Data were analyzed by paired t-tests, or by analysis of variance followed by Tukey's multiple ... attenuated the effect of TNF-α on Sox9 activity, but regulation of Sox9 activity by atRA was maintained Data are ratios of Sox9 -regulated firefly luciferase units to constitutive SV40 -regulated renilla...
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Báo cáo y học: " Regulation of cardiac microRNAs by serum response factor" potx
... expression of mature miR-21 at the post-transcriptional Page 11 of 13 level through accelerating the process of pri-miR-21 into precursor miR-21 (pre-miR-21) by the DROSHA complex [41] Mir-21 is one of ... the level of polycistronic transcription, rather than at each individual miRNA (pri-mir-1 or pri-mir-133a) transcription, Figure 10 A model of miRNA regulation mediated by SRF and its cofactors, ... expression level of miR-499 is similar to that of U6-snRNA 2D Differential expression of pri-miRNA transcripts Both pri-mir-1-1 and pri-mir-1-2 are processed into mature miR-1, but pri-mir-1-1 transcript...
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Báo cáo y học: "Preferential regulation of duplicated genes by microRNAs in mammals" ppt
... both of which are regulated by a number of microRNAs These genes are transcription factors that show divergent expression patterns [16,37,38], yet deletion of Myod1 leads to the up-regulation of ... are regulated by a common set of transcription factor(s), denoted as U Protein products of both T1 and T2 regulate the target protein P However, the effect of T1 regulation on P is attenuated by ... time Figure Dynamic simulation of regulation of duplucate genes by microRNA Dynamic simulation of regulation of duplucate genes by microRNA (a) A schematic diagram of a hypothetical microRNA-mediated...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 1
... Identification of NHE1 gene as a transcriptional target of PPARγ…… 169 4.1.2 The mechanism of PPARγ-mediated repression of NHE1 gene 171 4.1.3 Production of ROS/RNS by PPARγ ligands ... areas: identification of estrogen -regulated target genes, ERassociated cofactors that influence the transcriptional activity of ER, characterization of histone and DNA modification of ER specific genes, ... Figure 26: Binding of PPARγ to PPRE is blocked in the presence of estrogen Figure 27: Transcriptional activity of PPARγ is blocked in the presence of estrogen Figure 28: Binding of ERα to ERE is...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 2
... consists of Direct Repeat (DR) of AGGTCA spaced by one nucleotide (DR1) However, binding of PPAR to direct repeat of AGGTCA spaced by two nucleotides (DR2) has also been found in the promoter of myeloperoxidase ... with increasing doses of 15d-PGJ2 Overexpression of PPARγ after 48h of transfection is shown at top panel After 16h of drug treatment, the mRNA expression of NHE1 was analyzed by real-time PCR, normalized ... as a transcriptional target of PPARγ To test the involvement of transcriptional activity of PPARγ in its inhibitory effect on NHE1 expression, we overexpressed a dominant-negative form of PPARγ...
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THE MECHANISM OF PPARN3 MEDIATED DOWN REGULATION OF SODIUM HYDROGEN EXCHANGER 1 (NHE1) GENE EPXRESSION AND ITS INHIBITION BY ESTROGEN RECEPTOR n1 4
... inhibitory effect of E2 on PPARγ-mediated down-regulation of NHE1 Since re-expression of ERα and its activation by E2 in ER negative MDA-MB231 cells rescued the inhibition of NHE1 expression by PPARγ ... reduction of NHE1 mRNA caused by 3μM of 15d-PGJ2 However, when ERα receptor was silenced in these cells, 3μM of 15d-PGJ2 resulted in similar decrease of NHE1 mRNA in the absence or presence of E2 ... pre-incubated with 1μM of E2 before they were exposed to 3μM of 15d-PGJ2 or 10μM of ciglitazone or 15μM of troglitazone, and the cells were next harvested and subjected to NHE1 mRNA analysis by real-time...
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